一株多芽生皮炎芽生菌

关于皮炎芽生菌的生芽问题,多年来国内外有关文献报道其组织相均认为是单芽生的,而无双芽及多芽生的,但经我们多次动物试验发现,该菌除单芽外,还有双芽、多芽及子芽连续发芽的菌体,为进一步证实这一发现,我们特对该菌的生芽问题进行了试验观察,现将结果报告如下.     

芽生菌病一例

患者男,29岁,南京人,未婚,1989年6月2日入院.     

着色芽生菌病继发皮肤鳞癌一例

患者，男，57岁，农民。右腕部红斑、结痂20余年，右前臂肿物伴疼痛1月余。7年前因增生性斑块于我科就诊，真菌镜检：见棕色厚壁孢子，病理结果示着色芽生菌病。明确诊断着色芽生菌病。给予伊曲康唑服用7个月，皮疹明显消退，真菌检查为阴性。2018年3月29日，患者食用网购“熊胆粉”1月后，右前臂出现新生暗红色肿物，渐增大，伴疼痛。体检：右腋窝可扪及一核桃大小淋巴结。皮肤科查体：右手无名指和中指关节僵直，右手背、指背见陈旧性挛缩性粉红色疤痕，表面较光滑，右前臂可见20x10cm大暗红色肿块，表面成颗粒状增生，见污褐色结痂及脓性分泌物，有臭味，触痛明显。经病理检查诊断为鳞状细胞癌。     

皮肤着色芽生菌病1例

1临床资料 患者男,72岁,农民;面部发现红色结节、进行性增大1年.1年前左侧面颊不慎被马"踢伤",由于"伤势不重"没有处理.之后出现受伤部位红色结节,豆粒大小,有刺痒感;结节逐渐缓慢扩大并出现眶内侧皮损,未进行治疗,来本院就诊.发病以来,无低热、咳嗽、皮肤破溃,无浅表淋巴结累及.     

皮肤着色芽生菌病1例

1临床资料 患者男,35岁,农民,主因右下肢皮肤疣状结节斑块破溃、渗出,反复发作进行性加重13年,于2003年4月26日收住院.患者入院前13年,小腿内侧外伤后出现散在黄豆及蚕豆大小暗红色疣状结节,逐渐增大形成斑块,表面破溃,有脓性分泌物.     

皮肤着色芽生菌病1例

临床资料 患者男,71岁.因左手背疣状斑块9年多来本院就诊.9年多前患者打扫卫生时不慎左手背被木刺刺伤,未作处理,2周后于受伤处出现1个小红丘疹,无痛痒感,丘疹渐扩大,呈疣状斑块,曾多次在多家医院诊断为"湿疹",外用糖皮质激素类药物(具体不详)治疗无效,斑块逐渐增大,并出现小溃疡,脓液和结痂.患者平素尚体健,无结核病史,否认有药物和食物过敏史,家族中无类似患者.     

皮肤着色芽生菌病1例

1临床资料 患者,男,41岁,农民。因左下肢内侧足缘处皮肤疣状结节,斑块。进行性增大7yr就诊。患者7yr前因于农活不慎被镰刀划伤后未经任何处理,出现伤口周围黄豆大及蚕豆大红色疣状结节,颜色逐渐变深,面积逐渐增大,因无自觉症状,未曾就医及接受任何治疗。患者自发病以来,无发热、关节痛等症状,既往身体健康,无结核、肝炎病史。家族中无类似病史。本次就医,因看病人,顺便就诊。     

皮肤着色芽生菌病1例

临床资料患者男,71岁。因左手背疣状斑块9年多来本院就诊。9年多前患者打扫卫生时不慎左手背被木刺刺伤,未作处理,2周后于受伤处出现1个小红丘疹,无痛痒感,丘疹渐扩大,呈疣状斑块,曾多次在多家医院诊断为“湿疹”,外用糖皮质激素类药物（具体不详）治疗无效,斑块逐渐增大,并出现小溃疡,脓液和结痂。     

皮炎芽生菌病近代治疗新进展

皮炎芽生菌病是一种侵犯系统、内脏、生命攸关的深部真菌病。随着近30年来抗真菌药的不断问世,治疗有了新的进展。用之有效的系统抗真菌药有两性霉素B,唑类衍生物酮康唑、伊曲康唑。新一代三唑类抗真菌药:SCH39304、ICI195739、BayR3783和D0870很有希望,正在开发的真菌几丁质合成酶抑制剂如多氧菌素,尼可霉素也有很好的兆头。     

皮炎芽生菌病近代治疗新进展

皮炎芽生殖病是一种侵犯系统，内脏，生命攸关的深部真菌病，随着近３０年来抗真菌药的不断问世，治疗有了新的进展，用之有效的系统抗真菌有两性霉素Ｂ，唑类衍生物酮康唑，伊曲唑，新一代三唑类抗真菌药：ＳＣＨ３９３０４，ＩＣＩ１９５７３９，ＢａｙＲ３７８３和Ｄ０８７０很有希望，正在开发的真菌几丁质合成酶抑制剂如多氧菌素，尼可霉素也有很好的兆头。     

