凯妮汀治疗妊娠合并外阴阴道念珠菌病临床观察

目的　观察凯妮汀一次疗法治疗妊娠合并外阴阴道念珠菌的临床效果。方法　选择门诊就诊妊娠合并外阴阴道念珠菌病妇女 110例 ,随机分为凯妮汀组和制霉菌素组。凯妮汀 5 0 0mg ,放置阴道深部 ,一次为一疗程。制霉菌素 10万U1次 /天 ,放置阴道深部 10天为一疗程。观察用药后 7天及 30天临床症状的改善、病原体转阴情况及复发率。结果　用药后7天及 30天凯妮汀组临床症状改善 ,病原体转阴率高于制霉菌素组 (P <0 .0 5 ) ,30天复发率低于制霉菌素组 (P <0 .0 5 )。结论　凯妮汀治疗妊娠合并外阴阴道念珠菌病明显改善临床症状 ,病原体转阴率高 ,复发率低     

凯妮汀治疗妊娠合并外阴阴道念珠菌病的临床观察

目的探讨凯妮汀治疗妊娠合并外阴阴道念珠菌病的临床效果.方法将172例妊娠合并外阴阴道念珠菌病病人随机分为两组,观察组87人,用凯妮汀治疗;对照组85人,用克霉唑栓治疗,对治疗1周、1个月的临床效果进行比较,观察其治疗效果及复发率的差别.结果观察组与对照组的治疗有效率分别是90.8%和89.9%,两组比较差异无显著性意义(P＞0.05),两组治疗后1个月复发率分别为13.8%和25.6%,两组比较差异有显著性意义(P＜0.05).结论凯妮汀用于治疗妊娠合并外阴阴道念珠菌病,具有用药方法简单、疗效满意、预防复发、无不良反应等优点.     

定君生联合凯妮汀治疗复发性外阴阴道念珠菌病临床观察

目的研究联合运用定君生和凯妮汀对复发性外阴阴道念珠菌病的临床治疗效果及治疗后复发情况。方法复发性外阴阴道念珠菌病患者97例,随机分为治疗组和对照组,分别给予定君生（0．25g／d）联合凯妮汀（500mg/3d）,及凯妮汀（500mg/3d）单用治疗。结果单用凯妮汀能有效降低患者症状积分,治愈率为54．2％,复发率达到30．1％;定君生联合凯妮汀显著降低患者症状积分,并且治愈率达到85．7％,且复发率仅为4．8％。结论定君生和凯妮汀联用能显著提高对复发性外阴阴道念珠菌病的治愈率,且显著降低复发率,是一种有效的治疗方法。     

达克宁栓与凯妮汀一次一疗程治疗外阴阴道假丝酵母菌病的疗效观察

外阴阴道假丝酵母菌病（Vulvo vagiral candidiasis VVC）是常见外阴、阴道炎症,也称外阴阴道念珠菌病.国外资料显示约75%妇女一生中至少患过1次外阴阴道假丝酵母菌病.治疗本病通常有两种方法：一是全身用药,通常采取口服伊曲康唑、氟康唑等,经体内吸收后,使阴道粘膜及分泌物中的药物浓度达到一定水平,进而发挥其治疗作用,使药物与致病菌互相充分接触,而达到治疗效果,这种方法也是目前临床最为常用的一种治疗方法,常用药物有达克宁栓剂、凯妮汀、制霉菌素等. 本文选用了两种临床上常用的咪唑类外用抗真菌药物,即达克宁栓1 200 mg（硝酸咪康唑栓）和凯妮汀（克霉唑阴道片）进行对比,观察1日疗法的疗效.现报道如下.     

妊娠期外阴阴道假丝酵母菌病的治疗探讨

目的观察乳杆菌活菌胶囊(定君生胶囊)配合凯妮汀栓用于妊娠期外阴阴道假丝酵母菌病的疗效。方法随机选取120例外阴阴道假丝酵母菌病的妊娠妇女。采用凯妮汀栓治疗作为对照组,定君生胶囊和凯妮汀栓联合治疗为治疗组,比较两组疗效。结果治疗组治愈率为81.7%,对照组治愈率65%,两组有效率分别为95%和83.3%。有显著性差异(P<0.05)。结论定君生胶囊和凯妮汀栓联合治疗妊娠期外阴阴道假丝酵母菌病疗效显著。     

