皮脂腺痣并发乳头状汗管囊腺瘤、毛母细胞瘤及血管瘤

报告1例皮脂腺痣并发乳头状汗管囊腺瘤、毛母细胞瘤及血管瘤。患者男,33岁。因右侧头皮及面部暗红色无毛斑丘疹33年就诊。皮肤科检查:右颞部、右上睑、右侧面颊部及腮部一暗红色斑丘疹,18 cm×10 cm,质软,边界清楚。皮损组织病理检查:表皮增生呈疣状,皮脂腺和大汗腺增生,局部形成乳头状结构,被覆双层上皮细胞,间质内较多的浆细胞浸润;真皮内可见多个肿瘤细胞团块,外周细胞排列呈栅栏状,无人工收缩间隙,真皮浅层有大量血管腔。诊断:皮脂腺痣并发乳头状汗管囊腺瘤、毛母细胞瘤及血管瘤。     

皮脂腺痣并乳头状汗管囊腺瘤及基底细胞癌1例

患者女,47岁。头顶部淡黄色斑块47年,出现结节6年,糜烂、并增生3年。皮肤科情况:头顶部见一6cm×5cm大小淡黄色斑块,边界清楚,表面光滑,无毛发生长,质软,中央可见1.5cm×2cm大小糜烂面,表面呈肉芽样增生;斑块左后方见一约1cm×2cm大黑褐色结节,表面稍不平,质韧。诊断:皮脂腺痣。分别取头顶部两块皮损活检见:乳头状汗管囊腺瘤、基底细胞癌。皮脂腺痣同时合并乳头状汗管囊腺瘤及基底细胞癌临床罕见。     

皮脂腺痣并发乳头状汗管囊腺瘤及基底细胞癌

报告1例皮脂腺痣并发乳头状汗管囊腺瘤及基底细胞癌。患者男,46岁。因头皮疣状斑块46年,破溃出血2个月就诊。皮损组织病理学检查诊断为皮脂腺痣并发乳头状汗管囊腺瘤及基底细胞癌。皮脂腺痣有恶变的可能,建议临床密切随访,一旦出现短期内增大或破溃等表现建议立即手术切除并行组织病理学检查。     

皮脂腺痣并发生乳头汗管囊腺瘤1例

报告1例皮脂腺痣并发生乳头汗管囊腺瘤、患者男，16岁。生下即发现左侧头部斑块并左侧颞部肿物，随年龄增长而增大。斑块约4cm×20cm，表面粗糙呈疣状、结节状。颞部肿物呈菜花状，约1.5cm×1.5cm，质软，见脓性、血性分泌物肿物组织病理由囊壁及绒毛状突起构成，衬有两层上皮细胞，可见顶浆分泌。手术切除肿瘤治愈。     

皮脂腺痣并发乳头状汗管囊腺瘤及基底细胞癌

报告1例皮脂腺痣患者,曾接受数次肿块平皮面削除手术后复发,全部皮损经组织病理学检查,病理诊断为皮脂腺痣并发乳头状汗管囊腺瘤及基底细胞癌.故皮脂腺痣皮损应彻底切除,并送组织病理检查,而不宜简单进行削平.     

皮脂腺痣伴发少见肿瘤2例

例1女,26岁。左侧头皮黄色斑块26年,局部蓝色丘疹5年就诊。组织病理示:表皮呈乳头瘤样增生,真皮内皮脂腺增生,且局部见基底样细胞组成的团块样结构,其间黑素颗粒沉积。免疫组化示:肿瘤细胞Bcl-2(-),CD34(-),CK7(-),Ki-67(+);诊断:皮脂腺痣伴色素性毛母细胞瘤。例2女,45岁。右侧头皮、前额黄色斑块40余年,局部灰褐色肿物伴渗液、糜烂7年。病理诊断为皮脂腺痣并乳头状汗管囊腺瘤、色素性毛母细胞瘤及局部结缔组织增生样改变。     

斑点状集簇性色素痣1例并文献复习

患者女,24岁,腰背部黑褐色斑片24年。主要表现为密集排列的黑褐色丘疹,丘疹中心可见毳毛,褐色的丘疹可融合成斑块。皮损组织病理示:痣细胞呈团状或条索状分布,主要分布于毛囊皮脂腺周围。诊断为斑点状集簇性色素痣。     

