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Primarysclerosingcholangitis(PSC)isadiseaseofunknownetiologythatischaracterizedbychronicin flammation ,fibrosis ,andobliterationofportionsoftheextraphepaticandintrahepaticbiliarytreethatimpairsbileflowandleadstosymptomsandsignsofchroniccholestasisandbiliarycirrhosis .ThediseaseappearstobeincreasinginprevalenceinChinainrecentyears .Thismaybedue ,inpart ,totheimprovementinlabo ratoryexaminationandprecisionofcholangiography .1.Etiolgoy(1)Immunefactors Nearly 70 %fosubjectshavecoexistinginflammatoryboweldisease... 相似文献
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Backgroundandaim :Primary biliarycirrhosis(PBC)isauncommonliverdiseaseinChina .OnlysomesporadiccaseswerereportedinChinesemedicallitera turebefore 2 0 0 0 .Bytheawarenessandcarefulcasefinding ,includinganti mitochondriaantibodies(AMA)test ,theprevalenceincreasedinrecentdecadeinChina .Recently,therewerethreereportsregradingPBCin2 0 0 1,thetotalnumberofpatientsexceeded 10 0cases .TheobjectiveofthisstudyistosummarizedtheclinicalmanifestationsandnaturalcourseofPBCinourunitsince 195 8,andemphasizetheimportanceofe... 相似文献
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Thetransforminggrowthfactor(TGF) βshavemultiplepotentialeffectsoncells ,includinggrowthcontrolandmatrixdeposition ,butthefactorsthatdeterminethenatureofaparticularcell’sresponsetoTGFβarenotwellun derstood .Wehaveusedhepaticstellatecells(HSC)inculturetostudydifferencesinTGFβsignalingassociatedwithdifferentresponsestoTGFβ .HSC ,whicharethemajorcelltyperesponsibleformatrixdepositioninliverfibrosis ,transdifferentiatewhenculturedonuncoatedplastic ,mirroringinmanywaysthechangestheyundergoinchronicliv erdisease .... 相似文献
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Livertransplantationisindicatedforcirrhosiswhen thesyntheticfunctionoftheliverispoortotheextentthatthequalityoflifeofthepatientismuchaffected(e .g .serumalbuminlessthan 2 0 gm/Lorprothrombintimelongerthan 2 3seconds)orwhenvarioustypesofcomplicationsofcirrhosisdevelop (e .g .intractableorinfectedascites,recurrentvaricealbleeding ,hepatorenalsyndrome,hepatopulmonarysyndrome ,recurrenthep aticencephalopathy ,andhepatocellularcarcinoma[HCC]) . Theresultoflivertransplantationforcirrhosisisgood (5 yearsurvivalr... 相似文献
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《岭南心血管病杂志》2000,6(4):262-263
标 题 1 Rationalc ,Degign ,andBaselineCharacteristicsoftheProspectiveRandomizedEvaluationoftheVascularEffectsofNorvascTrial (PREVENT)2 AmlodipineDeducesCostofInpatientCareAssociatedwithTreatmentofCardiovascularDiseasesinPatientswithClinicalCoronaryArteryD… 相似文献
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《中国寄生虫学与寄生虫病杂志》2000,(5)
QIANMin1,BAIYan jun1,ZHANGPing1,WUZi rong1,YANZi zhu2(1 DepartmentofBiology ,EastChinaNormalUniversity,Shanghai 2 0 0 0 6 2 ;2 ChineseAcademyofPreventiveMedicine ,InstituteofParasiticDiseases ,Shanghai 2 0 0 0 2 5 )TheeggofSchistosomajaponicumisachiefpathogenicfactor .Theprep… 相似文献
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Rapid mitogen-activated protein kinase activation by transforming growth factor α in wounded rat intestinal epithelial cells 总被引:2,自引:0,他引:2
RapidmitogenactivatedproteinkinaseactivationbytransforminggrowthfactorαinwoundedratintestinalepithelialcelsMichaelGkee,Michi... 相似文献
