共查询到20条相似文献，搜索用时 31 毫秒
1.
Yen-Chih Chen Ming-Yen Hsiao Yi-Chian Wang Chih-Pin Fu Tyng-Guey Wang 《中华民国医用超音波学会杂志》2017,25(2):90-95
Background
Timely and adequate laryngeal elevation along with hyoid bone movement is an essential component of the swallowing movement under normal physiological conditions. The purpose of this study was to verify the reproducibility of using ultrasonography to evaluate hyoid bone displacement during swallowing through the assessment of inter- and intrarater reliability and examine its accuracy by comparing the results with videofluoroscopic swallowing study (VFSS).Methods
A self-designed water balloon was fixed to the transducer, which provided good contact between the transducer and the submental skin. Ten participants with dysphagia were recruited. The measurements of hyoid bone displacement using ultrasonography were performed by two of the authors. All the participants underwent ultrasonographic examinations and VFSS within 24 hours.Results
The intrarater intraclass correlation coefficient (ICC) of the two examiners was 0.996 and 0.959, respectively (p < 0.01); the interrater ICC between the two examiners was 0.892 (p < 0.05). ICCs between VFSS and ultrasonography for two researchers were 0.815 and 0.916 (p < 0.01).Conclusion
Submental ultrasonography is a reliable and accurate method for assessing the hyoid bone movement. 相似文献2.
Objective
Medical ultrasound examinations are performed by diverse professional cohorts: sonographers are one group. Little evidence exists regarding the teaching practices used in medical ultrasonography and their effectiveness. We report the continued development and validation of an instrument to measure sonographer skill-teaching practice perceptions (SonoSTePs).Methods
An online survey was administered to a convenience sample of sonographers who were employed in Queensland, Australia. This paper reports on the continued psychometric testing of the measurement tool.Findings
The 25-item scale demonstrated good internal reliability. Exploratory factor analysis generated four factors with acceptable internal reliability: Factor 1 (Skill execution feedback, Cronbach’s α = 0.89), Factor 2 (Cognitive overload, Cronbach’s α = 0.68), Factor 3 (Teach new skill, Cronbach’s α = 0.70), and Factor 4 (Assist learners scanning, Cronbach’s α = 0.67). The combined instrument value was 0.83. The weighted kappa of the test–retest items identified that the majority of items achieved an interrater level of agreement of ≥0.5.Conclusion
Results indicate that the SonoSTePs instrument items and factors are underpinned by theories and principles related to teaching a complex psychomotor skill. The initial data suggest that the tool is both reliable and valid. 相似文献3.
Background
Impaired left atrial (LA) reservoir deformation has been found to be associated with poor functional capacity and outcomes in severe chronic mitral regurgitation (MR). Among patients with primary MR (valve incompetence due to mitral valve pathology), we focus on Carpentier II classification (prolapse or flail mitral valve) and aim to investigate determinants for decreased LA reservoir deformation and its impact on LA remodeling in severe MR.Methods
Among 159 consecutive patients with severe chronic Carpentier II MR (left ventricular ejection fraction ≥ 60%), 55 underwent follow-up echocardiography, which was compared with their baseline study. We used the change of LA volume index as the rapidity of LA remodeling, LA eccentricity index as LA sphericity, and peak LA reservoir strain as well as reservoir strain rate (LASRR) derived from two-dimensional speckle-tracking echocardiography as LA reservoir function.Results
Older age, elongated left atrium, increased LA volume index, as well as reduced left ventricular global longitudinal strain and LA ejection fraction all linked to a poor baseline LASRR (all p < 0.001). A second echocardiography during a mean follow-up of 15.3 ± 8.3 months revealed an enlarged left atrium (increased interval change of LA volume index; p < 0.001). In multivariate analysis, only the difference between the baseline and follow-up LASRR values (△LASRR; odds ratio (OR) 0.037, 95% confidence interval (CI) 0.003–0.496, p = 0.013) predicted accelerated LA remodeling. A poor baseline LASRR was significantly associated with its profound deterioration during the follow-up period (β = ?0.424, p = 0.002).Conclusion
In severe chronic Carpentier II MR, a reduced follow-up LASRR predicted future accelerated LA remodeling. Patients with a poor baseline LASRR are at a higher risk of its deterioration. 相似文献4.
