应用超声剪切波弹性成像技术定量评价兔深静脉血栓弹性研究

目的探讨应用超声剪切波弹性成像技术定量评价兔深静脉血栓(DVT)弹性的价值。方法建立DVT兔模型,应用超声剪切波弹性成像技术检测血栓形成后第1~14天及第21天血栓上、中、下三部分的杨氏模量值,取均值进行分析。结果前7 d连续检测的血栓杨氏模量值随时间而增大,增长趋势最明显,第1天、第4天、第7天之间差异有统计学意义(P<0.05);7 d后血栓杨氏模量值增长趋势减缓,第8、9天与第11天以后的杨氏模量值间差异有统计学意义(P<0.05);第10天以后杨氏模量值逐渐趋于稳定;第12、13、14天与第21天差异有统计学意义(P<0.05);两周后,杨氏模量值无明显变化。结论应用超声剪切波弹性成像技术定量评价兔DVT的杨氏模量值,可无创、客观地反映血栓弹性动态演变过程,可为评估DVT分期的定量检测提供依据。     

剪切波弹性成像模量值与桥本甲状腺炎临床表现的相关性研究

目的：探讨剪切波弹性成像杨氏模量值与桥本甲状腺炎（H T ）不同临床表现的相关性。方法将收集的86例临床确诊为HT的患者按照甲状腺功能分成甲亢组、甲功正常组、亚临床甲减组和临床甲减组,应用超声剪切波弹性成像技术,对各组进行超声剪切波弹性量化检测,用方差分析比较各组 HT 患者甲状腺组织剪切波模量值之间的关系。结果甲亢组、甲功正常组、亚临床甲减组和临床甲减组的 HT 患者甲状腺组织剪切波弹性模量值依次增大,分别为（15．543±4．319）kPa、（20．083±5．444）kPa、（26．682±5．676）kPa、（29．210±8．848）kPa ,组间差异有统计学意义（ F ＝14．925,P ＜0．01）。HT甲亢组剪切波弹性模量值低于 HT甲功正常组、HT亚临床甲减组、HT临床甲减组,差异均有统计学意义（ P均＜0．05）。HT甲功正常组剪切波弹性模量值低于 HT亚临床甲减组、HT 临床甲减组,差异有统计学意义（ P均＜0．05）。结论剪切波弹性成像杨氏模量值与桥本甲状腺炎不同时期的临床表现有一定相关性,可为 HT的治疗提供一定的参考信息。     

实时剪切波弹性成像技术在慢性肾病中的临床应用分析

目的 探讨实时剪切波弹性成像在慢性肾病诊断中的临床价值。方法 选取我院97例慢性肾病患者为观察组,并选择同一时间体检健康志愿者56例为对照组,两组均接受超声剪切波弹性成像检测,对两组检测值以及观察组组内参数对比等数据结果进行探讨和分析。结果 观察组患者的肾脏长径、实质厚度,低于对照组(P <0.05);观察组患者的Emean、Emax、Emin数值明显高于对照组(P <0.05);观察组患者不同分期所得影像检测结果相比差异明显(P<0.05); Emax的慢性肾病诊断特异度,相较于Emean以及Emin明显较高(P <0.05);而Emin的灵敏度,相较于Emax以及Emean明显较高(P <0.05);相关性分析中,慢性肾病不同分期,与肾脏长径、实质厚度存在负相关性,而与Emean、Emax、Emin则存在正相关性(P <0.05)。结论 慢性肾病采取超声剪切波弹性成像技术进行定量评估,对早期诊断具有临床价值。     

BI-RADS分类标准与剪切波弹性成像技术在乳腺良恶性病变鉴别诊断中应用价值分析

目的 探讨BI-RADS分类标准与剪切波弹性成像(SWE)技术在乳腺良恶性病变鉴别诊断中的应用价值.方法 选取自2019年1月至2020年9月于江南大学附属医院确诊乳腺肿物的310例患者(350个病灶)为研究对象.所有患者均行常规超声及SWE技术检查.描绘受试者工作特征(ROC)曲线评价BI-RADS分类标准、SWE技...     

