Venous malformation as source of a tarsal tunnel syndrome: treat the source or the cause of the complaints? A case report

Painful tarsal tunnel syndrome is a compression neuropathy with a variety of possible sources. As it presents a challenging differential diagnostic problem, it is often under-diagnosed. Among the intrinsic and extrinsic factors, varicose veins are the main source in case of a venous etiology.

We report a case of a 39-year old male patient who presented with complaints of paresthesia and excessive pain of the right foot, especially the medial side. Further work up by ultrasonography, magnetic resonance imaging and electromyography revealed an extensive congenital venous malformation of the right lower limb with subsequent compression of the tibial nerve in the tarsal tunnel. We did not treat the source, but the cause by open tarsal tunnel release. Excellent result with immediate full relieve of the patients complaints was achieved.     

Malignant peripheral nerve sheath tumor of kidney—A case report

INTRODUCTIONMalignant peripheral nerve sheath tumors (MPNSTs) are very rare soft-tissue tumors. These tumors originate from Schwann cells or pluripotent perineural cells of the neural crest. An isolated MPNST of the kidney is extremely rare and has been reported in only six cases to date.PRESENTATION OF CASEA 30-year-old female with an unremarkable past medical and surgical history presented with an enlarging, right-sided abdominal mass for the last 3 months. A CT scan of the abdomen and pelvis showed a large exophytic mass arising from the right kidney. A metastatic work-up was negative, so a right radical nephrectomy was performed. Histopathological and immunohistochemical studies confirmed the diagnosis of an MPNST.DISCUSSIONMPNSTs are rare and aggressive soft-tissue sarcomas that are usually associated with neurofibromatosis type 1 (NF-1) but that also occur post-radiation and sporadically. These tumors are highly malignant neoplasms with a high recurrence rate and distant metastases. Complete surgical excision remains the mainstay of treatment due to the limited response of MPNSTs to both chemotherapy and radiotherapy.CONCLUSIONMPNSTs arising from the kidney are very rare. Complete surgical resection provides the only hope for cure. Postoperative chemotherapy and radiotherapy are still controversial, although postoperative radiotherapy is currently recommended by an oncology consensus group.     

Nephrectomy as a cause of chronic kidney disease in the treatment of urolithiasis: a case–control study

Objective

To analyze the clinical course of nephrectomized patients due to complications related to nephrolithiasis and ascertain the prevalence of chronic kidney disease (CKD) in this population.

Methods

From 2005 to 2010, 658 patients were treated with urolithiasis. Among these, 30 (4.6%) were nephrectomized. For each case, a control was selected and matched to the case by age, sex and disease duration. All data were collected from medical records, which contained the clinical, laboratory evaluation and diagnostic imaging.

Results

Age of the study group was 51.5 ± 10.4 years and the control group 47.1 ± 5.2 years. There were 17 (85%) women and three men in each group. Patients from the study group reported 3 (range, 1–5) episodes of acute renal colic before nephrectomy. Urinary tract infection and hematuria was detected in 70% of cases before surgery. In addition, half of the patients had at least one previous urological procedure. The control group showed higher urinary levels of calcium (216.1 ± 114.3 vs. 130.9 ± 72.2), uric acid (530.2 ± 197.4 vs. 424 ± 75.2) and citrate (755 ± 533 vs. 380.2 ± 260.7), p < 0.01, 0.03 and 0.01, respectively. The creatinine clearance was lower in the study group, 52.5 ± 18.8 ml/min vs. 92.9 ± 24.2 ml/min in the control group (p < 0.001).

Conclusions

There was a decrease in kidney function in nephrectomized patients compared to a control group of stone-forming patients with both kidneys. Prospective studies are needed to assess the incidence of CKD in patients with nephrolithiasis submitted to nephrectomy.     

