慢性心力衰竭患者B型钠尿肽与血小板参数的相关性观察

【目的】探讨慢性心力衰竭（CHF）患者B型钠尿）tk（BNP）与血小板参数的相关性。【方法】分别检测116倒CHF患者（CHF组）和60例非心衰心脏病患者（对照组）的BNP、血小板计数（PLT）、平均血小板体积（MPV）、血小板体积分布宽度（PDW）和大血小板比率（P-LCR）,并进行对比性分析。【结果ICHF组的BNP水平明显高于对照组,差异有统计学意义（P〈0．01,z=7．276）;CHF组的MPV、PDW和P—LCR明显高于对照组,差异有统计学意义（均P〈0．01,t=4．203,8．484,5．760）;而两组间的PLT差异无显著性（P〉0．05,t=0．210）。CHF组患者BNP水平与MPV（r=0．246,P〈O．05）、PDW（r=0．299,P〈0．05）和P—LCR（r=0．329,P〈0．05）呈正相关。【结论】CHF患者血小板参数与BNP密切相关,检测这些指标有助于CHF患者的病情评估、疗效监测和预后判断。     

冠心病患者血小板参数的变化及临床意义

【目的】分析冠心病患者血小板参数的变化及临床意义。【方法】对100例冠心病患者[61例急性心肌梗死（AMI）和39例心绞痛（AP）]及50例健康人（正常对照组）的血小板四项参数：血小板比容（PCT）、血小板数量（PLT）、血小板体积分布宽度（PDW）、血小板平均体积（MPV）、血小板最大聚集率（PAGM）及血小板活化（CD62p）进行测定,分析其与冠心病之间的联系。【结果】三组间PCT差异无显著性。冠心病患者PLT明显要低于对照组（P〈0．01）,而PDW、MPV、PAGM明显高于对照组（P〈0．05）。AMI患者的PDW、MPV、PAGM相对AP组明显偏高（P〈0．05）,PLT明显降低（P〈0．05）。CD62p在冠心病患者中的阳性表达明显高于对照组（P〈0．05）,AMI患者的CD62p阳性表达明显高于AP组（P〈0．05）,Pearson,s相关分析结果显示冠心病患者的CD62p与PAGM、MPV之间具有正相关的关系（r=0．602、0．487,P〈0．05）。【结论】临床上监测血小板参数的变化对冠心痛患者的诊治及预防具有重要意义。     

冠心病患者血尿酸水平与血小板参数的关系探讨

目的探讨冠心病(CHD)患者血尿酸(SUA)水平与血小板参数的关系。方法对77例CHD患者及51例体检健康者进行SUA与血小板参数[血小板计数(PLT)、大血小板比率(P-LCR)、平均血小板体积(MPV)及血小板体积分布宽度(PDW)]检测。根据SUA水平另将CHD患者分为CHD伴高尿酸血症(HUA)组和CHD正常尿酸组。并对各组检测结果进行统计学分析。结果 CHD患者与健康对照组比较,SUA、P-LCR、MPV、PDW显著增高(P<0.01、P<0.05),PLT显著减低(P<0.01)。CHD伴HUA组与CHD正常尿酸组比较,P-LCR、MPV、PDW显著增高(P<0.05),PLT显著减低(P<0.01)。CHD正常尿酸组与健康对照组比较,血小板参数差异均无统计学意义(P>0.05)。CHD患者SUA与P-LCR、MPV、PDW呈显著正相关(r=0.207、0.213、0.238,P<0.05),与PLT无显著相关性(P>0.05)。结论 CHD患者SUA水平与血小板参数关系密切,HUA可能通过促进血小板活化、增强血小板黏附、聚集和释放功能而参与CHD的发生发展。     

New indicators in evaluation of hemolysis,elevated liver enzymes,and low platelet syndrome: A case-control study

