粟米草三萜皂苷抗实验性心律失常作用的研究

目的研究粟米草三萜皂苷抗实验性心律失常的作用。方法分别采用氯化钙、乌头碱、氯仿-肾上腺素三种药物诱发实验性心律失常的动物模型,通过BL-420生物机能实验系统记录动物心电图,并对心电图进行分析,观察粟米草三萜皂苷对各种实验性心律失常的影响。结果粟米草三萜皂苷能明显降低氯化钙所致大鼠心律失常的发生率和死亡率,不同程度地延长实验性心律失常的潜伏期和缩短持续期,并对氯仿-肾上腺素致家兔心律失常具有有效保护作用。结论粟米草三萜皂苷具有抗实验性心律失常作用。     

快律宁对实验性心律失常的干预作用

目的:研究快律宁对药物诱发实验性心律失常的干预作用。方法:制备乌头碱、氯化钡诱发大鼠实验性心律失常模型和哇巴因诱发豚鼠实验性心律失常模型,记录给予氯化钡后大鼠心律失常出现时间和维持时间以及大鼠/豚鼠出现室早、室速及室颤时的乌头碱和哇巴因的用量,观察快律宁不同剂量对上述模型的保护作用。结果:快律宁可明显推迟氯化钡诱发大鼠心律失常出现时间,并缩短其维持时间;可提高大鼠出现室早、室速、室颤时的乌头碱用量,并提高豚鼠出现室颤时哇巴因用量。结论:快律宁对药物诱发的实验性心律失常有保护作用,其抗心律失常机制可能与影响心肌多离子通道有关。     

纳洛酮对头针治疗大鼠实验性心律失常效应的影响

目的:研究头针治疗大鼠实验性心律失常效应的中枢作用机制.方法:在氯化钡诱发实验性心律失常模型上,在中脑导水管周围灰质(PAG)内注射阿片受体拮抗剂纳洛酮(naloxone,NX),头针电刺激大鼠头部双侧"额旁1线"区域,记录各组大鼠心电图.结果:PAG内注射NX对氯化钡诱发实验性心律失常大鼠心律及心率的变化无明显的影响,头针使实验性心律失常持续时间缩短,能有效调整异常心率(P＜0.01),其效应可以被PAG内注射NX完全翻转(P＜0.01).结论:头针电刺激治疗大鼠实验性心律失常的作用与PAG内的阿片受体介导有密切关系.     

阿片肽参与头针抗大鼠实验性心律失常作用的探讨

目的探讨头针"额旁 1线"抗大鼠实验性心律失常作用的中枢机制.方法在氯化钡诱发实验性心律失常模型上,予中脑导水管周围灰质 (PAG)内注射阿片受体拮抗剂纳洛酮 (NX),予头针电刺激大鼠头部双侧"额旁 1线"区域,记录各组大鼠心率和动脉血压.结果 PAG内注射 NX对大鼠心率增加和动脉血压升高无明显的影响,头针对大鼠实验性心律失常有显著的缓解作用,其效应可以被 PAG内注射 NX完全翻转.结论头针"额旁 1线"抗大鼠实验性心律失常作用与 PAG内阿片肽的介导有密切关系.     

红景天生脉口服液抗实验性心律失常的作用

目的：观察红景天生脉口服液抗实验性心律失常的作用。方法：采用氯仿、Adr、毒K、Bacl2建立小鼠，家兔，豚鼠，大鼠心律失常模型，分对照组，红景天生脉口服液组，慢心律组。结果：红景天生脉口服液能显著降低氯仿致小鼠室颤发生率；推迟及缩短Adr致家兔心律失常发生时闻及持续时间。提高毒K致豚鼠心律失常剂量；降低Bacl2致大鼠心律失常发生率，减慢心率。效果类似慢心律。结论：HSY具有对抗实验性心律失常的作用。     

