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1.
A. T. Staroverov O. B. Zhukov Yu. M. Raigorodskii 《Neuroscience and behavioral physiology》2009,39(9):891-895
A total of 54 patients with alcoholism were studied during abstinence. Of these, 29 patients in the experimental group received
basal therapy supplemented with physical treatment consisting of transcranial dynamic magnetotherapy (TcDMT), while the control
group of 25 patients received only basal therapy. Comparison of the status of patients in the experimental and control groups
during treatment demonstrated advantages of TcDMT in relation to improving the functional state of the CNS, memory, and attention,
the autonomic nervous system, and the psychoemotional status of the patients (with decreases in the severity of anxiety and
depression). 相似文献
2.
Noben (idebenone) at a dose of 120 mg per day for six months was used in the treatment of 35 patients aged 60–86 years with
Alzheimer’s-type dementia, mixed dementia, and memory impairments not reaching the stage of dementia. Patients were assessed
on the basis of data from somatic, neurological, and psychiatric investigations, as well as neuropsychological testing and
a series of psychometric and other scales and tests, before and after treatment. Significant improvements in patients’ conditions
on the MMSE were seen in patients with mild and moderate dementia. Improvements in daily activities were obtained in 27% of
patients. Neuropsychological investigations demonstrated improvements in short-term and long-term memory and attention, with
improvements in speech functions, performance of kinesthetic, spatial, and dynamic praxis tests, and in visuospatial gnosis,
thought, and writing. On the CGI scale, positive treatment effects were obtained in 37% of patients, while 48% of patients
remained in a stable state.
Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 108, No. 4, pp. 27–32, April, 2008. 相似文献
3.
Soroko SI Burykh EA Bekshaev SS Sidorenko GV Sergeeva EG Khovanskikh AE Kormilitsyn BN Moralev SN Yagodina OV Dobrodeeva LK Maksimova IA Protasova OV 《Neuroscience and behavioral physiology》2007,37(9):857-874
Results obtained from complex medical-physiological investigations performed during 10 scientific expeditions in the Arkhangel’sk
Region in 2003–2005 are presented. The effects of climatological-geographic, biogeochemical, and social conditions of the
conditions obtaining in the Far North region of Russia on sexual maturation, formation of the structural-functional organization
of the brain, autonomic functions, and immunological and biochemical status of schoolchildren were studied using state-of-the-art
neurophysiological methods (computerized electroencephalography, computerized rheoencephalography, computerized electric dipole
origin tomography, etc.), psychophysiological and psychometric methods (assessment of the state of cognitive and memory functions,
Wechsler intellectual scale), along with biochemical assay of monoamine oxidase (MAO, the key enzyme in adrenergic neurotransmitter
metabolism) and the liver enzyme butyrylcholinesterase (BuChE) and physicochemical analysis of the levels of macroelements
and trace elements in the body.
__________
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 92, No. 8, pp. 905–929, August, 2006. 相似文献
4.
Hemodynamic abnormalities have been documented in the chronic fatigue syndrome (CFS), indicating functional disturbances of
the autonomic nervous system responsible for cardiovascular regulation. The aim of this study was to explore blood pressure
variability and closed-loop baroreflex function at rest and during mild orthostatic stress in adolescents with CFS. We included
a consecutive sample of 14 adolescents 12–18 years old with CFS diagnosed according to a thorough and standardized set of
investigations and 56 healthy control subjects of equal sex and age distribution. Heart rate and blood pressure were recorded
continuously and non-invasively during supine rest and during lower body negative pressure (LBNP) of –20 mmHg to simulate
mild orthostatic stress. Indices of blood pressure variability and baroreflex function (α-gain) were computed from monovariate
and bivariate spectra in the low-frequency (LF) band (0.04–0.15 Hz) and the high–frequency (HF) band (0.15–0.50 Hz), using
an autoregressive algorithm. Variability of systolic blood pressure in the HF range was lower among CFS patients as compared
to controls both at rest and during LBNP. During LBNP, compared to controls, α-gain HF decreased more, and α-gain LF and the
ratio of α-gain LF/α-gain HF increased more in CFS patients, all suggesting greater shift from parasympathetic to sympathetic
baroreflex control. CFS in adolescents is characterized by reduced systolic blood pressure variability and a sympathetic predominance
of baroreflex heart rate control during orthostatic stress. These findings may have implications for the pathophysiology of
CFS in adolescents. 相似文献
5.
