急性脑梗死患者S-100b蛋白的动态检测及其临床意义

目的动态监测急性脑梗死(ACI)患者血清S-100b蛋白的变化,探讨其与脑梗死体积、神经功能缺损程度及预后的关系。方法采用ELISA对50例颈内动脉系统ACI患者血清S-100b蛋白进行动态检测,并与30例对照组进行比较,同时进行神经功能缺损评分(NIHSS)及CT扫描测定脑梗死体积,随访2个月进行日常生活能力评分(BI)。结果ACI患者血清100b蛋白在入院第1d开始升高,第3d达到峰值,第7d下降,第14、21d与对照组无明显差异;第3d血清S-100b蛋白浓度高峰水平与脑梗死体积、神经功能缺损程度呈正相关,与2个月后BI呈负相关。结论急性脑梗死后血清S-100b蛋白可作为缺血性脑损伤的生化指标,并可评估预后,对脑梗死的临床治疗有指导意义。     

S—lOO蛋白的动态变化在急性脑梗死诊断及预后中的临床价值

目的：观察脑梗死患者血浆S-100蛋白的浓度变化，以评价其与脑梗死诊断及预后的关系。方法：应用ELISA法对35例急性脑梗死患者血浆S-100蛋白水平进行动态检测，同时应用NIHSS进行神经功能缺损评分及CT扫描，并与30例对照组病人进行比较。结果：病例组病人S-100浓度明显升高，2-3天达到峰值，且严重神经功能缺失的病人，S-100升高更明显，S-100＞1．0ug／L或NIHSS＞12分提示患者预后不良。结论：缺血性脑梗死后血浆中S-100蛋白的出现与坏死的神经胶质细胞漏出有关，并通过受损的血脑屏障进入血液，S-100蛋白可作为缺血性脑损伤尤其是大面积脑梗死早期的外周标志物，是比CT更为敏感的指标，对指导治疗有帮助。     

S-100蛋白的动态变化在急性脑梗死诊断及预后中的临床价值

目的:观察脑梗死患者血浆S-100蛋白的浓度变化,以评价其与脑梗死诊断及预后的关系。方法:应用ELISA法对35例急性脑梗死患者血浆S-100蛋白水平进行动态检测,同时应用NIHSS进行神经功能缺损评分及CT扫描,并与30例对照组病人进行比较。结果:病例组病人S-100浓度明显升高,2～3天达到峰值,且严重神经功能缺失的病人,S-100升高更明显,S-100>1.0μg/L或NIHSS>12分提示患者预后不良。结论:缺血性脑梗死后血浆中S-100蛋白的出现与坏死的神经胶质细胞漏出有关,并通过受损的血脑屏障进入血液,S-100蛋白可作为缺血性脑损伤尤其是大面积脑梗死早期的外周标志物,是比CT更为敏感的指标,对指导治疗有帮助。     

神经元特异性烯醇化酶的动态变化在急性脑梗死患者中的临床意义

目的　动态观察急性脑梗死患者血浆中神经元特异性烯醇化酶 (neuron- specific enolase,NSE)的变化 ,探讨其与脑梗死体积、神经功能缺损程度、梗死部位以及患者年龄、性别等方面相关性。方法　该实验采用酶联免疫吸附法 (enzym e- linked imm unosorbent assay,EL ISA)对 5 0例急性脑梗死患者的血浆 NSE水平进行动态检测 ,并与 30例对照组患者进行比较 ,同时应用 NIHSS进行神经功能缺损评分及 CT扫描测定梗死体积 ,并应用SPSS11.5统计软件包进行统计学分析。结果　急性脑梗死患者 NSE浓度在发病早期明显升高 ,1～ 3d达到峰值 ,明显高于恢复期及对照组 ,有严重神经功能缺失的患者 NSE升高更明显 ,NSE>2 5 .0μg/ L、NIHSS>12分均提示患者预后不良 ;NSE的血浆浓度与梗死体积呈显著正相关 (P<0 .0 1) ,与神经功能缺损程度也呈显著正相关 (P<0 .0 1)。结论　缺血性脑梗死后血浆中 NSE的出现与神经元坏死有关 ,并通过受损的血脑屏障进入血液 ,NSE可作为缺血性脑损伤尤其是大面积脑梗死早期的外周标志物 ,对指导治疗有帮助。     

