Objective assessment of dyskinesia in children with cerebral palsy

The clinical classification of children with cerebral palsy is limited by multiple factors. Distinguishing between spasticity and dyskinesia is critical, because the outcome after standard orthopaedic and neurosurgical interventions is less predictable in children with cerebral palsy who have a significant dyskinetic component. This study applied computer-based analysis of gait to assess objectively the presence of significant dyskinesia in children with cerebral palsy. Three-dimensional gait analysis was performed on 18 normal children, 17 children with principally spastic cerebral palsy, and 23 children with significantly dyskinetic cerebral palsy. Children were assigned to the spastic or dyskinetic groups prospectively, based on clinical analysis by an experienced physician and physical therapist. The children with dyskinesia were found to have a significantly wider, and more variable normalized dynamic base of support, a smaller step profile (step length divided by step width), and a greater and more variable maximal lateral acceleration than the spastic and normal groups (mixed model analysis of variance, p = 0.0001). A predictive model of dyskinesia, (developed by logistic regression analysis), using these gait parameters, exhibited excellent sensitivity, correctly classifying 20 (87%) of 23 children as dyskinetic. This study shows that children with dyskinetic cerebral palsy have distinct gait parameters and that objective assessment of dyskinesia in children with cerebral palsy is possible with computer-based analysis of gait.     

Calcaneal lengthening for planovalgus foot deformity in children with spastic cerebral palsy

The purpose of this study was to evaluate the effectiveness of calcaneal lengthening in the treatment of planovalgus foot deformity of children with spastic cerebral palsy. Sixteen children (27 feet) with spastic cerebral palsy underwent calcaneal lengthening along with peroneal tendons. The results were assessed clinically and radiographically. Over an average of 3.2 years of follow-up (2.0-5.0), 20 (74.1%) feet showed a satisfactory clinical result, and 21 (77.8%) feet showed a satisfactory radiographic result, according to the modified Mosca's criteria. Dependent ambulators with severe pes planovalgus showed unsatisfactory results compared with independent ambulators with mild to moderate pes planovalgus. These findings suggest that for severe pes planovalgus of children with cerebral palsy, it may be difficult to correct the foot deformity by calcaneal lengthening with peroneal tendons.     

The role of intrathecal baclofen in the management of primary and secondary dystonia in children

Intrathecal baclofen (ITB) is a well-established method of treating spasticity in children with cerebral palsy. In our series, eight children with primary or dystonia secondary to cerebral palsy have benefited from ITB. The observations in this paper are subjective and based on the carer's impressions, but have confirmed the role of ITB in dystonia. Children with dystonia secondary to cerebral palsy benefited most and ITB can be used in these as a single treatment modality. The approach is different in dystonia secondary to cerebral palsy, where ITB can be used to palliate the spastic component, but other methods are necessary to treat the primary disease. We currently have three children in our series, where ITB in conjunction with deep brain stimulation (DBS) was used with satisfactory results.     

Scurvy: An unusual presentation of cerebral palsy

Scurvy is caused by prolonged severe dietary deficiency of ascorbic acid, in which the breakdown of intercellular cement substances leads to capillary hemorrhages and defective growth of fibroblasts, osteoblasts and odontoblasts, resulting in impaired synthesis of collagen, osteoid and dentine. It is characterized by hemorrhagic gingivitis, subperiosteal hemorrhages, perifollicular hemorrhages, and frequently petechial hemorrhages (especially on the feet). People with abnormal dietary habits, mental illness or physical disability are prone to develop this disease. Epiphyseal separation is known to occur in scurvy but is rarely seen now. Epiphyseal separation from the metaphysis is always through the zone of calcified cartilage, known as "scorbutic lattice", which in the radiographs is represented as "the white line of Frenkel". We report a case of multiple epiphyseal separations in a cerebral palsy child because of vitamin C deficiency. The child was treated with splintage of extremity and nutritional supplementation. All physeal separation healed completely without any deformity.     

The key-muscle concept: a long-term low-dose injection strategy for botulinum toxin A treatment in cerebral palsy

Botulinum toxin (BoNT) is a well established treatment in cerebral palsy. A uniform dose strategy is, however, missing. We reviewed 35 children with spastic cerebral palsy treated with BoNT according to a newly-developed Key-Muscle concept. All patients received at least 4 BoNT treatments. Systemic side effects or secondary non-response were not observed. After a mean follow-up of 303 months, none of these patients needed bone surgery whereas 6 underwent soft tissue procedures. The Key-Muscle concept is a safe and effective treatment in spastic cerebral palsy. It respects the need for long-term therapy during motor development. Contractures and lever arm disease can be avoided.     