剪切波超声弹性成像在乳腺增生性疾病诊断中的价值

目的：探讨Elastography Point Quantification （Elast PQ ）剪切波弹性成像技术检测乳腺增生病人乳腺硬度的可行性。方法应用Elast PQ技术,对90例乳腺增生患者以乳头为中心分象限进行乳腺弹性模量值检测,分析不同象限测量的影响,获得参考值范围;并与传统应力式弹性成像评分进行对照。结果同一患者,外下象限与乳头区测得弹性模量值显著低于其他象限;内上象限、内下象限、外上象限测量值之间无统计学差异;Elast PQ测得的弹性模量值按应力式弹性超声对乳腺硬度评分分组,组间差距有明显统计学意义。结论 Elast PQ技术评估乳腺硬度具有可行性,综合多种因素考虑以外上象限弹性模量值代表性较好。     

剪切波超声弹性成像在乳腺非肿物病变鉴别诊断中潜在价值初探

正目的报道应用剪切波弹性成像(SWE)在乳腺非肿物病变中应用的一些初级的经验,并提示在BI-RADS分级为4a的一些乳腺非肿物病变中,SWE可以减少一些不必     

常规超声、超声造影、剪切波弹性成像超声在甲状腺结节良恶性鉴别诊断中的应用价值

目的:研究常规超声、超声造影、剪切波弹性成像超声在甲状腺结节良恶性鉴别诊断中的应用价值.方法:选取我院2012年9月～2015年12月收治的甲状腺结节患者45例为研究对象,所有患者均接受常规超声、超声造影与剪切波弹性成像超声检查,并且将病理结果作为对照,对不同超声检查方式的诊断结果进行分析.结果:在甲状腺结节良恶性鉴别诊断中,常规超声、超声造影、剪切波弹性成像超声均具备有诊断价值,相对于其它诊断方式,剪切波弹性成像与病理诊断具有最高的诊断符合率,Kappa值高达0.578;常规超声+剪切波弹性成像在断甲状腺结节良恶性诊断上的特异性最高,为85.8％.结论:剪切波弹性成像诊断甲状腺结节良恶性的效果显著;联合应用剪切波弹性成像超声与常规超声,能够将诊断价值进一步增强.     

Use of shear wave elastography to differentiate benign and malignant breast lesions

PURPOSE

We aimed to determine the correlations between the elasticity values of solid breast masses and histopathological findings to define cutoff elasticity values differentiating malignant from benign lesions.

MATERIALS and METHODS

A total of 115 solid breast lesions of 109 consecutive patients were evaluated prospectively using shear wave elastography (SWE). Two orthogonal elastographic images of each lesion were obtained. Minimum, mean, and maximum elasticity values were calculated in regions of interest placed over the stiffest areas on the two images; we also calculated mass/fat elasticity ratios. Correlation of elastographic measurements with histopathological results were studied.

RESULTS

Eighty-three benign and thirty-two malignant lesions were histopathologically diagnosed. The minimum, mean, and maximum elasticity values, and the mass/fat elasticity ratios of malignant lesions, were significantly higher than those of benign lesions. The cutoff value was 45.7 kPa for mean elasticity (sensitivity, 96%; specificity, 95%), 54.3 kPa for maximum elasticity (sensitivity, 95%; specificity, 94%), 37.1 kPa for minimum elasticity (sensitivity, 96%; specificity, 95%), and 4.6 for the mass/fat elasticity ratio (sensitivity, 97%; specificity, 95%).

