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1.
Giorgia Querin Timothée Lenglet Rabab Debs Tanya Stojkovic Anthony Behin François Salachas Nadine Le Forestier Maria del Mar Amador Lucette Lacomblez Vincent Meininger Gaelle Bruneteau Pascal Laforêt Sophie Blancho Véronique Marchand-Pauvert Peter Bede Jean-Yves Hogrel Pierre-François Pradat 《Clinical neurophysiology》2018,129(11):2333-2340
Objective
Objective of this study is the comprehensive characterisation of motor unit (MU) loss in type III and IV Spinal Muscular Atrophy (SMA) using motor unit number index (MUNIX), and evaluation of compensatory mechanisms based on MU size indices (MUSIX).Methods
Nineteen type III and IV SMA patients and 16 gender- and age-matched healthy controls were recruited. Neuromuscular performance was evaluated by muscle strength testing and functional scales. Compound motor action potential (CMAP), MUNIX and MUSIX were studied in the abductor pollicis brevis (APB), abductor digiti minimi (ADM), deltoid, tibialis anterior and trapezius muscles. A composite MUNIX score was also calculated.Results
SMA patients exhibited significantly reduced MUNIX values (p?<?0.05) in all muscles, while MUSIX was increased, suggesting active re-innervation. Significant correlations were identified between MUNIX/MUSIX and muscle strength. Similarly, composite MUNIX scores correlated with disability scores. Interestingly, in SMA patients MUNIX was much lower in the ADM than in the ABP, a pattern which is distinctly different from that observed in Amyotrophic Lateral Sclerosis.Conclusions
MUNIX is a sensitive measure of MU loss in adult forms of SMA and correlates with disability.Significance
MUNIX evaluation is a promising candidate biomarker for longitudinal studies and pharmacological trials in adult SMA patients. 相似文献2.
Yu Hamamoto Miyuki Fujio Maiko Nonaka Natsumi Matsuda Toshiaki Kono Yukiko Kano 《Brain & development》2019,41(6):501-506
Objective
We aimed to clarify the current status of pharmacotherapy for tic disorders and comorbidities in Japan. We used a systematic survey to collate the consensus of Japanese experts and compare it with the recent international evidence.Methods
We devised a questionnaire on pharmacotherapy for tics and comorbidities and sent it to Japanese experts on tic disorders. Based on the response to the first survey, we revised the questionnaire and conducted a second survey to determine the consensus among the experts on a 4-point Likert scale by the Delphi method.Results
The first survey revealed variability in preferred medications and dosages among the experts in Japan. However, we were able to build a general consensus on pharmacotherapy for tic disorders and comorbidities based on the second survey. Aripiprazole and risperidone were the first- and second-line medication for tic disorders, respectively. Agonists of α-2 adrenergic receptors were seldom prescribed. Fluvoxamine was the first-line medication for comorbid obsessive-compulsive disorder, and atomoxetine for comorbid attention deficit/hyperactivity disorder.Conclusions
This study will help Japanese physicians choose medications for tic disorders more judiciously and will improve the quality of tic pharmacotherapy in Japan. 相似文献3.
《Brain & development》2022,44(1):2-16
BackgroundInternational reporting of epidemiological surveys of spinal muscular atrophy (SMA) in Japan has been limited to Shikoku, despite the epidemiology of the disease in countries worldwide becoming clearer. Treatments of 5q-SMA have been developed, and epidemiological studies are needed.PurposeThis study aimed to conduct a nationwide epidemiological survey of SMA in Japan to clarify the actual situation of SMA in Japan.MethodPatients with all clinical types of SMA, including neonates and adults, were selected from 1,005 medical facilities in Japan.ResultsAs of December 2017, the actual number of reported patients with SMA was 658 and the genetic testing rate was 79.5%. The estimated number of patients was 1,478 (95% confidence interval (CI), 1,122–1,834), with a prevalence of 1.17 (95%CI, 0.89–1.45) per 100,000 people and an incidence of 0.51 (95%CI, 0.32–0.71) per 10,000 live births. Incidence rates of 5q-SMA by clinical type were 0.27 (95%CI, 0.17–0.38) and 0.08 (95%CI, 0.04–0.11) per 10,000 live births for type 1 and 2, respectively, in cases with a definitive diagnosis by genetic testing. We found that 363 cases (82.7%) occurred less than 2 years and 88 (20.0%) occurred age of 2 months old or under.ConclusionThis study clarifies the prevalence and incidence of SMA in Japan. As infantile onset accounts for most cases of SMA, newborn screening and subsequent treatment are important to save lives. 相似文献
4.