急性脑梗死患者S-100蛋白的动态变化及其临床意义

目的　观察脑梗死患者血浆 S- 10 0蛋白的浓度变化 ,并评价其临床意义。方法　应用 EL ISA法对35例急性脑梗死患者的血浆 S- 10 0蛋白水平进行动态检测 ,同时应用 NIHSS进行神经功能缺损评分及 CT扫描 ,并与 30例对照组患者进行比较。结果　病例组患者 S- 10 0浓度明显升高 ,2～ 3d达到峰值 ,且有严重神经功能缺失的患者 ,S- 10 0升高更明显 ,S- 10 0 >1.0μg/ L、NIHSS 12分提示患者预后不良。结论　缺血性脑梗死后血浆中 S- 10 0蛋白的出现与坏死的神经胶质细胞漏出有关 ,并通过受损的血脑屏障进入血液 ,S- 10 0蛋白可作为缺血性脑损伤尤其是大面积脑梗死早期的外周标志物 ,是比 CT更为敏感的指标 ,对指导治疗有帮助。     

急性脑梗死患者血浆S-100蛋白含量的动态变化及其临床意义

目的研究急性脑梗死（ACI）患者血浆S-100蛋白含量的动态变化及其临床意义。方法采用酶联免疫吸附法（ELISA）检测30例ACI患者病后1d、2d、3d、5d、7d、10d的血浆S-100蛋白浓度,并与30名健康人作对照;在发病1d、10d进行中国卒中量表（CSS）评分。结果与对照组相比,ACI患者发病1d血浆S-100蛋白含量即明显升高（P〈0.01）,2~3d达到峰值,5d下降,7d降至正常;大面积脑梗死患者血浆S-100蛋白含量高于中、小面积梗死患者,中面积梗死又高于小面积梗死患者（P〈0.05~0.01）。发病后1-5d血浆S-100蛋白浓度与CSS呈正相关（r=0.468-0.642,均P〈0.01）。结论ACI患者血浆S-100蛋白含量的变化可以反映疾病的严重程度,对指导治疗、评估预后有重要意义。     

急性脑卒中患者血清神经元特异性烯醇化酶、S-100B蛋白、髓鞘碱性蛋白水平的变化

目的探讨急性脑卒中患者血清神经元特异性烯醇化酶(NSE)、S-100B蛋白、髓鞘碱性蛋白(MBP)水平变化及其临床意义。方法回顾性对照分析发病在48 h内的45例急性脑卒中患者(其中脑梗死组19例,脑出血组15例,短暂性脑缺血发作组11例)血清NSE、S-100B蛋白、MBP水平变化及其与脑梗死、脑出血患者神经功能缺损程度的相关性。结果脑梗死组和脑出血组患者血清NSE、S-100B蛋白、MBP水平均较对照组有不同程度增高(P<0.05),而短暂性脑缺血发作组与正常对照组比较均无明显变化。脑梗死组和脑出血组患者中神经功能缺损较重的中重型亚组患者血清NSE、S-100B蛋白、MBP水平较轻型亚组水平高(P<0.05)。结论血清NSE、S-100B蛋白、MBP水平可作为急性脑卒中患者病情判断、预后评估的指标之一,对早期脑梗死与短暂性脑缺血发作也有鉴别诊断价值,尤其适用于无法进行影像学检查的脑卒中患者。     