乳头状汗管囊腺瘤48例临床和组织病理分析

目的:分析总结乳头状汗管囊腺瘤的临床表现及组织病理特点。方法:回顾性分析我科诊断的48例乳头状汗管囊腺瘤患者临床表现和组织病理资料。结果:48例患者中,男26例,女22例,在出生时和婴幼儿发病者38例(79%),分布于头部者34例(71%)。皮损多表现为缓慢增大的单发丘疹、结节或斑块等多形性损害。组织病理表现为表皮向下凹陷形成囊状腔,囊状腔下部可见乳头状突起伸入囊腔,凹陷的囊状腔上部衬以鳞状上皮细胞,囊状腔下部及乳头状突起衬以腺上皮细胞。18例患者同时并发有皮脂腺痣表现。结论:该病出生时及婴幼儿好发,多分布于头部,组织病理学有表皮向下凹陷形成囊状腔及囊状腔下部乳头状突起伸入囊腔的特征性表现。临床表现多样,易和皮脂腺痣并发。     

皮脂腺痣伴发大汗腺囊腺瘤及先天性色痣一例

皮脂腺痣是一种较常见的皮肤肿瘤，可与其他皮肤附属器肿瘤并存，其中基底细胞上皮瘤及乳头状汗管囊腺瘤最为多见，伴有痣细胞痣的病例则十分罕见，现遇一例，报告如下。患者男，１７岁。出生时发现左颞部有斑片，数月后斑片上出现一小黑痣，无明显不适，随年龄增长斑片逐...     

先天性皮脂腺痣1例

患儿男,45d。左侧额头、颊部、颞部和耳廓及下颌部出现淡红色斑块和丘疹45d。全部皮损组织病理学检查均提示皮脂腺痣。予手术切除皮损。现愈合良好,继续随访中。     

Hairy Nevus Spilus: A Case Series

Abstract: Nevus spilus, also known as speckled lentiginous nevus, is a nevoid disorder characterized by hyperpigmented macules or papules scattered over a background of tan pigmentation. Although nevus spilus is mainly of cosmetic concern, malignant melanoma may rarely develop in the lesions. Although classically not mentioned as a hairy nevus, a few reports in literature mention overlying hypertrichosis in lesions of nevus spilus. We hereby report four cases of nevus spilus without malignant change with overlying terminal hairs that arose mainly from the background pigmented area.     

Nevus sebaceous and syringocystadenoma papilliferum.

A 52-year-old patient was admitted to the hosptial for evaluation of hypertension. He had two skin lesions, one on the forehead and one in the postauricular area, which had been present since birth. The forehead lesion was a nevus sebaceous and the postauricular lesion was a syringocystadenoma papilliferum. Except for a few patients with widespread nevus sebaceous and syringocystadenoma papilliferum associated with neurologic abnormalities, most of the previously reported patients with these nevi have had solitary lesions of one or the other. An association of nevus sebaceous and syringocystadenoma papilliferum in the same lesion is not uncommon. Despite bleeding and crusting in one of the lesions and despite informing the patient that a malignant neoplasm may develop in these nevi, he refused excision of either of the lesions.     

The spectrum of organoid nevi

Two patients in whom tumors developed in organoid nevi are reported. The first patient, a 50-year-old man, had a trichilemmoma arising from an organoid nevus on the scalp. The second patient, a 68-year-old woman, had a basal cell epithelioma, sebaceous epithelioma, syringocystadenoma papilliferum, and a trichilemmoma arising from an organoid nevus on the face.     

Widespread nevus spilus associated with torsion dystonia: a case report

Usually speckled lentiginous nevus or nevus spilus is a small solitary lesion consisting of a light tan patch with numerous dark brown macules or papules (or both) within it. It is occasionally associated with complex birth defects such as phacomatosis pigmentovascularis, phacomatosis pigmentokeratotica, or speckled lentiginous nevus syndrome. Uncommon presentations include large segmental lesions that may or may not be systematized and can sometimes be associated with other anomalies. We hereby report a 6-year-old Caucasian patient with systematized nevus spilus associated with torsion dystonia, a combination not published thus far.     