Kentaro Okamoto Mitsumasa Fukuda Isao Saito Isaku Horiuchi Tomoko Okazawa Eiichi Ishii 《Brain & development》2018,40(10):904-908
Introduction
Epilepsy is a common childhood neurological condition and a major public health concern worldwide. A higher incidence of epilepsy is reported in low- and middle-income countries, particularly in rural areas. However, no Japanese reports on the incidence of childhood epilepsy have been published in the past 25 years. We estimated the annual incidence of epilepsy in children aged 1–14 years in Uwajima, a city in a rural, relatively isolated area of Japan.Methods
Candidates were extracted from Japan’s public insurance database following the International Classification of Diseases code for epilepsy. Epilepsy was defined as two or more unprovoked seizures more than 24 hours apart, as per the International League Against Epilepsy definition. The study sample was divided into three cohorts based on age at diagnosis: 1–4, 5–9, and 10–14 years. The incidence of epilepsy was calculated as the number of children with epilepsy divided by the person-years in each cohort.Results
The annual incidence rate of epilepsy in children aged 1–14 years was 70.4/100,000 children (95% confidence interval, 44.8–96.0). There was no significant difference in incidence between boys and girls. This rate was similar to those reported in other countries, although the incidence in children aged 1–4 years was slightly higher in our study than in other countries.Conclusion
The annual incidence of childhood epilepsy in rural areas of Japan is generally comparable with rates of childhood epilepsy reported in other countries. 相似文献5.
Masaya Tachibana Ikuko Mohri Ikuko Hirata Ayano Kuwada Shihoko Kimura-Ohba Kuriko Kagitani-Shimono Hiroaki Fushimi Takeshi Inoue Masashi Shiomi Yukio Kakuta Makoto Takeuchi Shigeo Murayama Masahiro Nakayama Keiichi Ozono Masako Taniike 《Brain & development》2019,41(1):85-95
Background
Influenza-associated encephalopathy (IAE) is one of the most serious CNS complications of an influenza virus infection, with unclear pathophysiology. Clasmatodendrosis is a complex of morphological changes in astrocytes characterized by fragmentation of the distal processes and swollen cell bodies. Although pathologists in Japan have long been aware of the presence of clasmatodendrosis in IAE brains, no details of the phenomenon have been published to date. We aimed to confirm the existence, and characterize the spatial distribution of clasmatodendrosis in postmortem IAE brains.Methods
Autopsied brains from 7 patients with IAE and 8 non-IAE subjects were examined immunohistochemically. In addition, immunofluorescent staining and electron microscopy were performed.Results
Clasmatodendrosis was present in all examined regions of the IAE brains, but none of the control brains. Fragmented processes of astrocytes in IAE brains were closely adjacent to synapses on the dendritic spines, with the fragmentation especially prominent in the cerebellar molecular layer. In addition, the clasmatodendrotic astrocytes were negative for autophagy markers. Furthermore, whereas aquaporin 4 was predominantly detected in the perivascular endfeet of astrocytes in the control brains, its primary localization site shifted to the fragmented perisynaptic processes in the IAE brains.Conclusion
Clasmatodendrosis was distributed diffusely in the IAE brains in close association with synapses, and was not caused by astrocyte autophagy. Clasmatodendrosis may be a suggestive pathological feature of IAE. 相似文献6.
