磁共振诊断肾移植后合并脑后部可逆性脑病综合征四例

目的 探讨磁共振成像(MRI)在肾移植术后合并脑后部可逆性脑病综合征(PRES)诊断中的应用.方法 4例患者,均为女性,平均年龄为41.7岁,肾移植后使用环孢素A(或他克莫司)、霉酚酸酯和糖皮质激素预防排斥反应,其中1例于术后第2天采用抗淋巴细胞球蛋白.PRES的起病时间为术后4～17 d,平均为10 d,患者均于起病后2 d内进行MRI检查.结果 MRI结果提示,PRES病变累及顶叶4例,枕叶3例,额叶2例,小脑2例,桥脑1例,基底节区1例,病变占位效应均不明显.顶枕叶、额叶病变位于皮层下白质,其中1例累及皮质,为双侧大致对称性分布的斑片状影.病变区T1WI呈低、等信号,T2WI及冠状位液体衰减反转恢复(FLAIR)像呈高信号.3例磁共振扩散加权成像(DWI)呈等信号,1例呈略低信号;4例表观扩散系数(ADC)图均表现为高信号,其中1例病变周边DWI表现为高信号,ADC图为等信号.结论 肾移植术后合并RPES的MRI表现较具特征性,特别是DWI及ADC图,有助于疾病的早期诊断.     

隆突性皮肤纤维肉瘤影像学表现

目的探讨隆突性皮肤纤维肉瘤(DFSP)的影像学表现。方法回顾性分析9例DFSP患者的影像资料,结合病理分析其影像学特点。结果 9例患者均为单发病灶,均发生于皮肤或皮肤下,其中四肢4例、躯干5例。8例表现为皮下软组织肿块,6例呈圆形或类圆形,边缘较清晰,2例呈分叶状肿块,并沿周围肌肉间隙生长,1例大部分边界模糊;1例悬吊于皮肤外,呈分叶状。2例CT平扫病灶呈中等略低密度,多均匀或略不均匀;MRI示7例病灶呈较均匀等或稍长T1信号,1例呈不均匀稍短T1信号,6例呈不均匀稍长T2信号,可伴小斑片状、条索状稍短T2信号或小斑片状长T2信号,2例呈长T2信号,1例伴环状稍短T2信号;5例增强后明显强化,其中4例强化不均匀。结论 DFSP的影像学表现具有一定特征性,尤其MRI对定性诊断及术前评估有重要的临床应用价值。     

中枢神经系统原发性淋巴瘤的MRI诊断

目的探讨原发性脑淋巴瘤的MRI表现特征。方法回顾性分析15例经手术病理证实的脑淋巴瘤的MRI表现。结果病灶单发10例,多发5例,位于幕上12例,幕下3例,病灶呈圆形或不规则形,呈长T1长T2或等T1等T2信号,瘤周轻至中度水肿,呈"火焰状",增强后病灶明显团块状或片状强化。结论原发性脑淋巴瘤MRI表现有一定特征性,结合临床表现和发病年龄,大部分可做出正确诊断。     

颅内血管母细胞瘤的MRI表现及病理分析

目的探讨颅内血管母细胞瘤的MRI表现及其病理基础。方法回顾性分析26例颅内血管母细胞瘤的MRI和病理资料,分析其影像学特点。结果单发病灶22例,多发病灶4例,共31个病灶,均位于后颅窝内,其中右侧小脑半球14个,左侧小脑半球9个,4脑室下方小脑下蚓部2个,延髓4个,4脑室2个。19个病灶呈囊结节型、1个病灶呈囊肿型、11个病灶呈实质型或偏实质型。病灶囊性区呈长T1长T2信号,实性区T1WI多呈稍长T1稍长T2信号,其中12个病灶内见稍短T1信号,增强示实性区明显强化,囊性区无强化,3个囊结节型病灶囊壁轻度强化。DWI实性区呈低信号。MRS示胆碱峰明显升高,肌酸及N-乙酰天门冬氨酸峰明显减低或接近消失,可见高尖的脂质及乳酸峰。结论颅内血管母细胞瘤常规MRI及功能成像表现均有一定特征性,MRI对其定位、定性均有较大的临床诊断价值。     