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阻断ICAM-1与LFA-1介导的细胞间粘附——治疗肝细胞坏死的新战略 总被引:1,自引:0,他引:1
肝细胞广泛坏死是重型病毒性肝炎的基本病理特征。目前认为由细胞毒性T淋巴细胞 (Cytotoxic ityLymphocyte ,CTL)介导的细胞毒作用是导致肝细胞坏死的主要免疫机理 ,在此基础上继发的肠源性内毒素血症 ,激活肝内外单核巨噬细胞释放以肿瘤坏死因子α(TumorNecrosisFactorα ,TNF -α)为中心的各种细胞因子 ,将进一步加重肝细胞坏死。近年来发现粘附分子 ,特别是细胞间粘附分子 - 1(IntercellularAdhesionMolecule - 1,ICAM - 1)与其配基淋巴细胞功能相关… 相似文献
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Expression of insulin-like growth factor Ⅱ and its receptor in liver cells of chronic liver diseases 总被引:3,自引:0,他引:3
YANG Dong Hua XIU Chong YANG Bo GU Jian Ren QIAN Lian Fang QU Shu Ming 《World journal of gastroenterology : WJG》1997,(2)
ExpressionofinsulinlikegrowthfactorⅡanditsreceptorinlivercelsofchronicliverdiseasesYANGDongHua1,XIUChong1,YANGBo1,GUJianR... 相似文献
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Overthepastdecade,thefocusoftheetiopathogenesisofchronicinflammatoryboweldisease(IBD)hasturnedtowarddefiningadeficitinimmuner... 相似文献
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XuShu—Hui 《中国病原生物学杂志》1994,(3)
NATIONALPROGRAMOFMALARIACONTROLOFPEOPLE’SREPUBLICOFCHINAXuShu—HuiDepartmentofparasiticDiseases,MinistryofPublicHealthofChina(... 相似文献
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《中国寄生虫学与寄生虫病杂志》2000,(1)
TheChineseJournalofParasitologyandParasiticDiseases(CJPPD)isanacademicjournaloftheChinaPreventiveMedicalAssociationandpublishedbimonthlybytheInstituteofParasiticDiseases ,ChineseAcademyofPreventiveMedicine .CJPPDpublishesoriginalpapersfromallareasofhuma… 相似文献
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INTRODUCTION OncomelaniahupensisGredler (1881) [1] transmitsthehumanbloodflukeSchistosomajaponicumthroughoutsouthernChinafromYunnanProvincetotheEastChinaSea .OncomelaniasnailsareamajorproblemforChinaastheirpopulationsarenotreadilycontrollable ,especiallyalo… 相似文献
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《中国寄生虫学与寄生虫病杂志》2001,(1)
TheChineseJournalofParasitologyandParasiticDiseases(CJPPD )isanacademicjournaloftheChinaPreventiveMedicalAssociationandpublishedbimonthlybytheInstituteofParasiticDiseases ,ChineseAcademyofPreventiveMedicine .CJPPDpublishesoriginalpapersfromallareasofhum… 相似文献
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InhibitoryefectsoftwooligosaccharidesonmurinemelanomaexperimentallivermetastasisLIUYiPing1,ZHOURouLi2,WANGYongFu3andCAIMe... 相似文献
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Desmond Yip Michael Findlay Michael Boyer Martin H. Tattersall 《World journal of gastroenterology : WJG》1999,(6)
INTRODUCTIONHepatocellularcarcinoma(HCC)isthefourthmostcommoncauseofdeathfrommalignancyintheworldandthethirdmostcommoninmen[1].HighriskareassuchasAsiaandAfricaareassociatedwithendemichepatitisBandCinfections.InAustraliaHCCisstillarelativelyuncommonca… 相似文献
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周国标 《世界华人消化杂志》1997,5(6):380
复方猴头冲剂加呋喃唑酮治疗Hp阳性慢性胃炎40例周国标浙江省上虞市崧厦医院消化内科312365SubjectheadingsGastritis/drugtherapyChronicdiseasesFurazolidoneHelicobacter... 相似文献
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METHODSTreating132casesofGUandDUwithPPVPG,andcomparativestudiesmadewith24casestreatedwithBilrothⅠ(BⅠ)and20caseswithBilrothⅡ(B... 相似文献