Purpose
Motor skill screening tools are essential for the early detection of developmental coordination disorder (DCD). The present study aimed to examine any cultural and rater effects on these tools. This then enabled us to judge the validity of the original cut-off values for identifying diagnosable children.Methods
A community sample survey was performed in Japan; 3852 children aged 6–9?years were recruited. Both parents and teachers evaluated the motor skills of their children using the Movement Assessment Battery for Children – Second Edition Checklist. The psychometric properties were evaluated and the scoring characteristics examined based on the type of rater and country of origin, as compared to data originally sampled in the UK.Results
High reliability and validity of the Japanese samples were confirmed. The Japanese adults evaluated their children’s motor skills more rigorously than the Europeans. Additionally, there was a large disagreement between parent and teacher rating scores; the degree of agreement varied depending on the severity of motor deficits in the child.Conclusion
The first findings from a Japanese sample suggest that the assessment of motor skills in children is significantly affected by culture and rater. These cultural characteristics and rater biases strongly suggest that new cut-off values, reflecting country and rater type, be introduced for identifying children at risk of DCD. 相似文献7.
Emiko Momoki Tatsuo Fuchigami Yuki Kasuga Kaori Kimura Wakako Ishii Ayumi Fukuda Yukihiko Fujita Ichiro Morioka 《Brain & development》2019,41(6):559-562
Background
Confusional migraine is a rare type of migraine presenting as an acute confusional state. However, the mechanism of this confusional state remains unclear.Subject and methods
We examined an 11-year-old girl with confusional migraine, using electroencephalography, brain magnetic resonance imaging, cerebrovascular magnetic resonance angiography, and single-photon emission computed tomography to investigate cerebral blood flow changes.Results
Our findings revealed vessel narrowing in the left middle and posterior cerebral artery territory, indicating vasospasm and suggesting that the confusion was caused by hypoperfusion. However, abnormal increased cerebral blood flow in the left middle and posterior cerebral artery territory was observed during the non-confusional state.Conclusion
The recorded cerebral blood flow changes are similar to those associated with migraine attacks, gradually changing from abnormally low to abnormally high during the confusional and post-confusional state. 相似文献8.
Shin-ichiro Hamano Toshisaburo Nagai Ryuki Matsuura Yuko Hirata Satoru Ikemoto Atsuko Oba Erika Hiwatari 《Brain & development》2018,40(8):685-692
Objective
To clarify changes in clinical practice for infantile spasms, including West syndrome, in Japan over the past two decades.Methods
We investigated common treatment strategies for infantile spasms among 157 pediatric neurologists from a designated training facility for pediatric neurology and/or a designated training facility for epilepsy in Japan. A questionnaire was used to investigate use of adrenocorticotropic hormone (ACTH) therapy including daily dose, treatment duration, and tapering off period, and preferred first to fifth-line treatment choices.Results
Among 119 responses (75.8%), 107 enabled analysis of ACTH therapy and 112 were used to determine preferred order of first to fifth-line treatments. Over 80% respondents reported an initial ACTH dose of ≤0.0125?mg/kg/day, with a treatment duration of 14?days and various tapering periods. Following an unfavorable response of seizures to ACTH, 80% respondents increased the dose and/or extended treatment duration. The same ACTH therapy regimen was performed for symptomatic and cryptogenic patients at 95 facilities (88.8%). Preferred orders of therapeutic agents were the same for both symptomatic and cryptogenic patients at 64 facilities (57.1%). Over half the respondents selected vitamin B6 or valproate as the first and second-line treatments instead of ACTH therapy, while ACTH therapy was the most frequently selected third-line treatment.Conclusions
Current ACTH therapy regimens have lower doses and shorter durations than previously reported. However, treatment strategies for infantile spasms have not changed much in two decades. ACTH therapy should be the first/second-line treatment rather than third-line or later, especially for cryptogenic infantile spasms. 相似文献9.