艾滋病继发弓形体脑炎的CT及MRI表现

目的探讨艾滋病(AIDS)继发弓形体脑炎的CT及MRI表现。方法收集经临床及病理证实的AIDS继发弓形体脑炎患者30例,其中21例接受CT平扫,增强16例;24例接受常规MR检查,增强18例;15例同时接受CT和MR检查。结果本组25例病灶多发,5例单发;病灶部位多位于灰白质交界处(21例),其次为侧脑室周围(16例)、半卵圆中心(6例)、小脑(5例)、脑干(4例)、基底节区(4例)。CT平扫表现为多发斑片状、片状低密度灶,部分夹有混杂密度影;MRI表现为斑片状、块状及结节状长T1长T2信号,FLAIR序列多为高信号;增强后表现为斑片状、环状强化,以环状强化多见(13例)。本组所有病例经抗弓形体治疗后症状均有好转。结论 CT及MRI对AIDS继发弓形体脑炎有重要的诊断价值。根据MRI的特征性表现,结合临床及血清HIV、弓形体IgG及IgM抗体阳性,可对本病进行确诊。     

脊柱骨髓瘤的MRI和CT诊断

目的探讨脊柱骨髓瘤的影像学表现。方法结合7例经骨髓穿刺或活检病理证实的脊柱骨髓瘤的临床特点,回顾性分析其MRI、CT表现。结果(1)发病部位：累及腰椎7例次,胸椎2例次,骶尾椎2例次;(2)病灶数目：6例多骨多发,1例脊椎骨单发;(3)MRI信号：骨髓异常表现为T1WI呈不均匀低信号,T2WI呈不均匀高信号;(4)病灶形态：7例呈多发灶状、斑片状,有椎体骨质破坏及变形;(5)据T1WI骨髓信号减低的形态分以下类型：弥漫型、局灶型、“盐和胡椒”型,腰椎病变以弥漫型多见;(6)病理性骨折：3例合并椎体病理性骨折。结论CT,尤其是MRI检查在骨髓瘤的诊断和鉴别诊断中有着重要的作用。     

MRI检查在腰椎间盘突出髓核摘除术后椎间隙感染病人中的诊断价值分析

目的探究MRI检查在腰椎间盘突出症髓核摘除术后椎间隙感染上的临床诊断价值。方法选择86例腰椎间盘突出症术后椎间隙感染病人的临床资料进行研究,所有病人行MRI检查,确诊后给予积极治疗,分析其MRI诊断结果,观察治疗前后所有病人的白细胞计数、血沉及C反应蛋白水平变化。结果 86例椎间盘感染病人的感染部位多数集中在L4～L5或L5～S1椎间隙,病变椎间表现为不同程度的椎间盘碎裂、变小、消失、边缘不齐。MRI检查结果显示病变椎间盘间隙失去正常形态和信号。其中长T1低信号77例,T1等信号9例;长T2高信号82例,短T2低信号4例。86例椎间盘感染病人的病变椎间盘间隙上下的椎体软骨终板以及周围邻近的椎体松质骨均表现有不同程度的损坏,周围邻近椎体部分出现信号异常(75例),整个椎体信号异常(11例)。多数表现为长T1信号、长T2信号,少部分病变部位表现处以T2为主的混杂信号。椎体旁软组织表现出肿胀增厚,T1表现为等信号、稍高信号或混杂信号,T2表现为高信号。21例行MRI增强扫描,病变椎间盘及邻近椎体、椎旁软组织明显强化。随访6个月后,临床症状完全消失的病人共计63例,占73. 26%,所有病人在治疗后的白细胞计数、血沉以及C反应蛋白水平均显著低于治疗前(P 0. 05)。结论在诊断腰椎间盘突出症髓核摘除术后椎间隙感染上,MRI检查能够对其病变感染部位进行充分显示,对于椎间隙感染的早期诊断鉴别及治疗具有重要意义。     

膝关节损伤的MRI诊断及其临床价值

目的：探讨MRI对膝关节损伤的诊断及临床应用价值。方法：回顾性分析266例膝关节损伤的MRI资料，男182例，女84例，年龄16～56岁，平均38岁。其中车祸损伤144例，运动损伤68例，其他54例。损伤类型，骨折31例，骨挫伤106例，软骨骨折11例，半月板损伤224例，韧带损伤198例，关节积液212例。结果：31例骨折表现为线状长T1长T2信号影；106例骨挫伤表现为斑片状等或长T1WI、等或长，T2WI信号，STIR序列呈高信号，边界不清；11例软骨骨折表现为软骨信号连续中断或凹陷，出现异常信号；224例半月板损伤表现为半月板低信号影内出现不同形状高信号灶；198例韧带损伤表现为韧带增厚、扭曲，韧带移行区有长T2信号和(或)短T1信号；212例关节积液表现为长T1长T2信号，血肿可见短T1高信号。结论：MRI对膝关节损伤的诊断具有重要的临床价值。     