BACKGROUNDIndices such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), platelet distribution width (PDW), and red cell distribution width (RDW) are considered new markers of the systemic inflammatory response (SIR), and have been widely implemented for the diagnosis of patients with inflammatory diseases. These new indicators have also been widely investigated in preeclampsia (PE) but less analyzed in hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome.AIMTo compare SIR markers among HELLP patients, PE only patients, and healthy gravidae.METHODSThis retrospective case-control study enrolled 630 cases, including 210 patients with HELLP syndrome (HELLP group), 210 patients with only PE (PE group) and 210 healthy gravidae (control group). The three groups were matched by age, parity, status of assisted reproduction, and multiple pregnancies. Birthweight, gestational age at complete blood count collection, gestational age at delivery, mode of delivery, etc. were recorded. The main indices as NLR, PLR, MPV, PDW, and RDW among the groups were compared, as well as some secondary outcomes including neutrophil, platelets, and hemoglobin.RESULTSThe NLR (6.4 vs 4.3 vs 3.5), MPV (11.9 vs 11.2 vs 10.7), PDW (16.4 vs 13.3 vs 14.2), leukocyte (12.4 × 10⁹/L vs 9.7 × 10⁹/L vs 8.7 × 10⁹/L) and neutrophil count (9.9 × 10⁹/L vs 7.3 × 10⁹/L vs 6.1 × 10⁹/L) were highest in the HELLP group, lower in the PE group, and lowest in the control group. Both the overall comparisons between the three groups (all ^bP < 0.01) and pairwise comparisons between every two groups elicited statistically significant differences (all ^dP < 0.01, except control vs PE: ^cP < 0.05 in PDW). The average lymphocyte counts were 1.4 (1.1, 2.0) × 10⁹/L in the HELLP group, 1.6 (1.3, 2.0) × 10⁹/L in the PE group and 1.7 (1.4, 2.0) × 10⁹/L in the control group. The overall comparison of lymphocyte count within the three groups had statistically significant differences (P = 0.000). The pairwise comparisons between every two groups demonstrated that the HELLP group had a lower lymphocyte count than both the PE (P = 0.019) and control groups (P = 0.000), but the difference between the PE and control groups was not statistically significant (P = 0.432). The overall comparisons on platelet counts and the PLR among these three groups also showed statistically significant differences (both P = 0.000), from low to high being those in the HELLP group (43.4 × 10⁹/L, 64.0), control group (180.5 × 10⁹/L, 103.6) and PE group (181.5 × 10⁹/L, 112.8). Pairwise comparisons of neither index displayed statistically significant differences between the PE and control groups (both P > 0.05), while the differences in the two indices between the HELLP group and the two other groups were still statistically significant (all P = 0.000). RDW values were highest in the HELLP group (14.5% [13.6, 15.3]), lower in the control group (14.1% [13.5, 14.8]) and lowest in the PE group (13.9% [13.4, 14.9]). The difference between the PE and control group did not show statistical significance (P = 1.000), while RDW values in the HELLP group were higher than those in the other two groups (^cP < 0.05 vs control, ^dP < 0.01 vs PE).CONCLUSIONSIR markers such as NLR, RDW, MPV, and PDW were increased and PLR was decreased in HELLP. These SIR markers may become new indicators in the evaluation of HELLP syndrome.     