Caroline B. Buchanan Jennifer L. Stallworth Alexandra E. Scott Daniel G. Glaze Jane B. Lane Steven A. Skinner Aubin E. Tierney Alan K. Percy Jeffrey L. Neul Walter E. Kaufmann 《Brain & development》2019,41(2):123-134
Introduction
Rett syndrome (RTT) is a complex neurodevelopmental disorder with known behavioral abnormalities, both internalizing (e.g., anxiety, social withdrawal) and externalizing (e.g., aggression, self-abuse). However, a broad evaluation of behavioral abnormalities in a large cohort is lacking.Objective
In this report, we describe profiles of internalizing and externalizing behaviors in individuals evaluated in the multi-center U.S. Rett Natural History Study.Methods
Cross-sectional and longitudinal data were collected from 861 females with RTT and from 48 females who have MECP2 mutations without meeting criteria for RTT. Standard statistical methods including linear regression evaluated internalizing behavioral components from the Child Health Questionnaire (CHQ-PF50) and externalizing components from the Motor Behavioral Assessment (MBA).Results
We found mildly to moderately severe internalizing behaviors in nearly all individuals with RTT, while externalizing behaviors were mild and uncommon. Internalizing behavior in RTT was comparable to groups with psychiatric disorders. Participants with mixed (internalizing and externalizing) behaviors were younger and less affected overall, but showed prominent self-injury and worsening internalizing behaviors over time.Conclusions
This study revealed that internalizing behaviors are common at a clinically significant level in RTT. Understanding clinical features associated with behavioral profiles could guide treatment strategies. 相似文献10.
Naojiro Tanaka Shinro Matsushita Yasushi Sonoda Yoshikatsu Maruta Yuta Fujitaka Masashi Sato Miki Simomori Rhyuki Onaka Keiji Harada Takashi Hirata Shoji Kinoshita Takatsugu Okamoto Hitoshi Okamura 《Journal of stroke and cerebrovascular diseases》2019,28(2):477-486
Background
Poststroke gait disorders negatively impact activities of daily living. Rehabilitation for stroke patients is aimed at improving their walking ability, balance, and quality of life. Robot-assisted gait training (RAGT) is associated with an increased number of task-specific exercises, which may benefit poststroke motor learning. We investigated the effects of RAGT using Stride Management Assist (SMA, which increases walk ratio by inducing hip-joint flexion and extension) in subacute stroke patients with hemiplegia.Methods
We conducted a single center, open-label randomized controlled trial in hemiplegia patients who experienced a first ever stroke and were admitted to the convalescent rehabilitation ward. A total of 41 were divided into the control (20 patients) and experimental group (21 patients). A 10-day, conventional gait training program was carried out for the control group; and RAGT with SMA was used for the experimental group. The maximum walking speed and other gait parameters were compared preintervention and postintervention. The intergroup differences in the improvement ratio were compared using an intention-to-treat analysis.Results
Ten-day intervention was completed by 36 patients. There was no difference between the 2 groups regarding gait parameters at intervention initiation. The improvement ratio of the maximum walking speed was significantly higher for the experimental group. Significant improvements were observed postintervention for maximum walking speed, paralysis-side step length, symmetry, and cadence in the experimental group. No adverse events attributable to the SMA were observed.Conclusions
Ten days of RAGT with the SMA was effective for improving gait disorders of subacute stroke patients. 相似文献11.
Yuki Amano Ayataka Fujimoto Tohru Okanishi Mitsuyo Nishimura Hideo Enoki 《Brain & development》2019,41(1):116-120
Purpose
Tuberous sclerosis complex (TSC) is a leading cause of epilepsy, with seizures affecting almost 80–90% of children. We used the concordance between magnetic resonance imaging (MRI) and dense array electroencephalography (dEEG) findings to detect epileptic focus in a patient with TSC.Methods
A 9-year-old boy with TSC exhibited daily choking spells. As we could not detect the seizure onset area with conventional scalp electroencephalogram (EEG) and long-term video monitoring, we performed dEEG and captured his regular seizures.Results
dEEG estimated that the clinical seizure activities from the right frontal region. This patient underwent focus removal, tuberectomy of the right frontal lobe, and removal of a subependymal giant cell astrocytoma. He has been seizure free for 7?years and 10?months.Conclusion
dEEG was useful for estimation of the placement of intracranial electrodes in a patient with TSC.This method may be useful for pre-surgical evaluation of epilepsy treatment. 相似文献12.