Mustafa Turgut Yildizgoren Onur Velioglu Ozcan Demetgul Ayse Dicle Turhanoglu 《中华民国医用超音波学会杂志》2017,25(3):145-149
Background
Patients with equinovarus deformity have an increased risk of fall and ankle ligament injury, because of inappropriate prepositioning of the ankle at the end of the swing phase, and inadequate leg and ankle stability during the stance phase. Accordingly, the aim of this study is to compare anterior talofibular ligament (ATFL) thickness of chronic stroke patients with that of healthy individuals using ultrasonography.Methods
This was a case-control study conducted in a university hospital between July 2015 and July 2016. We included 38 patients [study group; mean age, 59.0 ± 11.1 years; mean body mass index (BMI), 25.4 ± 4.3 kg/m2] and a control group of age-, sex-, and BMI-matched healthy individuals. Demographic and clinical characteristics of the patients (i.e., age, weight, height, Brunnstrom motor recovery stage, Functional Ambulation Scale, Ashworth Scale, and duration of hemiplegia) were recorded during their visits. Furthermore, ultrasound image of the ATFL was obtained from each ankle. The thickness of the ATFL was measured at the midpoint of the ligament between the attachments on the lateral malleolus and the talus using ultrasonography.Results
In the study group, the mean thickness of the ATFLs of the affected side (2.75 ± 0.41 mm) was thicker than both the unaffected side (2.42 ± 0.30 mm) and the healthy controls (2.35 ± 0.19 mm; p = 0.007, p < 0.001, respectively). No differences were seen between the two sides of the control group.Conclusion
Chronic stroke patients have a thicker ATFL on both the affected and unaffected sides, compared with healthy individuals. This architectural feature of the ATFL may be a result of equinovarus deformity together with spastic muscles. For this reason, early treatment of deformed ligaments and spastic muscles is needed to prevent equinovarus deformity in patients with stroke. 相似文献5.
S. Hraiech J. Bordes J.L. Mège X. de Lamballerie R. Charrel Y. Bechah B. Pastorino C. Guervilly J.M. Forel M. Adda J.M. Rolain H. Lepidi D. Raoult S. Lehingue L. Papazian 《Clinical microbiology and infection》2017,23(1):38-45
Objectives
Cytomegalovirus (CMV) reactivation in intensive care unit patients may increase mortality and favour bacterial pneumonia. We developed a murine model to compare the severity of staphylococcal pneumonia after CMV reactivation and in CMV-negative mice.Methods
Balb/c mice were primo-infected with murine cytomegalovirus (MCMV n = 90) or received saline (control n = 90). After latency, all mice underwent caecal ligation and puncture to trigger MCMV reactivation in MCMV primary-infected mice. Surviving animals received an intra-nasal inoculation with methicillin-susceptible Staphylococcus aureus (MSSA) to induce pneumonia. Mortality, lung bacterial count, histology and interferon-alpha and gamma serum levels were compared in MCMV reactivated and control mice 2, 5 and 15 days after pneumonia.Results
After MSSA pneumonia, MCMV mice showed a trend towards a higher mortality (9.4% versus 0%; p 0.09) and a higher weight loss (2.2 (0.6–4.1 g) versus 0.7 (–0.3 to 1.3 g); p 0.005).The lung bacterial count was higher in MCMV mice 2 days (5 × 103 (103 to 3 × 105) versus 102 (0 to 4 × 102) CFU/lung; p 0.007) and 5 days (2.5 × 104 (1.6 × 104 to 6.5 × 105) versus 15 (10–40) CFU/lung; p 0.005) after MSSA pneumonia. 8/40 (20%) MCMV mice developed lung abscesses compared to 0% in control (p 0.011). Interferon-alpha serum levels 2 days after staphylococcal pneumonia were higher in MCMV mice.Conclusions
MCMV reactivation decreased lung bacterial clearance and favoured the development of staphylococcal abscessing pneumonia. CMV reactivation may be responsible for a higher susceptibility to bacterial sepsis. 相似文献6.
