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1.
Primarysclerosingcholangitis(PSC)isadiseaseofunknownetiologythatischaracterizedbychronicin flammation ,fibrosis ,andobliterationofportionsoftheextraphepaticandintrahepaticbiliarytreethatimpairsbileflowandleadstosymptomsandsignsofchroniccholestasisandbiliarycirrhosis .ThediseaseappearstobeincreasinginprevalenceinChinainrecentyears .Thismaybedue ,inpart ,totheimprovementinlabo ratoryexaminationandprecisionofcholangiography .1.Etiolgoy(1)Immunefactors Nearly 70 %fosubjectshavecoexistinginflammatoryboweldisease...  相似文献   

2.
Backgroundandaim :Primary biliarycirrhosis(PBC)isauncommonliverdiseaseinChina .OnlysomesporadiccaseswerereportedinChinesemedicallitera turebefore 2 0 0 0 .Bytheawarenessandcarefulcasefinding ,includinganti mitochondriaantibodies(AMA)test ,theprevalenceincreasedinrecentdecadeinChina .Recently,therewerethreereportsregradingPBCin2 0 0 1,thetotalnumberofpatientsexceeded 10 0cases .TheobjectiveofthisstudyistosummarizedtheclinicalmanifestationsandnaturalcourseofPBCinourunitsince 195 8,andemphasizetheimportanceofe...  相似文献   

3.
Thetransforminggrowthfactor(TGF) βshavemultiplepotentialeffectsoncells ,includinggrowthcontrolandmatrixdeposition ,butthefactorsthatdeterminethenatureofaparticularcell’sresponsetoTGFβarenotwellun derstood .Wehaveusedhepaticstellatecells(HSC)inculturetostudydifferencesinTGFβsignalingassociatedwithdifferentresponsestoTGFβ .HSC ,whicharethemajorcelltyperesponsibleformatrixdepositioninliverfibrosis ,transdifferentiatewhenculturedonuncoatedplastic ,mirroringinmanywaysthechangestheyundergoinchronicliv erdisease ....  相似文献   

4.
Livertransplantationisindicatedforcirrhosiswhen thesyntheticfunctionoftheliverispoortotheextentthatthequalityoflifeofthepatientismuchaffected(e .g .serumalbuminlessthan 2 0 gm/Lorprothrombintimelongerthan 2 3seconds)orwhenvarioustypesofcomplicationsofcirrhosisdevelop (e .g .intractableorinfectedascites,recurrentvaricealbleeding ,hepatorenalsyndrome,hepatopulmonarysyndrome ,recurrenthep aticencephalopathy ,andhepatocellularcarcinoma[HCC]) .  Theresultoflivertransplantationforcirrhosisisgood (5 yearsurvivalr...  相似文献   

5.
《肝脏》2002,(Z1)
Backgroundandaim :Primary biliarycirrhosis(PBC)isauncommonliverdiseaseinChina .OnlysomesporadiccaseswerereportedinChinesemedicallit  相似文献   

6.
标  题  1 Rationalc ,Degign ,andBaselineCharacteristicsoftheProspectiveRandomizedEvaluationoftheVascularEffectsofNorvascTrial (PREVENT)2 AmlodipineDeducesCostofInpatientCareAssociatedwithTreatmentofCardiovascularDiseasesinPatientswithClinicalCoronaryArteryD…  相似文献   

7.
Effects of Fuzheng Huayu 319 recipe on liver fibrosis in chronic hepatitis B   总被引:20,自引:0,他引:20  
EfectsofFuzhengHuayu319recipeonliverfibrosisinchronichepatitisBLIUPing1,LIUCheng1,XULieMing1,HuYiYaang1,XUEHuiMing1,LIUCh...  相似文献   