Tomoki Maeda Hajime Iwata Kazuhito Sekiguchi Mizuho Takahashi Kenji Ihara 《Brain & development》2019,41(6):490-500
Aim
To clarify the morphologic characteristics of the brain, which are the foundation of the emergence of general movements (GMs) in very-low-birth-weight infants.Study design
Prospective cohort study. GMs were scored according to a semiquantitative scoring system: the GMs optimality score (GMOS) at preterm and term ages. Brain magnetic resonance imaging (MRI) at term-equivalent age was scored using a validated scoring system (MRI score). We examined the relationship between the two scores by multiple regression analysis with relevant clinical background.Subjects
We included 50 very-low-birth-weight infants cared for at Oita University Hospital from August 2012 to August 2018 who underwent MRI and GMs assessment. Their median gestational age and birth weight were 29w2d and 1145?g, respectively.Results
The MRI score and systemic steroid administration were related to preterm GMOS, and the MRI score was related to term GMOS. The component cerebellum score and cortical grey matter score of the MRI score were associated with preterm GMOS, and the cerebellum and the cerebral white matter scores were associated with term GMOS.Conclusion
The quality of GMs was associated with brain morphological development. The co-evaluation of GMs and brain morphology leads to accurate developmental prediction. 相似文献13.
Yuko Yamauchi Sayaka Aoki Junko Koike Naomi Hanzawa Keiji Hashimoto 《Brain & development》2019,41(4):320-326
Objective
This study investigated the relationship between motor and cognitive/language development in children with Down syndrome (DS). We also tested the hypothesis that acquisition of walking skills facilitates later cognitive/language development.Methods
Participants were 156 children with DS who were less than 48?months old and had undergone a health checkup by medical doctors and received rehabilitation treatment between April 2013 and March 2017 in Yokohama, Japan. To assess their development, the Kyoto Scale of Psychological Development (KSPD) 2001 was used, which measures development in three subdomains: Posture-Motor (P-M), Cognitive-Adaptive (C-A), and Language-Social (L-S). To investigate the relationship between motor and cognitive/language development, partial correlation analyses were conducted that controlled for participants’ age. To test the effect of achieving walking skills, regression analyses were conducted using only data from participants who took the KSPD at least twice and could not walk at the initial test.Results
P-M developmental age (DA) was significantly and positively correlated with both C-A DA and L-S DA in children 1–3?years old. The relationship strengthened with increased age. Acquisition of walking skills had a significant positive effect on both the C-A DA and L-S DA at the second test when controlling for the C-A DA and L-S DA at the first test and age at the second test.Conclusion
Motor development was correlated with both cognitive and language development in young children with DS. Results also suggested that achievement of walking could facilitate later cognitive/language development in children with DS. 相似文献14.
Background
Aromatic l-amino acid decarboxylase (AADC) deficiency (OMIM #608643) is a rare and severe disorder of biogenic amine synthesis caused by mutations in the DDC gene. The phenomenology of the movement disorder includes intermittent oculogyric crises and limb dystonia, generalized athetosis, and impaired voluntary movement.Objective
To identify clinical manifestations and DDC gene mutations in two Chinese mainland children who are siblings with AADC deficiency.Methods
We used targeted next-generation sequencing and quantitative polymerase chain reaction (qPCR) to reveal DDC mutations in these children.Results
Two DDC gene mutations were found: one missense mutation, c.1040G?>?A (p.Arg347Gln), is a reported mutation derived from the mother; the other mutation, a whole-exon 11 and 12 deletion, is a novel mutation derived from the father. The index patient and her brother both had poor sucking power and feeding difficulty at birth and episodes of oculogyric crises, truncal hypotonia, limb hypertonia, sleep disturbances, irritability, and motor delay. The siblings both died at 1?year and 10?months due to asphyxia and pneumonia during gaze and hypertonia episodes.Conclusion
This study identified a novel DDC gene deletion mutation in two siblings with AADC deficiency disease in the Chinese mainland population. 相似文献15.