Michael Worlicek Benedikt Moser Günther Maderbacher Raphael Zentner Florian Zeman Joachim Grifka Armin Keshmiri 《The Knee》2017,24(4):711-717
Background
Patellofemoral instability may lead to osteoarthritis, anterior knee pain, and patellar luxation. The purpose of this study was to conduct an exploratory investigation into the difference of patellar kinematics of healthy knees during extension/flexion cycles in neutral, varus and valgus alignment.Methods
The three-dimensional patellar kinematics of 10 lower extremities of whole body cadavers were examined during passive motion, in neutral position, and under valgus and varus stress. Kinematics was recorded by means of an optical computer navigation system.Results
The study samples did not significantly differ with regard to mediolateral patellar shift and epicondylar distance. Varus stress led to significantly higher external rotation than valgus stress (P = 0.04) and to a significantly higher lateral patellar tilt than neutral position (P = 0.016) and valgus stress (P = 0.016). No difference was found between valgus stress and neutral position.Conclusion
Analysis of tibiofemoral alignment alone is insufficient for predicting patellar kinematics. 相似文献7.
Ron Batash Guy Rubin Alexander Lerner Hussein Shehade Nimrod Rozen David E. Rothem 《The Knee》2017,24(3):622-626
Background
Successful total knee arthroplasty (TKA) includes accurate alignment. Controversy remains as to whether computer-navigated TKA improves the overall result and clinical outcome. Our aim is to compare the limb alignment and prosthesis positioning according to the pre- and postoperative computed tomography (CT) scans with the data collected from the navigation system.Methods
We compared the pre- and postoperative limb alignments and prosthesis alignment provided by the Orthopilot navigation system, Aesculap®, with CT scans measured by the Traumacad® software of 70 TKAs.Results
A positive correlation with statistical significance (P = 0.00001, r = 0.874) between the navigation system data and the CT images was found. Mean femoral cut was five degrees (valgus), and mean tibial cut was one degree (varus). Our study revealed that the navigation system assisted the surgeon to implant the prosthesis at a good acceptable alignment.Conclusion
We found that the navigation system is accurate and correlates to the pre- and postoperative CT scans. Furthermore, the navigation system can assist the surgeon to achieve good limb alignment and cutting planes of the prosthesis. 相似文献8.
Background
There are unanswered questions about knee–ankle alignment after total knee arthroplasty (TKA) for varus and valgus osteoarthritis (OA) of the knee. The aim of this retrospective study was to assess knee–ankle alignment after TKA.Methods
The study consisted of 149 patients who had undergone TKA due to varus and valgus knee OA. The alignment and angles in the selected knees and ankles were measured on full-length standing anteroposterior radiographs, both pre-operatively and post-operatively. The paired t-test and Pearson's correlation tests were used for statistical analysis.Results
The results showed that ankle alignment correlated with knee alignment both pre-operatively and postoperatively (P < 0.05). The pre-operative malalignment of the knee was corrected (P < 0.05), and the ankle tilt angle was accordingly improved in the operative side after TKA (P < 0.05). In addition, TKA had little effect on knee–ankle alignment on the non-operative side (P > 0.05).Conclusion
These findings indicated that routine TKA could correct the varus or valgus deformity of a knee, and improve the tilt of the ankle. Ankle alignment correlated with knee alignment both pre-operatively and postoperatively. Both pre-operative knee and ankle malalignment can be simultaneously corrected following TKA.Level of evidence
Level III. 相似文献9.
