肠易激综合征患者的个性与心理评估

目的 探讨个性、焦虑、抑郁等精神心理因素与IBS的关系.方法 采用龚耀先修定的艾森克个性问卷(EPQ)、症状自评量表(SCL-90)、Zung氏抑郁自评量表(SDS)、焦虑自评量表(SAS)评测100例肠易激综合征(IBS)患者的个性、精神心理状态,并与健康对照组(100例)的相数据对比.结果 在EPQ量表中,IBS组的E(性格内-外向)分值低于健康组(P＜0.05)、N(神经质)分值高于健康组(P＜0.05);在SCL-90中,IBS患者的躯体化、强迫症状、人际关系、抑郁、焦虑、敌对、恐怖、偏执、精神病性、睡眠饮食障碍各项分值高于健康组(P＜0.05);在SAS、SDS中,IBS患者的分值高于与健康组(P＜0.05).结论 个性、负性情绪(焦虑、抑郁)与IBS密切相关,并且较易产生各种躯体症状.     

三种量表对FD患者心理状态与生活质量的评价

目的 调查功能性消化不良(functional dispepsia, FD)患者与健康人在焦虑、抑郁状态方面的差异,并对FD患者的生活质量进行分析.方法 采用Zung焦虑自评量表(SAS)、抑郁自评量表(SDS)及汉化版SF-36量表对69例FD患者和69名健康对照者进行评分,比较两组受试者在焦虑、抑郁情绪方面及生活质量的的差异.结果 FD患者的SAS、SDS分值及SAS合并SDS的发生率均明显高于健康对照组( P ＜0.05),同时FD患者的生活质量评分较对照组明显下降( P ＜0.05).结论 功能性消化不良患者有明显的焦虑和抑郁倾向,躯体生理健康和精神心理健康均明显受损,生活质量较健康人低,尤其是在精神心理健康方面.     

肠易激综合征患者精神心理因素及生活质量分析

[目的]研究肠易激综合征(irritable bowel syndrome,IBS)患者的心理因素及生活质量状况.[方法]采用调查问卷方法,分别运用症状自评量表(SCL-90),艾森克个性问康对照进行调查和分析.[结果]IBS患者SCL-90中躯体化、抑郁、焦虑及精神病性因子分均显著高于对照组(P＜ 0.05);EPQ中的精神质与神经质分值显著高于对照组(P＜0.05);IBSQOL中各项分值均显著低于对照组(P＜0.01).[结论]IBS患者存在较多的精神心理问题,生活质量严重受影响.     

网络成瘾青少年心理健康状况及个性特征的研究

【目的】探讨网络成瘾青少年的心理健康状况及个性特征。【方法】采用焦虑自评量表（SAS）、抑郁自评量表（SDS）及艾森克个性问卷（EPQ）为工具对试验组30例网络成瘾青少年和正常对照组38例学生进行评估。【结果】试验组的焦虑自评量表（SAS）得分均值明显高于正常对照组，两组比较有统计学意义（P〈0．01）。试验组与正常对照组的抑郁自评量表（SDS）得分均值比较无统计学意义（P〉0．05）。艾森克个性问卷（EPQ）4个分量表中精神质、神经质、掩饰虚假分值明显高于正常对照组，两组比较有统计学意义（P〈001）。【结论】网络成瘾青少年的心理健康状况明显存在问题。     

网络成瘾青少年心理健康状况及个性特征的研究

 【目的】探讨网络成瘾青少年的心理健康状况及个性特征。【方法】采用焦虑自评量表（SAS）、抑郁自评量表（SDS）及艾森克个性问卷（EPQ）为工具对试验组30例网络成瘾青少年和正常对照组38例学生进行评估。【结果】试验组的焦虑自评量表（SAS）得分均值明显高于正常对照组，两组比较有统计学意义（P〈0．01）。试验组与正常对照组的抑郁自评量表（SDS）得分均值比较无统计学意义（P〉0．05）。艾森克个性问卷（EPQ）4个分量表中精神质、神经质、掩饰虚假分值明显高于正常对照组，两组比较有统计学意义（P〈001）。【结论】网络成瘾青少年的心理健康状况明显存在问题。     

在校大学生嗜酒人群的心理状况测查分析

目的 分析在校大学生中嗜酒人群的人格特征、焦虑抑郁状况及精神障碍.方法 应用艾森克成人个性问卷(EPQ)、焦虑自评量表(SAS)、抑郁自评量表(SDS)和症状自评量表(SCL-90)测查100例嗜酒在校学生,并与大学生常模比较.结果 嗜酒者个性外倾较多,SAS、SDS和SCL-90所有统计指标均明显高于常模.结论 大学生中嗜酒者普遍存在焦虑抑郁情绪,情感障碍突出.     

