目的 分析国内外互联网药学服务的研究现状和热点,为进一步开展互联网药学服务提供参考。方法 检索中国知网、万方数据库、PubMed和Web of Science核心合集数据库自建库至2021年发表的有关互联网药学服务研究的文献,采用BICOMB 2.02软件对纳入的中英文文献分别进行提取和统计,并生成高频关键词的词篇矩阵和共现矩阵;利用NetDraw 2.089软件对共现矩阵进行社会网络分析,绘制社会网络图,并利用Ucinet 6.212软件对网络进行中心度分析;利用gCLUTO 1.0软件对词篇矩阵进行聚类分析。结果 最终纳入关于互联网药学服务研究的中文文献159篇,互联网药学概念最早出现于2000年;英文文献纳入62篇,相关研究最早发表于1999年;发文量最多的中英文期刊分别是《中国药房》和Journal of Medical Internet Research;确定了当前关于互联网药学服务研究的6个主题:互联网药学服务在社区慢病患者中工作模式的研究、移动互联网平台在药学咨询服务中的研究、云药房(网上药店)互联网药学服务研究、新型冠状病毒肺炎疫情期间互联网药学服务模式研究、互联网药学实践在药师或临床药师继续教育培训体系中的应用研究、互联网药学服务的发展对药师的影响研究。结论 该研究全面深入分析了互联网药学服务的发展现状和研究热点,新型冠状病毒肺炎疫情催化加速了互联网药学服务的发展,在疫情防控新形势和国家各项政策支持下,伴随着"互联网+医疗健康"的发展,互联网药学服务也将蓬勃发展。 相似文献
摘 要 目的:深入了解利拉鲁肽的研究概况,客观反映相关国家、机构和科学家在研究利拉鲁肽的领域中具备的科学能力和影响力。方法:以科学引文索引(SCI)数据库Web of Science为检索平台,以liraglutide or victoza or saxenda”为主题词进行检索,采用文献计量学的方法,分析以利拉鲁肽为主题的相关文献在国家/地区、机构、作者来源、出版物、年发文量、年引文量和引用排名前10名的情况。同时,以中国知网(CNKI)中的中国期刊全文数据库为检索平台,检索以“利拉鲁肽或诺和力”为主题词的所有中文文献并进行文献计量学的分析。时间跨度为1986年1月1日~2015年10月5日。结果:在Web of Science数据库中检索到文献1 596篇,发文量与引文数呈递增趋势,h index 为63;美国和丹麦的研究超过总数的一半以上总被引前10 位的SCI 文章有7篇为LEAD项目的试验结果,我国发表的SCI 文献为110篇;CNKI中收录的中文文章有348篇,10家机构中的9家为综合性的三级甲等医院,发文量最多的为解放军总医院。结论:关于利拉鲁肽的研究,是逐渐上升的趋势,仍是目前研究的热点。中国与国际前沿研究间存在着一定差距。 相似文献
摘 要 目的:深入了解药品不良反应信号的研究概况,客观反映相关国家、机构和科学家在研究药品不良反应的领域中具备的科学能力和影响力。方法:以科学引文索引(SCI) 数据库Web of Science为检索平台,以“adverse reaction signal mining”“adverse reaction data mining”为主题词进行高级检索,采用文献计量学的方法,分析以不良反应信号挖掘为主题的相关文献在国家/地区、机构、作者来源、出版物、年发文量、年引文量和引用排名前10名的情况。同时,以中国知网(CNKI) 中的中国期刊全文数据库为检索平台,高级检索“不良反应信号挖掘”“不良反应数据挖掘”为主题词的所有中文文献并进行文献计量学的分析。检索时间截止到2018年6月30日。 结果:在Web of Science 数据库中检索到英文文献191篇,年发文量与年引文数以2013为最多,h index为36,美国和法国的发文量为103篇,占总数的53.93%。在CNKI中检索到的中文文献为41篇,研究最多的机构为第二军医大学,发文量为11篇,占总数的26.83%。结论:关于药品不良反应信号挖掘的研究发展迅速,且一直保持着一定的研究热度,但挖掘技术和数据利用的方法还需要进一步探索。 相似文献
ABSTRACTIntroduction: Lung cancer is the leading cancer-related cause of death worldwide. The introduction of immune checkpoint inhibitors (ICIs) for the treatment of lung cancer has significantly improved the outcome of these patients. Pembrolizumab, a monoclonal IgG4-kappa antibody against programmed-death-1 (PD-1) protein, nowadays represents a standard of care for NSCLC patients. Although it has a favorable toxicity profile, some immune-related adverse events (irAEs) can be life-threatening, therefore its knowledge may help to optimize the care of these patients.Areas covered: The authors review data regarding the efficacy and safety of pembrolizumab from the most relevant clinical trials as well as toxicities reported in the clinical use. Special considerations of use in special populations will be noted. Finally, its toxicity profile will be compared with other ICIs used in NSCLC.Expert opinion: In the scenario of NSCLC, pembrolizumab shows a favorable safety profile with less than 10% serious immune-related adverse events (irAEs) when used in monotherapy and without adding relevant extra-toxicity to chemotherapy when used in combination. Monotherapy with pembrolizumab is associated with better health-related quality of life than chemotherapy. Early recognition and appropriate treatment of irAEs is of prime importance as most are reversible if correctly managed. Rechallenge with pembrolizumab is frequently feasible. 相似文献