Ayako Kashimada Setsuko Hasegawa Toshihiro Nomura Hiroshi Shiraku Kengo Moriyama Tomonori Suzuki Keisuke Nakajima Tomoko Mizuno Kohsuke Imai Yuji Sugawara Tomohiro Morio Satoko Kumada Masatoshi Takagi 《Brain & development》2019,41(2):150-157
Objectives
Defects in DNA damage responses or repair mechanisms cause numerous rare inherited diseases, referred to as “DNA-repair defects” or “DNA damage deficiency”, characterized by neurodegeneration, immunodeficiency, and/or cancer predisposition. Early accurate diagnosis is important for informing appropriate clinical management; however, diagnosis is frequently challenging and can be delayed, due to phenotypic heterogeneity. Comprehensive genomic analysis could overcome this disadvantage. The objectives of this study were to determine the prevalence of ataxia-telangiectasia (A-T) and A-T-like DNA-repair defects in Japan and to determine the utility of comprehensive genetic testing of presumptively diagnosed patients in facilitating early diagnosis.Methods
A nationwide survey of diseases presumably caused by DNA-repair defects, including A-T, was performed. Additionally, comprehensive next-generation sequencing (NGS) analysis, targeting known disease-causing genes, was conducted.Results
Sixty-three patients with A-T or other diseases with characteristics of DNA-repair defects were identified. Thirty-four patients were genetically or clinically definitively diagnosed with A-T (n?=?22) or other DNA-repair defects (n?=?12). Genetic analysis of 17 presumptively diagnosed patients revealed one case of ataxia with oculomotor apraxia type 1 (AOA1); one ataxia with oculomotor apraxia type 2 (AOA2); two types of autosomal dominant spinocerebellar ataxia (SCA5, SCA29); two CACNA1A-related ataxias; one microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR); and one autosomal dominant KIF1A-related disorder with intellectual deficit, cerebellar atrophy, spastic paraparesis, and optic nerve atrophy. The diagnostic yield was 58.8%.Conclusion
Comprehensive genetic analysis of targeted known disease-causing genes by NGS is a powerful diagnostic tool for subjects with indistinguishable neurological phenotypes resembling DNA-repair defects. 相似文献16.
Purpose
Benign childhood epilepsy with centrotemporal spikes (BECTS) is strongly related to age, both to age at the time of seizure onset and to age at remission. However, the age of remission varies. The present study analyzed factors associated with remission of BECTS.Methods
Sixty-nine children with BECTS were retrospectively analyzed. Thirty-eight (55.1%) were boys and 31 (44.9%) were girls. Mean age at seizure onset was 86.36?±?24.55?months (range: 41–151?months).Results
The mean age at the time of EEG improvement or remission was 138.31?±?19.71?months. Of the 69 patients, 36 (52.2%) exhibited electroencephalography (EEG) improvement or remission before age 11.5?years, whereas 33 (47.8%) showed later improvement or remission. The two groups differed significantly in age at seizure onset. When patients were divided into groups using an age cutoff for last seizure of 9?years, the two groups differed significantly in age at seizure onset.Conclusions
The most important predictor of early BECTS remission is age at seizure onset. 相似文献17.