慢性阻塞性肺疾病患者不同状态下血浆B型钠尿肽水平的变化及其临床意义

目的探讨慢性阻塞性肺疾病（COPD）患者不同状态下血浆B型钠尿肽（BNP）水平的变化及其临床意义。方法回顾性分析急性加重就诊的72例COPD住院患者的临床资料,按诊断分为四组:单纯COPD组、COPD+肺心病代偿期组、COPD+肺心病心力衰竭组和COPD+冠心病心力衰竭组,比较四组患者血浆BNP水平的差异,并分析其影响因素。结果与单纯COPD组比较,其余三组患者的血浆BNP水平均明显增高,差异均有统计学意义（t分别=2.03、9.69、8.45,P均<0.05）;与COPD+肺心病代偿期组比较,COPD+肺心病心力衰竭组和COPD+冠心病心力衰竭组的血浆BNP水平增高,差异均有统计学意义（t分别=7.10、6.09,P均<0.05）;COPD+肺心病心力衰竭组和COPD+冠心病心力衰竭组的血浆BNP水平比较,差异无统计学意义（t=0.69,P>0.05）。相关分析结果显示:血浆BNP水平与动脉血二氧化碳分压（PaCO₂）、肺动脉收缩压和右心室前后径呈正相关（r分别=0.62、0.76、0.69,P均<0.05）,与动脉血氧分压（PaO₂）、第一秒用力呼气容积/用力肺活量（FEV₁/FVC）、FEV₁占预计值%呈负相关（r分别=-0.51、-0.27、-0.28,P均<0.05）。多元逐步回归分析显示:肺动脉收缩压对血浆BNP水平的影响最大（b′=0.37,P<0.05）。结论急性加重的COPD患者不同状态下的血浆BNP水平变化不尽相同,血浆BNP水平的测定对于COPD合并心力衰竭的诊断具有重要意义;COPD+肺心病心力衰竭和COPD+冠心病心力衰竭二者的血浆BNP水平的差异可能并不明显。     

血小板参数MPC、MPM、L-PLT等在冠心病诊断中的应用

目的探讨血小板新型参数——平均血小板内容物浓度(MPC)、平均血小板内容物含量(MPM)、大血小板(L-PLT)等在(CHD)患者中的变化及其临床意义。方法根据CHD的诊断标准及冠状动脉造影结果,选取CHD患者92例和正常对照98名,采用德国Bayer公司生产的ADVIA120血液分析仪测定血小板新型参数MPC、MPM、L-PLT及原有血小板参数血小板数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW),并用统计学方法(t检验)对其数据进行分析。结果CHD患者血中PLT明显低于正常对照组(P<0.01),而MPV、PDW均明显高于正常对照组(P<0.05),且MPC、MPM、L-PLT均明显高于正常对照组(P<0.05)。结论血小板新型参数MPC、MPM、L-PLT联合血小板原有参数PLT、MPV、PDW在辅助诊断CHD中有一定的临床价值。     

冠状动脉粥样硬化性心脏病血小板参数变化

目的探讨冠心病患者血小板参数变化的临床意义。方法采用深圳迈瑞BC5800血细胞分析仪测定60例冠心病患者和50例健康对照者外周血中血小板计数(PLT)、血小板平均体积(MPV)、血小板体积分布宽度(PDW)和大血小板比率(P-LCR),并进行统计分析。结果冠心病患者与健康对照组的PLT、MPV、PDW及P-LCR比较,差异均有统计学意义(P<0.05),其中MPV、PDW和P-LCR明显高于健康对照组,而PLT则明显低于健康对照组。结论临床上动态监测冠心病患者的血小板参数变化,对冠心病的预防、诊治及预后有一定的参考意义。     

Predictive value of NLR and PLR in missed miscarriage

BackgroundThe aim of the study was to investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in missed miscarriage.MethodsIn this retrospective cohort study, a total of 400 women (involving 200 with missed early miscarriage and 200 with normal pregnancy but terminate by artificial abortion) were included. General clinical data and complete blood count (CBC) such as white blood cells (WBC), red blood cells (RBC), platelet (PLT), red blood cell distribution width‐standard deviation (RDW‐SD), platelet distribution width (PDW), mean platelet volume (MPV), neutrophil count, and lymphocyte count were collected, and the NLR and PLR were calculated for both groups. Receiver operating characteristic curve (ROC) was used to calculate the predictive value.ResultsThere was no significant difference in the WBC, RBC, PLT, RDW‐SD, PDW, neutrophil, lymphocyte, NLR, and PLR between the two groups (p > 0.05).But MPV was lower in the missed early miscarriage group than in the control group (p < 0.05), and the area under the working curve (AUC) of ROC was 0.58, specificity and sensitivity was 69% and 47%, respectively.ConclusionNLR and PLR were not the suitable indictor for missed miscarriage, but MPV should be a concern in the first trimester.     