调脉饮拆方抗心律失常作用的研究

目的:观察调脉饮全方及拆方对3种实验性心律失常动物模型的影响。方法:将动物随机分为模型组、调脉饮全方组、凉血清热主药功效组、益气养心辅药功效组、行气通脉辅药功效组和阳性药普罗帕酮组。通过记录Ⅱ导心电图,观察调脉饮全方及拆方对乌头碱诱发大鼠室性心律失常、哇巴因诱发豚鼠室性心律失常、结扎冠状动脉诱发大鼠心律失常3个实验性心律失常模型的作用。结果:调脉饮全方组与凉血清热组对乌头碱致大鼠心律失常、哇巴因诱发豚鼠室性心律失和结扎冠状动脉诱发大鼠心律失常发生率具有抑制作用。结论:调脉饮全方组与凉血清热组具有对抗实验性心律失常的作用。     

君主安胶囊对实验性心律失常的影响

目的:观察君主安胶囊对实验性心律失常及各项相关指标的影响。方法:采用 CaCl_2、乌头碱、哇巴因及缺血再灌注所致心律失常模型观察药物作用。结果:君主安胶囊对4个心律失常模型有明显作用,心律失常持续时间缩短,程度减轻;对缺血再灌注所致心律失常模型,还能降低血清磷酸肌激酶(CK)、乳酸脱氢酶(LDH)及丙二醛(MDA)含量,增加血清超氧化物歧化酶(SOD)活性,增加再灌注心肌组织 Na~+、K~+-ATP 酶活性。结论:君主安胶囊对实验性心律失常有明显保护作用。     

心痛宁加味方对实验性急性心肌缺血大鼠心律失常记分的影响

通过心痛宁加味方对实验性心肌缺血大鼠的实验研究，探索传统中草药和新疆维吾尔药共同组方的复方制剂心痛宁加味方的疗效。采用结扎冠脉造成大鼠急性心肌缺血模型，检测冠脉结扎后不同时间点的心电图S-T段抬高程度及心律失常严重程度。结果表明，心痛宁加味方对大鼠实验性急性心肌缺血有明显的改善作用，与复方丹参片对照组比较，可较快降低心电图S—T段的抬高程度，降低实验性急性心肌缺血大鼠心律失常的严重程度。说明心痛宁加味方具有良好的抗心肌缺血、抗心律失常作用。     

双黄连粉针剂抗实验性心律失常作用的研究

目的：研究双黄连粉针剂抗实验性心律失常作用。方法：舌下iv氯化钡和氯化钙造成大鼠心律失常模型。结果：双黄连60、30mg/kg舌下iv治疗性给药可使85．71％、71．4％氯化钡心律失常的大鼠转为窦性心律;双黄连60mg/kg可减少氯化钙致室颤的大鼠死亡率并可使80％大鼠室颤后恢复窦性心律,且可耐受较大剂量氯化钙的快速注射。结论：双黄连粉针剂对氯化钡和氯化钙致大鼠实验性心律失常有良好的对抗作用。     

通脉养心丸对实验性心律失常的保护作用

目的：观察通脉养心丸对实验性心律失常的保护作用。方法：采用氯仿致小鼠心律失常及氯化钡（BaCl2）致大鼠心律失常模型,观察通脉养心丸对氯仿致小鼠心脏停搏（CA）的潜伏期（min）、室颤发生率（％）及BaCl2致大鼠心律失常持续时间（min）的影响。结果：通脉养心丸可明显降低氯仿所致小鼠的室颤发生率,延长CA的潜伏期,显著缩短BaCl2所致心律失常的持续时间,且4．0g／kg剂量组作用明显优于2．0g／kg、1．0g／kg剂量组。结论：通脉养心丸对实验性心律失常具有保护作用。     

