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1.
Shin-ichiro Masunaga Hitoshi Tatebe Yasumasa Nishimura Keizo Tano Yu Sanada Takahiro Moriwaki 《International journal of radiation biology》2016,92(4):187-194
Purpose To evaluate the effect of oxygen pressure during incubation with a 10B-carrier on 10B uptake capacity of cultured p53 wild-type and mutated tumor cells.Materials and methods Cultured human head and neck squamous cell carcinoma cell line transfected with mutant TP53 (SAS/mp53), or with a neo vector as a control (SAS/neo) was incubated with L-para-boronophenylalanine-10B (BPA) or sodium mercaptoundecahydrododecaborate-10B (BSH) as a 10B-carrier at the 10B concentration of 60 ppm for 24?h under aerobic (20.7% of oxygen) or hypoxic (0.28% of oxygen) conditions. Immediately after incubation, cultured tumor cells received reactor thermal neutron beams, and a cell survival assay was performed. 10B concentration of cultured SAS/neo or SAS/mp53 cells incubated under aerobic or hypoxic conditions was determined with a thermal neutron guide tube.Results Hypoxic incubation significantly decreased 10B concentration of cultured cells with a clearer tendency observed following BPA than BSH treatment in both SAS/neo and SAS/mp53 cells. Following neutron beam irradiation, SAS/mp53 cells showed significantly higher relative biological effectiveness values than SAS/neo cells because of the significantly lower radiosensitivity of SAS/mp53 to γ-rays than SAS/neo cells.Conclusion Oxygen pressure during incubation with a 10B-carrier had a critical impact on 10B uptake of cultured tumor cells. 相似文献
2.
A case is presented in which two neuro-ectodermal tumors, an infra- and a supratentorial glioma, developed in a young man
with multiple enchondromatosis of Ollier’s disease. This is the third such case of multifocal low-grade glioma in Ollier’s
disease, suggesting a predisposition for non-mesodermal tumors in Ollier’s disease. The related condition of multiple enchondromatosis
and hemangiomas (Maffucci’s syndrome) is well known for its malignant potential, developing both mesodermal and non-mesodermal
tumors. Along with other authors, we support the concept of two variants of the same disease with a predisposition to development
of tumors from various germ layers. 相似文献