Assessment and management of the lower extremity in cerebral palsy

For all lower extremity problems in children with cerebral palsy, early attention to overactive spastic muscle groups can aid in preventing bony deformities under most situations. More severely involved children need more aggressive treatment, with early soft tissue procedures to attempt balance of muscle groups surrounding joints. Early aggressive management of soft tissue problems can avoid long-term bony deformity and more severe posturing problems in the lower extremities of children with cerebral palsy.     

Hip surveillance in children with cerebral palsy. Impact on the surgical management of spastic hip disease

We studied prospectively the impact of a hip surveillance clinic on the management of spastic hip disease in children with cerebral palsy in a tertiary referral centre. Using a combination of primary clinical and secondary radiological screening we were able to detect spastic hip disease at an early stage in most children and to offer early surgical intervention. The principal effect on surgical practice was that more preventive surgery was carried out at a younger age and at a more appropriate stage of the disease. The need for reconstructive surgery has decreased and that for salvage surgery has been eliminated. Displacement of the hip in children with cerebral palsy meets specific criteria for a screening programme. We recommend that hip surveillance should become part of the routine management of children with cerebral palsy. The hips should be examined radiologically at 18 months of age in all children with bilateral cerebral palsy and at six- to 12-monthly intervals thereafter. A co-ordinated approach by orthopaedic surgeons and physiotherapists may be the key to successful implementation of this screening programme.     

Severe crouch gait in spastic diplegia can be prevented: a population-based study

We studied the prevalence of severe crouch gait over a 15-year period in a defined population of children with spastic diplegia and Gross Motor Function Classification System levels II and III, to determine if there had been a decrease following changes to the management of equinus gait. These changes were replacing observational with three-dimensional gait analysis, replacing single level with multilevel surgery, and replacing gastrocsoleus lengthening with gastrocnemius recession. Of 464 children and adolescents with spastic diplegia who underwent three-dimensional gait analysis, 27 had severe crouch gait. Seventeen of these had been managed by isolated lengthening of the gastrocsoleus. Following changes in the management of equinus gait, the prevalence of severe crouch gait decreased from 25% and stabilised at a significantly lower rate, fluctuating between 0% and 4% annually (p < 0.001). We conclude that severe crouch gait in this population was precipitated by isolated lengthening of the gastrocsoleus. These findings may be relevant to other surgical populations, as severe crouch gait may be a useful way to monitor the quality of the surgical management of abnormal gait in children with cerebral palsy and spastic diplegia.     

Ankle joint range of motion measurements in spastic cerebral palsy children: intraobserver and interobserver reliability and reproducibility of goniometry and visual estimation

The aim of this study was to assess the intra- and interobserver reliability and reproducibility of goniometry and visual estimation of ankle joint range of motion measurements in children with spastic cerebral palsy. Forty-six ankles of 24 spastic cerebral palsy children were measured under a strict protocol. The global mean measurement error was 5 degrees (SD, 5 degrees) for intra- and interobserver measurements and 3 degrees (SD, 3 degrees) for goniometry versus visual estimation. Statistical analysis showed a high reliability for intra- and interobserver measurements (r>0.75), between visual estimation and goniometry (correlation coefficient, r>0.967; concordance coefficient, r>0.957). Both visual estimation and goniometry ankle range-of-motion measurements are reliable and reproducible in spastic cerebral palsy children if a strict but simple protocol is applied.     

Etiopathogenesis of spastic hip pain and dislocation in children]

The hip joint dislocation is one of the most serious complications associated with severe type of spastic cerebral palsy in children. The natural history of this secondary problem is poorly defined: how often and why the dislocated hip joint is going to be painful. The aim of our study was to specify prevalence of hip pain in the quadriplegic spastic type of cerebral palsy children with dislocated one or two hip joints. The next purpose was to establish correlation between cartilage degenerative changes and pain appearance. MATERIAL AND METHOD: The clinical study population consisted of cerebral palsy children, who presented a unilateral or bilateral dislocation of the hip joint, operated in Department of Pediatric Orthopedics during the period 2002 through 2005. Performed surgical procedures allowed us to evaluate degenerative changes of femoral head cartilage. In 45 operated hips (33 patients) we discovered that 33 had degenerative cartilage lesions which in 25 cases (75%) were associated with pain appearance. RESULTS: We observed correlation between anterior location of the femoral head lesion and pain appearance, between the size of the lesion and intensity of pain complaints and also between femoral antetorsion and magnitude of pain. CONCLUSIONS: Risk factors of pain appearance in spastic dislocated hip joint are degenerative lesions on anterior face of femoral head cartilage, age of the patient, large antetorsion angle and cartilage lesion bigger than 1/4 of femoral head surface.     

