老年子宫内膜癌患者临床病理分析及孕激素治疗对预后的作用

Objective To retrospectively analyze clinicopathological features and prognosis effect of progesterone therapy in elderly patients with endometrial carcinoma. Methods Two hundred and thirty-five patients were divided into three groups according to age: 30-49 years old group (n=54), 50-59 years old group (n= 102) and 60-82 years old group (n= 79). The relationship between age and clinicopathological features was analyzed, and the prognosis effect of progesterone therapy in patients of 60-82 years old was assesed. Results The incidences of special pathological type of endometrial cancer (serous eystadenocarcinoma, clear cell carcinoma and squamous cell carcinoma) , operation-pathological stage ≥Ⅲ and low differentiation were increased with advancing age. The incidences of the above mentioned special pathological type of endometrial cancer were 20.4% (11/54), 38. 2%(39/63), 48.1%(38/79) in the three groups, respectively, and there were statistical significances among the three groups (χ<'2> = 10.039, P<0.01). The positive rate of progesterone receptor was significantly decreased in the three groups (57.4% (31/54)vs. 45.1% (46/ 102) vs. 25.3%(20/79), P<0. 01]. The remission rate of progesterone therapy was higher (18/23) than that of radiotherapy and (or) chemotherapy (4/8) (78.3% vs. 50%, Z= 1.46, P<0. 05). Conclusions The incidence of clinical pathological factors of endometrial cancer is increased with advancing age, and the prognosis of progesterone therapy is better than treatment with radiotherapy and (or) chemotherapy.     

老年子宫内膜癌患者临床病理分析及孕激素治疗对预后的作用

Objective To retrospectively analyze clinicopathological features and prognosis effect of progesterone therapy in elderly patients with endometrial carcinoma. Methods Two hundred and thirty-five patients were divided into three groups according to age: 30-49 years old group (n=54), 50-59 years old group (n= 102) and 60-82 years old group (n= 79). The relationship between age and clinicopathological features was analyzed, and the prognosis effect of progesterone therapy in patients of 60-82 years old was assesed. Results The incidences of special pathological type of endometrial cancer (serous eystadenocarcinoma, clear cell carcinoma and squamous cell carcinoma) , operation-pathological stage ≥Ⅲ and low differentiation were increased with advancing age. The incidences of the above mentioned special pathological type of endometrial cancer were 20.4% (11/54), 38. 2%(39/63), 48.1%(38/79) in the three groups, respectively, and there were statistical significances among the three groups (χ<'2> = 10.039, P<0.01). The positive rate of progesterone receptor was significantly decreased in the three groups (57.4% (31/54)vs. 45.1% (46/ 102) vs. 25.3%(20/79), P<0. 01]. The remission rate of progesterone therapy was higher (18/23) than that of radiotherapy and (or) chemotherapy (4/8) (78.3% vs. 50%, Z= 1.46, P<0. 05). Conclusions The incidence of clinical pathological factors of endometrial cancer is increased with advancing age, and the prognosis of progesterone therapy is better than treatment with radiotherapy and (or) chemotherapy.     

老年子宫内膜癌患者临床病理分析及孕激素治疗对预后的作用

Objective To retrospectively analyze clinicopathological features and prognosis effect of progesterone therapy in elderly patients with endometrial carcinoma. Methods Two hundred and thirty-five patients were divided into three groups according to age: 30-49 years old group (n=54), 50-59 years old group (n= 102) and 60-82 years old group (n= 79). The relationship between age and clinicopathological features was analyzed, and the prognosis effect of progesterone therapy in patients of 60-82 years old was assesed. Results The incidences of special pathological type of endometrial cancer (serous eystadenocarcinoma, clear cell carcinoma and squamous cell carcinoma) , operation-pathological stage ≥Ⅲ and low differentiation were increased with advancing age. The incidences of the above mentioned special pathological type of endometrial cancer were 20.4% (11/54), 38. 2%(39/63), 48.1%(38/79) in the three groups, respectively, and there were statistical significances among the three groups (χ<'2> = 10.039, P<0.01). The positive rate of progesterone receptor was significantly decreased in the three groups (57.4% (31/54)vs. 45.1% (46/ 102) vs. 25.3%(20/79), P<0. 01]. The remission rate of progesterone therapy was higher (18/23) than that of radiotherapy and (or) chemotherapy (4/8) (78.3% vs. 50%, Z= 1.46, P<0. 05). Conclusions The incidence of clinical pathological factors of endometrial cancer is increased with advancing age, and the prognosis of progesterone therapy is better than treatment with radiotherapy and (or) chemotherapy.     

