皮肤B细胞淋巴瘤

报告２例皮肤Ｂ细胞淋巴瘤。例１．５６岁，男性，躯干、四肢多数皮肤结节，伴有淋巴结肿大５个月。例２，５１岁，男性胸部皮肤斑块３个月入院。２例皮损活检，组织病 理均示为淋巴瘤性浸润。侵犯皮肤附属器及血管周围，乳头层浸润稀疏，有无浸润滞。免疫组化均证实为Ｂ细胞性淋巴瘤。便１免疫球蛋白标记双重链（ＩｇＧ，ＩｇＭ）和双轻链（κ，γ）均呈阳性。     

以皮肤浸润性斑块为首发表现的B细胞淋巴瘤1例

报告 1例皮肤B细胞淋巴瘤。患儿男 ,9岁 ,全身皮肤淡红色浸润性斑块 1月。骨穿示淋巴瘤细胞浸润性骨髓 ,组织病理示淋巴瘤性细胞浸润 ,免疫组化证实为B细胞淋巴瘤。     

原发性皮肤弥漫大B细胞淋巴瘤,腿型

报告1例原发性皮肤弥漫性大B细胞淋巴瘤（腿型）。患者女，82岁。左小腿出现3个红色结节2个月，组织病理检查发现真皮内淋巴样细胞浸润，无嗜表皮现象，细胞体积大，肿瘤细胞CD20（＋），CD79α（＋），Bcl-2（＋），Bcl-6（＋），Ki-67 70％（＋），MUM-1（＋），Pax-5（＋），CD10（-），诊断为原发性皮肤弥漫性大B细胞淋巴瘤（腿型），全身检查未发现皮肤以外系统受累证据，行局部肿瘤切除及口服糖皮质激素治疗。     

原发性皮肤弥漫大B细胞淋巴瘤（腿型）一例

报告1例原发性皮肤弥漫性大B细胞淋巴瘤（腿型）。患者男,51岁。右小腿出现多个红色结节5个月,组织病理检查：表皮和真皮之间见无细胞浸润带,真皮内淋巴样细胞浸润,细胞体积大,异形。肿瘤细胞CD20（++）,Bcl-6(+),Bcl-2(+),Pax-5(+),Ki-67 50％-75％(+),CD79a(+),MUM-1（+）,CD10（-）,诊断为原发性皮肤弥漫性大B细胞淋巴瘤（腿型）,给予CD20单克隆抗体加CHOP方案治疗,病情好转。     

原发性皮肤弥漫大B细胞淋巴瘤1例

报告1例原发性皮肤弥漫大B细胞淋巴瘤。患者男,72岁,因四肢、躯干红斑、结节、肿块2年,加重伴溃烂3月,于2009年3月9日就诊。皮损组织病理检查报告见皮肤真皮内大量淋巴样细胞弥漫浸润,未侵及表皮,免疫组化染色结果示瘤细胞L26（＋）,Bcl-6（＋）,Mum-1（＋）,CD10弱（＋）,K i-67（＋）约90%。诊断为原发性皮肤弥漫性大B细胞淋巴瘤。     

原发性皮肤间变性大细胞淋巴瘤一例

［摘要］报告1例原发性皮肤CD30+大细胞性淋巴瘤。右前臂皮肤红肿浸润、溃疡结痂1月,左侧头面部红肿浸润10天。右前臂皮损组织病理检查：真皮深层以及皮下脂肪组织间瘤细胞浸润,密集分布。瘤细胞胞质丰富,呈嗜酸性,部分呈空泡状,细胞核大,异型性明显,核仁明显,染色质呈粗颗粒状,并可见病理性核分裂象;有少量成熟淋巴细胞浸润。行免疫组化检查示： 瘤细胞CD45R0（+）、CD30（+）,CD68（－）、CD20（-）、EMA（-）及ALK（-）。诊断为原发性皮肤间变性大细胞淋巴瘤     

