可脱性弹簧圈栓塞治疗脑血管痉挛期颅内动脉瘤

目的　探讨可脱性弹簧圈在脑血管痉挛期 (4～ 14d)栓塞治疗颅内动脉瘤的方法及效果。方法　 2 0 0 4年 3～ 8月共栓塞颅内动脉瘤 14例 ,其中颈内动脉瘤 1例 ,后交通动脉瘤 8例 ,前交通动脉瘤5例 ,所有患者均在 4～ 14d内采用DCS MATRIX材料进行栓塞。结果　 11例栓塞 10 0 % ,2例栓塞 70 %～ 90 % ,1例栓塞 5 0 % ;其中有 6例发现有脑血管痉挛。结论　在脑血管痉挛期 ,血管内栓塞动脉瘤也是一种安全、微创、有效的治疗方法。     

伴有脑血管痉挛破裂颅内动脉瘤的栓塞治疗

目的　 探讨伴有脑血管痉挛 (CVS)破裂颅内动脉瘤的栓塞治疗经验。方法　回顾 2 4例脑血管造影显示有CVS的破裂颅内动脉瘤的血管内治疗。Hunt&Hess1 5级分别有 2、8、7、4和 3例。前交通动脉瘤 8例、后交通动脉瘤 10例 ,颈内动脉床突旁动脉瘤 3例 ,大脑中动脉动脉瘤 3例。采用全麻下 ,超选动脉瘤囊内弹簧圈 (GDC或EDC)栓塞后 ,动脉内注射 0 .3%罂粟碱 ,部分血管痉挛改善不明显者予行球囊血管成形术 ,术后均给予“三高”治疗。结果　脑血管造影CVS位于动脉瘤近端 9例、远端 5例、两者均有 10例。CVS位于一侧 13例、双侧 6例、弥漫性 5例。 2 2例成功地进行了动脉瘤栓塞和动脉内注射罂粟碱 ,并有 4例行球囊血管成形术 ,动脉瘤 10 0 %闭塞 17例、闭塞 90 %以上 5例。 2例因微导管无法通过载瘤动脉而放弃。本组无栓塞术中动脉瘤破裂和载瘤动脉闭塞 ,球囊成形术者没有出现动脉夹层瘤或破裂。随访无动脉瘤再出血 ,GOS优良 17例、中重残 3例、死亡 2例。结论　伴有CVS的动脉瘤行血管内治疗并不增加危险 ,可同时治疗动脉瘤和伴发的CVS ,可降低因等待手术而发生的院内再出血和改善CVS患者的预后 ,降低病死率和残废率。     

电解可脱式弹簧圈栓塞治疗颅内动脉瘤破裂

目的　探讨血管内电解可脱式铂金微弹簧圈 (GDC)早期栓塞治疗破裂后颅内动脉瘤的临床价值。方法　对 15例破裂后颅内动脉瘤施行血管内GDC早期栓塞治疗 ,15例患者按Hunt Hess分级 :I级 8例、II级 6例、IV级 1例 ,所有病例均经DSA造影和CT扫描诊断。结果　GDC栓塞手术成功13例 ,占 86 .7% (13/ 15 ) ;13例随访 3～ 2 5个月无再次出血和并发症 ,其中 2例 6个月后复查DSA未见复发 ,全部病例头颅正侧位片显示GDC形态、位置无改变 ;栓塞手术失败的 2例患者分别于术后第 4天和 4个月死亡。结论　早期GDC血管内栓塞治疗破裂后颅内动脉瘤为有效方法 ,可以防止再次破裂出血。     

Matrix可脱弹簧圈栓塞治疗颅内动脉瘤

目的　探讨Matrix可脱弹簧圈血管内栓塞治疗颅内动脉瘤的临床价值。方法　对 5 1例共 5 6枚颅内动脉瘤施行血管内Matrix可脱弹簧圈栓塞治疗 ,5 1例患者按Hunt Hess分级 :Ⅰ级 15例、Ⅱ级 2 4例、Ⅲ级 8例、Ⅳ级 4例 ,所有病例均经CT扫描和DSA造影诊断。 4例宽颈动脉瘤和 2例梭形动脉瘤采用Neuroform支架结合Matrix可脱弹簧圈栓塞治疗。结果　应用Matrix可脱弹簧圈栓塞成功 4 8例 5 3枚动脉瘤 ,占 94 .3% ;3例因严重血管痉挛导致微导管无法到位而实施动脉瘤夹闭术 ;1例弹簧圈尾端残留于载瘤动脉 ,但未导致临床后果 ;无死亡及严重并发症 ;4 8例随访 3～ 12个月无再次出血和并发症。结论　Matrix可脱弹簧圈血管内能够有效栓塞颅内各部位动脉瘤 ,术中有明显的促进动脉瘤腔内形成血栓的作用 ,术后促进血管内皮细胞生长覆盖动脉瘤颈口的作用。可以防止再次破裂出血。     

