共查询到20条相似文献,搜索用时 15 毫秒
1.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(2):126-131
The relationship between the intensity of lipid peroxidation and the activity of the antioxidant system in the heart, liver,
and brain is studied in male Wistar rats with low and high resistance to hypoxia tested by being “raised” to an altitude of
11.5 km and in intact outbred rats. It is found that in all groups of rats the content of lipid peroxidation products is highest
in the liver, lower in the heart, and lowest in the brain. In all groups, the rate of the ascorbate-induced lipid peroxidation
is highest in the brain, lower in the liver, and lowest in the heart. The activity of the antioxidant system is highest in
the brain, lower in the liver, and lowest in the heart of low-resistance and outbred rats, while in high-resistance rats it
is the same in all the organs. Thus, the difference in the parameters of lipid peroxidation and, particularly, of the antioxidant
system in the studied organs is most pronounced in rats with a low resistance to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 138–143, February, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
2.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1995,120(1):733-736
Lipid peroxidation and the antioxidant system of the myocardium of adult male Wistar rats with low and high resistance to
acute hypoxia tested by “raising” to an altitude of 11.5 km are studied in winter and in summer. It is found that the winter
season is a mild stressor inducing changes in the myocardial antioxidant system and lipid peroxidation which are similar to
those observed at the early stages of catecholamine stress in the summer season. In both cases alterations are more pronounced
in low-resistance than in high-resistance rats. In winter, in low-resistance rats the intensity of lipid peroxidation and
the activity of the antioxidant system are lower, while the ratio of their parameters (chemiluminescence data) is higher.
At the same time, the levels of thiobarbituric acid-reactive substances are higher in winter in both groups. The relationship
between the studied parameters and the resistance of rats to hypoxia is more obvious in winter than in summer, i.e., it is
season-dependent and is also more pronounced in catecholamine stress.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, Nolo 7, pp. 87–90, July, 1995
Presented by N. A. Agadzhanyan, Member of the Russian Academy of Medical Sciences 相似文献
3.
I. G. Vlasova N. A. Agadzhanyan 《Bulletin of experimental biology and medicine》1994,118(5):1149-1152
The correlation between the pattern of a neuron's reaction to acute hypoxia and individual resistance to oxygen deficit is
studied on ratsin vivo as well as on surviving slices of their cerebellumin vitro. According to the survival time in a pressure chamber simulating an altitude of 11 km all the rats were divided into groups
of high resistance, medium resistance, and low resistance to hypoxia. Survival time was 4.2 times longer in the high resistance
group than in the low resistance group. In the cerebellar slices of high resistance animals 61.5% high-resistance neurons
and 38.5% low-resistance neurons were recorded. On the other hand, in the high resistance animals the percentage of high-resistance
neurons and low-resistance neurons was 31.2 and 68.8, respectively. The period of hypoxia development was 4.32 times longer
in the high-resistance neurons as compared to low-resistance neurons. It is speculated that individual differences in the
resistance to O2 deficit are of a hereditary nature and manifest themselves not only on the level of the whole organism, but also in the individual
nerve cell.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
11, pp. 454–457, November, 1994 相似文献
4.
A study of kinetic parameters of brain respiratory enzymes revealed that the maximal velocity and the Michaelis apparent constant
for NADH-cytochrome C-reductase are significantly lower in low-resistant rats than in rats with a high resistance to hypoxia.
Adaptation to periodic hypoxia increases total resistance only in low-resistant rats. It is accompanied by an increase in
the values of kinetics parameters for NADH-cytochrome C-reductase and cytochrome oxidase. Kinetic parameters for these enzymes
in the brain of high-resistant rats are either unaltered or even decreased. It is suggested that the first enzymatic complex
of the respiratory chain is one of the limiting or regulating links in energy metabolism determining the brain's resistance
to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3, pp. 252–255, March, 1996. 相似文献
5.