Background
Medial meniscus posterior root tear (MMPRT) has been reported to play a key role in the development of spontaneous osteonecrosis of the knee (SONK) and osteoarthritis (OA) of the knee. However, little is known about the differences in the development of SONK and OA after MMPRT. The purpose of this study was to investigate the factors contributing to the development of these conditions.Methods
We evaluated the existence of MMPRT and the extent of medial meniscal extrusion in preoperative magnetic resonance images and proximal tibial morphology in radiographs of 45 patients with SONK and 104 patients with OA who underwent knee surgery.Results
There were no significant differences in age, gender, height, weight, and body mass index between the two groups. The incidence of MMPRT and the mean posterior tibial slope (PTS) were significantly higher in SONK than in OA patients (62.2% versus 34.3%, P = 0.002, and 12.8° versus 10.5°, P < 0.001, respectively). The mean extent of meniscal extrusion was larger in OA than in SONK patients (7.5 mm versus 5.3 mm, P < 0.001). The mean tibial varus angle was 4.8° in SONK and 5.4° in OA, with no significant difference between the two (P = 0.088). Multivariable logistic regression analysis showed that compared with OA, SONK was more closely associated with the existence of MMPRT and had a smaller extent of medial meniscus extrusion and higher PTS.Conclusion
MMRPT and higher PTS were more closely associated with the development of SONK than with that of OA. 相似文献10.
Marcela Caleffi da Costa Lima Caniatti Sueli Donizete Borelli Ana Lúcia Falavigna Guilherme Luiza Tamie Tsuneto 《Human immunology》2017,78(2):88-94
Background
Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic asthma and rhinitis.Objective
This study aimed to investigate the association between HLA class I (-A, -B, and -C), and HLA class II (-DRB1) genes in individuals sensitive to dust mites (Dermatophagoides farinae, Dermatophagoides pteronyssinus, or Blomia tropicalis) and mite-insensitive controls.Methods
396 participants were grouped as mite-sensitive and mite-insensitive according to immediate hypersensitivity as determined by skin-prick tests, and to HLA genotyping by polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO).Results
After chi-square heterogeneity testing no significant differences were observed in HLA-A, B, and C genes, except for the HLA-DRB1 locus, which, showed a negative association for DRB1104, between mite-sensitive and mite-insensitive individuals. In high resolution, DRB1104:11 allele was significantly different from all other results (P = 0.0042, OR = 0.26, and 95%CI = 0.09–0.70). The analysis stratified by etiologic agent confirmed these associations.Conclusion
Our results suggest a possible association between HLA-DRB1 genes and hypersensitivity to dust mites. 相似文献11.
Ryan T. Lewinson Chad P. Maag Victor M.Y. Lun J. Preston Wiley Chirag Patel Darren J. Stefanyshyn 《The Knee》2017,24(1):31-39
Background
Clinical effectiveness of lateral wedges for knee osteoarthritis is inconsistent across studies. One explanation is that knee loading is not fully described by the peak frontal-plane knee moment. The purpose of this study was to propose a 3D resultant approach to describing moments at the knee and evaluate how this moment changes in response to lateral wedges.Methods
Walking gait analysis was performed on 20 individuals with knee osteoarthritis, in their own shoes, with and without a six millimeter lateral wedge insole. Frontal-plane and 3D resultant moments were calculated for each participant and footwear condition. Paired t-tests identified differences between footwear conditions, correlations identified relationships between frontal-plane and 3D resultant moments, and regressions assessed relationships between moments and pain.Results
Significant reductions to peak frontal-plane moments (p = 0.001) and 3D resultant moments at the same time point (p = 0.042) were observed with lateral wedges. While an overall significant correlation was observed between change in frontal-plane moments and change in 3D resultant moments with a lateral wedge (r = 0.68, p = 0.001), 5/20 participants experienced disparate results where the frontal-plane moment was reduced yet the 3D moment increased.Conclusions
While lateral wedges alter frontal-plane moment magnitude, the direction of change does not always correspond to the direction of change observed in the 3D resultant moment. Thus resultant knee load may sometimes increase with lateral wedges.Clinical relevance
Future prospective studies should evaluate if changes in 3D resultant moments, and thus total knee load, offer an explanation as to why some participants do not experience clinical benefit from lateral wedges. 相似文献12.