Wang SM Ho TS Lin HC Lei HY Wang JR Liu CC 《European journal of clinical microbiology & infectious diseases》2012,31(6):1219-1224
Enterovirus 71 (EV71) infection commonly strike children under the age of 3 years, with an occasionally unfavorable outcome
in children. This study was designed to explore the relationship between age and the severity of complications, which may
associate with antibody-dependent enhancement (ADE) in EV71. All EV71-infected patients during the outbreak of 2008 were recruited.
In total, 134 patients were enrolled and categorized into two age groups, 0–12 months (n = 18) and >12 months (n = 116). Pulmonary edema/hemorrhage more commonly occur in patients younger than 12 months. No difference in the occurrence
of herpangina/hand-foot-and-mouth disease (HFMD), uncomplicated brainstem encephalitis (BE), or autonomic nervous system (ANS)
dysregulation was noted between the two age groups. Patients with pulmonary edema/hemorrhage (11.9 ± 14.7 months) were younger
than patients with herpangina/HFMD (35.8 ± 26.4 months) or ANS dysregulation (33.9 ± 20.9 months). Our findings are in agreement
with the data regarding the outbreak in Taiwan, in which a decrease in age corresponded to an increase in disease severity
with regard to central nervous system complications. A reduction of maternal antibodies to the subneutralizing level within
1 year of age may be associated with the ADE of the infection. This study could provide possible clinical significance with
regard to ADE phenomena in young infants infected by EV71. 相似文献
6.
B. V. Agafonov L. A. Podrezova E. A. Karavashkina T. I. Vishnyakova L. A. Smirnova M. N. Dadasheva N. N. Shevtsova 《Neuroscience and behavioral physiology》2011,41(9):916-919
The efficacy and safety of Axamon were studied in patients aged 65–88 years with motor and cognitive disorders during the
residual period of stroke: 25 patients received basal treatment and Axamon prescribed for 12 weeks at a dose of 20 mg three
times daily, while 25 patients of the control group received basal treatment only. Along with neurological studies, assessment
of the efficacy and safety of complex therapy was performed using neuropsychological tests and scales. Decreases in the severity
of cognitive and motor disorders were seen in patients given Axamon. Axamon promoted optimization of the rehabilitation potential
of patients during the residual period of stroke. 相似文献
7.
Middleton PM Tang CH Chan GS Bishop S Savkin AV Lovell NH 《Medical & biological engineering & computing》2011,49(3):337-347
Sepsis is associated with impairment in autonomic regulatory function. This work investigates the application of heart rate
and photoplethysmogram (PPG) waveform variability analysis in differentiating two categories of sepsis, namely systemic inflammatory
response syndrome (SIRS) and severe sepsis. Electrocardiogram-derived heart period (RRi) and PPG waveforms, measured from
fingertips (Fin-PPG) and earlobes (Ear-PPG), of Emergency Department sepsis patients (n = 28) with different disease severity, were analysed by spectral technique, and were compared to control subjects (n = 10) in supine and 80° head-up tilted positions. Analysis of covariance (ANCOVA) was applied to adjust for the confounding
factor of age. Low-frequency (LF, 0.04–0.15 Hz), mid-frequency (MF, 0.09–0.15 Hz) and high-frequency (HF, 0.15–0.60 Hz) powers
were computed. The normalised MF power in Ear-PPG (MFnuEar) was significantly reduced in severe sepsis patients with hyperlactataemia (lactate > 2 mmol/l), compared to SIRS patients
(P < 0.05). Moreover, in a group of normal controls, MFnuEar was not altered by head-up tilting (P > 0.05), suggesting that there may be a link between 0.1 Hz ear blood flow oscillation and tissue metabolic changes in sepsis,
in addition to autonomic factors. The study highlighted the value of PPG spectral analysis in the non-invasive assessment
of peripheral vascular regulation in sepsis patients, with potential implications in monitoring the progression of sepsis. 相似文献
8.
