皮下结节型环状肉芽肿

报告1例皮下结节型环状肉芽肿.患者男,26岁.因左上臂、腹部及下肢反复出现红斑、结节、溃疡4个月就诊.临床表现为左上臂内侧、左侧腹部及双小腿有暗红色结节和浸润性斑块,部分斑块上伴有溃疡,中心有脐凹状薄痂.左上臂内侧皮损组织病理检查示表皮突轻度向下延伸,真皮中下部可见纤维蛋白样变性,周围有由上皮样细胞、组织细胞、少量多核巨细胞和淋巴细胞组成的肉芽肿.     

结节型环状肉芽肿1例报告

环状肉芽肿(granulomas annulare)是发生于真皮或皮下组织以环状丘疹或结节性损害为特征的慢性皮肤病。临床上可分为:播散性、结节型、穿孔型等多种类型。结节型环状肉芽肿临床上少见,现将我科所见1例报道如下:1病历摘要患儿,男,2岁6个月,因“右手腕环形红斑1年余,结节2月余”于2006年8月到我院就诊。患儿右手腕部1年前无明显诱因出现红斑,初为绿豆大小,渐扩大成环状,为暗红色,无瘙痒,无疼痛,一直未行诊治。2月前皮损处出现结节,渐增大至黄豆大小。既往史:既往体健,无结核病史,无关节炎病史,无肝肾疾病,无外伤病史。体检:系统检查无阳性体征…     

皮下结节型环状肉芽肿

患者女，62岁。因全身结节、斑块、痒，半年就诊。 半年前无明显诱因，患者臀部、踝部、手、足背起红色丘疹、斑疹，逐渐增大融合，形成斑块、结节，轻痒。在当地医院曾多次按湿疹等治疗，皮损不见好转且渐增大。     

皮下型环状肉芽肿并发斑片型环状肉芽肿1例

皮下型环状肉芽肿(subcutaneous granuloma annulare,SGA)又称深在型环状肉芽肿、假性类风湿结节、渐进性坏死性环状肉芽肿、皮下型栅栏状肉芽肿[1],是一种自限性炎症性皮肤病,好发于儿童,临床少见,且易误诊,并发斑片型环状肉芽肿(patch-type granuloma annulare,PGA)更罕见,现报告我院诊治的1 例如下.     

儿童皮下型及丘疹型环状肉芽肿1例

患儿女,2岁3个月.因四肢结节、肿块3个月于2009年7月20日就诊.患儿3个月前右肘后出现一皮下结节,鹌鹑蛋大,无不适;1周后左侧肘后、左膝前出现1～3个丘疹,无瘙痒;2个月后右下肢出现一皮下结节,1个月内缓慢增大至核桃大;且双足背、足趾亦出现一二个小丘疹.均无痛痒.患儿系足月顺产,发病期饮食睡眠可,否认家族成员中有类似疾病患者.     

局限型环状肉芽肿一例

<正>临床资料患者,男,63岁。额头结节6个月。患者6个月前无明显诱因于额头部出现淡红色的丘疹,患者未重视,皮疹逐渐增大为结节,无水疱、破溃,自觉轻度瘙痒,无疼痛,未于院外诊治。患者既往体健,无高血压、冠心病、肝炎、结核等病史,无手术、药物过敏史,家族史中无类似疾病史。体格检查:一般     

播散型环状肉芽肿1例

播散型环状肉芽肿临床较少见，我们见到1例报道如下。     

2型糖尿病并发巨大型环状肉芽肿1例

患者男,66岁.因颈、胸部和手背斑疹6年加重1年,于2009年6月4日来上海市皮肤病性病医院门诊.6年前患者无明显诱因于颈部、双手背出现红斑.无自觉症状,随后红斑逐渐扩大,中间消退变平,边缘隆起.     

穿通性环状肉芽肿1例

临床资料 环状肉芽肿是以环状丘疹或结节性损害为特征的慢性皮肤病，病变主要发生于真皮和皮下组织，病理示灶状胶原变性和栅栏状肉芽肿形成。穿通性环状肉芽肿是环状肉芽肿中一种特殊类型，较少见。我科遇到1例报道如下。     

播散型环状肉芽肿1例

报告播散型环状肉芽肿1例。患者男,54岁。以全身皮肤弥漫性丘疹1年余就诊。全身对称分布环状排列的数个圆滑群集小丘疹,中央皮肤稍凹陷,圆形,米粒大小,孤立或者融合。皮损组织病理示:真皮浅层不规则胶原纤维变性,周围组织细胞和淋巴细胞浸润,呈栅栏状排列在变性胶原纤维周围。诊断:播散型环状肉芽肿。     