急性脑梗死患者血浆神经肽Y与血清一氧化氮合酶水平的变化及其临床意义

目的探讨急性脑梗死(ACI)患者血浆神经肽Y(NPY)、血清一氧化氮合酶(NOS)水平的变化及其临床意义。方法分别用放射免疫法、化学比色法、酶法检测30例ACI患者(ACI组)(发病<48 h和第12 d)及27名正常对照者(NC组)血浆NPY、血清结构型NOS(cNOS)、诱导型NOS(iNOS)及三酰甘油(TG)水平,头颅MRI检查测量脑梗死灶体积,应用美国国立卫生研究院卒中量表(NIHSS)评定神经功能缺损程度。结果与NC组比较,ACI组NPY水平差异无统计学意义;血清cNOS水平发病<48 h显著降低(P<0.01),并与梗死体积、同期NIHSS评分呈负相关(r=-0.368、-0.457,均P<0.05),与NIHSS评分差值呈正相关(r=0.466,P<0.05);血清iNOS水平发病<48 h显著升高(P<0.01),与梗死体积、同期NIHSS评分及两次检测的血TG水平呈正相关(r=0.390、0.362、0.411、0.395,均P<0.05),与NIHSS评分差值呈负相关(r=-0.461,P<0.05)。NPY差值与cNOS差值呈负相关(r=-0.369,P<0.05)。结论 ACI患者发...     

S-100b蛋白、神经元特异性烯醇化酶与进展性卒中的关系

目的探讨血清S-100b蛋白、神经元特异性烯醇化酶与进展性缺血性脑卒中的关系。方法应用ELISA法检测150例急性脑梗死患者入院72h内S-100b蛋白及NSE的水平变化,并根据美国国立卫生院卒中量表判断是否为进展性卒中。同时进行神经功能缺损评分(NIHSS评分)、改良神经功能评分(mRS评分)及颅脑MRI/MRA扫描。结果 150例急性脑梗死患者中有30例(20%)于入院后3d内发展为进展性脑卒中,进展组患者入院后24h、36h、48h、72h血清S-100b蛋白、NSE明显高于无进展组(P0.01)。急性脑梗死患者S-100b蛋白、NSE与NIHSS评分、mRS评分及脑梗死体积呈正相关(r=0.65～0.75,P0.01;r=0.59～0.69,P0.01),颈内动脉颅内段、大脑中动脉M1段闭塞/狭窄的患者血清S-100b蛋白、NSE的水平较无血管闭塞组明显增高(P0.05)。结论急性脑梗死患者血清S-100b蛋白及NSE水平可能是进展性脑卒中的有效预测指标,且S-100b蛋白及NSE水平与颅内动脉狭窄、神经功能评分以及脑梗死体积密切相关。     

血清S-100β神经元特异性烯醇化酶水平与脑卒中患者神经功能损害程度的相关性研究

目的探讨血清S-100β、神经元特异性烯醇化酶(NSE)与脑卒中患者神经功能损害程度的相关性。方法选取2017-02—2020-02开封市人民医院治疗的115例急性缺血性脑卒中患者为观察组,同时选取健康志愿者50例为对照组,检测2组血清S-100β、NSE水平。结果观察组血清S-100β、NSE水平明显高于对照组(P<0.05);观察组中大面积梗死患者S-100β、NSE水平高于腔隙性梗死和小面积梗死患者(P<0.05);观察组美国国立卫生研究院卒中量表(NIHSS)评分≥31分患者血清S-100β、NSE水平高于NIHSS评分16~30分和≤15分患者(P<0.05);血清S-100β、NSE水平与梗死面积呈正相关(P<0.05),与NIHSS评分亦呈正相关(P<0.05)。结论急性缺血性脑卒中患者血清S-100β、NSE水平升高,与梗死面积、神经功能损害程度存在正相关关系。     

Physical and Sexual Abuse and Neglect and Eating Disorder Symptoms

For eating-disordered patients with a history of post-traumatic stress, childhood abuse and neglect, and dissociative disorder, eating behavior symptoms may function as a rational response to unmetabolized traumatic experiences. This paper will review trauma-based theory, dissociation, abreactive, and ego-states therapy as they apply to eating disorder patients.     

Efficacy and Effectiveness of Child and Adolescent Psychotherapy and Pharmacotherapy

Decades of intervention research have produced a rich body of evidence on the effects of psychotherapies and pharmacotherapies with children and adolescents. Here we summarize and critique that evidence. We review findings bearing on the efficacy of psychosocial treatments and medications under controlled experimental conditions. We also report evidence, where available, on the effectiveness of both classes of treatment with clinically referred youth treated in real-world clinical contexts. In general, the large body of evidence on efficacy contrasts sharply with the small base of evidence on effectiveness. Addressing this gap through an enriched research agenda could contribute importantly to linking scientific inquiry and clinical practice—to the benefit of both ventures. This is one element of a multifaceted agenda for future research and for synthesis of research, which will require the interplay of multiple disciplines related to child and adolescent mental health.     

