更昔洛韦治疗带状疱疹的疗效观察

目的：探讨更昔洛韦治疗带状疱疹的临床效果。方法随机将100例带状疱疹患者分为更昔洛韦治疗组50例和阿昔洛韦对照组50例。治疗组予更昔洛韦300mg,静脉滴注,1次/d;对照组予阿昔洛韦500mg,2次/d。疗程均为1周,比较两组临床疗效。结果更昔洛韦组与阿昔洛韦组在止痛时间、止疱时间、结痂时间、病程方面比较,所需时间明显减少（P〈0.05）。结论更昔洛韦治疗带状疱疹在疗效及安全性方面优于阿昔洛韦。     

更昔洛韦治疗老年性三叉神经带状疱疹疗效观察

目的观察更昔洛韦治疗老年性三叉神经带状疱疹的疗效。方法老年性三又神经带状疱疹患者97例，治疗组50例用更昔洛韦治疗，对照组47例用阿昔洛韦治疗。结果治疗组水疱吸收结痂、止痛、眩晕缓解及伴发病毒性结膜炎消失时间均短于对照组，无后遗神经痛及不良反应发生。结论更昔洛韦治疗老年性三叉神经带状疱疹较阿昔洛韦有效，且不良反应小。     

更昔洛韦治疗带状疱疹77例临床疗效观察

更昔洛韦可选择性抑制疱疹病毒的复制,对单纯疱疹病毒(HSV)巨细胞病毒(CMV),水痘-带状疱疹病毒(VZV)及人类乳头瘤病毒(HPV)等均有很强的抗病毒作用.作者对77例带状疱疹患者采用更昔洛韦治疗,并与阿昔洛韦进行比较,现将结果报告如下.     

更昔洛韦治疗带状疱疹77例临床疗效观察

更昔洛韦可选择性抑制疱疹病毒的复制，对单纯疱疹病毒（HSV）、巨细胞病毒（CMV），水痘-带状疱疹病毒（VZV）及人类乳头瘤病毒（HPV）等均有很强的抗病毒作用。作者对77例带状疱疹患者采用更昔洛韦治疗，并与阿昔洛韦进行比较，现将结果报告如下。     

更昔洛韦与阿昔洛韦治疗带状疱疹的疗效对比观察

目的 评价更昔洛韦治疗带状疱疹的疗效和安全性。方法 将80例带状疱疹患者随机分为更昔洛韦治疗组和阿昔洛韦对照组,治疗组每日静滴更昔洛韦200mg,对照组每日静滴阿昔洛韦750mg,共7天。用药前和用药后定期观察、记录,计算疗效指数,并记录不良反应。结果 治疗组痊愈率明显优于对照组,在促进结痂、减轻疼痛、完全止痛等方面均明显优于对照组,未发现明显副作用。结论 更昔洛韦是治疗带状疱疹的一种有效、安全的药物。     

更昔洛韦联合匹多莫德治疗带状疱疹疗效观察

目的观察更昔洛韦联合匹多莫德治疗带状疱疹疗效。方法将140例带状疱疹患者,随机分为观察组和对照组各70例。治疗组给予更昔洛韦联合匹多莫德治疗,对照组给予更昔洛韦治疗,疗程结束后对比分析两组治疗效果。结果两组患者治疗后疼痛消失时间、水疱结痂时间、皮损愈合时间的差异有统计学意义(P<0.05);观察组治疗总有效率为98.57%,对照组治疗总有效率为88.57%,差异有统计学意义(P<0.05)。结论两组患者治疗过程中未观察到明显的不良反应。     

更昔洛韦联合阿米替林治疗带状疱疹疗效观察

目的:观察更昔洛韦联合阿米替林治疗带状疱疹的疗效。方法:随机分成两组,对照组给予更昔洛韦0.25g静滴,1次/d;治疗组在上述治疗的基础上,同时加用阿米替林25mg,每晚睡前1次。两组治疗均为10d。结果:治疗组5例发生后遗神经痛(PHN),明显低于对照组的16例("2=8.58,P<0.05)。治疗组的平均止痛、止疱、结痂时间均比对照组短(t分别为3.17,3.21,3.07,3.52,P<0.05)。治疗后治疗组与对照组SDS、SAS评分比较差异有统计学意义(tSDS=3.62,tSAS=3.37,P<0.05)。治疗后治疗组与对照组两组总有效率在统计学上差异有显著性("2=5.33,P<0.05)。疗效指数与SDS及SAS评分呈明显正相关(rSDS=0.24,rSAS=0.39,P<0.05)。结论:更昔洛韦联合阿米替林治疗老年性带状疱疹,对减轻和消除PHN收到了良好的功效,且副作用少,值得临床推广。     