成人T细胞白血病／淋巴瘤与皮肤淋巴瘤的鉴别

伴皮肤损害的成人Ｔ细胞白血病／淋巴瘤（ＡＴＬＬ）与皮肤Ｔ细胞淋巴瘤有极相似的临床病理和免疫分型，为了区别两者，对４例伴皮肤损害的ＡＴＬＬ和１８例皮肤淋巴瘤进行临床病理、免疫学分型及嗜人Ｔ淋巴细胞病毒Ｉ型（ＨＴＬＶ－Ｉ）前病毒ＤＮＡ的比较性研究，２例光线性类网织细胞增多症和２例皮肤淋巴细胞浸润症为阴性对照。结果：４例ＡＴＬＬ出现皮肤损害的同时表现系统症状如：广泛的浅淋巴结肿大，乳酸脱氢酶和白介素２受     

皮下脂膜炎样T细胞淋巴瘤二例

皮下脂膜炎样T细胞淋巴瘤（SPTCL）是原发于皮肤的外周T细胞淋巴瘤,主要累及皮下脂肪组织,现将我们收治的２例SPTCL报道如下。例１女,１７岁。全身皮肤反复出现结节、破溃伴乏力、全身酸痛６个月。曾以泼尼松１mg·kg－１·d－１连续治疗３个月,疗效欠佳。体检：双腋、腹股沟淋巴结肿大,无压痛,右眼瞳孔增大,直接、间接对光反射迟钝;全身皮肤见以四肢为主散在的结节及萎缩性瘢痕。结节无压痛,表面呈皮色、红色、紫红色,部分中央破溃,周边隆起如环堤状,基底浸润,部分结节及周围皮肤有淤点、紫斑（图１）。实验室检查：６次…     

假性淋巴瘤1例

假性淋巴瘤１例吴铁锋江西医学院第二附属医院皮肤科（邮政编码３３０００６）假性淋巴瘤（Ｐｓｅｕｄｏｌｙｍｐｈｏｍａ）是一种在临床和病理上酷似恶性淋巴瘤的良性炎症现象，损害内有以淋巴细胞为主的炎症细胞浸润，皮肤、胃肠、淋巴结、肺和乳房都可被侵犯［‘１。现...     

系统疾病的皮肤表现

980529 成人T细胞白血病/淋巴瘤与皮肤淋巴瘤的鉴别/汪晨（北京中日友好医院）…//中华皮肤科杂志.-1997,30（4）.-237 对4例伴皮肤损害的成人T-细胞白血病/淋巴瘤（ATLL）和18例皮肤T-细胞淋巴瘤（CTCL）进行了临床病理、免疫学分型及嗜人T淋巴细胞病毒1型（HTLV-1）前病毒DNA的比较性研究,结果:4例ATLL出现皮肤损害同时有系统症状如:广泛的浅淋巴结肿大,乳酸脱氢酶和白介素2受体异常增高,外周血有花瓣样细胞和骨髓异常,其外周血、骨髓、皮肤和淋巴结的HTLV-1前病毒DNA均阳性,而18例CT-CL均阴性。2例光线性点网织细胞增多症和2例皮肤淋巴细胞浸润均为阴性对照。足资鉴别。参6 （贾泰元）     

非霍奇金淋巴瘤1例

报告1例以皮肤肿瘤为首发表现的儿童非霍奇金淋巴瘤。患儿女,8岁。右侧鼻翼出现肿块3个月余,伴进行性增大1个月就诊。体格检查示局部淋巴结不增大,系统检查无异常。皮损组织病理检查示真皮内有异形淋巴样细胞浸润,免疫组化染色结果示：CD45RO（＋）,CD20,HMB45,CK,CD30和CD68均阴性,证实为T细胞淋巴瘤。     

Aggressive subcutaneous panniculitis-like T-cell lymphoma: complete remission with fludarabine, mitoxantrone and dexamethasone