第三脑室孤立性纤维性肿瘤/血管外皮细胞瘤1例

正患者女,54岁,7个月前无明显诱因出现双下肢无力,偶有头晕,无恶心、呕吐,3个月前发现记忆力下降;发病以来神志清、精神可,睡眠正常。MRI:第三脑室可见不规则斑片状混杂等长T1等T2信号,约36.6mm×41.5mm×49.2mm,病灶内见斑片状囊性长T1长T2信号,瘤周见多发流空血管影,双侧丘脑及中脑受压移位,内见斑片状稍长T2信号(图1A、1B);增强扫描病灶呈明显强化,囊性区无强化(图1C)。MRI诊断:脑     

射频消融治疗肝脏恶性肿瘤急性热损伤的MRI表现及疗效判定

目的探讨肝脏恶性肿瘤射频消融后急性热损伤的MRI表现及疗效判定。方法回顾性分析MRI引导下158例共266个肝脏恶性肿瘤病灶的射频消融术后即刻MRI表现。结果147个原发性肝癌及59个肝转移癌病灶消融后表现为T2WI低信号、T1WI低信号;2个原发性肝癌及55个肝转移癌病灶消融后表现为T2WI呈稍高信号,T1WI低信号;3个原发性肝癌消融后T2WI呈低信号,而T1WI呈高信号。瘤周消融带均呈短T1短T2信号,周边见薄环状长T2-信号环绕。151个原发性肝癌及106个转移癌病灶被瘤周消融带完全包绕,1个原发性肝癌及8个肝转移癌病灶未完全被瘤周消融带包绕。结论肝脏恶性肿瘤射频消融后急性热损伤的即刻MRI表现具有特征性,据以评价疗效确切、可靠。     

改良乳腺BI-RADS-US分级在乳腺良、恶性病变诊断中的应用

目的评价改良乳腺BI-RADS-US分级对乳腺良、恶性病变的诊断价值。方法术前对947例乳腺病变患者的1015个乳腺病灶进行改良BI-RADS-US分级及原BI-RADS-US分级,并以术后病理结果为＂金标准＂进行回顾性分析。结果改良BI-RADS-US分级诊断乳腺恶性病变的敏感度、特异度、阳性和阴性预测值分别为95.27%（463/486）、78.83%（417/529）、80.52%（463/575）、94.77%（417/440）;原BI-RADS-US分级对乳腺恶性病变诊断的敏感度、特异度、阳性和阴性预测值分别为96.71%（470/486）、71.27%（377/529）、75.56%（470/622）、95.93%（377/393）。改良BI-RADS-US分级诊断乳腺恶性病变的特异度和阳性预测值均高于原BI-RADS-US分级（P均〈0.05）,而两者敏感度和阴性预测值差异均无统计学意义（P均〉0.05）。结论改良乳腺BI-RADS-US分级可提高超声对乳腺恶性病变诊断的特异度和阳性预测值,对临床选择治疗方案有重要作用。     

Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses

PurposeTo investigate the diagnostic role of new metrics, defined as individualized-thresholding of Shear Wave Elastography (SWE) parameters, in association with clinical factors (such as age, mammographic density, lesion size and depth) and the BI-RADS features in differentiating benign from malignant breast lesions.MethodsOf 644 consecutive patients (median age, 55 years), prospectively referred for evaluation, 659 ultrasound detected breast lesions underwent SWE measurements. Multivariable logistic regression analysis was used to estimate the probability of malignancy. The area under the curve (AUC), optimal cutoff value, and the corresponding sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were determined.Results265 of 659 (40.2%) masses were malignant. Using two E_mean cutoffs, 69.6 kPa for large superficial lesions (size >10 mm, depth ≤5 mm) and 39.2 kPa for the rest, the overall specificity, sensitivity, PPV and NPV were 92.6%, 86.8%, 88.8% and 91.3%, respectively. Combining multiple factors, including E_mean with two cutoffs, age and BI-RADS, the new ROC curve based on the malignancy probability calculation showed the highest AUC (0.954, 95% CI: 0.938–0.969). Using the optimal probability threshold of 0.514, the corresponding specificity, sensitivity, PPV and NPV were 92.9%, 89.1%, 89.4% and 92.7%, respectively.ConclusionsThe false-positive rate can be significantly reduced when applying two E_mean cutoffs based on lesion size and depth. Moreover, the combination of age, E_mean with two cutoffs and BI-RADS can further reduce the false negatives and false positives. Overall, this multifactorial analysis improves the specificity of ultrasound while maintaining a high sensitivity.     