Schwannoma of the upper cervical spine–a case report

Upper cervical schwannoma is rare, and belongs to benign tumors that is usually asymptomatic. It accounted for only ten percent of schwannomas cases and mostly occurs in 40e50 years old patients. Aggressive and total resection is the treatment of choice for this tumor. Preoperative diagnosis is difficult, relying on clinical suspicion, and confirmed by surgical pathology. We report a 54-year-old male patient with chief complain of progressive weakness and numbness of his right arm for four months. He had a history of lymph node tumor in 2007 and excised in 2011. Neurological decrease was found on the right arm. The radiographic examination showed lytic lesion on the second, third, and fourth cervical spine. Computed tomography scan showed destruction extending to the first cervical vertebra. Capsulated extradural and extramedullary mass and compression to the spinal cord was found from the magnetic resonance imaging. Two-stage operation was performed. The first stage was posterior decompression with occipitocervical fusion and instrumentation, while the second was anterior decompression and iliac strut graft. Both operations performed using the surgical ultrasonic dissector. During three months'' follow-up, it showed neurological improving. Neurological deficit appears when there is compression on the spinal cord. Total resection is the treatment of choice for these tumors. Preoperative imaging should be performed to exclude malignant tumor and found tumor extension.     

Chemically-induced chronic nerve compression in rabbits —a new experimental model for the carpal tunnel syndrome

Summary In order to create an experimental model for the carpal tunnel syndrome without the use of the commonly applied foreign bodys (silicone or rubber tubes, tourniquets etc.), the present study tried to induce a chemically provoked compression of the median nerve in rabbits. In 9 female rabbits 1 ml of Aethoxskerol® 3% (Hydrox-polyethoxy dodecan) was instilled into the carpal tunnel around the median nerve after visualisation of the nerve. The other foreleg served as the control and was treated with the same amount of saline solution. Electroneurophysiologic parameters were registered preoperatively, 1 month and 6 months post surgery and histomorphologic investigations by light and electron microscopy were performed after 6 months. 6 months after treatment with Aethoxysklerol®, a statistically significant lenghtening of the distal latency period as well as a significant reduction of the compound potential amplitude could be observed. In accordance with these findings, morphological investigation revealed the presence of extensive granulation tissue around the median nerve together with signs of demyelination. Our results indicate that we were able to produce the development of extensive granulation tissue in the carpal tunnel of rabbits with subsequent compression of the median nerve which was confirmed by histomorphologic investigation as well as by measurement of nerve conductive velocity.

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Chemisch induzierte, chronische Nervenkompression bei Kaninchen — ein neues Tiermodell für das Karpaltunnelsyndrom

Zusammenfassung Die vorliegende Studie versuchte eine chemisch induzierte, chronische Kompression des N. medianus in einem experimentellen Kaninchenmodell, ohne Verwendung der bis dato implantierten Fremdkörper (Silikon-oder Gummischläuche, Tourniquets, etc.) zu verursachen. Nach Darstellung des N. medianus wurde bei neun weiblichen Kaninchen 1 ml Äthoxysklerol® perineural im Karpalkanal instilliert. Die andere vordere Extremität diente als Kontrolle und wurde mit der gleichen Menge Kochsalzlösung behandelt. Elektroneurophysiologische Parameter wurden präoperativ, 1 und 6 Monate nach dem Eingriff bestimmt, histomorphologische Untersuchungen mittels Licht- und Elektronenmikroskopie wurden nach 6 Monaten durchgeführt. 6 Monate nach Behandlung mit Äthoxysklerol® fand sich eine signifikante Verlängerung der distalen Latenzzeit sowie eine signifikante Erniedrigung der Summenpotentialamplitude. In Übereinstimmung mit diesen Befunden zeigte sich morphologisch überschieendes Granulationsgewebe um den N. medianus mit Zeichen der Demyelinisierung. Unsere Ergebnisse zeigen, da wir die Entstehung von Granulationsgewebe im Karpalkanal von Kaninchen provozieren konnte, welche mit einer nachfolgenden Nervenkompression einherging. Diese Veränderung manifestierte sich sowohl histomorphologisch als im Rahmen der Nervenleitgeschwindigkeit.