单纯皮肤受累的成人朗格汉斯细胞组织细胞增生症一例

患者男,60岁, 躯干泛发褐色大斑片3年,斑片上及其周边出现结节半年合并溃疡2个月。患者3年前腹部皮肤出现红褐色斑片约1.0 cm × 2.0 cm,无明显自觉症状。当时未予任何处理,期间皮疹面积逐渐增大,并泛发到背部、臀部、侧腰部及腹股沟上方,颜色逐渐变深呈褐色,予口服及外用药治疗（具体不详）,皮损未见好转。半年前背部斑块上成簇出现粉红色黄豆大小结节,结节逐渐增大并变硬,数量增多,并很快发展到其他斑块及周围皮肤上,期间伴随着新结节的出现及老结节的消退……     

皮炎外瓶霉致皮肤暗色丝孢霉病一例

患者男,78岁,右前臂红肿1个月,加重伴破溃半月。患者1个月前无明显诱因右前臂出现小片状红斑,无自觉症状,表面皮温稍高,无压痛、水疱、破溃,无畏寒、发热,自行外用喜辽妥无改善,红斑面积渐扩大。半月前红斑上出现血疱,很快形成溃疡,伴有渗出,疼痛明显,来我院就诊,予青霉素抗感染治疗无改善。后考虑可能为血管炎类疾病,予泼尼松治疗,皮损很快扩大,溃疡加重,疼痛明显,收住入院治疗。既往病史无特殊……     

Cutaneous lesions showing giant yeast forms of Blastomyces dermatitidis

BACKGROUND: The yeast forms of Blastomyces dermatitidis usually range from 8 to 15-20 micro m in diameter. Larger yeast forms have previously been reported only twice in immunosuppressed patients. In both patients these large forms were seen within the lung. CASE REPORT: We present a 14-year-old cardiac transplant patient, who presented 36 days following his transplantation with acute respiratory distress followed a few days later by erythematous cutaneous papules. RESULTS: Biopsy of a skin lesion showed yeast forms, some greater than 40 micro m in diameter, within and surrounding dermal vessels. Cultures later grew Blastomyces dermatitidis. CONCLUSIONS: To our knowledge this is the first reported case of giant forms of Blastomyces dermatitidis within the skin. With increased iatrogenic immunosuppression, we may expect to see more diverse morphologic forms with deep fungal infections.     

Sarcoidosis in a preschooler with only skin and joint involvement

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology. It is relatively rare in children less than 15 years of age and especially in those less than 5-6 years of age. Sarcoidosis characteristically involves the skin, eyes, and synovial tissues in patients less than 5-6 years of age. We report a 3-year-old boy with sarcoidosis who had cutaneous findings with joint symptoms. Dermatologic examination revealed lichenoid, erythematous, 2-3 mm papules, some of them grouped, all over his extremities and trunk. There were symmetric swellings on his ankles and wrists without erythema or pain which did not interfere with function. However, until now, no eye involvement had been detected in the patient.     

An imported case of cutaneous leishmaniasis caused by Leishmania (Leishmania) donovani in Japan

Leishmaniasis is a major world health problem, and 12 million people are estimated to be infected in 88 countries. There have been few reports of leishmaniasis in Japan and all were of foreign origin; therefore diagnosis is difficult for Japanese physicians. There are 21 different pathogenic Leishmania species, and identification is obtained by polymerase chain reaction (PCR). Here we report an imported case of leishmaniasis by Leishmania (Leishmania) donovani infection from Sri Lanka. L. (L.) donovani usually causes visceral leishmaniasis, but in this case, the patient manifested cutaneous leishmaniasis. The identification of Leishmania species by PCR and investigation of the patient's background such as nationality and disease endemicity are important for diagnosis and treatment. This is the first report of cutaneous leishmaniasis by L. (L.) donovani in Japan.     

单纯外阴受累的朗格汉斯细胞组织细胞增生症一例

患儿女,5岁,因外阴丘疹、结节伴痒痛间歇发作3个月于2016年4月26日就诊。初发皮疹为阴唇多发的红色丘疹、结节,有痒痛感,曾于当地医院就诊,疑诊单纯疱疹病毒感染,给予抗病毒治疗及中药外用（具体不详）,无明显疗效。外阴皮损时轻时重,有时可自行缓解,之后再次发生,且逐渐加重,遂来山东大学齐鲁医院（青岛）就诊……     

单纯外阴受累的朗格汉斯细胞组织细胞增生症一例

患者女,44岁,因反复外阴溃疡8年,加重3个月于我科住院治疗。初起为外阴大量针头大小红色丘疹,伴痒,搔抓后破溃,形成糜烂面及溃疡,使用醋酸泼尼松片和复方甘草酸苷片、麝香等治疗后,外阴溃疡可暂时好转,但皮损反复。2013年因甲状腺结节行双侧甲状腺切除术……