急诊静脉溶栓治疗急性心肌梗死26例疗效观察

目的 评价采用静脉溶栓治疗急性心肌梗死患者的疗效.方法 对2006年5月-2009年6月我院治疗的26例急性心肌梗死患者进行急诊静脉溶栓治疗,并分析临床效果.结果 经治疗后,19例患者冠状动脉再通,再通率为73.1%,无严重出血等不良反应,无1例需要输血,住院期间死亡1例.结论 急诊静脉溶栓疗效迅速,并发症少,是重建急性心肌梗死患者冠状动脉灌注的有效治疗方法 .     

国产尿激酶静脉溶栓治疗急性心肌梗死的临床观察

静脉溶栓治疗急性心肌梗死 (ＡＭＩ)的疗效已经由大规模 ,安慰剂对照 ,随机试验所证实 ,显示溶栓治疗可使病死率降低 18% [1] 。对于不同的溶栓剂的疗效 ,各地报道不一 ,但尿激酶有良好的疗效已有许多报道。我们考虑尿激酶价格便宜 ,无抗原性 ,副作用少 ,且可以一次大剂量注射 ,基层医院使用方便 ,故我们用国产尿激酶对 5 3例ＡＭＩ进行溶栓治疗 ,并与同期 90例ＡＭＩ未用溶栓者的 2 8日内病死率及并发症进行对比 ,探讨在基层使用尿激酶的疗效与安全性。材料与方法　　 1 一般资料 ,本文收集从 1996年 1月～ 2 0 0 0年 12月的 5年住院病例 1…     

早期静脉溶栓治疗急性心肌梗死52例临床观察

目的评价早期静脉溶栓治疗急性心肌梗死临床疗效,并观察其不良反应。方法对急性心肌梗死早期病人静脉滴注国产尿激酶进行静脉溶栓治疗。结果血管再通率75％(39／52);12例出现轻微不良反应,用药后短期内消失。结论早期静脉溶栓治疗急性心肌梗死疗效好,使用方便,相对安全。     

急性心肌梗死院前尿激酶静脉溶栓疗效分析

1997年10月～2002年12月，我们对43例确诊为急性心肌梗死(AMI)的患者在发病后12小时内进行尿激酶静脉溶栓治疗，并对再通疗效进行了临床观察，现报告如下。     

国产尿激酶静脉溶栓治疗急性心肌梗死19例

近年来 ,我们应用国产尿激酶 (10万 U/支 ) ,静注治疗急性心肌梗死 (AMI) 19例次 ,效果良好。一般资料 :本组男 14例 ,女 5例 ;年龄 47～ 64岁 ,平均 5 7岁。广泛前壁梗死 8例 ,前间壁 6例 ,下壁 5例 ,发病时间为 1～ 3 .5 h,平均 1.2 h。给药方法 :即刻内服阿司匹林 0 .3 g,以后每日 0 .3 g,3天后改为每日 5 0 mg,以后长期服用。先静注尿激酶 5 0万 u,然后用 10 0万 U加入 5 %葡萄糖液 2 5 0 ml中静滴。溶栓开始后密切观察胸痛变化。给溶栓药物后 2小时内每 2 0分钟记录12导联心电图一次 ,观察到用药后 2 4小时。每 2小时测一次出凝血时…     

静脉溶栓治疗老年急性心肌梗死45例

急性心肌梗死(AMI)是常见的危急重症,起病急,病情进展快,患者病死率较高.在AMI的治疗措施中,静脉溶栓方法简单,容易操作,能够提高患者预后,提高患者存活率.本文选择我院老年AMI病例,观察静脉溶栓的治疗效果.1 资料与方法1.1 一般资料 所选90例AMI患者均为我院2010年11月至2012年12月的住院病例,均符合AMI诊断标准,发病到治疗时间均在6h以内,同时排除静脉溶栓治疗禁忌,心电图检查显示两个或者两个以上导联ST段抬高约0.2 mV,胸痛时间持续超过30 min舌下含服硝酸甘油不能缓解.     

尿激酶静脉溶栓治疗老年人急性心肌梗死25例分析

尿激酶静脉溶栓治疗老年人急性心肌梗死２５例分析马希贤，马京炬，李全亲，张健，唐水龙，李淑平急性心肌梗死（ＡＭＩ）早期溶栓治疗已成为ＡＭＩ的重要治疗方法。我院自１９９０年６月至１９９５年３月应用尿激酶（ＵＫ）静脉溶栓治疗老年人ＡＭＩ２５例，效果满意，现...     