BackgroundAlthough colitis has been reported in patients treated with immune checkpoint inhibitors (ICIs), associations between colitis and ICIs had not been thoroughly assessed in real-world studies. Here, we identified and characterized significant colitis-associated with ICIs.MethodsBased on the Food and Drug Administration Adverse Event Reporting System (FAERS) from January 2004 to December 2019, the disproportionality analysis and Bayesian analysis, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN) and the multi-item gamma Poisson shrinker (MGPS) algorithms were adopted to data mining of the suspected adverse events of colitis after ICIs administrating. Clinical characteristics of patients with ICIs-associated colitis and the time to onset of colitis following different ICI regimens were collected.ResultsA total of 3786 reports of colitis adverse events were identified with ICIs. Seven ICI monotherapies were associated with the reporting of colitis. Statistically significant ROR, PRR, information component (IC), and empirical Bayesian geometric mean (EBGM) emerged for all ICI monotherapies and combination therapies. ICIs-associated colitis affected mostly male (53.51%), with a wide mean age range (60.65 to 72 years). Colitis adverse events were commonly reported in patients with melanoma and lung cancer. Adverse outcomes of colitis concerning ICI were mainly outcomes of hospitalization-initiated or prolonged and other serious. Among colitis cases, 17.43% cases of colitis concerning ICI lead to death. The adverse event of colitis occurred earliest in ipilimumab monotherapy with a median time to onset of 64.21 days (IQR: 27–69 days) among all monotherapies.ConclusionsICI may lead to severe and disabling ICIs-associated colitis during therapy. Analysis of FAERS data identified signals for adverse events of colitis with ICI regimens. Practitioners should consider the factors that may increase the likelihood of colitis. The findings support a continued surveillance and risk factor identification studies. 相似文献
Immune checkpoint inhibitors (ICIs) are widely used in the treatment of many cancers as they improve clinical outcomes. However, ICIs have also been associated with the development of immune-related adverse drug reactions (ADRs). Among immune-related ADRs, cardiac immune-related ADRs are rare, but also associated with high mortality rates.
Objective
The objective of this study was to evaluate the occurrence of cardiac ADRs reported with ICIs in the European spontaneous reporting system.
Methods
We retrieved individual case safety reports on ICI-induced cardiac ADRs from the website of suspected ADR (www.adrreports.eu) of the European pharmacovigilance database (Eudravigilance). Data were retrieved from the date of marketing authorization of each ICI (ipilimumab, nivolumab, pembrolizumab, atezolizumab, durvalumab, avelumab, and cemiplimab) to 14 March, 2020. The reporting odds ratio and its 95% confidence interval were computed to assess the reporting frequency of cardiac ADRs for each ICI compared to all other ICIs.
Results
A total of 2478 individual case safety reports with at least one ICI as the suspected drug were retrieved from Eudravigilance, of which 249 (10%) reported more than one ICI. The three most reported ICIs were nivolumab (43.2%), pembrolizumab (32.5%), and the association of nivolumab/ipilimumab (9.4%). A total of 3388 cardiac ADRs were identified. Cardiac ADRs were serious (99.4%) and had a fatal outcome (30.1%). The most reported cardiac events were myocarditis, cardiac failure, atrial fibrillation, pericardial effusion, and myocardial infarction. Nivolumab was reported with a small increased reporting frequency of individual case safety reports with cardiac ADRs compared to all other ICIs (reporting odds ratio 1.09, 95% confidence interval 1.01–1.18).