8.
QIANMin1,BAIYan jun1,ZHANGPing1,WUZi rong1,YANZi zhu2(1 DepartmentofBiology ,EastChinaNormalUniversity,Shanghai 2 0 0 0 6 2 ;2 ChineseAcademyofPreventiveMedicine ,InstituteofParasiticDiseases ,Shanghai 2 0 0 0 2 5 )TheeggofSchistosomajaponicumisachiefpathogenicfactor .Theprep…  相似文献   

9.
RapidmitogenactivatedproteinkinaseactivationbytransforminggrowthfactorαinwoundedratintestinalepithelialcelsMichaelGkee,Michi...  相似文献   

10.
肝细胞广泛坏死是重型病毒性肝炎的基本病理特征。目前认为由细胞毒性T淋巴细胞 (Cytotoxic ityLymphocyte ,CTL)介导的细胞毒作用是导致肝细胞坏死的主要免疫机理 ,在此基础上继发的肠源性内毒素血症 ,激活肝内外单核巨噬细胞释放以肿瘤坏死因子α(TumorNecrosisFactorα ,TNF -α)为中心的各种细胞因子 ,将进一步加重肝细胞坏死。近年来发现粘附分子 ,特别是细胞间粘附分子 - 1(IntercellularAdhesionMolecule - 1,ICAM - 1)与其配基淋巴细胞功能相关…  相似文献   

11.
ExpressionofinsulinlikegrowthfactorⅡanditsreceptorinlivercelsofchronicliverdiseasesYANGDongHua1,XIUChong1,YANGBo1,GUJianR...  相似文献   

12.
Overthepastdecade,thefocusoftheetiopathogenesisofchronicinflammatoryboweldisease(IBD)hasturnedtowarddefiningadeficitinimmuner...  相似文献   

13.
NATIONALPROGRAMOFMALARIACONTROLOFPEOPLE’SREPUBLICOFCHINAXuShu—HuiDepartmentofparasiticDiseases,MinistryofPublicHealthofChina(...  相似文献   

14.
TheChineseJournalofParasitologyandParasiticDiseases(CJPPD)isanacademicjournaloftheChinaPreventiveMedicalAssociationandpublishedbimonthlybytheInstituteofParasiticDiseases ,ChineseAcademyofPreventiveMedicine .CJPPDpublishesoriginalpapersfromallareasofhuma…  相似文献   

15.
INTRODUCTION  OncomelaniahupensisGredler (1881) [1] transmitsthehumanbloodflukeSchistosomajaponicumthroughoutsouthernChinafromYunnanProvincetotheEastChinaSea .OncomelaniasnailsareamajorproblemforChinaastheirpopulationsarenotreadilycontrollable ,especiallyalo…  相似文献   

16.
TheChineseJournalofParasitologyandParasiticDiseases(CJPPD )isanacademicjournaloftheChinaPreventiveMedicalAssociationandpublishedbimonthlybytheInstituteofParasiticDiseases ,ChineseAcademyofPreventiveMedicine .CJPPDpublishesoriginalpapersfromallareasofhum…  相似文献   

17.
InhibitoryefectsoftwooligosaccharidesonmurinemelanomaexperimentallivermetastasisLIUYiPing1,ZHOURouLi2,WANGYongFu3andCAIMe...  相似文献   

18.
INTRODUCTIONHepatocellularcarcinoma(HCC)isthefourthmostcommoncauseofdeathfrommalignancyintheworldandthethirdmostcommoninmen[1].HighriskareassuchasAsiaandAfricaareassociatedwithendemichepatitisBandCinfections.InAustraliaHCCisstillarelativelyuncommonca…  相似文献   

19.
复方猴头冲剂加呋喃唑酮治疗Hp阳性慢性胃炎40例周国标浙江省上虞市崧厦医院消化内科312365SubjectheadingsGastritis/drugtherapyChronicdiseasesFurazolidoneHelicobacter...  相似文献   

20.
METHODSTreating132casesofGUandDUwithPPVPG,andcomparativestudiesmadewith24casestreatedwithBilrothⅠ(BⅠ)and20caseswithBilrothⅡ(B...  相似文献   

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