A. M. Dudchenko L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1995,120(6):1193-1195
After a prolonged (for 30 days) adaptation of rats to intermittent hypoxia, their brains contained lowered levels of mitochondrial
cytochromes, despite an increase in the number of mitochondria in the brain tissue mass, along with similar levels of high-energy
compounds and more protein as compaired to the brains of unadapted controls. A mitochondrial population with novel properties
presumably emerged in the brain. These effects were all more strongly marked in rats with an initially low resistance to hypoxia.
In the liver of hypoxiaadapted animals, unlike in their brain, cytochrome levels in the mitochondrial and microsomal redox
chains were lowered and the biogenesis of mitochondria was much less intensive.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
12, pp. 576–579, December, 1995 相似文献
6.
In contrast to short-term exposure, prolonged exposure to ethanol in the anternatal period is found to inhibit lipid peroxidation
in the brain and liver of rats. Activation of the system of antioxidant defense in the brain and liver is observed after both
short-and long-term exposure to ethanol. After short-term ethanol exposure, limontar normalizes lipid peroxidation.
Translated fromByulleten' Eksperimental'noii Biologii i Meditsiny, Vol. 117, N
o
1, pp. 41–44, January, 1994
Presented by M. Ya. Studenikin, Member of the Russian Academy of Medical Sciences 相似文献
7.
T. G. Sazontova Yu. V. Arkhipenko F. Z. Meerson 《Bulletin of experimental biology and medicine》1995,120(1):687-690
The relationship between the level of accumulation of lipid peroxidation products and the status of the Ca2+-transporting system in the sarcoplasmic reticulum of the rat myocardium is studied against the background of two cardioprotective
factors, namely adaptation to periodic hypoxia and a diet enriched in polyunsaturated fatty acids of the ω-3 class. It is
shown that the diet leads to an increase of level of lipid peroxidation products by 1.8 times in the heart and by 19 times
in the liver, whereas a adaptation has no effect on the level of lipid peroxidation products in either of these organs. At
the same time, the combined action of both factors considerably enhances the resistance of the myocardial Ca2+-transporting system to free radical-induced oxidation. Inin vitro experiments it is shown that adaptation to periodic hypoxia results in a more than twofold deceleration of Ca2+ transport inhibition during the oxidation induction by the Fe2+/ascorbate system; the diet causes a 3.5-fold deceleration of such inhibition. The results show that the accumulation of a
high level of lipid peroxidation products is not always followed by damage to the Ca2+-transporting system in the myocardial sarcoplasmic reticulum.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
7, pp. 42–45, July, 1995
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
8.
Protective effects of trimetazidine in acute hypoxia 总被引:1,自引:0,他引:1
A. V. Smirnov I. Krivoruchko I. B. Zarubina O. P. Mironova 《Bulletin of experimental biology and medicine》1998,125(4):361-363
Trimetazidine improves resistance to acute hypobaric hypoxia. Intraperitoneal injection of this preparation in an optimal
protective dose (25 mg/kg) to rats prevents serious disturbances of energy metabolism and activation of lipid peroxidation
in the brain, heart, and liver.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 4, pp. 410–412, April, 1998 相似文献
9.
N. A. Agadzhanyan L. V. Sorokin E. P. Tambovtsev V. I. Torshin 《Bulletin of experimental biology and medicine》1995,120(3):878-881
It is shown that the geometric mean of survival time and the deviation of σ from τ are measures of a population's resistance
to acute hypoxia; that a measure of the individual resistance of an animal to such hypoxia is Student's parameter for that
animal; that the distribution of Student's parameter in a population is a lognormal distribution under any conditions; and
that the number of animals with low resistance is always equal to the number of highly resistant animals. The procedure described
makes it possible to limit the number of animals used in an experiment by recording with the requisite accuracy the proposed
measures of resistance to acute hypoxia at the population and individual levels.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 239–241, September, 1995 相似文献
10.