先天性心脏病改良Blalock-Taussig管道闭塞的危险因素分析

目的探讨先天性心脏病改良Blalock-Taussig(BT)管道闭塞的危险因素。方法行改良BT分流术患儿290例,根据术后是否发生管道闭塞分为闭塞组9例和非闭塞组281例。收集患儿临床资料,测定2组患儿术后24 h血小板计数(platelet count, PLT)、血小板分布宽度(platelet distribution width, PDW)、平均血小板体积(mean platelet volume, MPV)和血小板压积(plateletcrit, PCT);采用多因素logistic回归分析改良BT分流术后发生管道闭塞的危险因素。结果 2组患儿年龄、性别比例、身高、体质量、人造管道直径以及肺动脉闭锁、法洛四联症等其他病种比率比较差异均无统计学意义(P>0.05);闭塞组PDW[(21.03±6.37)%]和MPV[(15.12±6.59)fL]高于非闭塞组[(14.95±2.14)%、(8.03±3.17)fL](P<0.05),PLT[(210.13±26.54)×10~9/L]和PCT[(0.17±0.03)%]与非闭塞组[(197.25±28.43)×10~9/L、(0.16±0.04)%]比较差异无统计学意义(P>0.05);PDW>17%和MPV>10 fL为改良BT分流术后发生管道闭塞的独立危险因素(OR=2.442,95%CI:1.675~3.943,P=0.008;OR=2.227,95%CI:1.521~2.563,P=0.028)。结论 PDW、MPV升高是先天性心脏病患儿行改良BT分流术后发生管道闭塞的独立危险因素。     

小儿急性阑尾炎患者血小板参数检测的临床意义

目的通过分析小儿急性阑尾炎患者血小板各项参数的变化情况,探讨血小板指标在该疾病诊断中的临床意义,为该疾病的诊断提供更多实验室依据。方法选择52例急性阑尾炎患儿及49例健康对照者,采用Sysmex2100全自动血液分析仪检测血小板参数,包括血小板计数（plateletcount,PLT）、平均血小板体积（meanplateletvolume,MPV）、血小板分布宽度（plateletdistributionwidth,PDW）及外周血细胞计数。采用SPSS17．0软件对检测结果及各参数间相关性进行统计学分析。结果与对照组相比,阑尾炎患者组WBC及PLT明显升高,而MPV和PDW降低,差异均具有统计学意义（P均〈0．01）。相关性分析结果显示MPV与PDW（r=0．974,P〈0．01）,以及PLT与WBC（r=0．451,P〈0．01）均呈正相关关系,PLT分别与MPV和PDW（r=-0．610,r=-0．621,P均〈0．01）,WBC分别与PDW和MPV（r=-0．335,r=-0．364,P均〈0．05）均呈负相关。结论急性阑尾炎患儿外周血存在PLT增高、而MPV和PDW降低的血小板模式,用这些参数联合其他炎性指标建立诊断模型可能对小儿急性阑尾炎具有较大的实验室诊断价值。     

小儿重症肺炎血小板参数的动态变化分析

目的:探讨重症肺炎患儿血小板参数动态变化。方法:动态测定38例重症肺炎患儿(A组)的血小板参数包括血小板计数(PLT)、血小板分布宽度(PDW)、平均血小板容积(MPV)及大血小板比率(P-LCR),同时与普通肺炎患儿80例(B组)和正常儿童(C组)100例作对照。结果:入院24h内A组PLT明显高于B、C组,均P<0.01,而PDM、MPV、P-LCR低于C组,差异有显著性,P<0.05;B组PLT高于C组,P<0.05,而PDW、MPV、P-LCR与C组比较无差异,P>0.05。入院72h后复查,B组各血小板参数基本恢复正常,与C组比较无差异,P>0.05;A组PLT明显下降,而PDM、MPV、P-LCR明显升高,与C组比较有显著性差异,P<0.05;入院第7d复查,各参数基本恢复正常。结论:动态检测肺炎患儿的血小板参数有助于准确评估病情的危重度。     