迎春花提取物抗心律失常作用

目的:研究迎春花提取物的抗心律失常作用。方法:常规抗心律失常方法,即小鼠氯仿法、大鼠乌头碱法、小鼠氯化钙法及兔肾上腺素法。结果:迎春花提取物对氯仿诱发的小鼠心室颤动有明显的预防作用,而对氯化钙诱发的小鼠心室颤动没有预防作用,迎春花提取物对乌头碱诱发的大鼠心律失常有治疗作用,迎春花提取物能够对抗肾上腺素引起的家兔心律失常。结论:迎春花提取物有抗心律失常作用。     

大豆苷元抗心律失常作用的研究

目的 :研究大豆苷元抗心律失常作用。方法 :常规抗心律失常方法。结果 :大豆苷元 (3.0,5.0mg·kg^-1)对氯仿诱发的小鼠室颤有明显的预防作用 ,大豆苷元 (0.8,1.0mg·kg^-1)对乌头碱诱发的大鼠心律失常有明显的治疗效果。大豆苷元 (0.2,0.3mg·kg^-1)还能对抗肾上腺素诱发的家兔心律失常 ,大豆苷元 (0.03% ,0.05%)能明显降低蟾蜍离体坐骨神经动作电位振幅。大豆苷元 (0.8,1.0mg·kg^-1)对氯化钙诱发的大鼠室颤具有预防作用 ,且能明显的降低大鼠的死亡率。以上作用具有明显的剂量依赖性。结论 :大豆苷元有明显的抗心律失常作用。其抗心律失常作用可能与其抑制Na⁺内流或Ca²⁺ 内流及与阻断-β 肾上腺素受体有关。     

Effect of the water extract of Galega officinalis L. on human platelet aggregation in vitro

Galega officinalis L. is a traditional medicinal plant from Bulgaria. It was found that the aqueous extract of Herba Galegae suppressed platelet aggregation in vitro induced by adenosine diphosphate, epinephrine, thrombin and collagen. The compounds with antiaggregating action have not as yet been isolated from Galega officinalis.     

The effects of Mikania cordata (Burm) B. L. Robins. Root extract on gastro-duodenal ulcer models in rats and guinea pigs

The methanolic fraction of the root extract M. cordata was found to possess significant anti-ulcer activity in different experimental models. In preventive tests the extract demonstrated significant protective action in gastric lesions induced by acetylsalicylic acid, serotonin and indomethacin in experimental rats. Significant protection was observed with the extract in chemically-induced duodenal lesions. Significant enhancement of the healing process was also found to occur in acetic acid-induced chronic gastric lesions in experimental animals.     

Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy

The aim of this study was to investigate the anti-inflammatory effects and the mechanism of action of the aqueous extracts obtained from rhizomes, leaves and inflorescences of Solidago chilensis in the mouse model of pleurisy. The extracts were prepared by infusion and were lyophilized. RESULTS: The aqueous extracts of rhizomes, leaves or inflorescences inhibited leukocytes, neutrophils and exudation (P<0.05) in the inflammation induced by carrageenan. The rhizomes aqueous extract, butanolic and aqueous residual fractions inhibited leukocytes, neutrophils, myeloperoxidase, adenosine-deaminase, and tumor necrosis factor alpha levels in the inflammation induced by carrageenan (P<0.05). The rhizome aqueous extract and butanolic fraction also inhibited exudation, nitric oxide, and interleukin-1 beta levels (P<0.05). The rhizomes aqueous extract and its two derived fractions reduced leukocytes and mononuclears in the pleurisy induced by bradykinin, histamine, or substance P (P<0.05) and neutrophils in the pleurisy induced by histamine or substance P (P<0.05). Only aqueous residual fraction inhibited neutrophils induced by bradykinin (P<0.05). CONCLUSION: Solidago chilensis aqueous extracts from leaves, inflorescences and rhizomes demonstrated an important anti-inflammatory effect, inhibiting cells in the inflammation caused by carrageenan. In addition, the rhizomes aqueous extract and its derived fractions also decreased pro-inflammatory mediators release into the site of the inflammatory process. The rhizomes aqueous extract and the butanolic fraction showed more evident anti-inflammatory actions.     