Birhane Alem Berihu Abadi Leul Welderufael Yibrah Berhe Tony Magana Afework Mulugeta Selemawit Asfaw Kibrom Gebreselassie 《Brain & development》2019,41(1):11-18
Introduction
Unlike developing countries, including Ethiopia the identification of the risk factors in decreasing the burden of neural tube defects (NTDs) is well established in the developed world. Hence, we sought to determine the factors associated with NTDs in Tigray – Ethiopia.Methods
We undergo a case-control analysis where all NTDs cases were compared to a group of controls derived randomly from the same hospitals where cases were recruited from. The NTDs survey tool which contains a standard questionnaire was prepared. Parental socio-demographic and clinical information such, maternal age, obstetric history, illnesses, drug intake, radiation, occupation, education, history of congenital anomalies, residence, exposure to pollutants such as smoking, chemicals, paternal history, and folic acid utilization was collected and analyzed using SPSS version 20.Result
This study has shown the maternal age, and residency, birth order 3 and 4, unplanned pregnancy, history of breastfeeding above 2?years, history of stillbirths, history of male gender predominance were found to have a strong association with an occurrence of NTDs (p?=?0.0001). Though the binary logistic regression analysis showed no significant association in some of the risk factors such as maternal health and drug history, the frequency analysis showed they may have an impact on the incidence of NTDs.Conclusion
This study has shown the majority of the maternal risk factors and other lifestyle patterns had a significant impact on the occurrence of NTDs. Therefore, efficient monitoring of NTDs in Ethiopia is vital, so our study could be groundwork information in Ethiopia for future programs. 相似文献18.
Michihiko Takasu Tetsuo Kubota Takeshi Tsuji Hirokazu Kurahashi Shingo Numoto Akihisa Okumura 《Brain & development》2019,41(1):72-76
Objective
The aim of this study was to clarify the effects of antihistamines on the semiology of febrile seizures.Methods
The manifestations of febrile seizures were recorded using a structured questionnaire immediately after patients arrived at the hospital. We focused on events at seizure commencement, including changes in behavior and facial expression, and ocular and oral symptoms. The presence or absence of focal and limbic features was determined for each patient. Drugs taken within 6?h prior to seizure were noted. Seizure manifestations were compared between children who did not take antihistamines and those who took antihistamines.Results
Seizures lasting ≥5?min were relatively more frequent in children who did not take antihistamines, although the difference was not statistically significant. One or more focal features were present in 60 of 78 children with no antihistamines and 17 of 23 children with antihistamines. One or more limbic features were present in 32 of 78 children with no antihistamines and 9 of 23 children with antihistamines. No significant difference in the numbers of focal or limbic features was apparent between children who did not take antihistamines and those who took antihistamines.Conclusion
Antihistamines did not significantly affect the semiology of febrile seizures. 相似文献19.
Marlou J.G. Kooiker Hélène J.M. Verbunt Johannes van der Steen Johan J.M. Pel 《Brain & development》2019,41(2):135-149
Background
Peripheral and central visual processing development highly depends on the integrity of the visual sensory system and the allocation of visuospatial attention.Method
We quantitatively followed visual sensory functions (VSF) and visuospatial orienting functions (VOF) over two years in 77 children (1–13?years) with different types of visual pathology.Results
Within the clinical groups, VSF were relatively constant over two years, except visual acuity, and VOF were characterized by longer reaction time, shorter fixation duration, and lower fixation accuracy than normal for their age. Children with peripheral pathology had high rates of abnormal VSF, of changes to abnormal visual acuity at 1–6?years, and larger and more abnormal VOF (fixation inaccuracy). Children with central pathology had relatively good VSF, whereas two-third had delayed orienting reaction times that differed from other groups mainly at 1–6?years.Conclusion
The distinct patterns of quantitative VSF and VOF over time between the visual pathology groups, and the finding that both methods provided complementary information, argues for combining both types of assessments to provide comprehensive monitoring of visual functioning in children from a young age. 相似文献20.
Ken Sakurai Toya Ohashi Nobuyuki Shimozawa Seo Joo-Hyun Torayuki Okuyama Hiroyuki Ida 《Brain & development》2019,41(1):50-56