Ultrasonographic assessment of cardiac function and disease severity in coronary heart disease

BACKGROUNDCoronary heart disease (CHD) causes many adverse cardiovascular events and poses a threat to the patient’s health and quality of life. AIMTo evaluate ultrasonography for evaluation of cardiac function and lesion degree in patients with CHD.METHODSA total of 106 patients with CHD (study group) and 106 healthy individuals (control group) in our hospital from March 2019 to September 2020 were selected for this study. All subjects were examined by ultrasound, and the mitral orifice’s early-to-late diastolic blood flow velocity ratio (E/A), left ventricular end-diastolic volume (LVDd), and left atrial diameter (LAD) were measured. Values were compared between the study group and healthy group, and the correlation between the ultrasonic parameters of patients with different cardiac function grades and the degree of CHD were assessed. In addition, the ultrasonic parameters of patients with different prognoses were compared after a follow-up for 6 mo.RESULTSE/A (1.46 ± 0.34) of the study group was smaller than that of the control group (1.88 ± 0.44), while LVDd (58.24 ± 5.05 mm) and LAD (43.31 ± 4.38 mm) were larger (48.15 ± 3.93 and 34.94 ± 2.81, respectively; P < 0.05). E/A for patients with grade III disease (1.41 ± 0.43) was smaller and their LVDd (60.04 ± 4.21 mm) and LA (44.16 ± 2.79 mm) were larger than those in patients with grade II disease (1.71 ± 0.48, 52.18 ± 3.67 mm, and 39.68 ± 2.37, respectively; P < 0.05). Patients with grade IV disease had smaller E/A (1.08 ± 0.39) and larger LVDd (66.81 ± 5.39 mm) and LAD (48.81 ± 3.95 mm) than patients with grade II and III disease (P < 0.05). In patients with moderate disease, E/A (1.44 ± 0.41) was smaller and LVDd (59.95 ± 4.14 mm) and LAD (45.15 ± 2.97 mm) were larger than in patients with mild disease (1.69 ± 0.50, 51.97 ± 3.88 and 38.81 ± 2.56 mm, respectively; P < 0.05). In patients with severe disease, E/A (1.13 ± 0.36) was smaller and LVDd (67.70 ± 6.11 mm) and LAD (49.09 ± 4.05 mm) were larger than in patients with moderate disease (P < 0.05). E/A was negatively correlated with cardiac function classification and disease severity, while LVDd and LAD were positively correlated with cardiac function classification and disease severity (P < 0.05). E/A (1.83 ± 0.51) for patients with good prognosis was higher than that for those with poor prognosis (1.39 ± 0.32), while LVDd (49.60 ± 4.39 mm) and LAD (36.13 ± 3.05 mm) were lower (P < 0.05).CONCLUSIONThe ultrasonic parameters of patients with CHD are abnormal, and differ significantly in patients with different cardiac function grades, lesion degree, and prognosis.     

检测血小板参数在血小板减少性疾病中的意义

目的探讨血常规检测中血小板（PLT）计数、血小板平均体积（MPV）及血小板分布宽度（PDW）在血小板减少性疾病中的意义。方法使用雅培CD-1800全自动血细胞分析仪进行检测。结果与健康对照组相比，在疾病组中，再生障碍性贫血PLT计数降低（P〈0．01），MPV降低（P〈0．01），PDW无变化；而急性白血病PLT计数降低（P〈0．01），MPV降低（P〈0．01）；PDW升高（P〈0.01）；特发性血小板减少性紫癜（ITP）组中，PLT计数减少（P〈0．01），MPV升高（P〈0．05），PDW升高（P〈0．01）。结论PLT、MPV、PDW在血小板减少性疾病的鉴别诊断中有较大的临床应用价值。     