更昔洛韦联合复方甘草酸苷注射液治疗带状疱疹的临床分析

选取我院收治的160例带状疱疹患者为研究对象,随机平均分成A组与B组各80例。A组患者给予更昔洛韦联合复方甘草酸苷注射液进行治疗,B组患者单纯给予更昔洛韦进行注射治疗,观察两组患者的临床效果。A组患者总有效率为82.5%%,B组患者总有效率为53.7%,A组患者效果明显优于B组,差异具有统计学意义(P<0.05)。两组均未发生明显不良反应。临床应用更昔洛韦联合复方甘草酸苷注射液治疗带状疱疹,其效果较为显著,值得应用。     

更昔洛韦和中药联合治疗头面部带状疱疹的临床观察

目的：观察静脉滴注更昔洛韦和中药治疗头面部带状疱疹的疗效。方法：将90例患者随机分成两组，治疗组48例，静脉滴注更昔洛韦2.5mg／kg，一日一次，共6日，同时按照中医辩证服用汤剂；对照组42例，静脉滴注阿昔洛韦5mg～10mg／kg，一日3次，共6日，同时服用汤剂。结果：更昔洛韦组有效率明显高于对照组，差异有显著性，且起效时间、疼痛消失时问均明显比对照组短。结论：更昔洛韦配合中药治疗头面部带状疱疹，具有起效快、疗程短、治愈率高，有效地控制并发症的发生等优点，值得临床应用。     

Aseptic meningitis after amenamevir treatment for herpes zoster ophthalmicus with oculomotor nerve palsy in a patient taking immunosuppressant

A 79-year-old woman presented with vomiting after being prescribed amenamevir by her primary care physician. She had a medical history of rheumatoid arthritis and was administered prednisolone and methotrexate. She was finally diagnosed with herpes zoster ophthalmicus and aseptic meningitis, and intravenous antiviral therapy was initiated. However, the patient developed oculomotor nerve palsy on the 11th day of hospitalization. In this case, there was a time lag between the administration of antiviral drugs and clinical improvement. Our case suggests the necessity of selecting antivirals, especially in high-risk cases of CNS complications, to avoid the low intracerebral transferability of antiviral drugs, including amenamevir.     

老年眼带状疱疹合并糖尿病患者急性期的疼痛管理

目的：探讨老年眼带状疱疹合并糖尿病患者急性期的疼痛管理。方法选择2010年1月至2012年6月老年眼带状疱疹合并糖尿病患者108例,随机分为对照组和观察组,每组54例。对照组实施传统的护理,观察组在此基础上,强化急性期主动实施有效疼痛管理,早期进行准确疼痛评估,有效的药物或物理镇痛治疗。结果观察组患者接受镇痛治疗态度、急性期镇痛治疗频率以及疼痛治疗满意度均优于对照组( P<0.05);观察组后遗神经痛例数以及住院时间与对照组相比,差异均有统计学意义( P<0.05)。结论对老年眼带状疱疹合并糖尿病患者急性期实施有效的疼痛管理,能减轻患者疼痛,减少后遗神经痛等并发症,缩短病情,提高患者生活质量。     

Reassessing the link between herpes zoster ophthalmicus and stroke

This editorial will assess a proposed link between herpes zoster ophthalmicus and subsequent stoke. Herpes zoster (also called shingles) is caused by varicella-zoster virus (VZV), one of the 9 human herpesviruses. When children contract their primary VZV infection, virus often travels to the trigeminal ganglia and establishes latency. Upon reactivation in late adulthood, the same virus travels anterograde to cause herpes zoster ophthalmicus. In some people, the virus also traffics from the same trigeminal ganglion along afferent fibers around the carotid artery and its branches. Subsequently VZV-induced inflammation within the affected cerebral arteries leads to occlusion and stroke. In one retrospective analysis of people with herpes zoster ophthalmicus, there was a 4.5 fold higher risk of stroke than in a control group. Two other studies found a less compelling association.     