F. El Garch M. Sauget D. Hocquet D. LeChaudee F. Woehrle X. Bertrand 《Clinical microbiology and infection》2017,23(1):51.e1-51.e4
Objectives
In November 2015, a plasmid-mediated colistin resistance, MCR-1, was described in animals, food and humans in China, and it was considered as a potential emerging threat to public health. Therefore, we screened for the mcr-1 gene a European collection of colistin-resistant Escherichia coli (n = 218) and Salmonella spp. (n = 74) isolated from diseased food-producing animals between 2004 and 2014 and characterized the mcr-1-positive clones.Methods
Screening for mcr-1 gene was performed by PCR on isolates for which inhibition diameter was <15 mm around a 50 μg disk of colistin. Positive E. coli isolates were then characterized by phylogrouping, multilocus sequence typing and pulsed-field gel electrophoresis typing. Antibiotic susceptibility was determined by disk diffusion testing or by broth microdilution.Results
Among the collection, 42 E. coli and three Salmonella spp. were positive for mcr-1, with continuous detection since 2004 mainly from bovine and swine digestive infections. Most of the mcr-1-positive strains were resistant to amoxicillin and cotrimoxazole but remained susceptible to cephalosporins, carbapenems and piperacillin/tazobactam. All but one isolate were resistant to colistin, with a minimum inhibitory concentration of >2 mg/L. Most of the mcr-1-positive E. coli belonged to the phylogroup A with two prevalent clonal complexes, CC10 and CC165, in which sequence type 10 and sequence type 100 were overrepresented and pulsed-field gel electrophoresis typing revealed a high diversity of pulsotypes.Conclusions
MCR-1 was detected yearly in European food-producing animal since 2004 with a high diversity of pulsotypes supporting the dissemination of mcr-1 via plasmids. 相似文献13.
Luqman Aribidesi Olayaki Isiaka Abdullateef Alagbonsi Hawau Olaide Abdulkadir Felix Oluwaseyi Idowu 《Journal of the Anatomical Society of India》2017,66(1):67-71
Introduction
Cryptorchidism has been associated with spermatotoxicity and oxidative stress while melatonin is a well-known anti-oxidant. This study investigated the possible ameliorative effect of melatonin on cryptorchidism-induced spermatotoxicity and oxidative stress.Methods
Thirty six male Wistar rats were randomised into sham-operated (n = 18) and bilaterally cryptorchid (n = 18) groups, each of which were subdivided into 3 oral treatment groups (n = 6 rats each) that received normal saline, low dose (4 mg/kg) and high dose (10 mg/kg) melatonin.Results
Cryptorchidism reduced sperm parameters, oestradiol, luteinising hormone, follicle stimulating hormone and glutathione peroxidase activity, but increased testosterone and lactate dehydrogenase activity. The cryptorchidism-induced spermatotoxicity and oxidative stress were ameliorated by low dose of melatonin but exacerbated by its high dose.Discussion
Melatonin’s effect on cryptorchidism-induced spermatotoxicity is dose-dependent. 相似文献14.
Fernando Sanz-López César Berzosa Fidel Hita-Contreras Antonio Martínez-Amat 《The Knee》2017,24(3):570-579
Background
The analysis of structural changes in patellar tendon and muscle of healthy subjects in response to mechanical loads provides useful insight into the mechanism underlying overuse injuries.Methods
Changes produced in tendon and muscles structures after eccentric overload training and three consecutive running days were examined. Twenty healthy subjects were recruited and divided into two groups. One group (ECC) performed eccentric overload squat training (six weeks). After such training, the ECC group performed three running sessions on consecutive days, as did the control group (CONT). The structure of their patellar tendons and vastus lateralis muscles was quantified using ultrasound and Doppler imaging. Images were obtained before and after eccentric training for the ECC group and on every day of running performance for both groups.Results
After eccentric training, the ECC group experienced an increase in cross-sectional area (CSA) of patellar tendon (P = 0.012). After every day of running, the ECC group experienced a decrease in CSA (P = 0.027). In the CONT group, after one day of running a significant increase was observed in anteroposterior width of their patellar tendon (P = 0.028), as well as a decrease in pennation angle of vastus lateralis muscle (P = 0.028) within three days of running sessions.Conclusions
Eccentric overload training brought about changes in the patellar tendon consistent with an improvement in the quality of the tissue. The ECC group in our study showed a more normalised pattern than the CONT group in the running performance, in agreement with previous research.Level of evidence
Level 3, controlled trial. 相似文献15.