肺癌患者化疗前后血小板参数动态变化及黄芪注射液的影响

目的:探讨血小板参数在肺癌患者化疗前后的变化及黄芪注射液对血小板参数的影响。方法:回顾性分析55例分别采用单纯化疗和化疗加黄芪注射液治疗的肺癌患者,2组患者均采用日本Sysmex XT-1800i型全自动血液分析仪检测化疗前后血小板(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、血小板分布宽度(PDW)等血小板参数,观察并比较血小板参数在肺癌患者化疗前后的变化及单纯化疗组与化疗加黄芪注射液组间的差异。以30例健康体检者作对照。结果:肺癌患者PLT、MPV、PCT较正常人高(P<0.01),而PDW差异没有显著性(P>0.05)。单纯化疗后肺癌患者PLT、MPV、PCT明显下降,其最低值与化疗前比较有显著差异(P<0.01),PDW无明显变化(P>0.05);化疗第21天,PLT、MPV、PCT、PDW值升高,与化疗最低值比较有显著性差异(P<0.05)。化疗加黄芪组血小板下降最低值、MPV及PCT值明显高于单纯化疗组(P<0.05),化疗第21天恢复期PLT、PCT高于单纯化疗组(P<0.05),而PDW、MPV变化不如单纯化疗组明显(P>0.05)。结论:检测血小板参数对于了解肺癌化疗患者骨髓造血情况有一定意义。应用黄芪注射液能保护骨髓造血功能,防止严重血小板减少症的发生。     

糖尿病患者血管病变与糖化血红蛋白和血小板参数的相关性

目的 探讨糖尿病（DM）患者糖化血红蛋白（GHB）,空腹血糖（FBG）和血小板参数的变化,及其与血管并发症的相关性分析.方法 采用LH750全自动血细胞分析仪检测108例糖尿病患者（其中有血管病变患者56例,无血管病变患者52例） 及60名健康对照者的血小板计数（PLT）、血小板平均体积（MPV）、血小板分布（PDW）,同时采用 Unicel Dxc800全自动生化仪检测糖化血红蛋白和空腹血糖.结果 DM有血管病变组与DM无血管病变组和健康对照组比较,PLT显著减少（ P〈0.01）,除FBG外,MPV、PDW和GHB显著增高（P 〈0.01）, FBG在糖尿病患者二组间无明显差别（P〉0.05）;而DM无血管病变组与健康对照组比较,PLT无明显差别（P〉0.05）, MPV、PDW、GHB和FBG显著增高（P〈0.05）.结论 糖尿病患者动态监测血小板参数,联合检测GHB、FBG能及时有效发现微血管病变,有助于早期发现微血管病变发生,及时干预治疗,对减少糖尿病并发症的发生有一定的临床意义.     

肝移植患者血小板及其参数变化的临床意义

目的探讨肝移植患者血小板及其参数变化的临床意义。方法采用全自动血细胞分析仪（拜耳ADVIA2120型）测定128例肝移植术前患者、81例肝移植术后（60d）无出血患者、13例肝移植术后有出血患者及150例健康对照者的血小板及其参数等相关指标。结果与健康对照组比较,（1）肝移植术前组血小板计数（PLT）、平均血小板体积（MPV）、血小板比容（PCT）、血小板分布宽度（PDW）差异有统计学意义（P〈0．05）;（2）肝移植术后无出血组PLT、MPV、PCT、PDW差异无统计学意义（P〉0．05）;（3）肝移植术后有出血纽PLT、MPV、PCT差异有统计学意义（P〈0,05）,PDW差异无统计学意义（P〉0．05）。与肝移植术前组比较,（1）肝移植术后无出血组PLT、MPV、PCT差异有统计学意义（P％0．01）,PDW差异无统计学意义（P〉0．05）;（2）肝移植术后有出血组PLT、MPV、PCT、PDW差异无统计学意义（P〉0．05）。肝移植术后有出血组与无出血组比较,PLT、MPV、PCT差异有统计学意义（P〈0．05）,PDW差异无统计学意义（P〉0．05）。结论血小板及其参数相关指标的检测表明,（1）可配合临床观察肝移植术后疗效以及判断病情的变化;（2）间接反映肝移植术后PLT的恢复功能。     