18F-FDG PET/CT在胆道系统恶性肿瘤中的应用

目的探讨~(18)F-FDG PET/CT诊断胆道系统恶性肿瘤的价值。方法回顾性分析34例临床疑似胆道恶性肿瘤患者的PET/CT影像资料,均获得术后病理结果,其中12例经手术切除淋巴结或淋巴结穿刺活检对18枚淋巴结获得病理诊断;与病理结果对照,计算PET/CT对胆道恶性病变原发灶、淋巴结转移的灵敏度、特异度、阳性预测值、阴性预测值及准确率。结果 34例中,31例为恶性病变,3例为良性病变。PET/CT诊断胆道恶性肿瘤原发灶的灵敏度100%(31/31),特异度66.67%(2/3),阳性预测值96.88%(31/32),阴性预测值100%(2/2),准确率97.06%(33/34)。胆道恶性病变原发灶最大标准摄取值(SUV_(max))为8.42±4.27;3例胆道良性疾病SUV_(max)分别为12.90、2.00及1.90。共18枚淋巴结获得病理结果,包括转移性淋巴结13枚,良性增生5枚。PET/CT诊断淋巴结转移的灵敏度76.92%(10/13),特异度60.00%(3/5),阳性预测值83.33%(10/12),阴性预测值50.00%(3/6),准确率72.22%(13/18)。结论 PET/CT对胆道系统恶性肿瘤的诊断具有重要价值。     

An assessment of the performance of elastography for the investigation of BI-RADS 4 and BI-RADS 5 breast lesions: Correlations with pathological anatomy findings

PurposeTo study the diagnostic value of static elastography of the breast (score, histogram, quantitative ratio) in masses classed as BI-RADS 4 and BI-RADS 5 on sonography using the findings from pathological anatomy analyses on the masses as a reference.Materials and methodsA prospective study using a representative sample into 68 masses seen on sonography and their elastography results. For each mass, we determined the elastography colourimetry score (UENO et al. classification, scores 1–3 = benign and 4–5 = malignant). We studied quantitative elastography parameters based on the Z2/Z1 (fat/lesion) ratio and a histogram showing the pattern of mass stiffness distribution. The results were compared with histology findings (68 lesions assessed, 22 benign lesions and 46 malignant lesions).ResultsElastography was consistent with histology (sensitivity: 73.9%, specificity: 86.4%, PPV: 91.9%, NPV: 61.3%). There were twelve false negatives and three false positives. With the Z2/Z1 ratio, we set a cut-off point of 3.05 for 99.0% specificity.ConclusionElastography is a reliable technique that is able to assist radiologists in their diagnostic approach to breast pathology.     

Surgical specimen ultrasound: Is it able to predict the status of resection margins after breast-conserving surgery?

PurposeTo evaluate the accuracy of surgical specimen ultrasound in the assessment of the status of resection margins after breast-conserving surgery.Methods and materialsSonographic examination of 46 surgical specimens of US-detectable malignant tumors was performed. Distance of the lesion from the specimen margins in four radial directions was measured and compared with distances measured on pathologic examination. Positive pathologic margins were defined when invasive or intraductal carcinoma was found within 2 mm of the specimen margin. Sensitivity, specificity, positive(PPV) and negative predictive values(NPV) of US in predicting surgical margins were calculated, considering both a 10-mm and a 4-mm sonographic threshold.ResultsOf 184 margins(4 per lesion), pathology demonstrated 28 positive and 156 negative margins. Considering the 10-mm cut-off, US identified 32 positive and 152 negative margins, showing the following sensitivity, specificity, PPV and NPV: 28.5%, 84.6%, 25% and 86.8%, respectively. Considering the 4-mm cut-off, US identified 7 positive and 177 negative margins, with a sensitivity of 7.1%, a specificity of 96.8%, a PPV of 28.2% and a NPV of 85.3%. False-negative results were more frequent in case of invasive lobular carcinoma (20%) and presence of intraductal component (60%).ConclusionSonography demonstrated a poor performance in the evaluation of the status of resection margins in breast specimens; however, because of the high NPV -both with 10-mm and 4-mm thresholds- it might be helpful in confirming complete excision of a US-detected neoplasm and in ruling out the presence of macroscopic invasive ductal carcinoma at surgical margins.     