颅内破裂动脉瘤栓塞术后早期破裂再出血危险因素分析

目的探讨颅内破裂动脉瘤栓塞术后早期破裂再出血的临床特点及危险因素,以减少动脉瘤栓塞术后早期再出血的发生率,为临床治疗方法的选择提供依据。方法回顾性分析我科2002年7月至2007年10月经全脑血管造影确诊的颅内破裂动脉瘤并行血管内介入栓塞治疗的病例,分析栓塞术后早期再出血病例(病例组)的临床及影像学特征,从同期治疗的未再出血的患者中随机抽取123例病例作为对照组,对两者的可疑危险因素进行单变量与多变量的统计学分析。结果881例行介入栓塞治疗的颅内破裂动脉瘤中有17例(1.93%)发生早期破裂再出血,其中12例(占70.6%)死亡。颅内破裂动脉瘤栓塞术后早期破裂再出血的独立危险因素为动脉瘤的真假性、术前动脉瘤的破裂次数、术中造影有明显的脑血管痉挛及动脉瘤的栓塞程度4项。并得到预测栓塞术后早期再出血概率的方程。结论本研究显示栓塞术后早期破裂再出血的发生率低,但预后差,病死率高。术前针对危险因素进行预防、术中尽可能致密栓塞动脉瘤、术后早期及时复查脑血管造影有利于减少颅内破裂动脉瘤栓塞术后早期再出血率,积极再治疗可以改善早期再出血患者的预后。     

电解可脱性弹簧圈栓塞颅内动脉瘤相关问题的探讨

目的　总结使用电解可脱性弹簧圈 (GDC)栓塞颅内动脉瘤时旋转DSA的应用及GDC操作要点。方法　对 38例共 4 0个颅内动脉瘤常规行旋转DSA检查 ,动脉瘤直径 4～ 2 5mm ,平均(12 5 1± 5 37)mm。瘤体直径 <12mm的小动脉瘤 2 9个 ,12～ 2 5mm的大动脉瘤 11个。术前Hunt Hess分级Ⅰ～Ⅳ级分别是 2 6例、8例、3例、1例。随后使用GDC栓塞治疗。结果　 37例 39个颅内动脉瘤栓塞成功 ,1例死亡。完全栓塞 (>95 % ) 2 2个 ,大部分栓塞 (80 %～ 95 % ) 12个 ,部分栓塞(<79% ) 5个。并发动脉瘤破裂 2例 ,治疗后痊愈。并发脑动脉痉挛 6例 ,治疗后 2例遗留轻偏瘫和单瘫。 2例弹簧圈部分遗留于动脉瘤外 ,经抗凝治疗未发生并发症。 2例复发再次栓塞后痊愈。结论GDC栓塞治疗颅内动脉瘤是 1种安全、可靠、有效的治疗方法。合理应用旋转DSA技术、熟练的GDC操作可提高诊断的准确性及治疗的安全性     

电解可脱式微弹簧圈栓塞治疗颅内动脉瘤

目的：探讨电解可脱式微弹簧圈(GDC)栓塞治疗颅内动脉瘤的方法。方法：采用美国波士顿公司GDC栓塞治疗17例患者18个颅内动脉瘤，其中15例蛛网膜下腔出血患者，术前Hunt和Hess分级：I、Ⅱ级l0例；Ⅲ级3例；Ⅳ级2例。结果：13例痊愈，3例轻度短期神经功能障碍，1例死亡。结论：GDC栓塞是治疗颅内动脉瘤较为理想的方法之一。     

动脉瘤性蛛网膜下腔出血的电解可脱卸弹簧圈栓塞治疗(附14例报告)

目的:探讨电解可脱卸弹簧圈(GDC)治疗颅内动脉瘤的临床效果。方法:应用GDC栓塞治疗14例16个颅内动脉瘤,并复习其临床特点及影像。Hunt Hess分级:Ⅰ级4例、Ⅱ级7例、Ⅲ级2例、Ⅳ级1例。14例均在栓塞术后行腰椎穿刺脑脊液置换,7例术后6个月内造影复查。结果:14例16个动脉瘤中,位于后交通动脉5例,前交通动脉3例,基底动脉3例,椎动脉3例。16个动脉瘤完全闭塞15个,部分闭塞(>于95 % ) 1个。3例神经系统症状彻底恢复,4例睑下垂改善明显,7例眼外肌麻痹恢复较慢。无1例术中动脉瘤破裂出血。结论:短期的随访结果表明,对引起蛛网膜下腔出血的颅内动脉瘤,GDC栓塞术是一种安全、有效、创伤小值得信赖的治疗方法。尽管此报告的病例数目较少,脑血管造影证实其良好效果与相关报道相似。     

经颅多普勒在前循环动脉瘤破裂致脑血管痉挛中的应用价值

目的 探讨经颅多普勒(TCD)在前循环动脉瘤破裂致症状性脑血管痉挛中的应用价值.方法 回顾性分析我院神经外科2010年4月～2020年4月收治的前循环动脉瘤性蛛网膜下腔出血,诊断为症状性脑血管痉挛的患者62例,所有患者在发病后连续每天行TCD检查,连续观察大脑中动脉血流速度,诊断为症状性脑血管痉挛后行脑血管造影检查(D...     

