平阳霉素加地塞米松局部注射治疗面部血管瘤38例

血管瘤是面部常见的先天性良性肿瘤,传统的治疗方法很多,包括手术切除、放射治疗、低温冷冻、激光治疗、硬化剂注射药物等,但各有其局限性,疗效多不尽人意。2002年9月至2006年3月,我们采用平阳霉素(pingyangmycin,PYM)加地塞米松(deexamthasone,DXM)局部瘤内注射治疗面部血管瘤38例,取得了满意效果。现总结如下。资料与方法1.一般资料2002年9月至2006年3月,我们采用平阳霉素(PYM)加地塞米松(DXM)局部注射治疗面部血管瘤38例,其中男8例,女30例,年龄3个月-45岁,平均年龄18.2岁。单发36例,多发2例。草莓状血管瘤27例,葡萄酒斑状血管瘤8例,…     

平阳霉素加地塞米松注射治疗婴幼儿血管瘤132例

目的 观察平阳霉素加地塞米松局部注射治疗婴幼儿血管瘤的疗效.方法 用2%利多卡因和生理盐水将平阳霉素和地塞米松配制成每毫升含1mg平阳霉素和1.0mg地塞米松和1%的利多卡因混合液行血管瘤内注射至局部肿胀、苍白.若血管瘤面积较大或多发时,可分次、分点注药,每次间隔1个月,直至治愈为止.共治疗132例,结果面积较小者经1～3次注射治愈,面积较大或多发血管瘤分别经7～8次注药后治愈.经8～12个月随访,总有效率为100%.结论 本方法具有操作简单、疗效显著、并发症少等优点,只要使用方法正确,治疗后不留畸形,特别适于体表中小面积血管瘤的治疗.     

平阳霉素和地塞米松治疗颌面部海绵状血管瘤

目的 探讨平阳霉素加地塞米松瘤体内注射治疗小儿颌面部海绵状血管瘤疗效。方法对20例小儿颌面部海绵状血管瘤患者行平阳霉素加地塞米松瘤体内注射治疗。结果随访1年，20例中治愈15例（75％），有效4例（20％），好转1例（5％）。结论 平阳霉素加地塞米松瘤体内注射治疗小儿颌面部海绵状血管瘤疗效较好。     

平阳霉素联合地塞米松治疗头面部血管瘤疗效观察及护理

目的探讨平阳霉素联合地塞米松治疗头面部血管瘤的疗效及护理。方法头面部血管瘤60例,采用平阳霉素加地塞米松瘤体间质内注射,每次注射平阳霉素最大剂量不超过0.5mg/kg,年长儿及成人不超过8mg。经第一次注射有效者间隔1个月重复注射,直至瘤体消退。结果治愈48例(占80%),有效12例(占20%),全部病例均未出现严重不良反应,总有效率达100%。结论平阳霉素注射治疗头面部血管瘤是一种较为理想的治疗方法     

平阳霉素联合地塞米松治疗小儿颌面部血管瘤疗效观察

目的观察平阳霉素和地塞米松联用治疗小儿颌面部血管瘤的临床疗效。方法对45例颌面部血管瘤患儿采用平阳霉素、地塞米松及利多卡因进行瘤体多点腔内注射治疗,注射后至瘤体表面皮肤或黏膜变白,用无菌棉球按压针孔2-3min,治疗后随访1年,观察患儿临床疗效、全身和局部不良反应。结果 45例患儿中,治愈34例（75.56%）,基本治愈8例（17.77%）,有效3例（6.67%）,总有效率为100%,随访1年后患儿均未见血管瘤复发。结论平阳霉素联合地塞米松治疗小儿颌面部血管瘤临床疗效显著,且操作简单、微创,全身和局部不良反应少,值得临床推广应用。     

平阳霉素与地塞米松局部注射治疗儿童口腔颌面部血管瘤24例

目的 探讨平阳霉素与地塞米松联合局部注射治疗儿童口腔颌面部血管瘤的临床疗效.方法 42例口腔颌面部血管瘤患儿,其中观察组24例,给予平阳霉素、地塞米松联合局部注射治疗;对照组18例,给予平阳霉素局部注射治疗,比较2组总体疗效及不良反应发生情况.结果 观察组痊愈率83.3％,对照组为38.9％,总有效率比较有统计学意义(x2=10.2,P＜0.05).观察组发生皮肤溃疡(16.7％)、局部肿胀(12.5％)、腹部不适(16.7％)及低热(8.4％),对照组发生皮肤溃疡(11.1％)、局部肿胀(11.1％)、腹部不适(16.7％)及低热(16.7％),2组比较无统计学意义(P＞0.05).结论 平阳霉素、地塞米松联合局部注射治疗口腔颌面部血管瘤,疗效确切,具有给药方便、起效迅速、疗程短、不良反应小等优点,值得临床推广.     

平阳霉素局部注射治疗口腔颌面部血管瘤88例临床体会

目的 :探讨平阳霉素局部注射治疗口腔颌面部毛细血管瘤的临床效果。方法 :将 2 mg盐酸平阳霉素溶解于 1m L 生理盐水 ,并加 1m L(2 mg)地塞米松 ,对毛细血管瘤局部注射 (不超过 1.0 cm× 1.5 cm)大面积 (3.0 cm× 3.5cm)做分点注射 ,局部颜色发白为止。结果 :88例血管瘤应用盐酸平阳霉素注射 ,随访观察均获得了理想的效果。结论 :应用此方法避免了外科手术的难度及危险性 ,保护了面神经与大血管功能     

平阳霉素注射治疗颌面部血管瘤疗效观察

为探讨一种简便、安全的治疗颌面部血管瘤的疗法，采用平阳霉素加地塞米松局部注射。共46例，其中治愈33例，占71.74%；显效13例，占28.26%。结果提示：平阳霉素局部注射是一种安全、有效的治疗颌面部血管瘤的方法。     

平阳霉素与地塞米松联合治疗颌面部海绵状血管瘤的临床分析

目的 总结分析平阳霉素与地塞米松联合治疗颌面部海绵状血管瘤的疗效。方法 选取颌面部海绵状血管瘤36例，采用平阳霉素和地塞米松配伍注射治疗，观察疗效。结果 经过3个月～2年的随访，治愈31例（86％），好转5例（14％），无效0例，总有效率100％。结论 平阳霉素和地塞米松配伍注射治疗颌面部海绵状血管瘤，疗效好，副作用小，是安全、简便、有效的治疗方法。     

平阳霉素联合地塞米松局部注射治疗口腔颌面部血管瘤

目的总结平阳霉素、地塞米松联合治疗口腔颌面部血管瘤的疗效.方法用平阳霉素、地塞米松联合局部注射治疗28例口腔颌面部血管瘤患者.7-14天注射一次,3-5次为一疗程.结果经6-24个月观察随访,治愈和基本治愈25例,瘤体缩小的2例,无效的1例,有效率97.2%.结论平阳霉素、地塞米松联合局部注射治疗口腔颌面部血管瘤,具有疗程短,不良反应小等优点,是一种安全、可靠、简便的治疗疗法.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.