Cohen B Martinelli GP Ogorodnikov D Xiang Y Raphan T Holstein GR Yakushin SB 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2011,210(1):45-55
Blood pressure (BP) and heart rate (HR) were studied in isoflurane-anesthetized Long-Evans rats during sinusoidal galvanic
vestibular stimulation (sGVS) and sinusoidal oscillation in pitch to characterize vestibular influences on autonomic control
of BP and HR. sGVS was delivered binaurally via Ag/AgCl needle electrodes inserted over the mastoids at stimulus frequencies
0.008–0.4 Hz. Two processes affecting BP and HR were induced by sGVS: 1) a transient drop in BP (≈15–20 mmHg) and HR (≈3 beat*s−1), followed by a slow recovery over 1–6 min; and 2) inhibitory modulations in BP (≈4.5 mmHg/g) and HR (≈0.15 beats*s−1/g) twice in each stimulus cycle. The BP and HR modulations were approximately in-phase with each other and were best evoked
by low stimulus frequencies. A wavelet analysis indicated significant energies in BP and HR at scales related to twice and
four times the stimulus frequency bands. BP and HR were also modulated by oscillation in pitch at frequencies 0.025–0.5 Hz.
Sensitivities at 0.025 Hz were ≈4.5 mmHg/g (BP) and ≈0.17 beat*s−1/g (HR) for pitches of 20–90°. The tilt-induced BP and HR modulations were out-of-phase, but the frequencies at which responses
were elicited by tilt and sGVS were the same. The results show that the sGVS-induced responses, which likely originate in
the otolith organs, can exert a powerful inhibitory effect on both BP and HR at low frequencies. These responses have a striking
resemblance to human vasovagal responses. Thus, sGVS-activated rats can potentially serve as a useful experimental model of
the vasovagal response in humans. 相似文献
9.
V. I. Kulakov Z. M. Alikhanova E. M. Il'ina G. T. Sukhikh E. M. Molnar 《Bulletin of experimental biology and medicine》1994,117(4):379-382
The functional state of the autonomic nervous system was evaluated in 38 women after total ovariectomy. Clinical analysis
of autonomic disorders and challenging tests indicated the disturbance of autonomic regulation and inhibition of vascular
reactivity against the background of total autonomic lability. One month after transplantation of fetal human tissues vascular
responses were improved: the number of positive dialatatory reactions increased and moderate pulse waves were recorded. The
general condition of the patients improved, their work capacity increased, and sleep patterns normalized, which led to a reduction
of anxiety. However, the transplantations had varying effects on hot flashes, which may be associated with their diverse nature.
The positive effect that transplantation of fetal human tissues elicited in most patients may be attributed to normalization
of their hormonal status.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
4, pp. 378–381, April, 1994 相似文献
10.
Thirty-four patients with glossalgia were studied. The painful part of tongue was electrically stimulated using an ‘élektronika-2M’
apparatus with a current of 45 μA for 10–20 min (current strength was patient-controlled to produce the sensation of local
prickling); courses consisted of 10–12 treatments. The results of electrical stimulation therapy were compared with results
obtained using standard methods of treatment (novocaine blockade, analgesics, etc.), which were used in a control group of
30 patients. Transcutaneous electrical nerve stimulation was highly effective: improvements were noted after the first session,
and significant reductions in pain syndrome occurred after 1–3 sessions; therapeutic effects were obtained at the end of treatment
in all 34 patients, i.e., in 100% of cases, as compared with 70% in the control group, with remission lasting more than one
year in 20 patients and from 3–12 months in 14.
Department of Nerve Diseases, Faculty of Stomatology, N. A. Semashko Moscow Medical Stomatological Institute; Department of
Therapeutic Stomatology, N. N. Burdenko Voronezh State Medical Institute. Translated from Zhurnal Nevrologii i Psikhiarii
imeni S. S. Korsakova, Vol. 95, No. 5, pp. 19–21, September–October, 1995. 相似文献
11.
N. A. Il’ina 《Neuroscience and behavioral physiology》2009,39(3):305-309
Thirty patients (seven men and 23 women, mean age 35.3 ± 7.8 years) with anxious and anxious-apathic depression were studied.
Of these, 24 patients were treated in hospital and six in out-patient clinics. Patients were treated for eight weeks with
venlafaxine at doses of 225–375 mg/day. Mental state was assessed using a series of scales (CGI, HDRS, BDI, HADS-21). A total
of 27 patients (90%) completed treatment. There were 25 (83.3%) responders on the CGI scale: “improvement” in mental state
occurred in 16 (59.3%) of patients and “marked improvement” occurred in nine (33.3%). “Insignificant improvement” was seen
in two cases (7.4%). Complete elimination of symptoms of depression occurred in 33.3% of cases. Velaxin was found to be safe
at intermediate therapeutic doses and there were improvements in laboratory results characterizing patients' somatic status.
Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 108, No. 3, pp. 24–28, March, 2008. 相似文献
12.