L. D. Luk'yanova G. N. Chernobaeva V. E. Romanova 《Bulletin of experimental biology and medicine》1995,120(6):1189-1192
After long-term adaptation to intermittent hypoxia, rats with an initially low resistance to acute oxygen deficiency were
2 to 4 times more resistant to it, while highly resistant rats did not show a significant change in resistance. The adaptation
was accompanied by weakening of the electron-transporting function of the respiratory chain and increasing efficiency of oxidative
phosphorylation in the brain mitochondria oxidizing NAD-dependent substrates, indicating that energy was produced in a more
economical way. The succinate oxidase pathway of oxidation was found to be utilized to only a limited extent as a compensatory
mechanism in animals exposed to intermittent hypoxia over a prolonged period. The effects of adaptation were more marked in
the brain mitochondria of rats initially highly sensitive to oxygen deficiency.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
12, pp. 572–575, December, 1995 相似文献
11.
N. G. Kolosova N. A. Solov'eva I. G. Shabalina R. I. Salganik 《Bulletin of experimental biology and medicine》1996,121(3):259-261
It is shown that at the age of 2–3 months S rats with genetically determined hyperproduction of free radicals have the same
content of tocopherol in the heart, epididymal fat, adrenals, liver, and liver mitochondria as Wistar rats but a lower content
of plasma tocopherol. At 10–12 months, the tocopherol content in all studied tissues and organs, except the liver, is higher
than in young S rats and age-matched Wistar rats. This is regarded as a compensatory response facilitating the stabilization
of LPO under conditions of increased free radical formation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3, pp. 282–284, March, 1996 相似文献
12.
Newborn rats were born of females exposed to high-altitude hypoxia. Pregnant females were injected i.p. either nonopiate leu-enkephalin
analog or hydra peptide morphogen 10 μg/kg 30 min prior to being placed in a pressure chamber. Prenatal hypoxia causes the
inhibition of the proliferative processes in tracheal epithelium and activation of lipid peroxidation (LPO) in lungs of newborn
rats. The administration of nonopiate leu-enkephalin analog prevents the development of posthypoxic alterations in newborn
rats. The administration of hydra peptide morphogen inhibits the proliferation of tracheal epithelium and lowers the activity
of the antioxidant defense of the lungs in newborn rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
5, pp. 535–537, May, 1994
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences 相似文献
13.
S. S. Pertsov T. S. Balashova A. A. Kubatiev A. S. Sosnovskii G. V. Pirogova V. M. Abramov 《Bulletin of experimental biology and medicine》1995,120(3):884-886
Acute emotional stress is shown to raise the level of malonic dialdehyde in the hypothalamus of August rats. After intraventricular
administration of interleukin-1β, the malonic dialdehyde level and the activity of antioxidant enzymes tended to rise selectively
in the hypothalamus (but not in the sensorimotor cortex) of August, Wistar, and WAG rats. In the presence of this interleukin,
acute emotional stress did not cause increases in lipid peroxidation products in the hypothalamus of August rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 244–247, September, 1995 相似文献
14.
V. V. Malyshev L. S. Vasil'eva S. B. Belogorov T. V. Nefedova 《Bulletin of experimental biology and medicine》1995,119(6):567-570
Preadaptation of rats to altitude hypoxia results in reduced activation of lipid peroxidation during subsequent stress, inflammation,
or both, as compared to hypoxiaunadapted animals, with the result that secondary changes in organs and tissues of adapted
rats are much less pronounced and conditions are created for alleviating the acute inflammation and the stress reaction.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
6, pp. 590–593, June, 1995
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
15.
A statistically significant circadian rhythm of hypnogenic effect of hexenal is revealed in intact Wistar rats, with the maximum
recorded in the daytime and the minimum at night, and an amplitude of at least 30% of the mesor. Circadian rhythms of the
analgetic action of hexenal and of α-tocopherol concentrations in the blood serum are found to be in reciprocal relationship.