老年子宫内膜癌患者临床病理分析及孕激素治疗对预后的作用

Objective To retrospectively analyze clinicopathological features and prognosis effect of progesterone therapy in elderly patients with endometrial carcinoma. Methods Two hundred and thirty-five patients were divided into three groups according to age: 30-49 years old group (n=54), 50-59 years old group (n= 102) and 60-82 years old group (n= 79). The relationship between age and clinicopathological features was analyzed, and the prognosis effect of progesterone therapy in patients of 60-82 years old was assesed. Results The incidences of special pathological type of endometrial cancer (serous eystadenocarcinoma, clear cell carcinoma and squamous cell carcinoma) , operation-pathological stage ≥Ⅲ and low differentiation were increased with advancing age. The incidences of the above mentioned special pathological type of endometrial cancer were 20.4% (11/54), 38. 2%(39/63), 48.1%(38/79) in the three groups, respectively, and there were statistical significances among the three groups (χ<'2> = 10.039, P<0.01). The positive rate of progesterone receptor was significantly decreased in the three groups (57.4% (31/54)vs. 45.1% (46/ 102) vs. 25.3%(20/79), P<0. 01]. The remission rate of progesterone therapy was higher (18/23) than that of radiotherapy and (or) chemotherapy (4/8) (78.3% vs. 50%, Z= 1.46, P<0. 05). Conclusions The incidence of clinical pathological factors of endometrial cancer is increased with advancing age, and the prognosis of progesterone therapy is better than treatment with radiotherapy and (or) chemotherapy.     

老年子宫内膜癌患者临床病理分析及孕激素治疗对预后的作用

Objective To retrospectively analyze clinicopathological features and prognosis effect of progesterone therapy in elderly patients with endometrial carcinoma. Methods Two hundred and thirty-five patients were divided into three groups according to age: 30-49 years old group (n=54), 50-59 years old group (n= 102) and 60-82 years old group (n= 79). The relationship between age and clinicopathological features was analyzed, and the prognosis effect of progesterone therapy in patients of 60-82 years old was assesed. Results The incidences of special pathological type of endometrial cancer (serous eystadenocarcinoma, clear cell carcinoma and squamous cell carcinoma) , operation-pathological stage ≥Ⅲ and low differentiation were increased with advancing age. The incidences of the above mentioned special pathological type of endometrial cancer were 20.4% (11/54), 38. 2%(39/63), 48.1%(38/79) in the three groups, respectively, and there were statistical significances among the three groups (χ<'2> = 10.039, P<0.01). The positive rate of progesterone receptor was significantly decreased in the three groups (57.4% (31/54)vs. 45.1% (46/ 102) vs. 25.3%(20/79), P<0. 01]. The remission rate of progesterone therapy was higher (18/23) than that of radiotherapy and (or) chemotherapy (4/8) (78.3% vs. 50%, Z= 1.46, P<0. 05). Conclusions The incidence of clinical pathological factors of endometrial cancer is increased with advancing age, and the prognosis of progesterone therapy is better than treatment with radiotherapy and (or) chemotherapy.     

老年子宫内膜癌患者临床病理分析及孕激素治疗对预后的作用

Objective To retrospectively analyze clinicopathological features and prognosis effect of progesterone therapy in elderly patients with endometrial carcinoma. Methods Two hundred and thirty-five patients were divided into three groups according to age: 30-49 years old group (n=54), 50-59 years old group (n= 102) and 60-82 years old group (n= 79). The relationship between age and clinicopathological features was analyzed, and the prognosis effect of progesterone therapy in patients of 60-82 years old was assesed. Results The incidences of special pathological type of endometrial cancer (serous eystadenocarcinoma, clear cell carcinoma and squamous cell carcinoma) , operation-pathological stage ≥Ⅲ and low differentiation were increased with advancing age. The incidences of the above mentioned special pathological type of endometrial cancer were 20.4% (11/54), 38. 2%(39/63), 48.1%(38/79) in the three groups, respectively, and there were statistical significances among the three groups (χ<'2> = 10.039, P<0.01). The positive rate of progesterone receptor was significantly decreased in the three groups (57.4% (31/54)vs. 45.1% (46/ 102) vs. 25.3%(20/79), P<0. 01]. The remission rate of progesterone therapy was higher (18/23) than that of radiotherapy and (or) chemotherapy (4/8) (78.3% vs. 50%, Z= 1.46, P<0. 05). Conclusions The incidence of clinical pathological factors of endometrial cancer is increased with advancing age, and the prognosis of progesterone therapy is better than treatment with radiotherapy and (or) chemotherapy.     