Presence and severity of anorexia and bulimia among male and female Omani and non-Omani adolescents

OBJECTIVE: The population of Oman is a heterogeneous mix of nationalities providing a natural setting for studying the cross-cultural differences in the presence and severity of eating disorders as well as an opportunity for evaluating the performance of measurement instruments for these disorders. METHOD: Disordered eating screening instruments (the Eating Attitude Test and the Bulimic Investigatory Test) were administered to Omani teenagers, non-Omani teenagers, and Omani adults. RESULTS: On the Eating Attitude Test, 33% of Omani teenagers (29.4% females and 36.4% males) and 9% of non-Omani teenagers (7.5% of males and 10.6% females) showed a propensity for anorexic-like behavior. On the Bulimic Investigatory Test, 12.3% of Omani teenagers showed a propensity for binge eating or bulimia (13.7% females and 10.9% males). Among the non-Omani teenagers, 18.4% showed a tendency toward bulimia, with females showing a slightly greater tendency than males. In contrast, barely 2% of Omani adults showed either a presence of or a severity of disorderly behavior with food. CONCLUSION: Omani teenagers scored significantly higher than other ethnic groups and Omani adults. This finding is discussed in the light of emerging evidence from many parts of the world suggesting that cultural transition, compounded by demographic constraints, plays a significant role in abnormal eating attitudes.     

Physical and Sexual Abuse and Neglect and Eating Disorder Symptoms

Abstract

For eating-disordered patients with a history of post-traumatic stress, childhood abuse and neglect, and dissociative disorder, eating behavior symptoms may function as a rational response to unmetabolized traumatic experiences. This paper will review trauma-based theory, dissociation, abreactive, and ego-states therapy as they apply to eating disorder patients.     

Micro-affirmations and Recovery for Persons with Mental Health and Alcohol and Drug Problems: User and Professional Experience-Based Practice and Knowledge

Recurrent factors contributing to a recovery process from co-occurring mental health and addiction problems mentioned by users and professionals have been analyzed as part of working alliances and helpful relationships. Still, we lack knowledge about how helpful relationships are developed in daily practice. In this article, we focus on the concrete construction of professional helpful relationships. Forty persons in recovery and fifteen professionals were interviewed. The interviews were analyzed according to thematic analysis, resulting in three themes presented as paradoxes (1) My own decision, but with the help of others; (2) The need for structures and going beyond them; and (3) Small trivial things of great importance. Micro-affirmations have a central role in creating helpful relationships by confirming the individuals involved as more than solely users or professionals. More attention and appreciation should be paid to practices involving micro-affirmations.

     

Opiate and digitalis receptor assays distinguish between neuroexcitant and inactive organochlorines and between anesthetics and convulsants

Specific binding of [3H]naloxone to rat brain tissue in vitro was inhibited by the excitant organochlorinated insecticides (OCI), by ether (E) and octanol (OCT), and by the convulsant indoklon (IND) and its anesthetic isomer, isoindoklon (ISO). In the presence of 100 mM NaCl the inhibition of naloxone binding by E, OCT and ISO was greatly potentiated, whereas that by OCI and IND was attenuated. KCl (100 mM) was equally effective as NaCl on the action of anesthetics, but the effect of the excitant drugs was, in contrast to NaCl, unaffected by KCl. Specific binding of [3H]ouabain in the absence of Na, was depressed by anesthetics and enhanced by neuroexcitants. In the presence of NaCl, which by itself inhibits ouabain binding to brain, both anesthetics and excitants enhanced ouabain binding. DDE, a non-insecticidal analog of DDT, and the dimethyl derivative of the OCI, lindane, were inactive in the receptor assays. These observations point to a unique isolated system which responds consistently to anesthetic agents as a class and, in a different way, to neuroexcitant compounds.