     

Schistosomiasis as a rare cause of recurrent acute appendicitis – A case report

INTRODUCTION

We are presenting a case of schistosomiasis in a 41 year old lady who presented with right iliac fossa pain for 3 years. The pain worsened and the frequency increased in the last 3 months prior to referral. The ultrasound was unremarkable. Her bowel habits were normal and there was no vomiting. There was no blood in the stool or in the urine.

PRESENTATION OF CASE

The abdomen was soft except on deep palpation. There was slight tenderness in the right lower quadrant. A repeat ultrasound was unremarkable. The full blood count was within the normal range. A diagnosis of recurrent acute appendicitis was made and an interval appendicectomy was performed.

DISCUSSION

Histopathology results revealed schistosomiasis of the appendix. There was no acute inflammation but there was fibrous obliteration of the distal lumen of the appendix and reactive lymphoid hyperplasia.

CONCLUSION

This is the first case in a country with relatively clean drinking water. There are no irrigation schemes but there are seasonal rivers and streams. The patient admits to swimming in these streams during childhood. Clinical features of schistosomiasis were not elicited.     

Tibial nerve neuropathy following medial opening-wedge high tibial osteotomy—case report of a rare technical complication

A 63-year-old woman developed tibial nerve injury caused by an overlong K wire and 4.5-mm cortical lag screw through the first distal hole below the osteotomy during medial opening-wedge high tibial osteotomy (HTO), leading to a lack of sensation on the sole of the foot with no disturbances in motor functions. The temporary lag screw in the first distal hole below the osteotomy is often inserted by an excessive length in order to compress the potentially fractured opposite cortex. By doing so, posterior neurovascular structures including the tibial nerve and the popliteal vessels can be injured. To avoid this type of injury during medial opening-wedge HTO, proper knee position and appropriate Hohmann retractor position in combination with meticulous insertion of the K wire or screw under fluoroscopic control are essential. In addition, our study reinforces the fact that different presentations of injury to the tibial nerve should be carefully considered in the absence of common diagnostic features, including weakness of the toe flexors and posterior tibial muscle of the leg with intractable pain.     

Stretching (?) of the spinal cord as a cause of paraplegia in a patient with Cushing's syndrome

Paraplegia with a total anesthesia level was found in a patient who had Cushing's syndrome. There was marked osteoporosis of the spine and a moderate wedge shaped compression fracture of the T4 vertebral body but no stenosis of the canal could be observed. On the grounds of the CT findings stretching of the spinal cord caused by the rapidly evolving kyphosis of the thoracic tract has been thought to be the responsible factor of the clinical deficits.     

Medial tibial stress syndrome: A skeleton from medieval Rhodes demonstrates the appearance of the bone surface – a case report

The effect of immobilization on bone formation in the knee and hip was studied by means of oxytetracycline. One leg of 11 growing and 13 adult rabbits was immobilized so that the knee was held in extension but the hip was free. In the knee, degenerative changes developed consistently with a severity proportional to the length of the immobilization time. In most of the rabbits given oxytetracycline 1–13 days before they were killed considerably more oxytetracycline was incorporated in the bone in the immobilized knee region and slightly more in the hip region of the same leg than in the corresponding areas of the other leg. This indicates an increased turnover of bone tissue in the immobilized leg compared with the non-immobilized leg.     

Myxopapillary ependymoma as a cause of back pain in a young male – A case report

Objective:

Primary spinal cord tumours are rare causes of low back pain but can be a significant cause of morbidity if undiagnosed and untreated. The following is a case of a young male patient presenting with low back pain and radicular symptoms caused by myxopapillary ependymoma.

Clinical Features:

A nineteen year old male presented to an orthopaedic surgeon with a long history of back pain. He was initially diagnosed with soft tissue injuries and discharged. He began to experience erectile and bowel dysfunction two years later and was re-referred to the orthopaedic surgeon by his family physician but was lost to follow-up. The patient did not present to the surgeon until two years after his symptom profile changed. At that point, MRI examinations revealed a large myxopapillary ependymoma extending from T12 to L4 that was confirmed by a pathologist.

Intervention and Outcome:

The tumour was surgically resected with subsequent adjuvant radiotherapy. After one year, the patient required continued catheterization and had poor anal tone. His back and leg complaints were almost normal. Follow-up MRI examinations revealed no disease progression or new spinal lesions at 4 years after the initial diagnosis.

