间断光疗新生儿高胆红素血症临床观察

我们于１９９８年５—６月对２２例住院的高胆红素血症的患儿采用间断光疗,并与同期２８例持续光疗的高胆红素血症的患儿作对照,以观察黄疸消褪情况,现总结如下。１．一般资料２２例中,男１２例,女１０例。其中母乳性黄疸８例,感染所致黄疸１０例,血培养有致病菌生长者３例,Ｔｏｒｃｈ筛查阳性者３例;围产因素所致黄疸２例;红细胞增多症所致黄疸１例;原因不明所致黄疸１例。入院时查总胆红素在２０５μｍｏｌ／Ｌ～２５５μｍｏｌ／Ｌ间１８例;≥２５５μｍｏｌ／Ｌ５例。对照组２８例中,男１６例,女１２例。其中母乳性黄疸１…     

新生儿黄疸的胆红素浓度与碳氧血红蛋白及血氧饱和度关系研究

对２２例新生儿黄疸患儿同步监测血中碳氧血红蛋白、血氧饱和度及胆红素浓度。发现随胆红素浓度增加，血中碳氧血红蛋白同时增加，两者呈线性正相关（Ｐ〈０．０５）。胆红素〉３４２μｍｏｌ／Ｌ组患儿的血氧饱和度低于胆红素〈２０５．２μｍｏｌ／Ｌ（Ｐ〈０．０５）。本研究证实监测血中碳氧血红蛋白可准确反映出胆红素分解代谢。     

新生儿高间接胆红素血症病因及治疗探讨

新生儿高间接胆红素血症病因及治疗探讨王西阁王玉红河南医科大学第三附属医院（４５００５２）黄疸是新生儿时期常见症状之一。足月儿血清胆红素值≥２０５．２μｍｏｌ／Ｌ，早产儿血清胆红素值≥２５６．５μｍｏｌ／Ｌ称为高胆红素血症（简称高胆）。其病因较多，少数...     

新生儿高间接胆红素血症382例病因分析

目的：了解不同原因所致新生儿高间接胆红素血症的发病率及其临床特点。方法：对３８２例高间接胆红素血症患儿进行末梢血胆红素监测。结果：围产因素占２２８％、新生儿溶血占１７８％、感染因素占１９４％、母乳性黄疸占１４４％、不明原因者占２１５％、其它原因占４２％。结论：新生儿溶血性黄疸出现最早，峰值最高，重度黄疸的比例最大；围产因素次之，感染因素所致高间接胆红素血症多为早期感染，病程较短，与治疗是否及时、感染程度有关；母乳性黄疸出现黄疸最晚，病程最长；不明原因组黄疸的特点与生理性黄疸有一定的相似，认为可能包括部分“生理性”黄疸。     

母乳性黄疸29例临床诊治体会

母乳性黄疸２９例临床诊治体会张淑梅崔丽霞冯万松郑州市妇幼保健院（４５００５３）１９９２年至今，我科共收治新生儿高胆红素血症２３８例，其中母乳性黄疸２９例，占１２％。日龄在１６～４７天之间，入院时胆红素在１０２μｍｏｌ／ｌ～３３０μｍｏｌ／ｌ之间，间接...     

临床表现特殊的甲亢2例误诊分析

例１：男性，６６岁，腹泻２月余，纳差黄疸１５ｄ入院。查：消瘦明显，巩膜中度黄染，甲状腺无肿大，肝脾肋下未触及，肝区轻叩痛，肠鸣音活跃。实验室检查：总胆红素９２μｍｏｌ／Ｌ，直接胆红素５１．３μｕｏｌ／Ｌ，间接胆红素４０．７μｍｏｌ／Ｌ，谷丙转氨酶２１...     

蓝光照射治疗新生儿高胆红素血症的临床护理

作者对２０例新生儿高胆红素血症应用蓝光治疗，并就其护理中注意事项进行了严密观察。２０例患儿中原发病为败血症者１１例，头颅血肿２例，宫内窘迫窒息５例，母乳性黄疸２例，血清胆红素值均超过了２５０μｍｌ／Ｌ，直接胆红素均低于６８μｍｏｌ／Ｌ。结果表明，黄疸程度越重，所需光疗时间相对越长，但光疗前准备工作及适应症选择、光疗中体温监测、供氧、保证足够热卡供应及维持水电解平衡、补充核黄素等治疗效果均至关重要。     

胆总管内壁部分倒袋畸形1例

例１患者女性 ,６１岁 ,因右上腹疼痛伴发热及全身皮肤、巩膜黄染４ｄ于１９９６年７月８日经外科门诊以“阻塞性黄疸”而收往入院。入院后追问病史方知１０年来均有类似发作史 ,均作保守治疗缓解。体检 :生命体征稳定 ,全身皮肤及巩膜轻度黄染 ,颈静脉无怒张 ,腹软 ,莫菲征 (++)。实验室检查 :总胆红素５７．３μｍｏｌ／Ｌ,直接胆红素３４．２μｍｏｌ／Ｌ,间接胆红素２３．１μｍｏｌ／Ｌ。血Ｈｂ１４．１ｇ／Ｌ,ＷＢＣ１３．４×１０９／Ｌ ,Ｎ０．８４,Ｌ０．１６。Ｂ型超声检查示胆囊多发性泥沙样结石 ,胆总管直径１．７ｃｍ(内含泥砂…     

新生儿高胆红素血症临床相关因素分析

新生儿高胆红素血症是新生儿常见病症之一。近年来由于母乳喂养的推广和普及,发病率有增高趋势。高胆红素血症的构成因素也有所变化,现将１９９７年３月至２０００年３月我院收治的４８例新生儿高胆红素血症的相关因素分析如下。１临床资料４８例新生儿高胆红素血症均符合足月儿≥２０５μｍｏｌ／Ｌ,早产儿≥２５６μｍｏｌ／Ｌ,以间接胆红素为主的诊断标准［１］。男２９例,女１９例;早产儿８例,足月儿３９例,过期产儿１例;发病日龄＜２４小时４例,～７２小时３８例,～２８天６例。２结果本组病因以围生期因素占首位,共２２例…     

母乳性黄疸33例临床分析

收集母乳性黄疸３３例，其中男１９例，女１４例，平均出生年龄为１８ｄ，平均就诊时间为１８ｄ，均为足月儿．３３例中单纯母乳喂养者３０例，混合喂养者３例；早发型２０例，迟发型１３例，胆红素升高以间接胆红素轻，中度增高为主（９０％），停母乳３～５ｄ后黄疸全部消退，无１例出现胆红素脑病．     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.