Experimental hepatosis induced by intragastric administration of CCl4 is attended by alteration of the time organization of the antitoxic function of the liver and of the concentrations of iron,
α-tocopherol, and lipid peroxidation products in the blood collected from the hepatic and portal veins.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
5, pp. 540–543, May, 1995
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
16.
V. V. Belousova A. M. Dudchenko L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1995,119(1):23-27
It is demonstrated that the lactate-Po2 dependence is the same in hepatocytes of rats with high and low resistance to hypoxia and does not correlate with phasic
changes in the ATP concentration in the 890–50 μM O2 region. Strong activation of lactate formation against the background of ATP decrease indicates that glycolysis is not the
major mechanism determining the steady-state ATP level in the cell and affecting the ATP-Po2 relationship in a wide range of oxygen concentrations. The intensity of glycolysis in hepatocytes of rats with high resistance
to hypoxia is markedly increased after periodic adaptation to hypoxia but remains practically unchanged in the hepatocytes
of low-resistance rats. This indicates that fundamentally different compensatory mechanisms are involved in this process in
the liver of high- and low-resistance rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
1, pp. 28–32, January, 1995 相似文献
17.
V. V. Malyshev L. S. Vasil'eva S. B. Belogorov 《Bulletin of experimental biology and medicine》1994,118(3):940-943
The dynamics of lipid peroxidation and of the aseptic inflammatory process is studied in rats adapted to high altitude hypoxia.
A greater activity and shorter duration of the acute period of inflammation are found in these animals, while in the reparative
period stimulation of the proliferative processes and slowed formation of the fibroblast capsule are noted.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
9, pp. 243–246, September, 1994
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
18.
I. M. Solopaeva K. N. Kontorshchikova 《Bulletin of experimental biology and medicine》1994,117(6):571-573
A study is performed of the effect of chorionic gonadotropin on lipid peroxidation in the liver and myocardium of white rats
injected subcutaneously with tetrachloromethane for a long time. Chorionic gonadotropin is shown to reduce the content of
diene conjugates and Schiff bases, which suggests an antioxidant effect of the hormone.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
6, pp. 572–573, June, 1994
Presented by Yu. A. Romanov. Member of the Russian Academy of Medical Sciences. 相似文献
19.
V. Kh. Vaizov T. M. Plotnikova T. V. Yakimova O. E. Vaizova A. S. Saratikov 《Bulletin of experimental biology and medicine》1994,118(3):975-977
It is demonstrated that ammonium succinate is capable of increasing the survival of rats with acute brain ischemia. In transient
brain ischemia therapeutic injection of ammonium succinate prevents the development of postischemic hypoperfusion and hypooxygenation
of the brain. The antiischemic effect of ammonium succinate is due to a decrease of the oxygen affinity of hemoglobin and
to limitation of the accumulation of malonic dialdehyde, a secondary product of lipid peroxidation, in the brain. No vasotropic
activity of ammonium succinate is revealed.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
9, pp. 276–278, September, 1994
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
20.
B. Kh. Yagmurov A. A. Timofeev S. K. Soodaeva A. G. Chuchalin 《Bulletin of experimental biology and medicine》1994,117(6):622-625
The development of bronchospasm is shown to be accompanied by lipid peroxidation (LPO) activation; 3-fold and 8-fold rises
of malondialdehyde concentration are found in homogenate of lung from sensitized animals and from animals provoked with egg
albumin antigen, respectively. The use of luminol-dependent chemiluminescence (CL) reveals that in sensitized rats the production
of oxygen free radicals is increased by alveolar macrophages activated with phorbol myristate acetate. Troventol at 10−3 mg/ml inhibits the CL response of phagocytes both in intact and in sensitized rats and lowers the level of Fe2+-induced LPO in lung tissue but not in the liver of intact animals.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
6, pp. 619–621, June, 1994 相似文献