Conclusion:

The clinical presentation of primary spinal cord tumours is non-specific and can easily be missed. In cases of chronic back pain, signs and symptoms should be regularly monitored for changes indicative of progressive neurological compromise such as sensory, motor and bowel/bladder dysfunction. If there is deterioration of clinical signs and symptoms, a spinal tumour should be considered in the list of differential diagnoses. Delayed diagnosis and treatment of these rare causes of back pain could lead to poor outcomes; therefore, a referral to a surgeon should be done immediately with proper follow up to ensure continuity of care.     

Injury to the infrapatellar branch of the saphenous nerve,a possible cause for anterior knee pain after tibial nailing?

The purpose of this study was to determine the long-term incidence of infrapatellar nerve damage after tibial nailing and its relation to anterior knee pain. We retrospectively evaluated 71 patients in whom 72 isolated tibial shaft fractures were treated with an intramedullary nail. The mean follow-up time was 84 months. Twenty-seven patients (38%) complained of chronic anterior knee pain. Infrapatellar nerve damage was found in 43 patients (60%). Of the 27 patients with knee pain, 21 (78%) had sensory deficits in the distribution area of the infrapatellar nerve, compared to 22 of the 45 patients (49%) without knee pain (p=0.025). Patient and fracture characteristics showed no significant differences between the two groups. At time of follow-up a total of 33 nails were removed of which twelve were taken out because of knee pain. The pain persisted in seven of these twelve patients (58%). The incidence of iatrogenic damage to the infrapatellar nerve after tibial nailing is high and lasting. Injury to this nerve appears to be associated with anterior knee pain after tibial nailing.     

Thickening of the synovium of the digital flexor tendons: cause or consequence of the carpal tunnel syndrome?

Using a monofilament wire suture, the radial and ulnar edges of the flexor retinaculum were approximated in 14 white New Zealand rabbits. As a result, the volume of the carpal tunnel was diminished, and "carpal tunnel syndrome" was produced. At various intervals after this procedure the animals were sacrificed. The median nerve and all the digital flexor tendons passing through the carpal tunnel were excised "en bloc", and sent for histological examination. Vascular proliferation with perivascular round cell infiltration and oedema, and large areas of fibroblastic activity were observed around the digital flexor tendons. This was probably due to increased vascular permeability secondary to ischaemic endothelial damage. These findings are similar to those observed in the synovium of patients operated on for carpal tunnel syndrome.     

Parathyroid adenoma in a young female presenting as recurrent acute pancreatitis with a brown tumour of the mandible—A case study

INTRODUCTIONPrimary hyperparathyroidism is usually seen in females above the age of 50 years, with a prevalence of 21/1000,¹ whereas the incidence in patients aged 12–28 years is less than 5%.² A solitary adenoma is responsible for 80% of cases of primary hyperparathyroidism.³ Primary hyperparathyroidism is most commonly asymptomatic.⁴ The incidence of acute pancreatitis associated with hyperparathyroidism is less than 10%.5, 6 The incidence of hyperparathyroidism associated with a Brown tumour is less than 5%.⁷PRESENTATION OF CASEA 19 year old female patient presented with recurrent acute pancreatitis and swelling over the mandible. Complete investigative workup revealed a solitary parathyroid adenoma causing hyperparathyroidism. Surgical exploration with excision of the parathyroid adenoma was performed, following which the patient recovered uneventfully.DISCUSSIONThe patient was initially managed as a case of acute pancreatitis, and although not suspected initially, a high index of suspicion for hyperparathyroidism developed after a biopsy of the mandibular swelling showed the presence of osteoclastic giant cells indicating the possibility of a Brown tumour. Further investigations then revealed the presence of a solitary parathyroid adenoma with coexistent hyperparathyroidism which was then managed surgically.CONCLUSIONThe young age of the patient, and her presentation with acute pancreatitis and a Brown tumour of the mandible make this an extremely rare presentation of parathyroid adenoma.