CONCLUSION

SWE yields additional valuable quantitative data to ultrasonographic examination on solid breast lesions. SWE may serve as a complementary tool for diagnosis of breast lesions. Long-term clinical studies are required to accurately select lesions requiring biopsy.Breast cancer is associated with high morbidity; ∼1.38 million new cases and 458 000 deaths occur annually worldwide (1). Breast cancer is by far the most common cancer in females of both developed and developing countries, and remains a major public health problem.Annual mammographic screening is valuable for early detection of breast cancer, reducing mortality and morbidity, particularly of patients with tumors in fatty breast tissue (2). Increase in breast tissue density over time is a serious problem; this reduces the diagnostic accuracy of breast cancer, especially in younger females (3). Thus, as the proportion of glandular breast tissue rises, other imaging methods are required (4).Gray-scale ultrasonography is a valuable adjunct to mammography and other breast imaging methods, affording highly sensitive assessment of breast masses and differentiating benign solid breast lesions from those that are malignant (5–7). However, ultrasonography is strongly subjective and poorly specific (8–10).Breast biopsy remains the gold standard for definitive diagnosis of suspicious breast lesions. Although the total number of females referred for interventional diagnostic procedures represents a small percentage of any screened population, the healthcare resources consumed by such females are disproportionately high (11). Further, the pathological result is benign in up to 75% of all cases (11–13). Therefore, a reliable, noninvasive, costeffective method helping to differentiate benign from malignant breast lesions, thus reducing the number of unnecessary interventional diagnostic procedures, would be valuable.Sonoelastography uses ultrasound to assess tissue stiffness (elasticity), which can be described using Young’s modulus: E=σ/ε, where σ is the applied stress and ε the resultant tissue deformation. Two principal sonoelastographic approaches are available; these are static (strain) and transient (vibration; shear wave) elastography. In static elastography, a transducer is used to compress tissue and the resulting strain is presented as a color map of tissue elasticity superimposed on the real-time gray-scale sonogram.Static elastography is associated with significant interobserver variability, and uses elastographic scoring (ES) or strain ratio (SR) measurement as a diagnostic parameter. Both ES and SR are subjective semi-quantitative measures (14, 15). Shear wave elastography (SWE) is a novel technique applicable to soft tissue. In SWE, transverse shear waves spreading laterally from the tissue are tracked, and the speed of propagation calculated. SWE yields real-time quantitative data and is highly reproducible compared to static elastography (16, 17). Reproducibility of the latter technique is considered to be a major problem and may compromise patient outcomes. Thus, further work on the utility of SWE is needed.In the present study we sought to correlate the SWE values of a series of solid breast masses with histopathological findings, and to determine cutoff elasticity values allowing benign and malignant tumors to be distinguished.     

实时超声弹性成像技术在乳腺良恶性疾病鉴别诊断中的应用

超声技术在乳腺疾病的诊断中发挥着越来越重要的作用,常规二维超声,彩色多普勒及脉冲多普勒能在对病灶大小,位置,边缘情况,内部回声,血流情况,阻力指数等方面提供很多重要信息。随着医学领域对生物体的组织弹性和超弹性特性的关注,在传统二维超声成像基础上同时使用结合了组织弹性自相关方法的超声弹性成像技术,使组织的质地差异通过超声图像表现出来。该项技术能够获得常规超声所不能探测到的组织弹性信息,在对病变的良恶性鉴别诊断中起到了很大的作用。     

超声弹性成像对乳腺肿瘤良恶性的鉴别诊断价值

 目的 探讨超声弹性成像技术对乳腺良恶性肿瘤的鉴别诊断价值。方法 对我院186例患者的205个乳腺肿块,行超声弹性成像检查,评分采用改良5分法,4~5分为恶性,1~3分为良性,并以病理诊断作为金标准。结果 灵敏度80%,特异度98.7%,准确率94.1%,阳性预测值95.2%,阴性预测值93.9%,一致性检验χ²为138.9,P<0.01。被误诊为良性的肿块分别是浸润性癌4例,黏液腺癌1例,髓样癌3例,纤维腺癌2例;被误诊为恶性的均为纤维腺瘤。结论 超声弹性成像检查在鉴别诊断乳腺肿瘤良恶性方面准确率较高。     

剪切波弹性成像对甲状腺良恶性结节的诊断价值

目的:探讨超声剪切波弹性成像(SWE)对甲状腺良恶性结节的诊断价值.方法:收集104例(126个结节)甲状腺结节为研究对象,采用常规超声检查结节的回声、边缘、内部钙化程度、组成及形状;采用CDFI评估结节血流;采用SWE定性和定量评估结节弹性,获取剪切波速度(SWV),并通过ROC曲线计算SWV的最佳临界值.以最大SW...     