尿激酶静脉溶栓治疗急性心肌梗死的疗效观察

目的探讨早期尿激酶静脉溶栓治疗急性心肌梗死（AMI）的临床疗效。方法回顾性分析45例经溶栓治疗的心肌梗死患者,23例使用尿激酶静脉溶栓治疗的AMI患者作为观察组,22例常规治疗的AMI患者作为对照组,比较两组的再通情况。结果尿激酶观察组与对照组的冠脉再通率分别为68.5%和16.7%,两组再通率比较,差异有统计学意义。结论尿激酶溶栓治疗可提高急性心肌梗死疗效,值得基层医院推广应用。     

尿激酶静脉溶栓治疗93例急性心肌梗死报告

目的：观察不同时间静脉溶栓对冠脉再通率的影响。方法：93例具有溶栓指征的急性心肌梗死患在多参数监测下用尿激酶静脉溶栓，观察其冠脉再通状况。结果：发病3小时溶栓再通率较6小时与12小时再通率显增高（P＜0．01）。结论：早期溶栓可提高再通率，改善左室功能，降低死亡率。     

急性心肌梗死静脉溶栓治疗的疗效分析

目的 探讨分析静脉溶栓治疗早期急性心肌梗死的安全性及临床疗效.方法 在心电监测下应用尿激酶静脉溶栓治疗93例急性心肌梗死患者,并对其临床资料进行回顾分析.结果 93例患者中冠脉达到再通标准69例,再通率为74.19%;24例未达再通标准,其中3例死亡,病死率为3.23%.发病<6 h溶栓治疗的成功率明显高于6～12 h的再通成功率,差异有统计学意义(P＜0.05).结论 急性心肌梗死患者应尽早行静脉溶栓治疗,以减少并发症、降低病死率、提高再通的成功率.     

Role of heparin after intravenous thrombolytic therapy for acute myocardial infarction

The optimal approach to management of patients after thrombolytic therapy for acute myocardial infarction (AMI) is unclear. The role of anticoagulation with heparin was evaluated in 75 consecutive patients who received intravenous streptokinase for AMI. Heparin therapy was titrated to keep the partial thromboplastin time (PTT) between 90 and 120 seconds. Seventeen episodes of definite myocardial ischemia (associated with reversible electrocardiographic changes) were observed in 13 patients. When episodes of probable myocardial ischemia are included (typical chest pain relieved by nitroglycerin or associated with more than a 15-mm Hg change in blood pressure but without electrocardiographic changes), 52 episodes occurred in 28 patients. Four episodes of definite and 4 of probable myocardial ischemia occurred within 24 hours of discontinuation of heparin. Analysis of the level of anticoagulation as assessed by PTT at the time of the ischemic events shows that ischemia occurred more often at lower PTTs. Nine hemorrhagic complications occurred, all within 24 hours of streptokinase infusion. In 4 patients bleeding was believed to be major and heparin administration was discontinued; 2 patients with gastrointestinal bleeding required blood transfusions. Our data suggest that after thrombolytic therapy for AMI, the level of anticoagulation is inversely related to the frequency of recurrent ischemic events; that discontinuation of heparin is frequently associated with ischemia; and that administration of heparin is associated with a low incidence of hemorrhagic complications.     

溶栓抗凝治疗急性心肌梗死伴发重复再灌注心律失常临床分析

目的　分析溶栓治疗急性心肌梗死时重复再灌注心律失常的发生情况及意义。方法　随机选择急性心肌梗死溶栓治疗再通病例 30例 (再通组 ) ,溶栓治疗未再通病例 15例 (非再通组 )。溶栓药物尿激酶 ,每例 15 0万 u溶于生理盐水 10 0 ML ,30分钟内静脉滴入。治疗前后测心肌酶谱 ,两组病例均在溶栓后做冠状动脉造影。结果　下壁心肌梗死 15例中 8例在首次发生再灌注心律失常后 5 0± 10分钟 ,出现与首次心律失常相似但程度不同的心律失常 ,本组病例多表现为一度或二度房室传导阻滞 (AVB) ,但这一重复心律失常 ,严重程度及持续时间均较首次再灌注心律失常轻和短。 15例非再通组下壁心梗 9例中有 5例发生 AVB,发生时间与溶栓治疗无关 ,持续时间长。结论　溶栓治疗急性心肌梗死时出现首次再灌注心律失常后仍应重视重复再灌注心律失常的发生。     

急性心肌梗塞溶栓患者的2周康复治疗

目的 :探索 2周康复程序对急性心肌梗塞溶栓患者早期康复治疗的安全、有效性。方法 :根据个体化及活动量循序递增的原则 ,对 2 3例急性心肌梗塞重组链激酶 (r- SK)静脉溶栓患者和 2 3例急性心肌梗塞无严重并发症常规治疗患者均进行 2周程序的康复治疗。结果 :r- SK溶栓组的再通率为78.2 6 % ,死亡率和并发症低于非溶栓组 (P<0 .0 5) ,正常进入康复程序的患者多于非溶栓组 (P<0 .0 5) ,住院天数也短于非溶栓组 (分别为 13.2 2± 6 .0 7、 14.2 6± 6 .4 5天 )。康复运动中无一例出现严重合并症。结论 :2周康复程序是安全、有效的 ,而且溶栓配合康复治疗效果更明显。     

Clinical controversies surrounding thrombolytic therapy in acute myocardial infarction

The treatment of acute myocardial infarction has changed tremendously in the past decade because thrombolytic therapy has become the treatment of choice for the patient with acute myocardial infarction. Although many issues have been resolved, several controversial issues remain unresolved. This article addresses thrombolytic agents in terms of their superiority in achieving infarct vessel patency and mortality reduction as well as the role of thrombolysis in patients who present with chest pain of greater than 6 hours' duration, who are elderly, and who have an inferior infarction.     