Effects of Bixa orellana L. Seeds on Hyperlipidemia

Bixa orellana L., urucum, or urucu, a native tropical tree of Central and South American rain forests is used to treat various diseases in popular medicine. In Ceará, Northeast of Brazil, the seeds of urucum have been used for the treatment of high lipid blood levels. The present study investigated the effects of the aqueous extract from Bixa orellana seeds (AEBO) in mice with hyperlipidemia induced by tyloxapol, fructose and ethanol. In hyperlipidemia induced by Triton WR1339, 400 and 800 mg/kg AEBO reduced triglycerides (TG) serum levels at 24 h and 48 h. In the study of hypertriglyceridemia induced by fructose, AEBO in doses of 400 mg/kg and 800 mg/kg reduced TG levels by 48.2% and 48.7%, respectively. Finally, the ethanol experimental model with 400 mg/kg AEBO promoted a reduction of 33.6% of TG levels, while the 800 mg/kg concentration reduced hypertriglyceridemia in 62.2%. In conclusion, the aqueous extract of the seeds of Bixa orellana was capable of reversing the hypertriglyceridemia induced by Triton, fructose and ethanol, demonstrating a hypolipidemic effect. However, further studies are necessary to discover the precise mechanism of action. Copyright © 2012 John Wiley & Sons, Ltd.     

心复康Ⅳ号的抗心律失常作用

心复康Ⅳ号灌胃给药,剂量39.8g/kS,对氯仿、氯化钡、氯化钙、乌头碱、哇巴因、结扎冠脉及电刺激等方法诱发的小鼠、大鼠、豚鼠及兔心律失常均有显著的对抗作用。心复康Ⅳ号具有抗缺氧及降低心肌耗氧量的作用,故其抗心律失常作用的机制可能与其降低心肌耗氧量有关。     

生脉饮合煎、分煎剂抗心律失常及抗休克作用比较

以同等剂量对生脉饮合煎、分煎剂进行了抗乌头碱诱发小鼠心律失常及抗大鼠失血性休克作用比较，结果表明：二者之间无明显差异     

Sedative activity in mice of a hydroalcohol extract of Hypericum perforatum L.

The sedative activity of a hydroalcohol extract of Hypericum perforatum L. (Hypericaceae) and some of its isolated constituents was evaluated in mice. A dry hydroalcohol extract, orally administered at 26.5 mg/kg, induced a marked sedation as measured by two different tests (actimeter and sleep potentiation), compared with controls (diazepam, 2 mg/kg, per os). Several fractions were isolated from this hydroalcohol extract: hypericin, flavones, butanol fraction, aqueous fraction; a separation and purification method was developed for hypericin. None of the isolated fractions exhibited the same sedative activity as the hydroalcohol extract. © 1997 John Wiley & Sons, Ltd.     

Antihyperglycaemic effect of Mangifera indica in rat.

The leaves of Mangifera indica are used as an antidiabetic agent in Nigerian folk medicine. To determine whether or not there is a scientific basis for this use, the effect of the aqueous extract of the leaves on blood glucose level was assessed in normoglycaemic, glucose - induced hyperglycaemic and streptozotocin (STZ)-induced diabetic rats. The aqueous extract given orally (1 g/kg) did not alter the blood glucose levels in either normoglycaemic or STZ-induced diabetic rats. In glucose - induced hyperglycaemia, however, antidiabetic activity was seen when the extract and glucose were administered simultaneously and also when the extract was given to the rats 60 min before the glucose. The hypoglycaemic effect of the aqueous extract was compared with that of an oral dose of chlorpropamide (200 mg/kg) under the same conditions. The results of this study indicate that the aqueous extract of the leaves of Mangifera indica possess hypoglycaemic activity. This action may be due to an intestinal reduction of the absorption of glucose. However, other different mechanisms of action cannot be excluded.