O. S. Levin L. A. Batukaeva I. G. Smolentseva N. A. Amosova 《Neuroscience and behavioral physiology》2009,39(6):597-604
Lewy body dementia (LBD) is a progressive brain disease manifest as dementia and parkinsonism, along with psychotic and autonomic
disorders. Although studies in recent years have demonstrated the positive effects of cholinesterase inhibitors in LBD, the
search for therapeutic agents with other mechanisms of action remains relevant. An open, controlled, 16-week study was performed
with the aim of evaluating the efficacy and safety of memantine in patients with clinically diagnosed LBD (criteria of McKeith
et al., 1999). The study included 23 patients (mean age 69.2 ± 5.9 years), who were divided into two groups: 14 patients received
memantine at a dose of 20 mg/day and nine patients constituted the control group. Efficacy was evaluated using a battery of
quantitative neurospychological tests, clinical scales for assessment of fluctuations in mental states, scales for assessment
of behavioral and psychotic disorders, and the general clinical impression scale. The results demonstrated that memantine
had positive effects on the patients’ general status and cognitive functions (increases on the mini mental state examination
by 1.5 points), mainly because of improvements in attention and control functions. There were also reductions in the severity
of fluctuations in mental state, aggressivity, lack of spontaneity, and disinhibition. The severity of psychotic and motor
disorders did not change significantly. Tolerance of the agent was good, only two patients withdrawing from the study because
of episodes of confusion during the dose titration period.
Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 108, No. 5, pp. 39–46, May, 2008. 相似文献
13.
A measure for quality of life assessment in chronic pain: preliminary properties of the WHOQOL-pain 总被引:1,自引:0,他引:1
Chronic pain has a considerable impact on patient-reported outcomes such as quality of life (QoL). To assess QoL in people
with chronic pain, a pain and discomfort module (PDM) was developed for use with the WHOQOL-100 and its psychometric properties
assessed. Sixteen items covered four facets on pain relief; anger and frustration; vulnerability, fear and worry; and uncertainty.
Chronic low back pain patients (n = 133) (age 56; pain duration 85 months; 65% female) completed the WHOQOL-100 and PDM, McGill Pain Questionnaire, and SF-12.
The PDM showed good internal consistency reliability (α = .88) (alphas .66–.81). Except for anger, all facets associated most
strongly with their ‘parent’ domain. Pain and poorer QoL were strongly associated, supporting construct validity. The SF-12
physical health component associated strongly with pain relief, and the mental health score with other facets, indicating
good concurrent validity. Discriminant validity tests showed that PDM scores distinguished between ill and well patients,
and between those reporting different health statuses. The PDM has fair to good psychometric properties indicating its value
as a patient-reported outcome measure for clinical trials. 相似文献
14.
I. Suárez-García A. Rodríguez-Blanco J. L. Vidal-Pérez M. A. García-Viejo M. J. Jaras-Hernández O. López A. Noguerado-Asensio 《European journal of clinical microbiology & infectious diseases》2009,28(4):325-330
The setting for this retrospective cohort study was a specialised tuberculosis unit in Madrid, Spain. The objective was to
describe the risk factors for multidrug-resistant tuberculosis (MDR-TB). The medical records of all patients admitted to the
unit were reviewed retrospectively to identify factors associated with multidrug resistance. Patients with positive culture
for M. tuberculosis and with available drug-susceptibility tests were included. The variables assessed were age, gender, country of origin, homelessness,
alcohol consumption, intravenous drug use, methadone substitution therapy, contact with a tuberculosis patient, sputum smear,
site of disease, previous tuberculosis treatment, HIV infection, history of imprisonment, diabetes mellitus and chronic obstructive
pulmonary disease. Thirty patients with MDR-TB and 666 patients with non-MDR-TB were included from the years 1997 to 2006.
The only factors associated with MDR-TB in multivariate analysis were previous tuberculosis treatment (OR: 3.44; 95% CI: 1.58–7.50;
p = 0.003), age group 45–64 years (OR: 3.24; 95% CI: 1.34–7.81; p = 0.009) and alcohol abuse (OR: 0.12; 95% CI: 0.03 to 0.55; p = 0.003). In our study, patients who had had previous treatment for tuberculosis, who were 45–64 years of age or who had
no history of alcohol abuse were more likely to have MDR-TB. 相似文献
15.