Subcutaneous panniculitis-like T-cell lymphoma (SCPTCL) is a rare cutaneous T-cell lymphoma. The optimal treatment of this disease is undefined. A 36-year-old woman presented with swinging pyrexia, weight loss and disseminated SCPTCL involving her limbs and trunk. Typical histological features of panniculitic infiltration with rimming of fat cells and sparing of the dermis and epidermis were seen. Immunophenotyping confirmed a CD8+ cytotoxic T-cell phenotype. The patient was successfully treated with a combination of fludarabine, mitoxantrone and dexamethasone (FND), and has remained in remission 15 months after cessation of treatment. FND may be an effective regimen for aggressive SCPTCL.     

成人种痘样水疱病样淋巴瘤一例并文献复习

本文报道1例种痘样水疱病样淋巴瘤并对WHO最新分类、EBV感染相关发病机制、鉴别诊断及治疗方面的相关文献进行复习。患者,男,38岁。全身反复皮疹30年,加重1年,患者病程中伴有发热,皮损预后遗留凹陷性瘢痕。血清EB病毒抗体IgG阳性。皮损组织病理示：真皮全层及皮下脂肪小叶内大量淋巴细胞浸润。免疫组化染色示：CD2(+++),CD3(++),CD8(++),TIA-1(++),CD56(少量+),CD20(灶状+) ,Ki-67＞30%。EB病毒原位杂交：阳性。诊断：种痘样水疱病样淋巴瘤。     

A case of cutaneous T cell lymphoma treated with recombinant interleukin 2 (rIL-2)

We report a case of cutaneous T cell lymphoma (CTCL) treated with local injection of recombinant interleukin 2 (rIL-2). The biopsy specimen showed marked infiltration of large convoluted cells admixed with small lymphocytes and histiocytes in the epidermis, dermis and subcutis. After six injections of rIL-2, 4 nodules out of 5 on the left lower leg disappeared and the remaining large nodule was diminished in size. A biopsy specimen from the diminished nodule showed infiltration of small lymphocytes with histiocytes and plasma cells in the dermis. The atypical cells, large hyperconvoluted lymphocytes, had disappeared. A large number (28%) of lysozyme- and alpha 1-anti-chymotrypsin-positive cells were demonstrated by immunohistochemistry. The patient maintained complete remission for a period of 13 months. He then noticed a small red nodule on the back of the left foot, which was histologically confirmed as a recurrence. Chemotherapy cleared the lesion.     

Human herpesvirus type 8 and Epstein–Barr virus-associated cutaneous lymphoma taking anaplastic large cell morphology in a man with HIV infection

Human herpesvirus type 8 (HHV-8, Kaposi's sarcoma-associated herpesvirus)-positive lymphoma taking anaplastic large cell morphology in the skin is described in a 46-year-old man with AIDS. Multiple erythematous nodules appeared on the trunk and extremities during the treatment of AIDS. Histological examination of cutaneous nodules showed dense infiltration of CD30 + atypical lymphoid cells in the deep dermis. Immunoglobulin JH gene rearrangement was detected in these lymphoma cells. Both Epstein-Barr virus-encoded small RNA and HHV-8 mRNA (T1.1/nut-1) were detected in these lymphoma cells by in situ hybridization. Remarkable retention of the pericardial fluid was observed at the same time that cutaneous lesions grew, and lymphoma cells in the pericardial fluid showed the same phenotype as the cutaneous lymphoma. Chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone effectively reduced both the cutaneous nodules and pericardial fluid. However, the patient died 4 months after diagnosis because of cytomegalovirus infection. As far as we know, this is the first report of an HHV-8-positive cutaneous lymphoma taking anaplastic large cell morphology. This case suggests the association of AIDS-related anaplastic large cell lymphoma with HHV-8.     

