激光治疗太田痣500例临床分析

太田痣是临床常见病之一 ,其传统治疗方法有磨削、冷冻、植皮、化学剥脱等 ,但疗效不满意[1 ] 。我科自 1998年 6月开始采用Ｎｄ :ＹＡＧ激光 (波长 10 6 4ｎｍ)治疗色素性疾病 2 971例 ,其中太田痣 5 0 0例 ,取得了满意的效果 ,现报告如下。1　材料与方法1.1　临床资料　自 1998年 6月～ 2 0 0 0年9月共收治太田痣患者 5 0 0例 ,其中男 133例 ,女 36 7例 ,男女比例 1:2 .76 ;年龄 6个月～ 6 1岁 ,平均 2 1.6 9岁 ;皮损面积 2ｃｍ2～2 4 0ｃｍ2 ,平均 2 4 .7ｃｍ2 ;按三岛分类标准 ,Ｉ型 (轻型 ) 2 10例 ,ＩＩ型 (中型 ) 10 7例 ,ＩＩＩ型 (…     

多波长激光仪治疗太田痣135例临床分析

我们自1997年4月使用新一代激光仪———多波长、多功能固体皮肤激光器治疗171例太田痣患者,其中失访12例,有24例手术后未满1个月,可总结病例共135例,收到满意临床疗效,现报告如下。1　病例选择135例太田痣患者中男性26例,女性109例;年龄最大54岁,最小5岁,平均254岁,小于30岁者     

Q开关Nd-YAG激光治疗太田痣78例临床分析

太田痣是皮肤科的常见病.传统的治疗方法有磨削、植皮、冷冻、CO2激光疗法等,但治疗效果欠佳,易产生瘢痕、色素沉着等,患者不满意.我院自2000年1月-2003年3月应用Q开关激光治疗太田痣78例,获得满意的效果,现分析如下.     

调QALEXLAZR激光治疗太田痣196例临床疗效分析

目的：探讨调Q ALEXLAZR激光（以下简称ALEX激光）治疗太田痣的疗效。方法：我所运用ALEX激光器对196例患者进行了多次皮损区照射治疗。治疗间期3－6个月，对年龄大小、治疗次数、面积大小、皮损类、皮损颜色、皮损部位、不良反应等进行了分组观察研究。结果：其年龄小、面积小、随治疗次数增加疗效越显著，经过1－8次治疗：痊愈80例，显效81例，有效35例，无无效病例。80例痊愈患者平均治愈次数为4．13次。其中1－6岁为3．1次。一般治疗4次左右可以治愈，无1例留下瘢痕.结论：ALEX激光为目前治疗太田痣的一种安全，有效的方法。     

288例带状疱疹临床分析

目的：进一步了解和掌握带状疱疹的发病时间，年龄及与皮损类型、部位、病程、伴发症状的关系。方法：对288例带状疱疹住院患临床资料进行分析。结果：发病时间以春夏季较高181例(62．8％)，发病年龄以中老年较多231例(80．2％)。结论：带状疱疹发病率随年龄增大而增加，中老年患病情重，头面部受累多，病程长，合并症及后遗症较多。     

多波长脉冲激光治疗太田痣140例临床疗效分析

我科自 1998年开始使用新一代多波长、多功能皮肤激光仪治疗太田痣 389例 ,对其中 14 0例进行疗效分析 ,现总结如下。1　临床资料14 0例太田痣患者女 12 2例 ,男 18例 ,年龄 8个月～ 5 4岁 ,平均 2 7.5 4岁 ,病程 8个月～ 5 0年 ,平均 2 0 .31年 ,皮损面积 2～12 0ｃｍ2 ,平均 2 3ｃｍ2 ,单侧分布 133例 ,双侧 7例。2　治疗方法2 .1　方法采用　美国科以人公司生产的激光仪。根据不同皮损颜色、部位、年龄及治疗经验 ,选用不同波长。多数患者采用Ｑ开关ＮｄＹＡＧ10 6 4ｎｍ ,Ｑ开关翠绿宝石75 5ｎｍ联合应用 ,光斑直径 3～ 5ｍｍ ,频率3～ …     

调Q翠绿宝石激光治疗169例太田痣的临床分析

太田痣又名“眼上腭褐青色斑痣” ,于193 9年由日本医生太田首先予以系统描述 ,它属于一种真皮黑素细胞增生的良性皮肤肿瘤[1] ,主要侵犯颜面部 ,影响容貌 ,至今病因未明。国内对其流行病学资料的分析报道尚少 ,我们对 169例太田痣的流行病学资料及激光治疗的远期效果进行了分析 ,现报道如下。1　临床资料1.1　病例来源　 169例患者全部来自我科门诊。1.2　性别与年龄　 169例太田痣患者 ,其中男 3 2例 ,女 13 7例。发病年龄为出生至 3 9岁不等 ,其中 1岁以内发病者 ,男 2 2例 ,女 71例 ,共 93例 ,1～ 10岁发病者 ,男8例 ,女 2 4例 ,共 3 2…     