院前静脉溶栓治疗急性心肌梗死的临床随机对照研究

目的　评价重组组织型纤溶酶原激活剂 (rt PA)在院前救治急性心肌梗死 (AMI)的近期临床治疗效果 ,并探讨在院前对AMI患者进行静脉溶栓治疗的安全性和可行性。方法　对所收治的AMI患者进行分组 ,均给予rt PA( 5 0mg)进行静脉溶栓治疗 ,对比两者的冠状动脉再通率以及发病至溶栓时间延迟对rt PA静脉溶栓疗效的影响。结果　从患者发病至进行溶栓治疗的时间间隔 ,院前组平均比院内组缩短 2 .2小时 [( 2 .9± 1.4)小时比 ( 5 .1± 1.1)小时 ] ,P <0 .0 5 ;院前治疗组的冠状动脉总再通率为 90 % ,明显高于院内治疗组的 61.8% (P <0 .0 5 )。结论　院前应用rt PA( 5 0mg)进行静脉溶栓治疗安全、可行。     

Usefulness of intravenous thrombolytic therapy with pro-urokinase in acute myocardial infarction

Treatment of acute myocardial infarction (AMI) with plasminogen activators reduces infarct size and mortality rate.¹ This therapy has been attended by significant problems. Both urokinase and streptokinase lack clot selectivity and promote generalized fibrinogenolysis, at times resulting in severe bleeding.² Tissuetype plasminogen activator and pro-urokinase are more fibrin specific.^3,4 Although tissue-type plasminogen activator has been more extensively studied, only 1 clinical report is available for pro-urokinase.⁵ This study determines whether intravenously administered pro-urokinase could be confirmed to be an effective and clot-selective fibrinolytic agent and reports information about the minimal dose required for effective coronary thrombolysis in patients with AMI.     

Protective effect of intravenous magnesium in acute myocardial infarction following thrombolytic therapy

The role of intravenous magnesium therapy in patients with acute myocardial infarction (AMI) who received thrombolytic therapy is controversial. The results from previous clinical trials were not in consonance. We therefore conducted a prospective, randomized, double-blind, placebo controlled study in 350 patients with confirmed AMI during the period January 1994 to December 1996. The role of intravenous magnesium sulphate therapy (2 g over 5 min followed by 16 g over 24 h) was evaluated in patients with AMI who received thrombolytic therapy. Study group consisted of 169 patients who were administered magnesium sulphate. Control group comprised of 181 patients who were given isotonic saline. Among those in the magnesium group, 70% received magnesium within 6 h after the onset of symptoms. All patients received magnesium immediately after the completion of thrombolytic therapy. Patients were followed up for 30 days after AMI. The number of deaths in the study group was 6 (3.5%) compared with control arm in which 18 patients (9.9%) died (P value <0.01 95% Confidence intervals [CI] 1.2 to 11.6). Ventricular arrhythmias were also less in the magnesium arm; 27 patients (13%) compared with 83 patients (48.6%) in the control arm (P value 0.00001 95% Cl 26.7 to 44.5). In the magnesium group 15 patients (8.8%) had re-infarction compared with 23 patients (12.7%) in the placebo arm (P value not significant). Post myocardial infarction angina was observed in 47 patients (27.8%) in the magnesium arm compared with 60 patients (33.1%) in the placebo arm (P value not significant). The main side effect of intravenous magnesium was transient flushing observed in 152 (90%) patients. Intravenous magnesium sulphate in patients with AMI is a safe and useful adjunct to thrombolytic therapy in reducing the short-term mortality and ventricular arrhythmias after AMI.     

Clinical benefits of thrombolytic therapy in acute myocardial infarction.

The value of coronary artery reperfusion resulting from pharmacologically induced fibrinolysis in patients with evolving myocardial infarction has been rigorously evaluated. Improved left ventricular function and even more impressive improvements in survival rates have been demonstrated consistently in controlled studies. Benefit is related to the restoration of myocardial blood flow. Maximal benefit is achieved with early and sustained restoration of coronary artery patency. Benefits observed during initial hospitalization are sustained for at least 1 year in the majority of patients, even without subsequent mechanical revascularization. To date, analysis of subgroups has not identified a population of patients with evolving infarction that should routinely be excluded from consideration for thrombolysis. As with many potent pharmacologic agents, activators of the fibrinolytic system are associated with a degree of risk whenever they are administered to a patient. Therefore, patients must be assessed carefully prior to initiating treatment, especially for potential bleeding hazards, and appropriate follow-up evaluation and concomitant therapy needs to be planned. However, given the overwhelming body of data now available regarding its benefits and relative safety, thrombolysis should be considered as conventional therapy for patients with acute evolving myocardial infarction (AMI).