Impact of Preoperative Ultrasonography and Fine-Needle Aspiration of Axillary Lymph Nodes on Surgical Management of Primary Breast Cancer

Purpose

To evaluate the accuracy of preoperative ultrasonography (US) and US-guided fine-needle aspiration (US-FNA) for detecting axillary lymph node (ALN) metastasis.

Patients and Methods

We retrospectively reviewed 382 breast cancer patients with clinically negative ALN who underwent US and/or US-FNA for ALN. US-FNA of ALN was performed in 121 patients with suspicious findings on US. The diagnostic performance of US alone or with the addition of US-FNA for detecting ALN metastasis was calculated on the basis of final pathologic reports of ALN surgery.

Results

Among a total of 382 patients, 129 had metastatic ALNs while 253 exhibited no signs of axillary metastasis on final pathology. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of axillary US alone were 56.6% (73/129), 81.0% (205/253), 60.3% (73/121), and 78.5% (205/261), respectively. Addition of US-FNA resulted in sensitivity, specificity, PPV, and NPV of 39.5% (51/129), 95.7% (242/253), 82.3% (51/62), and 75.6% (242/320), respectively. Excluding complete responders to neoadjuvant chemotherapy, specificity and PPV after adding US-FNA were increased to 99.6% (242/243) and 98.1% (51/52), respectively. The sensitivity and specificity of ALN metastasis were similar between the palpable and nonpalpable breast cancer groups; however, after adding US-FNA, NPV was increased in the nonpalpable breast cancer group compared with the palpable breast cancer group (p = 0.0398). By including preoperative axillary US and US-FNA, 16.2% (62/382) of all breast cancer patients were able to avoid unnecessary sentinel lymph node biopsy (SLNB).

Conclusions

The combination of axillary US and US-FNA is useful in preoperative work-up of breast cancer patients and provides valuable information for planning proper breast cancer management.     

Evaluation of physician performance using a concurrent-read artificial intelligence system to support breast ultrasound interpretation

PurposeThe purpose of this study was to compare the diagnostic performance and the interpretation time of breast ultrasound examination between reading without and with the artificial intelligence (AI) system as a concurrent reading aid.Material and methodsA fully crossed multi-reader and multi-case (MRMC) reader study was conducted. Sixteen participating physicians were recruited and retrospectively interpreted 172 breast ultrasound cases in two reading scenarios, once without and once with the AI system (BU-CAD™, TaiHao Medical Inc.) assistance for concurrent reading. Interpretations of any given case set with and without the AI system were separated by at least 5 weeks. These reading results were compared to the reference standard and the area under the LROC curve (AUCLROC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for performance evaluations. The interpretation time was also compared between the unaided and aided scenarios.ResultsWith the help of the AI system, the readers had higher diagnostic performance with an increase in the average AUCLROC from 0.7582 to 0.8294 with statistically significant. The sensitivity, specificity, PPV, and NPV were also improved from 95.77%, 24.07%, 44.18%, and 93.50%–98.17%, 30.67%, 46.91%, and 96.10%, respectively. Of these, the improvement in specificity reached statistical significance. The average interpretation time was significantly reduced by approximately 40% when the readers were assisted by the AI system.ConclusionThe concurrent-read AI system improves the diagnostic performance in detecting and diagnosing breast lesions on breast ultrasound images. In addition, the interpretation time is effectively reduced for the interpreting physicians.     

A Prospective Analysis of Positron Emission Tomography and Conventional Imaging for Detection of Stage IV Metastatic Melanoma in Patients Undergoing Metastasectomy