冠心病合并糖耐量减低患者血小板参数与超敏C 反应蛋白的相关性研究

【目的】探讨冠心病(CHD)合并糖耐量减低(IGT)患者血小板参数与超敏 C 反应蛋白(hs-CRP)的相关性。【方法】选取本院收治的CHD合并 IGT患者49例作为 A 组,单纯 CHD患者52例作为 B组,同期入院体检正常者55例作为对照组(C组),入院后均检测 hs-CRP及血小板计数(PLT)、血小板压积(PCT)、血小板分布宽度(PDW)、平均血小板体积(MPV)、大血小板比率(P-LCR)5项血小板参数水平,并了解其相关性。【结果】A 组 hs-CRP、PCT、PDW、MPV、P-LCR 分别为(7.94±0.51)mg/L、(0.24±0.04)%、(22.86±3.05)%、(16.04±3.97)fl、(59.68±8.24)%均显著高于B,C组,PLT为(148.37±29.79)×109/L显著低于 B, C组,B组和C组之间相比较差异亦具有显著性(P <0.05);Pearson相关分析显示hs-CRP与PLT呈负相关关系,与PCT、PDW、MPV、P-LCR呈正相关关系。【结论】CHD合并 IGT 患者血小板参数与 hs-CRP 具有显著相关性。     

血小板体积及分布宽度检测儿童川崎病价值

目的 平均血小板体积(MPV)与血小板分布宽度(PDW)与血小板功能有关,相比血小板数量可能更能成为血小板功能异常的敏感指标。研究血小板参数在川崎病中的变化及临床意义。方法 本研究共回顾性分析439例KD患儿和261例健康对照儿童;统计分析患儿的临床资料及实验室检查MPV、PDW、血小板数量(PLT)、WBC、CRP和血沉指标。根据心脏彩色超声有无冠状动脉损伤,将川崎病患儿分为:伴冠状动脉损伤组(CALs组)、不伴冠状动脉损伤组(非CALs组)。同时,比较了完全性川崎病组(cKD)与不完全川崎病组(iKD)各指标的差异。结果 与健康对照组比较,KD组WBC、PLT、CRP和ESR水平显著升高(P<0.01),而MPV与PDW明显下降(P<0.01,<0.05);尤其相比于cKD组,MPV与PDW水平在iKD组明显降低(P=0.003、0.014)。结论 提示川崎病患儿急性期MPV与PDW降低,尤其在不完全川崎病降低显著,故低水平的MPV与PDW可能对iKD的诊断有提示意义。     

窒息新生儿血小板参数与病情程度的关系探讨

目的 探讨窒息新生儿血小板参数变化及其与窒息程度、器官损害程度的关系。方法对50例窒息新生儿进行血小板数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）测定，分别按窒息程度、器官损害程度分组并进行组间比较。结果与轻度窒息组、单器官损害组比较，重度窒息组、多器官损害组PLT显著降低，MPV与PDW明显增高，差异有显著性意义（P〈0．01）。结论血小板参数测定有助于判断新生儿窒息及器官损害程度。     

脑梗塞患者血小板参数的变化及意义

目的探讨血小板5项参数对脑梗塞患者的临床意义.方法分别测定108例脑梗塞住院患者和40例中老年体检者的血小板数(PLT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW)、血小板比积(PCT)和血小板最大聚集率(MAR),对血小板5项参数进行比较并作相关分析,同时对脑梗塞组中40例患者治疗前后的5项参数进行配对比较.结果脑梗塞组PLT减少、MPV和MAR增高较对照组有显著差异(P<0.01,0.05).PDW、 PCT两组间无显著差异.对照组PLT与MPV为中度负相关(r =-0.55,P<0.01),脑梗塞组二者为低度负相关(r =-0.37,P<0.05).脑梗塞组治疗后MPV减小,有显著差异(P<0.05);PLT、PDW、PCT和MAR无显著差异.结论 MPV增大是脑梗塞的独立危险指标,观察PLT、 MPV和 MAR的变化对脑梗塞的诊断和预防有指导意义.