乳头状汗管囊腺瘤1例

报告1例乳头状汗管囊腺瘤。患者女,16岁。左耳前丘疹逐渐增多16年。临床表现为左耳前带状排列淡红色丘疹,部分中央有脐凹。组织病理诊断为乳头状汗管囊腺瘤。     

Hybrid follicular cyst (pilomatrical and infundibular) arising within a sebaceous nevus

A 7-year-old girl presented with a 3-month history of a small blue-brown papule arising within a large sebaceous nevus on her temporal scalp. A punch excision was performed that demonstrated a hybrid follicular cyst. The majority of the cyst wall displayed pilomatrical differentiation consisting of basaloid matrical-type cells with luminal shadow cell keratinization. The matrical epithelium displayed strong membranous, cytoplasmic, and nuclear staining for β-catenin. Only a small component of the wall displayed infundibular differentiation. These findings were consistent with a hybrid follicular cyst predominantly displaying pilomatrical differentiation with only a small component of infundibular lining. The most common tumors arising within sebaceous nevi are the syringocystadenoma papilliferum and trichoblastoma. Follicular cysts with infundibular (sebaceous cyst) and trichilemmal (pilar cyst) differentiation are exceedingly common, although their development within sebaceous nevi appears to be rare. We report a rare case of a hybrid follicular cyst with matrical differentiation occurring within a sebaceous nevus.     

Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case

Syringocystadenoma papilliferum is a benign tumor most commonly located on the scalp or face, and it often arises within a nevus sebaceus of Jadassohn. We describe a 61-year-old man with syringocystadenoma papilliferum developing within a nevus sebaceus with sebaceous differentiation in an intradermal tubular apocrine component of the syringocystadenoma papilliferum. Although some adnexal neoplasms that develop in association with a nevus sebaceus may exhibit conjoint sebaceous, follicular, or apocrine differentiation, reflecting close embryological relations of the folliculosebaceous-apocrine unit, the feature we report on has not previously been described to the best of our knowledge.     

Metastasizing adenocarcinoma and multiple neoplastic proliferations arising in a nevus sebaceus

Nevus sebaceus of Jadassohn is a hamartoma of multiple skin structures. Many neoplasms have been reported to arise in association with nevus sebaceus, most commonly trichoblastoma/basal cell carcinoma and syringocystadenoma papilliferum. We report a case of a 66-year-old woman with an adenocarcinoma as well as multiple neoplastic proliferations arising in a long standing nevus sebaceus on the scalp, with subsequent occipital neck metastatic disease. On histologic evaluation, the epidermis showed changes reminiscent of tumor of the follicular infundibulum as well as basaloid proliferations resembling superficial trichoblastoma. A focus suggestive of syringofibroadenoma was also present. A small dermal collection of basaloid and more mature sebocytes was consistent with a sebaceoma/sebaceous epithelioma. Most of the lesion was composed of an adenocarcinoma with areas showing ductal differentiation with decapitation secretion, well-formed papillae and focal cribriform structures. Other portions demonstrated a high-grade neoplasm with prominent nuclear atypia and a solid pattern of growth resembling high-grade breast carcinoma. Anti-epithelial membrane antigen strongly labeled tumor cells and highlighted ductal structures. Less than 1% of cells expressed progesterone or estrogen receptors. Her2/neu reactivity was focally present, showing 1+ membranous reactivity in 10% of cells. Anti-p63 labeled basaloid cells surrounding the tumor lobules. A breast primary was ruled out by clinical and radiologic examination. This report illustrates an extraordinary case of adnexal neoplasia displaying various lines of differentiation arising in association with nevus sebaceus.     

Multiple tumors arising in nevus sebaceus.

A forty-three year old woman with nevus sebaceus of Jadassohn involving the scalp is described. The unusual features of this case include the presence of adenoidal basal cell epithelioma, pigmented basal cell epithelioma, syringocystadenoma papilliferum, and nevocytic nevus. This case suggests the importance of prophylactic removal and close follow-up of nevus sebaceus.     

皮脂腺痣继发肿瘤16例临床与组织病理分析

目的 探讨皮脂腺痣继发肿瘤的组织病理学特征。方法 回顾性分析所收集到的16例皮脂腺痣继发肿瘤患者的临床、病理资料和组织病理学特征。结果 ≥18岁12例,11 ~ 17岁4例。7例伴有乳头状汗管囊腺瘤,4例伴有管状顶泌汗腺腺瘤,3例伴有毛鞘瘤,2例伴有基底细胞癌,汗孔角化样汗孔和真皮导管痣及鲜红斑痣各1例。6例有1个以上的肿瘤,尤以乳头状汗管囊腺瘤伴管状顶泌汗腺腺瘤最多,占有4例。结论 皮脂腺痣基础上有任何继发肿瘤发生,都应密切关注。