探讨超声弹性成像对甲状腺良恶性结节鉴别诊断的应用价值

目的:研究超声弹性成像在鉴别甲状腺良、恶性结节临床诊断中的应用价值。方法:对术前52例(93个)甲状腺结节进行常规二维、彩色多普勒超声及弹性成像检查,对弹性成像进行分析,并与病理结果进行对照。结果:93个甲状腺结节中,良性结节64个,恶性结节29个。其良性结节中,47个结节评为1～2分,恶性结节中,27个结节评为4～5分,两组弹性成像评分比较有统计学差异(P<0.01)。其诊断恶性结节的敏感性87.10%、特异性96.77%、准确性93.55%。结论:超声弹性成像对鉴别甲状腺良恶性病变提供很大的帮助。     

超声弹性成像分级法及评分法在甲状腺结节鉴别诊断中的应用

目的 探讨超声弹性成像分级法及评分法在甲状腺结节鉴别诊断中的应用价值.方法 选取106例甲状腺结节患者,分别进行二维超声TI-RADS分类评分、超声弹性成像分级评分、以及联合评分诊断,构建受试者工作特征(ROC)曲线,分析各自诊断效能.结果 二维超声评分、超声弹性成像评级评分、及联合诊断的ROC曲线下面积分别为0.83...     

Role of supersonic shear wave imaging quantitative elastography (SSI) in differentiating benign and malignant solid breast masses

Purpose

To evaluate sensitivity and specificity of supersonic shear wave imaging quantitative elastography (SSI) for distinguishing benign and malignant solid breast masses.

Materials and methods

100 patients with small solid breast masses, were included. The lesions were classified according to the BIRADS (Breast Imaging and Reporting Data System) by SSI. Measurement of the kilopascals (kPa) in different areas of the examined region of interest (ROI) was performed. Ultrasound-guided Tru-cut needle biopsy with an 18-gauge needle was done in all cases.

Results

From the malignant lesions (according to histopathological data), 15% were classified as BIRADS 4 and 85% as BIRADS 5 by SSI. Of the benign lesions, 98%, were classified as BIRADS 3% and 2% as BIRADS 4. According to the histological data, 100% of the lesions with a score of 5 (by SSI) were malignant and 100% of the lesions with a score of 3 were benign. 10% of the lesions with a score of 4 were benign and 90% were malignant. The mean elasticity values were significantly higher for malignant lesions than for benign lesions.

Conclusions

SSI has high sensitivity and specificity in the differentiation of benign and malignant solid breast masses.     

实时剪切波弹性成像鉴别乳腺肿瘤良恶性的初步探讨

目的 :探讨实时剪切波弹性成像技术(shear wave elastography,SWE)对乳腺肿块良恶性的鉴别诊断价值。方法 :选择我院行乳腺彩色多普勒超声和SWE检查检出乳腺肿块且经手术病理证实的女性患者54例,共72个乳腺肿块,对其SWE图像进行回顾性分析。应用ROC曲线确定SWE判断乳腺恶性肿瘤的最佳指标,获得其最佳诊断界值。结果:1乳腺良性肿瘤SWE典型表现:蓝色为主,颜色分布均匀;恶性肿瘤SWE典型表现:红色为主,颜色分布较杂乱。2与良性肿瘤相比,恶性肿瘤的平均弹性模量值(Emean)、标准差(SD)、与周边正常乳腺组织弹性模量的比值(Ratio)均明显增加,差异均有统计学意义(均P0.01)。3以病理结果为金标准,绘制SWE技术参数Emean、SD、Ratio的ROC曲线,其曲线下面积分别为0.933、0.891和0.753,表明Emean是诊断乳腺恶性肿瘤的最佳指标,截断值为46.41 k Pa。结论:SWE可定量测定乳腺肿块的弹性模量值,为乳腺肿块的良恶性鉴别诊断提供依据。     

实时组织弹性成像对乳腺肿瘤鉴别诊断的价值

目的探讨实时组织弹性成像对乳腺肿瘤鉴别诊断的临床应用价值。方法采用实时组织弹性成像进行良恶性鉴别和诊断,采用实时弹性成像评分法进行实时组织弹性成像对乳腺肿瘤鉴别诊断的效能分析。结果以实时组织弹性成像评分3分以下（包括3分）为良性病灶标准,实时组织弹性成像评分在4分以上（包括4分）为恶性病灶标准,进行实时组织弹性成像评分鉴别诊断乳腺病灶良恶性的效能分析发现,实时组织弹性成像评分对良恶性鉴别诊断的灵敏度、特异度、阳性预测值、阴性预测值分别为84．21％、95．83％、76．19％、97．46％。结论超声实时组织弹性成像技术具有无创、无痛重复性较好等各种优势,在乳腺方面的应用有较大的临床意义。