电解可脱性弹簧圈栓塞颅内动脉瘤结合低分子肝素治疗蛛网膜下腔出血

我院自 2 0 0 0年 1月～ 2 0 0 3年 12月采用电解可脱性弹簧圈血管内栓塞治疗颅内动脉瘤 35例 ,取得良好的临床效果。结果报道如下。材料与方法一、一般资料35例患者 ,男 19例 ,女 16例 ,年龄 2 7～ 6 6岁 ,平均 4 8岁。 32例表现为自发性蛛网膜下腔出血 ,2例表现为动眼神经麻痹 ,1例仅表现为单纯头痛。动脉瘤Hunt Hess分级 :I～II级 33例 ,Ⅲ级 2例。 3d内实施手术 7例 ,其余 2 8例于 14～ 2 8d内实施手术。二、影像学检查本组 35例患者均行颅脑CT和全脑血管造影(DSA)检查。(一 )CT检查　表现为蛛网膜下腔出血 32例 ,其中破入脑室 5例…     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

High Intensity Interval Training:New Insights

KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief，intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.，≥90%of VO2 peak).     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

Developmental validation of the PowerPlex(®) ESI 16 and PowerPlex(®) ESI 17 Systems: STR multiplexes for the new European standard

In response to the ENFSI and EDNAP groups’ call for new STR multiplexes for Europe, Promega^® developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex^® ESI 16 (European Standard Investigator 16) and the PowerPlex^® ESI 17 Systems. The PowerPlex^® ESI 16 System combines the 11 loci compatible with the UK National DNA Database^®, contained within the AmpFlSTR^® SGM Plus^® PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR^® SGM Plus^® kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex^® ESI 17 System amplifies the same loci as the PowerPlex^® ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR^® SGM Plus^® kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex^® ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5 pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54–86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons has substantially improved the quantity of data obtained from degraded samples, and the improved chemistry confers exceptional tolerance to high levels of laboratory prepared inhibitors.     

Bronchial stump fistula :treatment with covered retrievable hinged metallic stents-preliminary clinical experience

Objective To evaluate the preliminaily clinical efficacy and retrievability of a retrievable hinged covered metallic stent in the treatment of the bronchial stump fistula （BSF）. Methods Between April 2003 and March 2005, 8 patients with bronchial stump fistula after pneumonectomy or lobectomy were treated with two types （A and B） of retrievable hinged covered metallic stents. Type A stent was placed in 6 patients and type B in 2 under fluoroscopic guidance. The stent was removed with a retrieval set when BSF was healed or complications occurred. Results Stent placement in the bronchial tree was technically successful in all patients, without procedure-related complications. Immediate closure of the BSF was achieved in all patients after the procedure. Stents were removed from all patients but one. Removal of the stents was difficult in two patients due to tissue hyperplasia. Patients were followed up for 6 - 21 months. Placement of the stents remained stable in all patients except one due to severe cough. Permanent closure of BSF was achieved in 7 （87.5%） of 8 patients. Conclusion Use of a retrievable hinged covered expandable metallic stent is a simple, safe, and effective procedure for closure of the BSF. Retrieval of the stent seems to be feasible. （J Intervent Radiol, 2007, 16： 253-257）     

Prevalence and severity of hip and groin pain in sub‐elite male football: a cross‐sectional cohort study of 695 players

The purpose of this study was twofold: (a) to investigate the prevalence of hip and groin pain in sub‐elite male adult football in Denmark and (b) to explore the association between prevalence and duration of hip and groin pain in the previous season with the Copenhagen Hip and Groin Outcome Score (HAGOS) in the beginning of the new season. In total 695 respondents from 40 teams (Division 1–4) were included. Players completed in the beginning of the new season (July–Sept 2011) a self‐reported paper questionnaire on hip and/or groin pain during the previous season and HAGOS. In total 49% (95% CI: 45–52%) reported hip and/or groin pain during the previous season. Of these, 31% (95% CI: 26–36%) reported pain for >6 weeks. Players with the longest duration of pain during the previous season had the lowest HAGOS scores, when assessed at the beginning of the new season, P < 0.001. This study documents that half of sub‐elite male adult football players report pain in the hip and/or groin during a football season. The football players with the longest duration of pain in previous season displayed the lowest HAGOS scores in the beginning of the new season.