Hip dysplasia in spastic cerebral palsy

Previous reports have noted a relationship between pelvic obliquity and hip dysplasia in spastic cerebral palsy but did not confirm its existence by scientific study. A study is reported that confirms the association of pelvic obliquity with hip dysplasia in spastic cerebral palsy. At presentation of subluxation or dislocation prior to surgery, 80 patients were indexed into five body alignment types. Reclassifications were performed with passage of time in order to study the natural history and effects of surgery. In all cases, hip dysplasia was found to be consistent with the forces related to pelvic obliquity.     

Acquired atlantoaxial instability in children with spastic cerebral palsy

The development of nontraumatic atlantoaxial instability in children with spastic cerebral palsy has not been reported. The authors present three patients with severe spastic quadriplegia who developed C1-C2 instability and cervical myelopathy at mean age 12.6 years. These patients demonstrated a similar clinical picture with symptoms attributed to cervical myelopathy in varied severity including apneic episodes, opisthotonus, alteration in muscle tone, torticollis, respiratory problems, hyperreflexia, and bradycardia. Patient 1 was scheduled for surgery but died due to an apneic episode. Patient 2 refused surgery and has been followed for 3 years while his neurologic condition remains unchanged. Patient 3 underwent occipitocervical decompression and fusion, recovered neurologically, and resumed his previous functional skills. Patients demonstrating considerable functional deterioration or insidious change in their established neurologic status should undergo detailed screening to rule out developing upper cervical instability. Early surgical intervention consisting of spinal decompression and fusion may prevent the development of myelopathy.     

Epiphyseal changes after proximal femoral osteotomy

This study was conducted to evaluate the risk factors for epiphyseal changes suggestive of osteonecrosis after proximal femoral osteotomy for hip subluxation associated with cerebral palsy. Forty-eight children with 94 hips were reviewed. Two observers rated the radiographs using a written protocol on two occasions each so that reproducibility of these observations could be assured. Concomitant pelvic osteotomy proved to have the greatest association with risk of epiphyseal changes. These findings, suggestive of osteonecrosis, were present in 7 of 68 (10%) hips that had isolated femoral osteotomy, and in 12 of 26 (46%) hips that had concomitant pelvic osteotomy.     

The effects of hamstring lengthening on hip rotation

The purpose of this study is to determine the effect on hip rotation of hamstring lengthening as measured by preoperative and postoperative motion analysis. Thirty-eight patients/76 hips in children with cerebral palsy spastic diplegia were retrospectively reviewed using presurgical and postsurgical gait analysis. Physical examination and gait analysis showed an increase in knee extension and decreased popliteal angles postoperatively. Kinematic analysis showed an increase in knee extension and decreased hip internal rotation throughout the gait cycle postoperatively as well. No difference was seen between those with internal and external rotation pattern at the hip preoperatively. As a group, the patients did not improve enough to change from internal to external rotation at the hip, suggesting that children with cerebral palsy spastic diplegia with significant internal rotation gait should have other surgical options besides hamstring lengthening when internal rotation gait of the hip is to be treated.     

Oxygen cost versus a 1-minute walk test in a population of children with bilateral spastic cerebral palsy

Difficulties with direct measurement of oxygen (O2) consumption have led to the use of simpler proxy measures to estimate energy efficiency in children with cerebral palsy. This study aimed to investigate the relationship between a fast 1-minute walk test and O2 cost in children with bilateral spastic cerebral palsy. Eighty-four children (31 girls, 53 boys; mean age, 10 years 11 months; Gross Motor Function Classification System level I n = 8, level II n = 41, level III n = 21, level IV n = 14) were eligible to participate in the study. Seventy-seven children completed the walk test and 47 children completed the O2 consumption protocol. Results showed significant differences between Gross Motor Function Classification System levels for both tests (P < 0.001) and a significant moderate quadratic relationship between the distance covered during the 1-minute fast-walk test and the net O2 cost (adjusted r = 0.477; P < 0.001). The 1-minute fast-walk test may provide useful information on the efficiency of gait in children with bilateral spastic cerebral palsy in the absence of more sophisticated equipment; however, further work is required to address its reliability and responsiveness.     

