电切电灼术＋抗癌药物灌注治疗腺性腺胱炎（附7例报告）

采用经尿道电切电灼术后，化疗药物灌注膀胱溯朱性腺胱炎７例。结果显示所有病例均无复发，效果满意，认为经尿道电切电灼术后化疗药物灌注膀胱，对腺性膀胱炎能起到积极，有效的治疗作用。     

经尿道等离子体双极电切加膀胱灌注治疗女性腺性膀胱炎的临床研究

目的：探讨经尿道等离子体双极电切加膀胱灌注治疗腺性膀胱炎的临床效果。方法对65例女性腺性膀胱炎患者采用经尿道等离子体双极电切膀胱粘膜术及术后膀胱内丝裂霉素灌注治疗。结果65例随访6~24个月治愈56例,好转6例,3例术后复发。结论经尿道等离子体双极电切术加膀胱灌注治疗腺性膀胱炎疗效确切,即消除可治临床症状,又可预防复发和恶变,值得基层医院推广。     

腺性膀胱炎临床研究报告

目的：探讨腺性膀胱炎的诊断和治疗方法及效果。方法：对17例腺性膀胱炎患者行抗感染,经尿道电切电灼、膀胱内灌注药物,部分或全膀胱切除等治疗。结果：随访13例经尿道电切电灼加药灌注者,平均随访时间46个月,9例一次治愈,1例经4次电切后,行膀胱全切术。结论：膀胱镜检查结合组织活检是诊断腺性膀胱炎的主要手段;经尿道电切电灼加膀胱内化疗是主要的治疗方法。     

女性腺性膀胱炎31例治疗体会

目的：探讨女性腺性膀胱炎的诊断和治疗。方法：膀胱镜检结合组织活检确诊31例女性腺性膀胱炎均行经尿道电切术加膀胱灌注治疗。结果：31例均获6～36个月随访,22例治愈,6例好转,2例复发,1例失访。无1例癌变。结论：经尿道电切术加膀胱灌注是治疗女性腺性膀胱炎的行之有效的手段。     

腺性膀胱炎51例报告

目的探讨腺性膀胱炎的诊断和治疗。方法对51例腺性膀胱炎患者行经尿道电切术和药物灌注治疗。结果51例患者随访6个月～48个月,平均32个月。其中46例治愈,5例6个月～12个月内复发。结论膀胱镜检查结合组织活检对腺性膀胱炎的早期诊断具有重要意义;经尿道电切或者电灼加膀胱内药物灌注是重要的治疗方法。     

35例腺性膀胱炎的治疗分析

目的探讨电气化镜电切加膀胱内灌注药物治疗腺性膀胱炎的疗效。方法对35例腺性膀胱炎患者行经尿道电气化镜电切术及术后膀胱内羟喜树碱灌注治疗。结果35例随访一年,治愈32例,好转2例,一例于术后4个月复发。结论经尿道电气化镜电切加膀胱内药物灌注治疗腺性膀胱炎,是理想的治疗方法,即可消除临床症状,又可预防复发及癌变。     

腺性膀胱炎诊断及治疗

目的:探讨腺性膀胱炎的诊断及回顾性分析腺性膀胱炎患者行经尿道腺性膀胱炎电切联合丝裂霉素膀胱灌注与单纯行经尿道腺性膀胱炎经尿道电切的疗效。方法:选择初发性腺性膀胱炎电切术后定期复查患者40例,其中术后坚持膀胱灌注和未坚持膀胱灌注的患者例数分别为26例和14例,分为联合组和单纯手术组。结果:40例随访6～30个月,平均24个月,联合组有效率为84.6%,对照组有效率为57.1%,两者比较差异有统计学意义(χ2=2.34,P<0.05),术后两组患者不良反应发生少,没有并发症发生,联合组患者没有因不良反应而停止药物灌注者。结论:经尿道腺性膀胱炎电切联合丝裂霉素膀胱灌注治疗腺性膀胱炎疗效好,可明显降低术后复发率;腺性膀胱炎检查方法首选膀胱镜检查及膀胱黏膜活组织检查。     

经尿道汽化电切术治疗腺性膀胱炎的临床体会

目的探讨腺性膀胱炎采用经尿道汽化电切术和术后膀胱化疗药物灌注治疗的疗效。方法对25例腺性膀胱炎患者采用经尿道汽化电切术和术后辅以膀胱灌注治疗。结果25倒患者全部治愈,术后随访3个月至2年,未见无复发。结论经尿道汽化电切术加术后膀胱化疗药物灌注是治疗腺性膀胱炎有效的方法之一。     

腺性膀胱炎的诊断和治疗

目的：探讨腺性膀胱炎的诊断和治疗效果。方珐：回顾分析32例腺性膀胱炎的临床资料，诊断和治疗方法。结果：32例中27例行经尿道电切术加膀胱药物灌注。5例只给予膀胱药物灌注。随访3—68mo，其中治愈26例，6例好转者在6—24mo内复发，1例在再次手术后4a恶变为膀胱腺癌。结论：膀胱镜检查并组织活检对腺性膀胱炎的早期诊断具有重要意义；经尿道电切加膀胱药物灌注是腺性膀胱炎的有效治疗方法。     

78例腺性膀胱炎的诊断和治疗

目的　探讨腺性膀胱炎的诊断和治疗效果。方法　对78例腺性膀胱炎患者行经尿道气化电切加膀胱内药物灌注等治疗。结果　78例随访3～2 4个月。其中5 4例膀胱镜检查正常,症状消失,治愈率69.2 3 % ;2 3例症状好转者6～15个月内复发,占2 9.49% ;1例在术后2年恶变为膀胱腺癌,占1.2 8%。结论　膀胱镜检查结合活检对腺性膀胱炎的早期诊断具有重要意义;经尿道气化电切加膀胱内药物灌注是腺性膀胱炎的有效治疗方法。腺性膀胱炎有恶变倾向,应密切随访。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.