The ultrastructure of granuloma annulare

Summary Nine cases of granuloma annulare at different stages of development were investigated electron microscopically. Special attention was given to collagen changes, to the cellular infiltrate, and to vascular changes. The necrobiotic changes of the collagen were: loosening of the fibers at the borders of the bundles; swelling and loss of cross-striation of the fibrils; and complete degradation of the collagen, with precipitation of mucinous and fibrin material and of glycogen. In 2 cases cross-banded filamentous aggregations were present. In later stages new collagen synthesis occurred. In the infiltrate, histiocytes/macrophages were seen developing into epithelioid and giant cells. In addition, numerous active lymphocytes and, at later stages, some neutrophils were found. Vascular changes consisted of endothelial swelling and duplications of the basal lamina. A perivascular infiltrate was present, but no distinct vasculitis was seen. Our results indicate that the necrobiosis of the collagen without primary vasculitis may be an initial event in granuloma annulare. A delayed hypersensitivity mechanism is discussed with regard to pathogenesis.Fellow of the Alexander-von-Humboldt-Stiftung from Warsaw, Poland     

成人结节型和播散型环状肉芽肿并发1例

报道1例结节型和播散型环状肉芽肿并发。患者女，56岁，双膝有淡红色皮肤结节，双面颊、颈部、腕屈面以及两手（指）背和手掌散在分布许多丘疹和环状斑块20多天。结节的病理改变为真皮深层和皮下脂肪组织有栅栏状肉芽肿、胶原纤维变性和黏蛋白沉积，丘疹和环状斑块的病变位于真皮内。用氯喹和α－干扰素治疗5个多朋后皮疹消退。     

耳轮多发环状肉芽肿

报告1例耳轮多发环状肉芽肿。患者男,33岁。双侧耳轮小结节伴触痛3年。系统检查无异常。实验室和辅助检查均正常。皮损组织病理检查示真皮中下部栅栏状肉芽肿,中央胶原变性坏死,周围上皮样细胞和组织细胞浸润,阿新蓝染色阳性诊断:环状肉芽肿。治疗:给予复方倍他米松局部封闭注射治疗后皮疹消退。     

Concomitant occurrence of patch granuloma annulare and classical granuloma annulare

Granuloma annulare (GA) is characterized clinically as annularly-distributed, erythematous papules on the extremities in children and adolescents. GA is recognized histologically as palisading granulomas with central degenerated collagen and mucin deposits. Here, we present a case of concomitant occurrence of patch GA (PGA), the most rare type of GA, and classical GA in a patient. A 60-year-old man was referred to our hospital for asymptomatic eruptions on the upper arms, forearms, right flank and right lateral chest. Clinical examination revealed annular erythematous plaques composed of numerous small papules on bilateral upper arms and forearms. Moreover, an indurative, exudative erythematous to violaceous plaque was present on the right lateral chest and right flank. Histopathology of the former was compatible with palisade-type GA, and the latter interstitial-type GA. This is the first report of PGA concomitant with "classical" annular papular lesions.     

先天性白甲病1例报告

先天性白甲病１例报告朱淳①范志莘②白甲系指甲板呈点状、线状或全部变白，有多种疾病可引起部分或全部白甲。先天性白甲甚为少见，现报道１例。患儿男性，２岁６个月，回族。１９９５年８月其父母亲随同来院就诊，主诉患儿出生后全部指甲呈白色，４个月时白色更加明显，...     

A case of granuloma annulare and sarcoidosis

Granuloma annulare (GA) and sarcoidosis are two diseases of unknown causes with epithelioid cell granuloma formation. In this paper, we discuss a patient with manifestations of GA and both systemic and cutaneous sarcoidosis. We examined serum MIF and serum MAF to study the relationship between GA and sarcoidosis. Only the serum from a patient in the active stage of sarcoidosis had significant MIF activity. Additional significant MAF activity was found in the active stages of sarcoidosis and GA, especially the stage of developing GA. It may be characteristic that GA has a high potential MAF activity.     

Subcutaneous granuloma annulare induced by acetazolamide

A 9-year-old boy presented with recurring subcutaneous nodules on both legs and knees temporally related each time to acetazolamide treatment for idiopathic intracranial hypertension. A biopsy of one of the lesions revealed palisaded granulomas in the hypodermis around necrobiotic collagen and interstitial accumulation of mucin, compatible with subcutaneous granuloma annulare (SGA). To the best of our knowledge, this is the first case that establishes an association between SGA and acetazolamide.     

类似环状肉芽肿的面部皮肤型孢子丝菌病一例

患者,女,54岁.左面颊红斑、丘疹、结节1个月.皮肤科查体见左侧面部类似环状肉芽肿的簇集浸润性环状红色斑块.皮损组织病理检查及真菌培养,确诊为"面部皮肤型孢子丝菌病".给予伊曲康唑胶囊口服治疗3个月,皮损消退,随访6个月无复发.