捏脊疗法合节段性按摩对痉挛型脑性瘫痪患儿坐位能力的影响

目的 探讨捏脊疗法合节段性按摩对痉挛型脑瘫患儿坐位能力的影响.方法 选取60 例尚无独坐能力的6～18个月痉挛型脑瘫患儿,治疗前均进行粗大运动功能评估中坐位功能区（A区、B区）的评分,采用捏脊疗法合节段性按摩法治疗,2次/d,20d为一个疗程,共3个疗程后观察GMFM（A区、B区）评分变化.结果治疗后GMFM A区、B区评分较治疗前均有提高,差异有统计学意义（P＜0.01）,总有效率达85%.结论 捏脊疗法合节段性按摩可有效改善痉挛型脑瘫患儿的坐位能力.     

Treatment of femur fractures in children with cerebral palsy

Purpose  Children with cerebral palsy may have low bone density stemming from various etiologies and are, thereby, at risk for fractures. The treatment of femur fractures in children with cerebral palsy may need to be tailored to address the management of spastic muscle tone and multiple medical co-morbidities. Methods  Our study is a retrospective review that evaluates the treatment of 47 femur fractures in children with cerebral palsy in both ambulatory and non-ambulatory patients. Results  Thirty-two fractures in non-ambulators were treated non-operatively, 11 of which resulted in malunions and five developed pressure sores. Six fractures in non-ambulators were treated operatively, one of which resulted in a malunion. In ambulators, five fractures were treated non-operatively; one of these fractures lost reduction after 2 weeks and required surgical intervention. One of four fractures in ambulators treated operatively developed a malunion. Conclusion  Our study results suggest that femur fractures in children with cerebral palsy can be treated non-operatively; however, because of the high risk of malunion in this patient population, fracture alignment needs to be followed closely during healing. Careful attention during casting is necessary to prevent pressure sores. Strong consideration should be given to initial operative treatment in ambulatory patients in order to preserve function.     

Proximal hamstring lengthening in the sitting cerebral palsy patient.

We retrospectively studied 62 nonambulatory children with spastic quadriplegic cerebral palsy who underwent proximal hamstring lengthening to improve hip and spine positioning. Preoperatively, all had hamstring contracture, with difficulty sitting due to hip extensor thrust and increased kyphosis. Thirty-five patients with follow-up greater than or equal to 2 years were studied using a modified Reimer scale to assess sitting ability. Sitting ability improved significantly (p less than 0.01) postoperatively, along with popliteal angle (p less than 0.001) and straight leg raising (p less than 0.001). Proximal hamstring lengthening is effective in treating severe hamstring contractures in the wheelchair-bound child with cerebral palsy.     

Gait electromyographic evaluation of the long-toe flexors in children with spastic cerebral palsy

In a prospective study of the phasic activity of the long-toe flexors of patients with spastic cerebral palsy, the electrical activity of the long-toe flexors in 37 children with varus or valgus hindfoot deformity was measured by wire electrode dynamic electromyography. Although gross abnormalities in the phasic timing of the flexor hallucis longus and flexor digitorum longus were observed, these muscles could not be implicated in the etiology of hindfoot deformity. In planning gait analysis protocols for children with cerebral palsy and hindfoot deformity, electromyography of the long-toe flexors is not necessary unless toe curling is clinically evident.     

Early mobilization after sliding achilles tendon lengthening in children with spastic cerebral palsy

Equinus deformity is a common finding in children with cerebral palsy and may be treated by Achilles tendon lengthening. To prevent recurrence, some authors recommend immobilizing the operated leg with an above-knee cast for six weeks, followed by use of a night splint or orthosis. Nevertheless, there are recurrence rates of up to 20.5%. The aim of this study was to evaluate the long-term result of postoperative immobilization for two weeks in a below-knee cast and early weight bearing, without the use of a splint or orthosis. Thirty-six children (52 feet) with spastic cerebral palsy underwent sliding Achilles tendon lengthening. Follow-up of five to ten years showed a comparable recurrence rate (19.2%) to that reported with the standard, more stringent management approach. Most of the recurrences were in children operated on before five years of age. We believe earlier motion helps to sustain the tendon length achieved at surgery and allows for earlier independent gait.