Background: Positron emission tomography with 2-deoxy-2-[¹⁸F]fluoro-d-glucose (FDG-PET) is available for evaluation of patients with melanoma. This study evaluates the potential of FDG-PET to improve on conventional imaging (CI) in patients with stage IV melanoma undergoing metastasectomy.Methods: This was a prospective study comparing radiological evaluation of patients who underwent metastasectomy for palliation or cure. Patients underwent preoperative evaluation by physical examination, CI by computed tomography and/or magnetic resonance imaging, and FDG-PET. Independent observers performed three separate analyses of CI alone, FDG-PET alone, or FDG-PET read with knowledge of CI (FDG-PET + CI). Abnormalities were reported as benign or malignant and assessed by pathologic analysis or by clinical outcome determined by disease progression detected on serial evaluations.Results: Ninety-four lesions were noted in 18 patients who underwent preoperative assessment, metastasectomy, and long-term follow up (median, 24 months). Lesion-by-lesion analysis for CI demonstrated a sensitivity of 76%, a specificity of 87%, a positive predictive value (PPV) of 86%, and a negative predictive value (NPV) of 76%. FDG-PET demonstrated a sensitivity of 79%, a specificity of 87%, a PPV of 86%, and an NPV of 80%. For FDG-PET + CI, the sensitivity was 88%, specificity was 91%, and PPV and NPV were 91% and 88%, respectively.Conclusions: Combined use of FDG-PET and CI may be an accurate strategy to identify sites of disease in patients with stage IV melanoma being considered for metastasectomy. Interpreted independently, FDG-PET and CI seemed to be equivalent modalities. FDG-PET + CI had both the highest sensitivity on lesion-by-lesion analysis and the best accuracy on patient-by-patient analysis.     

扩散加权成像诊断乳腺浸润性导管癌腋窝淋巴结转移

目的评价DWI对乳腺浸润性导管癌(IDC)腋窝转移性淋巴结的诊断价值。方法回顾性分析115例病理证实的IDC患者的MRI,选取154枚淋巴结,根据手术及病理确定其性质,测量并比较转移与非转移淋巴结的ADC值,确定诊断转移淋巴结的ADC值界值,计算其敏感度、特异度、阳性预测值、阴性预测值及准确率。结果 154枚淋巴结中,87枚存在转移,其ADC值[(0.921±0.161)×10-3 mm2/s]明显低于非转移淋巴结[(1.167±0.199)×10-3 mm2/s),P0.001]。以ADC值为1.005×10-3 mm2/s作为转移淋巴结的诊断界值,其敏感度为80.46%,特异度为88.06%,阳性预测值为89.74%,阴性预测值为77.63%,准确率为83.77%。结论 DWI结合ADC值对鉴别乳腺IDC转移与非转移性腋窝淋巴结是有价值的功能影像学方法。     

Significance of metabolic tumor volume and total lesion uptake measured using Ga-68 labelled prostate-specific membrane antigen PET/CT in primary staging of prostate cancer

ObjectiveTo evaluate the accuracy of Ga-68 prostate-specific membrane antigen positron-emission-tomography and computed-tomography(PSMA-PET/CT) in primary nodal staging of prostate cancer (PCa), and the predictive value of volumetric parameters derived from Ga-68- PSMA-PET/CT data in lymph node(LN) metastasis and correlation with histopathological and surgical outcomes.Materials and methodsSeventy-seven patients with newly diagnosed, biopsy-proven PCa who underwent Ga-68-PSMA-PET/CT for primary staging of disease and underwent radical prostatectomy with extendend pelvic LN dissection were evaluated retrospectively. 2 experienced nuclear medicine specialists have retrospectively reviewed PET/CT images blinded to all histopathological and clinical data. Sensitivity, specificity, positive predictive value(PPV), and negative predictive value(NPV) for the detection of LN metastases were analyzed per-patient. Volumetric and semiquantitative PET parameters of the primary prostate lesions including SUVmax,metabolic tumor volume(MTV), and total lesion uptake(TLU) were measured and recorded.ResultsPrimary tumor SUVmax, MTV and TLU were found significantly higher in patients who were in higher ISUP Grade groups 3,4,5 after surgical treatment (P = 0.021,P = 0.049,P = 0.032, respectively). The sensitivity, specificity, PPV and NPV on LN metastasis detection of Ga-68-PSMA-PET/CT was found 60%, 91%, 82% and 78% respectively. Although the distribution of the measured primary tumor MTV and TLU values were higher in histopathologically proven LN metastasis positive patients compared to negative patients, only TLU was statistically significant(P = 0.023). Increase in primary tumor TLU values were correlated with higher pT stages and surgical margin positivity(P = 0.034).ConclusionGa-68-PSMA-PET/CT is of clinically valuable for primary staging. Measuring and adding these 2 parameters in routine clinical evaluation may increase the prediction power of high-grade disease confirmed by surgery.