Q开关755 nm翠绿宝石激光与1064nm Nd:YAG激光治疗1039例太田痣的临床分析

<正>太田痣(nevus of Ota)是一种亚洲地区较为常见的皮肤、黏膜色素沉着性疾病,1939年由日本医生Ota首次报告^[1],并将其命名为眼上腭部褐青色痣。其好发于黄种人及其他有色人种,罕见于白种人,在我国的发病率为0.2%～0.6%^[2]。皮损多发生于面部,不仅严重影响患者容貌,还易引起患者的精神创伤^[3]。根据选择性光热作用原理,基于患者皮损颜色、病程及部位等因素可选择不同波长Q开关激光治疗,如Q开关694 nm、755 nm及1064 nm激光等,但对于患者个体如何选择合适波长的激光尚未见大样本研究报道。因此,本研究回顾性分析2012年8月—2018年12月于我院采用Q开关755 nm和(或)1064 nm激光治疗的1039例太田痣患者的临床资料,现报告如下。     

柯萨奇病毒B6所致青少年病毒疹30例临床分析

目的 探讨柯萨奇病毒B6所致病毒疹的流行病学特点。方法 对2003年3月～6月间出现高热、咽痛、皮疹伴白细胞数降低等病毒感染征象的30例青少年患者进行了病原学检测及临床分析。结果 30例患者均为柯萨奇病毒B6感染者，其发病有一定特点。结论 由柯萨奇病毒B6引起的病毒性皮肤病，其临床特征与麻疹、风疹有某些相似，但又具有明显的差异；采用RT—PCR方法证实病原体；及时治疗可完全治愈；其流行性及传染性尚需进一步跟踪调查。     

儿童银屑病35例临床分析

银屑病是皮肤科常见的慢性炎症性皮肤病。因病因和发病机制尚未完全明确，治疗棘手，且易复发，给患者生活质量带来不同程度的影响。银屑病可发生于任何年龄，在儿童中也较为常见。我科于2003年9月-2006年4月诊治35例儿童银屑病患者，现报道如下。     

太田痣合并鲜红斑痣3例

报告3例太田痣合并鲜红斑痣，3例患者均为先天发病，第1例为面部双侧太田痣合并躯干部大片鲜红斑痣，组织病理和电镜显示真皮中可见色素细胞；第2例为面部双侧同时太田痣合并鲜红斑痣；第3例为右侧面部太田痣合并颈部、下颌部鲜红斑痣。     

Bilateral Ota naevus

We present the case of a 22-year-old woman, who had presented since the age of 15 a pale-blue spot spread on the right-hand side of her forehead and in her bulbar conjunctiva (first and second branches of the trigeminus nerve), consistent with Ota naevus. A few years later another with similar characteristics appeared on the other side of her forehead, cheek and sclera. No deafness, neurological defect nor visual loss were detected. We comment on the rarity of this case because the patient is Caucasian and also we explain the main complications derived of this disease and consider the therapeutic options.     

Bilateral naevus of Ota: a rare manifestation in a Caucasian

The naevus of Ota (naevus fusculocoeruleus ophthalmomaxillaris) was first described by the Japanese dermatologist M. T. Ota in 1939. It has a reported incidence of 0.2% to 1% in the Japanese population. It usually occurs in the skin innervated by the first or second branch of the trigeminal nerve. The naevus comprises dermal melanocytes and is congenital or acquired during adolescence. Commonly associated lesions include scleral melanocytosis and other ocular manifestations as well as lesions of the tympanic membrane, oral and intranasal mucosa and leptomeninges. Diseases associated with Ota's naevus in rare cases are open-angle glaucomas and melanoma. The naevus of Ota in Europeans is a rare manifestation. We report the very rare case of a bilateral naevus of Ota associated with enoral melanocytosis in a white European person.     

Histopathological parameters determining lesion colours in the naevus of Ota: a morphometric study using computer-assisted image analysis

BACKGROUND: Naevus of Ota manifests various colours ranging from light brown to blue. Naevus colours have been claimed to reflect the depth of melanin pigments but the claim has rarely been substantiated by quantitative studies. OBJECTIVES: We attempted both quantitative and qualitative analyses of the naevus of Ota to find out relations between histological patterns or parameters of melanin/melanocytes and lesion colours. METHODS: Lesion colours were determined by one of the authors and were confirmed by a separate panel of dermatologists. Forty biopsy specimens of naevus of Ota were evaluated by both computer-assisted quantitative image analysis and a previously proposed conventional pattern analysis. RESULTS: The mean area fraction (AFmean) of melanin, the depth of the maximum area fraction of melanin (level of AFmax) and the depth of the deepest infiltrating melanocyte were significantly greater or deeper for bluish lesions than brownish lesions. Based on the qualitative pattern analysis we found that all the brownish lesions demonstrated superficial dermal melanin pigments, whereas bluish lesions tended to show more heterogeneous histological patterns. Eyelid lesions, all of which were bluish, revealed greater AF(mean) value than cheek lesions, presenting as either brownish or bluish colours. CONCLUSIONS: Quantitative analysis indicated that pigment density measures such as AFmean could be as important as the depth of melanocytes in the explanation of the lesion colours in naevus of Ota. However, qualitative pattern analysis failed to link specific patterns with lesion colours, especially in bluish lesions, probably due to the lack of consideration of the pigment density.     