老年带状疱疹早期综合治疗分析

目的观察采用阿昔洛韦联合泼尼松、VitB12等治疗老年带状疱疹的临床疗效。方法对2003年6月至2007年10月,病期4 d内的126例老年带状疱疹患者,随机分两组,综合治疗组以阿昔洛韦联合泼尼松治疗,对照组仅以阿昔洛韦治疗,观察治疗1个疗程（15 d）后带状疱疹的临床转归,并进行3个月以上随诊观察。结果综合治疗组及对照组治疗总有效率分别为93.65%和79.37%（P〈0.05）,后遗神经痛发生率为9.52%和26.98%（P〈0.05）。结论对老年性带状疱疹患者,早期采用阿昔洛韦联合小剂量泼尼松治疗有利于提高疗效,降低后遗症发生率。     

局部紫外线联合阿昔洛韦治疗带状疱疹的疗效观察

目的观察局部紫外线照射联合阿昔洛韦治疗带状疱疹的临床疗效。方法138例带状疱疹患者分为2组。治疗组用阿昔洛韦口服治疗加局部紫外线照射;对照组单用阿昔洛韦治疗带状疱疹。结果治疗组有效率（97．92％）明显高于对照组（P〈0．05）,带状疱疹后遗神经痛发生率亦比对照组明显降低。结论局部紫外线联合阿昔洛韦治疗带状疱疹起效快,疗程短,疗效显著,且能防止后神经痛的发生。     

Trigeminal extracranial thermocoagulation along with patient-controlled analgesia with esketamine for refractory postherpetic neuralgia after herpes zoster ophthalmicus: A case report

BACKGROUNDPrimary trigeminal neuralgia can achieve satisfactory results through clinical treatment and intervention. The pathogenesis of neuralgia caused by varicella-zoster virus infection of the trigeminal nerve is more complex, and it is still difficult to relieve the pain in some patients simply by drug treatment or surgical intervention.CASE SUMMARYA 66-year-old woman was hospitalized with herpetic neuralgia after herpes zoster ophthalmicus (varicella-zoster virus infects the ophthalmic branch of the trigeminal nerve). On admission, the patient showed spontaneous, electric shock-like and acupuncture-like severe pain in the left frontal parietal region, and pain could be induced by touching the herpes area. The numerical rating scale (NRS) was 9. There was no significant pain relief after pulsed radiofrequency and thermocoagulation of the ophthalmic branch of the trigeminal nerve. Combined with patient-controlled intravenous analgesia (PCIA) with esketamine, neuralgia was significantly improved. The patient had no spontaneous pain or allodynia at discharge, and the NRS score decreased to 2 points. The results of follow-up 2 mo after discharge showed that the NRS score was ≤ 3, and the Pittsburgh Sleep Quality Index score was 5 points. There were no adverse reactions.CONCLUSIONTrigeminal extracranial thermocoagulation combined with esketamine PCIA may be a feasible method for the treatment of refractory herpetic neuralgia after herpes zoster ophthalmicus.     

臭氧在治疗带状疱疹中的应用

目的评价臭氧在治疗带状疱疹中的作用。方法选择80名急性带状疱疹神经痛患者随机分为2组,分别采用传统治疗方法组（A组）和臭氧组治疗组（B组）,并且记录治疗前后的VAS。结果两组比较,B组治疗后的VAS明显降低。结论应用臭氧治疗带状疱疹神经痛是一种有效的方法。     

神经阻滞治疗带状疱疹神经痛临床疗效观察

目的 探讨神经阻滞在治疗带状疱疹神经痛及带状疱疹后神经痛(PNH)中的临床疗效.方法 总结我院麻醉科疼痛病房2003年3月至2007年10月所收治的167例带状疱疹神经痛及PNH患者,比较单纯药物治疗与合用神经阻滞治疗后疼痛缓解程度(VAS评分),自觉疼痛缓解程度评分、睡眠受影响率、并发症发生情况.结果 167例患者中,带状疱疹神经痛组(85例)中,单纯药物治疗后,VAS评分降低(1.61±1.8)分,72%患者仍存在中～重度疼痛;合用神经阻滞治疗后,VAS评分降低(4.14±2.17)分,63%患者睡眠改善.PNH组(82例)中,单纯药物治疗后,VAS评分降低(1.21±0.96)分,85%患者仍存在中～重度疼痛;合用神经阻滞治疗后,VAS评分降低(4.21±1.77)分,55%患者睡眠改善.结论 神经阻滞治疗对带状疱疹神经痛及PNH均有疗效.