Background
Massive transfusion is the clinical scenario where the presumed adverse effects of stored blood are expected to be more evident because the whole patient's blood volume is replaced by stored blood.Objective
To analyse the association between age of transfused red blood cells (RBC) and survival in massively transfused patients.Methods
In this retrospective study, clinical and transfusion data of all consecutive patients massively transfused between 2008 and 2014 in a large, tertiary-care hospital were electronically extracted from the Transfusion Service database and the patients’ electronic medical records. Prognostic factors for in-hospital mortality were investigated by multivariate logistic regression.Results
A total of 689 consecutive patients were analysed (median age: 61 years; 65% males) and 272 died in-hospital. Projected mortality at 2, 30, and 90 days was 21%, 35% and 45%, respectively. The odds ratio (OR) for in-hospital mortality among patients who survived after the 2nd day increased with patient age (OR: 1.037, 95% CI: 1.021–1.054; per year P < 0.001), with the number of RBC unit transfused in the first 48 hours (OR: 1.060; 95% CI: 1.038–1.020 per unit; P < 0.001), and the percentage of such RBC stored for more than 28 days (1.010, 95% CI: 1.005–1.018 per percent point; P = 0.01).Conclusion
Mortality after massive transfusion was associated with a higher proportion of old RBCs transfused in the first 48 hours. Other factors associated with poor prognosis were older patient's age and larger volumes of transfused RBCs. 相似文献16.
Charlotte Durtette Eric Hachulla Matthieu Resche-Rigon Thomas Papo Thierry Zénone Bertrand Lioger Christophe Deligny Marc Lambert Cédric Landron Jacques Pouchot Jean Emmanuel Kahn Christian Lavigne Benoit De Wazieres Robin Dhote Guillaume Gondran Edouard Pertuiset Thomas Quemeneur Mohamed Hamidou Arsène Mekinian 《Autoimmunity reviews》2017,16(12):1219-1223
Background
Cogan syndrome is mainly treated with steroids. We aimed to determine the place of DMARDs and biologic-targeted treatments.Patients and methods
We conducted a French nationwide retrospective study of patients with Cogan syndrome (n = 40) and a literature review of cases (n = 22) and analyzed the efficacy of disease-modifying anti-rheumatic drugs (DMARDs) and tumor necrosis factor α (TNF-α) antagonists.Results
We included 62 patients (31 females) (median age 37 years [range 2–76]. At diagnosis, 61 patients (98%) had vestibulo-auditory symptoms, particularly bilateral hearing loss in 41% and deafness in 31%. Ocular signs were present in 57 patients (92%), with interstitial keratitis in 31 (51%). The first-line treatment consisted of steroids alone (n = 43; 70%) or associated with other immunosuppressive drugs (n = 18; 30%). Overall, 13/43 (30%) and 4/18 (22%) patients with steroids alone and with associated immunosuppressive drugs, respectively (p = 0.8), showed vestibulo-auditory response; 32/39 (82%) and 15/19 (79%) ocular response; and 23/28 (82%) and 10/14 (71%) general response. Overall 61 patients had used a total of 126 lines of treatment, consisting of steroids alone (n = 51 lines), steroids with DMARDs (n = 65) and infliximab (n = 10). Vestibulo-auditory response was significantly more frequent with infliximab than DMARDs or steroids alone (80% vs 39% and 35%, respectively), whereas ocular, systemic and acute-phase reactant response rates were similar. Infliximab was the only significant predictor of vestibulo-auditory improvement (odds ratio 20.7 [95% confidence interval 1.65; 260], p = 0.019).Conclusion
Infliximab could lead to vestibulo-auditory response in DMARDS and steroid-refractory Cogan syndrome, but prospective studies are necessary. 相似文献17.