制霉菌素栓剂与凯妮汀阴道给药治疗复发性外阴阴道念珠菌病临床疗效和安全性分析

目的：比较制霉菌素栓剂与凯妮汀治疗复发性外阴阴道念珠菌病临床疗效。方法选取该院2011年12月-2012年12月治疗的100例复发性外阴阴道念珠菌病患者为研究对象。应用随机数字表法将复发性外阴阴道念珠菌病患者分为制霉菌素栓剂组与凯妮汀组。两组患者均采用阴道给药,比较两组患者临床疗效、复发率和药物不良反应。结果凯妮汀组患者治疗总有效率明显高于制霉菌素栓剂组患者的,差异有统计学意义（98.00%vs88.00%,Z=8.349,P=0.037）。制霉菌素栓剂组患者复发率明显高于凯妮汀组患者的,差异有统计学意义（20.00%vs6.00%,c2=4.332,P=0.037）。两组患者药物不良反应发生情况差异无统计学意义（P〉0.05）。结论凯妮汀治疗复发性外阴阴道念珠菌病临床疗效确切,具有给药方便、安全高效和不良反应少等特点,具有临床推广的实际意义。     

咪康唑与克霉唑治疗单纯性外阴阴道假丝酵母菌病的疗效对比

目的:对比硝酸咪康唑阴道栓1200mg和克霉唑阴道片500mg一日疗法治疗单纯性外阴阴道假丝酵母菌病的疗效.方法:将120例单纯性外阴阴道假丝酵母菌病患者随机分两组,分别予硝酸咪康唑阴道栓1200mg,单次阴道上药治疗及克霉唑阴道片500mg单次阴道上药治疗.停药后7-14d、30-35d对患者随访.对所有入选患者取阴...     

凯妮汀阴道片单次疗法治疗霉菌性阴道炎

霉菌性阴道炎是妇女阴道炎症的一种多发病,主要是由白色念珠菌感染所致.本病治疗药物较多,无论口服或局部用药均有一定效果.但多数疗效不稳定,易复发.我院于1998年6月至12月使用由上海拜耳医药保健公司生产的凯妮汀阴道片(每片含500mg乳酸配方的克霉唑)阴道给药治疗急性或复发性霉菌性阴道炎患者,并与同期由武汉军工医院制药厂生产的制霉菌素栓(每粒含10万U制霉菌素)治疗的患者进行比较.现报告如下:     

克霉唑阴道片治疗妊娠期外阴阴道假丝酵母菌病的疗效观察

目的观察克霉唑阴道片治疗妊娠期外阴阴道假丝酵母菌病（VVC）的疗效。方法将120例VVC患者随机分成两组。A组（n=60）：克霉唑阴道片500mg阴道用药,每晚1次,共1d。B组（n=60）：制霉菌素片100万单位阴道用药,每晚1次,共10d。观察两组疗效。停药7d为近期疗效,停药30d为远期疗效。对两组疗效进行统计学分析。结果两组停药7d和停药30d的疗效无显著性差异（P﹥0.05）。结论克霉唑阴道片和制霉菌素片治疗妊娠期外阴阴道假丝酵母菌病均有效,但克霉唑阴道片用药次数少,只需一次,患者临床症状消失快,患者依从性好,是治疗妊娠期外阴阴道假丝酵母菌病比较好的方法。     

凯妮汀治疗妊娠合并外阴阴道假丝酵母菌病的临床疗效

目的:观察凯妮汀治疗妊娠合并外阴阴道假丝酵母菌病的临床疗效。方法:选择于我院门诊治疗的妊娠合并外阴阴道假丝酵母菌病患者82例,随机分为观察组42例,对照组40例。两组患者年龄、孕周无统计学差异。观察组患者采用凯妮汀治疗,对照组采用制霉菌素泡腾片治疗。观察两组患者的临床总有效率及复发率,同时观察两组患者的不良反应。结果:经治疗后观察组的总有效率(90.48%)略高于对照组(87.5%),观察组的复发率(4.76%)略低于对照组(7.5%),但均未达到统计学差异。观察组患者无明显不适,对照组患者有5例出现不适症状。结论:凯妮汀治疗妊娠合并外阴阴道假丝酵母菌病的临床疗效佳、副作用少,适于临床推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.