大疱性类天疱疮并发原发性皮肤弥漫性大B细胞淋巴瘤

报告1例大疱性类天疱疮并发原发性皮肤弥漫性大B细胞淋巴瘤.患者男,80岁.全身水肿性红斑伴水疱、大疱,诊断为大疱性类天疱疮.在发病7个月后,右胫前出现多个暗紫红色结节,逐渐增多、增大,并扩展至右股内侧和背部.皮损组织病理检查示真皮全层及皮下脂肪小叶弥漫致密的淋巴细胞浸润,可见多数淋巴细胞体积增大,形态不规则,核大深染,可见核分裂相.免疫组化染色:CD20( ),bcl-2( ),bcl-6( ).诊断:原发性皮肤弥漫性大B细胞淋巴瘤.在肿瘤出现后1个月,患者大疱性类天疱疮的病情出现反复,通过CHOP方案治疗,病情明显好转.     

A case of hemophagocytic syndrome associated with B-cell lymphoma

A rare case of hemophagocytic syndrome (HPS) associated with B-cell lymphoma is reported. A 38-year old female with dyspnea and fever developed a subcutaneous nodule with purpuric erythema on her right thigh and consulted our department on September 2, 1991. The histologic picture of this nodule revealed a dense infiltration of atypical lymphocytes into the dermis and subcutaneous tissue. A surface marker study of these atypical cells were CD22, CD74, and HLA-DR positive, indicating a B-cell origin for these cells. Normal histiocytes phagocyting erythrocytes were mixed with the infiltrating cells. The patient also had pericardial effusion, liver dysfunction, hepatosplenomegaly, and bleeding tendencies. The diagnosis was HPS associated with B-cell lymphoma. She died of DIC on November 8, 1991.     

Myxoid variant of primary cutaneous anaplastic large cell lymphoma: First 2 cases

Anaplastic large cell lymphoma (ALCL) is a CD30+ T‐cell non‐Hodgkin lymphoma with 2 main clinical presentations: primary cutaneous ALCL (pcALCL) and systemic ALCL (sALCL). While rare cases of myxoid sALCL have been reported, there are no previous cases of myxoid pcALCL reported. We present 2 unusual cases of pcALCL showing prominent collections of dermal mucin closely intermingling with the anaplastic lymphocytes. Patient 1 was a 30‐year‐old woman who presented with ulcerated nodules on her neck, abdomen, chest and shoulders. A systemic lymphoma was excluded by physical examination, positron emission tomography and computed tomography (PET‐CT) scan, as well as by bone marrow biopsy and flow cytometry studies. The patient was closely followed‐up for 10 months without evidence of systemic involvement. The biopsy showed diffuse infiltration of the dermis by a CD2+, CD30+, anaplastic lymphoma kinase (ALK)‐negative ALCL. Patient 2 was a 55‐year‐old woman who presented with a single nodule on her right arm. A systemic lymphoma was excluded by physical examination as well as by a PET‐CT scan. The biopsy showed diffuse and dense lymphoid infiltration of the whole biopsy by a CD3+, CD4+, CD30+, ALK‐negative ALCL. The atypical lymphocytes were intermingled with large amounts of dermal stromal mucin.     

Granulomatous slack skin: successful treatment with recombinant interferon-gamma

Granulomatous slack skin is a rare variant of indolent cutaneous lymphoma, characterized by a cutis laxa-like clinical appearance and widespread granulomatous infiltration. A 25-year-old man had suffered from slowly progressive infiltrative, scaly and atrophic plaques and flaccid nodules with deep induration in the axillae, trunk and thighs. Histopathologically, dense lymphoid cell infiltration with numerous multinucleated giant cells (MGC) throughout the dermis to the subcutaneous tissue was observed. T-cell receptor gene rearrangement was detected in the skin lesions. Granulomatous infiltration with MGC was found in enlarged lymph nodes and the liver. Acute exacerbation was successfully treated with systemic recombinant interferon-gamma.