Karin Mani William F. Brechue Bernd Friesenbichler Nicola A. Maffiuletti 《The Knee》2017,24(2):237-242
Background
Conventional one-legged hop tests simply evaluate the total hop distance, thus neglecting important temporal and spatial parameters related to the strategy of execution, such as foot contact time.Aim
To examine the validity and reliability of an instrumented one-legged hop test, the “four hops, three contacts” (4H3C) test, in patients with knee injuries.Methods
The 4H3C test consists of four consecutive one-legged hops, of which individual hop distance and foot contact time are recorded by a validated floor-based photocell system. We examined the test–retest reliability, discriminant validity (involved vs. uninvolved side) and convergent validity (relation with maximal voluntary strength) of consecutive hop distance and foot contact time parameters in 50 patients with unilateral knee injuries.Results
Test–retest reliability was very high for hop distance (intraclass correlation coefficients: 0.91 to 0.97) and high for contact time variables (intraclass correlation coefficients: 0.75 to 0.88). The difference between the involved and the uninvolved side was significant for all hop distance and contact time parameters (p < 0.05). Maximal voluntary strength was correlated to both hop distance (r = 0.67; p < 0.001) and contact time (r = ? 0.42; p < 0.01) variables.Conclusion
The 4H3C is a valid and reliable test for the evaluation of single hops in patients with knee injuries and may be useful in sport and clinical settings. The interpretation of foot contact time data requires however some caution. 相似文献18.
Background
The purpose of this study was to evaluate the usefulness of three-dimensional (3D) printed models for open wedge high tibial osteotomy (HTO) in porcine bone.Methods
Computed tomography (CT) images were obtained from 10 porcine knees and 3D imaging was planned using the 3D-Slicer program. The osteotomy line was drawn from the three centimeters below the medial tibial plateau to the proximal end of the fibular head. Then the osteotomy gap was opened until the mechanical axis line was 62.5% from the medial border along the width of the tibial plateau, maintaining the posterior tibial slope angle. The wedge-shaped 3D-printed model was designed with the measured angle and osteotomy section and was produced by the 3D printer. The open wedge HTO surgery was reproduced in porcine bone using the 3D-printed model and the osteotomy site was fixed with a plate. Accuracy of osteotomy and posterior tibial slope was evaluated after the osteotomy.Results
The mean mechanical axis line on the tibial plateau was 61.8 ± 1.5% from the medial tibia. There was no statistically significant difference (P = 0.160). The planned and post-osteotomy correction wedge angles were 11.5 ± 3.2° and 11.4 ± 3.3°, and the posterior tibial slope angle was 11.2 ± 2.2° pre-osteotomy and 11.4 ± 2.5° post-osteotomy. There were no significant differences (P = 0.854 and P = 0.429, respectively).Conclusion
This study showed that good results could be obtained in high tibial osteotomy by using 3D printed models of porcine legs. 相似文献19.
E. Atilla P.A. Atilla S.C. Bozdag M.K. Yuksel S.K. Toprak P. Topcuoglu B.N. Akay H. Sanli H. Akan T. Demirer M. Beksac O. Arslan M. Ozcan G. Gurman O. Ilhan 《Transfusion Clinique et Biologique》2017,24(4):454-457
Objectives
Extracorporeal photo-chemotherapy (ECP, photopheresis) is an approved treatment modality for mycosis fungoides (MF). Our aim is to present our ECP data for MF.Methods
We retrospectively evaluated 50 MF patients who received ECP for clinical activity, toxicity, and response and outcome rates, and we compared these with combination therapies.Results
The overall response rate (ORR) was 42% (21/50), while the median time to response was 11 months (range, 3–48 months). Ten of the responders (48%) had 3 or more treatment lines prior to ECP. Eight patients (16%) had adverse events related to ECP. The overall survival (OS) of 50 patients was 72 months (range, 3–211). There was no statistically significant difference in the OS in early-stage vs late-stage patients (77 vs 69 months, P = 0.077). The stage 3 and 4 patients received an average of 31 cycles compared to 55 cycles in stage 1 and 2 patients (P = 0.006). The increased extent of ECP was not correlated with the response. Combined treatment with ECP significantly improved the OS (84 months vs 62 months, P = 0.005).Discussion
A low frequency of side effects and improved OS observed in combination therapy makes ECP a favorable option for treating MF. 相似文献20.
Manabu Kawata Yusuke Sasabuchi Hiroshi Inui Shuji Taketomi Hiroki Matsui Kiyohide Fushimi Hirotaka Chikuda Hideo Yasunaga Sakae Tanaka 《The Knee》2017,24(5):1198-1205