Siu-Man Ng Ted C. T. Fong Elaine Y. L. Tsui Friendly S. W. Au-Yeung Sally K. W. Law 《International journal of behavioral medicine》2009,16(2):91-97
Background Daily spiritual experience (DSE) refers to one’s interaction with the transcendent in day-to-day life. Underwood’s Daily Spiritual
Experience Scale mic(DSES) was developed to measure this experiential component of religiousness and spirituality. Addressing
ordinary daily experiences rather than particular beliefs, DSES has transcultural applicability potential.
Purpose The current study aimed to develop and evaluate the Chinese version of DSES (DSES-C).
Method The 16-item scale was translated faithfully through standard translation/back-translation procedures. The term “God” required
an extended definition embracing both a humanized and a philosophical higher power in Chinese culture. The translated scale
plus a battery of validation scales were administered to staff of a large rehabilitation service complex, resulting in 245
completed questionnaires.
Results Exploratory factor analysis revealed a similar factor structure as the original English version and similar problems with
items 13 (compassion) and 14 (mercy). After carefully deliberating on the Chinese conceptualization of spirituality and balancing
psychometric properties, the one-factor 16-item structure of the English version was supported. DSES-C showed high internal
consistency (Cronbach’s alpha = 0.97). Construct validity was supported by correlations with validation scales in expected
directions.
Conclusion The psychometric properties of DSES were similar to the English version in factor structure, internal consistency, and convergence/divergence
construct validity. 相似文献
16.
Gelabert E Subirà S Plaza A Torres A Navarro P Imaz ML Valdés M García-Esteve L Martín-Santos R 《Archives of women's mental health》2011,14(2):115-124
The Vulnerable Personality Style Questionnaire (VPSQ) is a nine-item self-report scale developed to asses personality traits
which increase the risk of postpartum depression. The aim of the present study was to examine the psychometric properties
of the Spanish version of the VPSQ in a sample of postpartum women. A cohort of 309 postpartum women was followed up for 32 weeks
after delivery. All women were assessed with the Spanish version of the VPSQ, the Eysenck Personality Questionnaire-R Short
Scale, the Frost Multidimensional Perfectionism Scale and the harm avoidance dimension of the Temperament and Character Inventory
at 2–3 days postpartum. Depressive symptoms were evaluated at 8 and 32 weeks after delivery by the Edinburgh Postnatal Depression
Scale, and a diagnostic interview was used to confirm the presence of major depression disorder. Factor analysis results revealed
the unidimensionality of the Spanish version of the VPSQ. Cronbach’s alpha coefficient for the VPSQ total score was 0.63.
The test–retest reliability indicated a good temporal stability (ICC = 0.88; 95% confidence interval (CI) = 0.82–0.91). A
moderate association between the VPSQ and other personality measures provided evidence for its construct validity. Logistic
regression analyses showed that women with higher scores on the VPSQ had a higher risk of developing depressive symptoms (OR = 1.20;
95% CI = 1.11–1.29) and major depression (OR = 1.16; 95% CI = 1.07–1.26) throughout the 32 weeks after delivery. Overall,
our results suggest adequate psychometric properties of the Spanish version of the VPSQ and its usefulness in identifying
women with a personality style that increases the risk of developing postpartum depression. 相似文献
17.
Ewa Lech-Maranda Jacques Bienvenu Florence Broussais-Guillaumot Krzysztof Warzocha Anne-Sophie Michallet Tadeusz Robak Bertrand Coiffier Gilles Salles 《Archivum immunologiae et therapiae experimentalis》2010,58(2):131-141
Tumor necrosis factor (TNF)-α and interleukin (IL)-10 are key cytokines involved in lymphoma development. Their pretreatment
plasma levels were reported to influence the clinical course of non-Hodgkin’s lymphoma. In this study the impact of combined
elevation of TNF-α and IL-10 on disease features and outcome of patients with diffuse large B-cell lymphoma (DLBCL) were investigated.