Conclusions
Immune checkpoint inhibitor-induced cardiac ADRs were serious and had unfavorable outcomes. In our study, nivolumab was the only ICI with a small increased reporting frequency of individual case safety reports with cardiac ADRs compared to all other ICIs. In this regard, further head-to-head studies are needed.
BackgroundAdvanced melanoma, one of the most lethal forms of skin cancer, remains a difficult condition to treat, despite the substantial scientific progression in cancer treatment. Oncolytic virotherapy (OV), either alone or combined with immune checkpoint inhibitors (ICIs), has often been administrated in an attempt to cure this malignancy. However, the clinical outcomes dramatically vary among different reports.MethodsIn this study, we performed a meta-analysis to evaluate the clinical efficacy and safety profile of OV, combined with ICIs in some cases, in advanced melanoma patients. The original clinical studies were identified based on the online query in PubMed, Cochrane, and Web of Science before December 30, 2018.ResultsA total of 18 publications involving 1472 patients were included for the final meta-analysis. The data concerning objective response rate (ORR) and incidence rate of severe immune-related adverse events (irAEs) were extracted accordingly from the text or supplementary materials. The results illustrated that a single treatment of OV could generate a 25% ORR for advanced melanoma, and the ORR could be improved to 45% if combined with ICIs. Further analysis demonstrated that the introduction of ICIs in OV could increase the incidence rate of severe irAEs (AE ≥ 3) from 12% to 39%. However, the rate attributed to OV remains at 12% in the combination group.ConclusionThe clinical efficacy of OV can be significantly improved by ICIs even though more onerous burden will be exerted simultaneously on the safety profile. 相似文献
The immune checkpoints, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein-1/ligand-1 (PD-1/PD-L1) are vital contributors to immune regulation and tolerance. Recently immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy; however, they come with the cost of immune related adverse events involving multiple organs such as the liver. Due to its constant exposure to foreign antigens, the liver has evolved a high capacity for immune tolerance, therefore, blockade of the immune checkpoints can result in aberrant immune activation affecting the liver in up to 20% of patients depending on the agent(s) used and underlying factors. This type of hepatotoxicity is termed immune mediated liver injury from checkpoint inhibitors (ILICI) and is more common when CTLA4 and PD-1/PD-L1 are used in combination. The underlying mechanisms of this unique type of hepatotoxicity are not fully understood; however, the contribution of CD8+ cytotoxic T lymphocytes, various CD4+ T cells populations, cytokines, and the secondary activation of the innate immune system leading to liver injury have all been suggested. This review summarizes our current understanding of the underlying mechanisms of liver injury in immunotherapy using animal models of ILICI and available patient data from clinical studies. 相似文献
BackgroundImmune checkpoint inhibitors (ICIs) have been identified as validated medications in non-small cell lung cancer (NSCLC). However, they are often associated with immune-related adverse events (irAEs) including liver dysfunction. Therefore, we conducted a systematic review of the literature and performed a meta-analysis to ascertain overall incidence and risk of immune mediated liver dysfunction in NSCLC patients.MethodsPubMed, the Cochrane Library, Embase and ClinicalTrials.gov (http://clinicaltrials.gov/) were searched from inception to December 2019. Studies regarding all grade (1–5), high grade (3–5) hepatitis and ALT or AST elevation were included.ResultsA total of 11 clinical trials including 7086 patients were selected for further assessment. The overall incidence of ALT elevation, AST elevation and hepatitis for the application of ICIs was 6.18%, 4.99% and 1.09%, respectively. Compared with chemotherapy group, treatment with ICIs had a significantly higher risk of all grade (RR: 7.27, p = 0.001) and high grade (RR: 6.70, p = 0.003) hepatitis. When ICIs combined with chemotherapy, the relative risk of all grade hepatitis was higher than monotherapy group (RR: 7.89, p = 0.044 vs RR: 6.94, p = 0.008).ConclusionThe application of ICIs could result in a higher incidence and relative risk of all grade immune-induced liver dysfunction. Moreover, immunotherapy combined with chemotherapy may also increase relative risk of all grade hepatic AEs when compared with monotherapy. Prompt recognition and proper administration is required for clinicians to prevent potentially hepatic deterioration. 相似文献