老年子宫内膜癌患者临床病理分析及孕激素治疗对预后的作用

Objective To retrospectively analyze clinicopathological features and prognosis effect of progesterone therapy in elderly patients with endometrial carcinoma. Methods Two hundred and thirty-five patients were divided into three groups according to age: 30-49 years old group (n=54), 50-59 years old group (n= 102) and 60-82 years old group (n= 79). The relationship between age and clinicopathological features was analyzed, and the prognosis effect of progesterone therapy in patients of 60-82 years old was assesed. Results The incidences of special pathological type of endometrial cancer (serous eystadenocarcinoma, clear cell carcinoma and squamous cell carcinoma) , operation-pathological stage ≥Ⅲ and low differentiation were increased with advancing age. The incidences of the above mentioned special pathological type of endometrial cancer were 20.4% (11/54), 38. 2%(39/63), 48.1%(38/79) in the three groups, respectively, and there were statistical significances among the three groups (χ<'2> = 10.039, P<0.01). The positive rate of progesterone receptor was significantly decreased in the three groups (57.4% (31/54)vs. 45.1% (46/ 102) vs. 25.3%(20/79), P<0. 01]. The remission rate of progesterone therapy was higher (18/23) than that of radiotherapy and (or) chemotherapy (4/8) (78.3% vs. 50%, Z= 1.46, P<0. 05). Conclusions The incidence of clinical pathological factors of endometrial cancer is increased with advancing age, and the prognosis of progesterone therapy is better than treatment with radiotherapy and (or) chemotherapy.     

老年子宫内膜癌患者临床病理分析及孕激素治疗对预后的作用

Objective To retrospectively analyze clinicopathological features and prognosis effect of progesterone therapy in elderly patients with endometrial carcinoma. Methods Two hundred and thirty-five patients were divided into three groups according to age: 30-49 years old group (n=54), 50-59 years old group (n= 102) and 60-82 years old group (n= 79). The relationship between age and clinicopathological features was analyzed, and the prognosis effect of progesterone therapy in patients of 60-82 years old was assesed. Results The incidences of special pathological type of endometrial cancer (serous eystadenocarcinoma, clear cell carcinoma and squamous cell carcinoma) , operation-pathological stage ≥Ⅲ and low differentiation were increased with advancing age. The incidences of the above mentioned special pathological type of endometrial cancer were 20.4% (11/54), 38. 2%(39/63), 48.1%(38/79) in the three groups, respectively, and there were statistical significances among the three groups (χ<'2> = 10.039, P<0.01). The positive rate of progesterone receptor was significantly decreased in the three groups (57.4% (31/54)vs. 45.1% (46/ 102) vs. 25.3%(20/79), P<0. 01]. The remission rate of progesterone therapy was higher (18/23) than that of radiotherapy and (or) chemotherapy (4/8) (78.3% vs. 50%, Z= 1.46, P<0. 05). Conclusions The incidence of clinical pathological factors of endometrial cancer is increased with advancing age, and the prognosis of progesterone therapy is better than treatment with radiotherapy and (or) chemotherapy.     