功能性消化不良患者焦虑?抑郁状况与生活质量的相关性研究

目的:探讨功能性消化不良(FD)患者焦虑、抑郁状况以及与生活质量的关系。方法:采用汉化版简明健康调查量表(SF-36)和ZUNG焦虑自评量表(SAS)、抑郁自评量表(SDS)对78例符合罗马Ⅲ标准的FD患者的心理状况和生活质量进行评分。结果:FD患者存在明显的焦虑和抑郁心理,与国内常模相比,SDS、SAS分值差异均有显著性(47±11vs42±11,42±11vs37±13,P<0.01);FD患者的生活质量明显下降,与中国常模相比,生理功能、生理职能、躯体疼痛、活力、情感职能、精神健康、社会功能、和总体健康8个维度差异均有显著性(P<0.01);SF-36各维度分值均与SAS、SDS分值呈负相关(P<0.01)。结论:FD患者存在明显的焦虑、抑郁心理,其生活质量显著降低,生活质量与焦虑、抑郁情绪密切相关。     

癌症患者的心身状况及心理干预

【目的】研究癌症患者的心身状况及心理干预对心身状况的影响。【方法】采用症状自评量表（SCL-90）、焦虑自评量表（SAS）、抑郁自评量表（SDS）评定癌症组（72例）、肝炎对照组（30例）及健康对照组（30例）的心身状况，并随机72例癌症患者分为两组，干预组（40例）接受生物学治疗及心理干预，对照组（30例）只接受生物学治疗，治疗后用上述量表再评定一次。【结果】癌症组的SAS标准分、SDS抑郁指数及各项抑郁特异症状评分、SCL-90总分、阳性均分、躯体化、抑郁、焦虑因子分高于肝炎组和健康组（P〈0．01）；干预组SAS标准分、SDS指数、SCL-90总分、躯体化、抑郁、焦虑及敌对因子分干预后评定显著低于干预前（P〈0．01），SAS标准分、SDS指数、SCL-90抑郁因子的减分值显著高于对照组（P〈0．01）。【结论】癌症患者有明显的焦虑抑郁症状，心身状况较差；心理干预能有效改善癌症患者的焦虑抑郁情绪，减轻心理症状。     

鼻部症状对常年性变应性鼻炎患儿心理行为学的影响

目的评估鼻部症状对常年性变应性鼻炎(PAR)患儿心理行为状态的影响。方法选取112例10～14岁PAR患儿作为PAR组及112例健康儿童作为对照组。采用鼻炎症状评分(TNSS)评价PAR组患儿鼻部症状严重程度,采用焦虑自评量表(SAS)、抑郁自评量表(SDS)、Piers-Harris儿童自我意识量表(PHCSCS)、艾森克个性(儿童)问卷(EPQ)评估两组儿童的焦虑、抑郁、自我意识状况和个性特征。比较两组的SAS评分、SDS评分、PHCSCS评分及EPQ评分,并分析PAR患儿的TNSS与各量表评分的相关性。结果 PAR组患儿的SAS评分、SDS评分、EPQ量表中的精神质维度评分和神经质维度评分均高于对照组,而PHCSCS量表中的行为、智力与学校、焦虑、合群、幸福与满足维度评分均低于对照组(均P<0.05)。PAR组患儿的TNSS与SAS评分、SDS评分、EPQ的内外向维度评分和神经质维度的评分均呈正相关,与PHCSCS的行为、躯体外貌与属性、焦虑、幸福与满足维度的评分均呈正相关(均P<0.05)。结论与健康儿童相比,PAR患儿的心理行为状态差,并且受到鼻部症状的影响。临床...     

肠易激综合征患者的心理健康状况分析

目的：探讨肠易激综合征（IBS）与心理健康状况之间的关系．方法：采用心理卫生自评量表（SCL-90）、抑郁自评量表（SDS）、焦虑自评量表（SAS）对40例IBS患者进行了调查．结果：IBS组在躯体化、强迫症状、抑郁、焦虑、恐怖、偏执因子分及总分方面均高于对照组和急性胃炎组（P〈0．05）;IBS组SDS,SAS分值均高于对照组（P〈0．05）．结论：IBS患者存在一定程度的心理异常,心理因素可能在IBS发病过程中起重要作用．     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.