Response of naevus of Ota to Q-switched ruby laser treatment according to lesion colour

Lesions of naevus of Ota range in colour from light brown to blue, and even greenish-black. To develop guidelines for optimal treatment, we evaluated the number of Q-switched ruby laser treatments required to eliminate the pigmentation of such lesions classified by colour. Over a period of 6 years, we evaluated 151 Japanese patients with naevus of Ota who had been treated with the Q-switched ruby laser at a low energy level (wavelength 694.3 nm; pulse duration 28 x 10-9 s; energy fluence 5 J/cm2; spot size 6.5 mm) every 2 months. Each lesion was classified by colour as brown (n = 22), brown-violet (n = 42), violet-blue (n = 81) and blue-green (n = 6). The 22 predominantly brown lesions attained an excellent (100-95%) or good (95-75%) cosmetic result following three laser treatments in all patients who received this number of treatments. In the 42 brown-violet lesions, 25 of the 29 good or excellent results were achieved after four treatments; the 13 less successful results were in patients who had one to three treatments. In the 81 violet-blue lesions, 54 of the 65 good or excellent results were achieved after four treatments and 64 of 65 after five treatments, whereas all 16 less good results were in patients who had only one to three treatments. However, in the six blue-green lesions, six or more treatments were required to achieve a similarly favourable result. At the end of treatment, the area was virtually free of scarring, and its texture resembled that of the surrounding normal skin. We have confirmed that the use of the Q-switched ruby laser at a low energy level can eliminate the pigmentation of naevus of Ota. While the desired improvement can be obtained within 1 year, the number of treatments appears to depend on the predominant colour of the lesion.     

Q开关Nd:YAG激光治疗双侧太田痣3例

报告3例双侧太田痣。患者均为女性,1例为早发型,2例为迟发型。皮损特点是蓝褐色斑疹,主要累及巩膜及受三叉神经支配的面部皮肤,无自觉不适。其中1例患者父亲及妹妹均患此病。予Q开关Nd:YAG激光(波长1064nm)治疗,疗效满意。     

Characteristics of Hori naevus: a prospective analysis

BACKGROUND: Acquired, bilateral naevus of Ota-like macules or Hori naevus (HN) is a common dyschromia seen in Orientals. Other than the original report which documented the clinical spectrum in a group of 22 patients, there have not been many epidemiological reports of this condition. OBJECTIVES: To evaluate the epidemiology and clinical characteristics of HN in Asian patients. METHODS: A prospective analysis of 161 patients with HN seen from June 2003 to June 2004 was performed. RESULTS: All 161 patients in the study were women. Patients were Chinese (n = 155), Eurasian (n = 4), Malay (n = 1) and Indian (n = 1). The median age at onset was 30 years. The malar region was the most frequently affected area. Discrete brown macules were the most common early presentation. Confluent slate-grey macules occurred later. Aggravating factors included sun exposure and pregnancy. Sixty-seven patients reported a positive family history. CONCLUSIONS: We report our data on the largest series of HN in the literature so far. Predisposing factors in our study are Chinese race, female sex and positive family history. HN became progressively more confluent and grey over time, suggesting migration from the epidermis to the deeper dermis. More studies are needed to confirm the pathogenesis.     

Cutaneous malignant melanoma arising in an acquired naevus of Ota

Naevus of Ota is a dermal melanocytosis most commonly found in black or Asian skin and is usually a benign malformation, but with a low risk of melanoma. We describe a 32-year-old Caucasian man with an acquired naevus of Ota with subtle pigmentation, in which a melanocytic papule developed. The lesion, deceptively, had no clinically suspicious features, but investigation revealed an aggressive cutaneous malignant melanoma, extensive orbital ring melanocytosis and metastatic brain and subsequent liver disease.     

调Q Alexandrite激光治疗522例太田痣

为评价调Q Alexandrite激光对太田痣的疗效，对522例患者进行了2次以上治疗。结果：522例患者中，无1例有疤痕形成。疗效随次数的增加而提高；治疗间隔5－6个月较为合理；睑、颞部的疗效逊于其他部位；多因素分析中，次数、剂量、间隔具有显著意义。研究表明，调Q Alexandrite激光能无创伤地治愈太田痣。