老年子宫内膜癌患者临床病理分析及孕激素治疗对预后的作用

Objective To retrospectively analyze clinicopathological features and prognosis effect of progesterone therapy in elderly patients with endometrial carcinoma. Methods Two hundred and thirty-five patients were divided into three groups according to age: 30-49 years old group (n=54), 50-59 years old group (n= 102) and 60-82 years old group (n= 79). The relationship between age and clinicopathological features was analyzed, and the prognosis effect of progesterone therapy in patients of 60-82 years old was assesed. Results The incidences of special pathological type of endometrial cancer (serous eystadenocarcinoma, clear cell carcinoma and squamous cell carcinoma) , operation-pathological stage ≥Ⅲ and low differentiation were increased with advancing age. The incidences of the above mentioned special pathological type of endometrial cancer were 20.4% (11/54), 38. 2%(39/63), 48.1%(38/79) in the three groups, respectively, and there were statistical significances among the three groups (χ<'2> = 10.039, P<0.01). The positive rate of progesterone receptor was significantly decreased in the three groups (57.4% (31/54)vs. 45.1% (46/ 102) vs. 25.3%(20/79), P<0. 01]. The remission rate of progesterone therapy was higher (18/23) than that of radiotherapy and (or) chemotherapy (4/8) (78.3% vs. 50%, Z= 1.46, P<0. 05). Conclusions The incidence of clinical pathological factors of endometrial cancer is increased with advancing age, and the prognosis of progesterone therapy is better than treatment with radiotherapy and (or) chemotherapy.     

Surgical management of gallbladder sarcomatoid carcinoma

AIM： To study the behavior as well as optimal treatment of gallbladder sarcomatoid carcinoma, we reviewed the results of treatment of gallbladder sarcomatoid carcinoma from Chang Gung Memorial Hospital. METHODS： From 1987 to 2005, six patients were diagnosed with gallbladder sarcomatoid carcinoma and treated at our institution. Tumor staging was based on 2002 revised tumor-node-metastasis （TNM） staging for gall bladder cancer from the American Joint Committee on Cancer. The clinical presentation, laboratory data and preoperative workup were reviewed retrospectively. RESULTS： Five patients were female and one was male. The age ranged from 51 to 66 years （median, 58 years）. Surgical procedures included three curative resections, two palliative resections and one biopsy. There were two surgical complications （33.3%） and one case of surgical mortality （16.7%）. The follow- up time ranged from 30 d to 5 mo. The median survival was 2.5 mo. The prognosis was extremely poor, even after curative resection and postoperative chemotherapy. CONCLUSION： The prognosis of gallbladder sarcomatoid carcinoma was not dependent on TNM stage and was always dismal. The clinicopathological features were different from those of gall bladder cancer.     

State of knowledge of helminth fauna of freshwater fishes of Poland

A total 89 fish and lamprey species has been recorded from Polish freshwater habitats. Twenty-seven of them (30.3%) have not been surveyed for parasitic helminthes. Some of the latter fishes are either rare or not easily accessible. Other live only in specific habitats in scattered localities. An important obstacle for studying parasite faunas of some fishes may be their status on an endangered species. Among the non-surveyed fishes, are those which have been relatively recently introduced to Poland or migrated there on their own. The present paper attempts to review all hitherto not studied helminthologically fish species, their habitats, localities and current protection status.     

高血压降压治疗目标的再认识

根据传统的高血压水平的定义,1993年WHO高血压治疗指南提出血压控制目标为<140/90mm Hg(1mm Hg=0.133kPa),但是并非所有患者都必须将血压降至同一水平,而应根据患者情况进行个体化治疗。Framingham进行的一项长达10～12年的心血管事件研究发现,第5年后,正常上限血压[收缩压(SBP     

Lack of correlation of degree of villous atrophy with severity of clinical presentation of coeliac disease

BACKGROUND AND AIM: Both the clinical presentation and the degree of mucosal damage in coeliac disease vary greatly. In view of conflicting information as to whether the mode of presentation correlates with the degree of villous atrophy, we reviewed a large cohort of patients with coeliac disease. PATIENTS AND METHODS: We correlated mode of presentation (classical, diarrhoea predominant or atypical/silent) with histology of duodenal biopsies and examined their trends over time. RESULTS: The cohort consisted of 499 adults, mean age 44.1 years, 68% females. The majority had silent coeliac disease (56%) and total villous atrophy (65%). There was no correlation of mode of presentation with the degree of villous atrophy (p=0.25). Sixty-eight percent of females and 58% of males had a severe villous atrophy (p=0.052). There was a significant trend over time for a greater proportion of patients presenting as atypical/silent coeliac disease and having partial villous atrophy, though the majority still had total villous atrophy. CONCLUSIONS: Among our patients the degree of villous atrophy in duodenal biopsies did not correlate with the mode of presentation, indicating that factors other than the degree of villous atrophy must account for diarrhoea in coeliac disease.