Plasma TNF-α and IL-10 levels were determined at the time of diagnosis in a group of 106 DLBCL patients uniformly treated
with anthracycline-based regimens. Three risk groups depending on the pretreatment levels of the cytokines were identified:
low-, intermediate-, and high-risk groups. In univariate analysis, the cytokine intermediate- and high-risk groups were associated
with lower probability of achieving a complete remission (odds ratio [OR] = 0.2, 95% confidence interval [CI] 0.06–0.6, p = 0.006 and OR = 0.05, 95% CI 0.01–0.2, p < 0.0001, respectively) and shorter progression-free survival (PFS) (OR = 4.4, 95% CI 1.9–10.2, p < 0.001 and OR = 9.7, 95% CI 4.1–23.0, p < 0.0001, respectively) and overall survival (OS) (OR = 4.2, 95% CI 1.7–10.1, p = 0.002 and OR = 11.2, 95% CI 4.4–28.4, p < 0.0001, respectively) in comparison with the cytokine low-risk group. In multivariate analysis, the cytokine intermediate-
and high-risk groups also correlated with shorter PFS (relative risk [RR] = 4.5, 95% CI 1.9–10.9, p = 0.001 and RR = 5.8, 95% CI 2.2–15.3, p < 0.0001, respectively) and OS (RR = 4.6, 95% CI 1.8–12.0, p = 0.001 and RR = 7.5, 95% CI 2.7–20.9, p < 0.0001, respectively) regardless of the International Prognostic Index (IPI) scoring system. The TNF-α and IL-10 level-based
index may work as an additional model to the IPI for predicting the survival of DLBCL patients. This model may help to identify
patients in a given IPI risk group for whom more accurate and risk-adapted treatment could be advised. 相似文献
18.
Maria Cristina Canavarro Adriano Vaz Serra Mário R. Sim?es Daniel Rijo Marco Pereira Sofia Gameiro Manuel Jo?o Quartilho Luís Quintais Carlos Carona Tiago Paredes 《International journal of behavioral medicine》2009,16(2):116-124
Background At the beginning of the 1990s, the World Health Organization (WHO) developed a project in order to create a cross-cultural
instrument of quality of life assessment: the World Health Organization Quality of Life (WHOQOL).
Purpose This paper describes the development of the European Portuguese version of the WHOQOL-100, according to the methodology recommended
by the WHO.
Method Special attention is given to the qualitative pilot study, which led to the development of the Portuguese Facet [Political P], and to the empirical pilot study and the psychometric studies, based on the application of the Portuguese version of the instrument to a sample of 315 subjects from the general population
and 289 patients. The assessment protocol also included the Beck Depression Inventory and the Brief Symptom Inventory.
Results The Portuguese version of WHOQOL-100 showed acceptable internal consistency (α range 0.84–0.94) and test–retest reliability in all domains (r range 0.67–0.86). Discriminant validity was significant for all domains, except in Spirituality. Convergent validity with
the Beck Depression Inventory and the Brief Symptom Inventory was satisfactory for most domains.
Conclusion The WHOQOL showed good psychometric characteristics, suggesting that the Portuguese version of WHOQOL is valid and reliable
in the assessment of quality of life in Portugal. 相似文献
19.
Lemmens VE de Haan N Rutten HJ Martijn H Loosveld OJ Roumen RM Creemers GJ 《Clinical & experimental metastasis》2011,28(3):283-290
We analysed population-based treatment and survival data of patients who presented with metastatic rectal cancer. All patients
diagnosed with primary synchronous metastatic rectal cancer between 1992 and 2008 in the Eindhoven Cancer Registry area were
included. Date of diagnosis was divided into three periods (1992–1999, 2000–2004, 2005–2008) according to the availability
of chemotherapy type. We assessed treatment patterns and overall survival according to period of diagnosis. The proportion
of patients diagnosed with stage IV disease increased from 16% in 1992–1999 to 20% in 2005–2008 (P < 0.0001). Chemotherapy use increased from 5% in 1992 to 61% in 2008 (P < 0.0001). Resection rates of the primary tumour decreased from 65% in 1992 to 27% in 2008 (P < 0.0001), while metastasectomy rates remained constant since 1999 (9%). Median survival increased from 38 weeks (95% confidence
interval (CI) 32–44) in 1992–1999 to 53 weeks (95% CI 48–61) in 2005–2008. Among patients not receiving chemotherapy median
survival remained approximately 30 weeks. Multivariable analysis confirmed the lower risk of death among patients diagnosed
in more recent years. Increased use of chemotherapy went together with improved median survival among patients with metastatic
rectal cancer in the last two decades. Stage migration as an effect of more effective imaging procedures is likely to be partly
responsible for this improved survival. 相似文献
20.
A. E. Lychkova 《Bulletin of experimental biology and medicine》2004,138(8):127-130
The participation of serotoninergic nervous system in the synergistic inhibitory effect of different subdivisions of the autonomic
nervous system on the heart and their stimulatory effect on smooth muscle organs of the biliary excretion system, stomach,
and small intestine were studied on rabbits under normal conditions.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 8, pp. 148–151, August, 2004 相似文献