Influencing factors on efficacy of summer acupoint application treatment for allergic rhinitis: a retrospective study

Objective

Allergic rhinitis (AR) is a common health problem. Summer acupoint application treatment (SAAT) is reported to effectively treat and prevent AR from seasonal onset. In the present study, we aimed to evaluate its effects, especially on the course of AR, through a retrospective study.

Method

A cross-sectional multicenter study was performed based on patients treated between 2008 and 2009 in 13 clinical centers in China. A total of 1058 outpatients aged ≥2 years with documented AR and ≥1 year SAAT were eligible for enrollment. A case report form (CRF) was completed by both patient and doctor. The CRF was designed to collect data on the patient's history of SAAT, AR condition, and self-reported health condition. The outcomes (dependent variables) were incidence and intensity of AR and concomitant medications used. Data were analyzed with ordinal logistic regression (OLR).

Results

Treatment course and seasonal pattern of AR were related to all dependent variables positively. After controlling for sample bias and confounding factors, the findings suggested that a 3-year treatment course had better efficacy (OR/incidence of AR: 2.57, 95% CI: 1.76–3.76; OR/intensity of AR: 2.17, 95%CI: 1.50–3.17; OR/concomitant medications: 2.20, 95% CI: 1.50–3.23) compared with a 2-year or less treatment course.

Conclusion

The results showed that: 1) the length of treatment course was positively associated with the efficacy of SAAT (the longer the treatment course, the better the efficacy); and 2) SAAT was more efficacious in treating seasonal AR than non-seasonal AR.     

过敏性鼻炎与中医体质的关系

过敏性鼻炎是临床常见病、多发病,近年来发病率有逐年增加的趋势。目前现代医学尚未发现根治的方法。中医体质影响过敏性鼻炎的发病、辨证、治疗、预后多个方面;从中医体质入手预防过敏性鼻炎既有必要性,也有可行性。体质是过敏性鼻炎发生的内在条件,决定正气的强弱,是过敏反应发生的关键因素。外因通过内因起作用,导致机体阴阳失衡而致病;体质影响人体对过敏原的反应程度,决定病情的轻重;体质影响证型,影响辨证的准确性;体质影响治疗的正确性;体质影响患者的预后。因此,从中医体质入手,对预防本病发生,控制其发展,选择准确治法,改善预后均有良好效果。     

鼻三针治疗过敏性鼻炎的方案优化实验研究

目的:探讨影响鼻三针治疗过敏性鼻炎的疗效之主要因素的最佳值,从而优化鼻三针治疗过敏性鼻炎的方案。方法:将造模后的豚鼠按照均匀设计的U63表分为6个试验组,每个试验组按照均匀设计方案进行治疗,然后利用均匀设计软件得出最佳组合的治疗方案。结果:作为鼻三针的特色疗法,药物注射和自血注射均对鼻三针治疗过敏性鼻炎的疗效影响较大,而留针过程的运针次数对疗效的影响则很小。结论:利用鼻三针进行针刺治疗后,加用穴位药物注射和自血注射,并取较长的疗程,可获得更佳疗效。     

Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis

Bu-zhong-yi-qi-tang, an ancient formula of Chinese medicine usually used in the treatment of allergic diseases, was evaluated in the treatment of patients with perennial allergic rhinitis. In this study, 60 patients allergic to house dust mite allergen confirmed by skin test and MAST test were recruited and randomized. An experimental group of 36 patients was treated with Bu-zhong-yi-qi-tang, whereas a control group of 24 patients was treated with a non-effective formula Ping-wei-san for 3 months. The nasal symptomatic scores and the responses of polymorphonuclear neutrophils (PMN) to IL-4-stimulation were measured after treatment. The nasal symptomatic scores in the experimental group were significantly improved (3.78+/-0.09 before treatment vs. 0.57+/-0.06 after treatment). In contrast, no change was found in symptomatic scores in the control group (3.17+/-0.12 before treatment vs. 2.79+/-0.14 after treatment). Moreover, total serum IgE and the IL-4-stimulated production of PGE(2) and LTC(4) by PMN was significantly suppressed in the experimental group after treatment compared to the control group. The COX-2 mRNA expression in IL-4-stimulated PMN was also significantly suppressed after Bu-zhong-yi-qi-tang treatment. These results suggest that Bu-zhong-yi-qi-tang but not Ping-wei-san was beneficial to the patients with perennial allergic rhinitis via suppressed nasal inflammation by an antiinflammatory effect.     

王士贞教授治疗鼻鼽经验介绍

王士贞为当代中医耳鼻咽喉科著名教授,本文阐述了中医鼻鼽病定义,分析了鼻鼽病寒热病因病机的历史沿革及相应的治疗方法,重点介绍了王士贞教授对岭南地区鼻鼽病的独到认识,及运用五指毛桃四君子汤及泻白散合辛夷清肺饮治疗鼻鼽的经验。     

中草药治疗过敏性鼻炎概况

过敏性疾病是常见病和多发病。概述近几年海内外名老中医经验和报道对中医治疗过敏性鼻炎-临床疗效,从而明确中草药治疗过敏性鼻炎的有效性和不足之处,完善中草药的临床和实验研究,为中草药治疗过敏性鼻炎的临床何实验研究逐步正规化、科学化、国际化发展提供了可循性依据。     

中药醒鼻凝胶滴剂治疗变应性鼻炎的药效学研究

目的:观察中药醒鼻凝胶滴剂对豚鼠变应性鼻炎(AR)的干预作用及与白三烯E4(LTE4)、免疫球蛋白E(IgE)的关系,探讨醒鼻凝胶滴剂干预治疗的可能机理,并为该药的临床应用提供药效学实验依据。方法:以卵清蛋白(OVA)+氢氧化铝基础致敏、局部以2%OVA激发复制豚鼠AR模型,实验豚鼠分为正常对照组(A组)、模型组(B组)和治疗组(C、D、E组),每组13只,C、D、E组分别予醒鼻凝胶滴剂Ⅰ号、醒鼻凝胶滴剂Ⅱ号及雷诺考特滴鼻给药治疗,A组及B组予生理盐水。每日3次,连续11天。比较各组豚鼠AR的行为学表现,测定血清中LTE4、IgE含量,观察鼻黏膜组织病理形态学和免疫学改变。结果:C、D、E组豚鼠的AR行为学评分明显减低(与B组比较P<0.01),血清中LTE4、IgE含量降低(与B组比较P<0.01),鼻黏膜嗜酸性粒细胞计数显著降低(与B组比较P<0.01),核因子-κB(NF-κB)免疫组化结果各组间比较无显著差异。结论:中药醒鼻凝胶滴剂治疗AR豚鼠有显著疗效,其作用机制是通过降低机体的LTE4、IgE含量及鼻黏膜的嗜酸性粒细胞等因素产生。     

过敏性鼻炎的中医特殊诊疗方法综述

本文通过对近年来中医治疗过敏性鼻炎的文献进行查阅,对以补肺、益肾、健脾为基本原则的内治法及以针法为主的外治法治疗变应性鼻炎进行阐述,并重点通过对相关文献的查询,得出上入穴循按、微量元素测定、大鱼际的掌纹形态及儿童目下黑特征等特殊诊断手段,同时通过自血疗法、热敏疗法、特殊针法、中医蜂疗、鼻周吸入式用药以及药食同源等特殊治疗方法,表明中医对过敏性鼻炎的诊疗并不局限于传统的内治法及外治法,而有更广阔的空间有待探求。     

中西医结合治疗变应性鼻炎临床疗效观察

目的:观察中西医联合治疗变应性鼻炎的疗效。方法:将变应性鼻炎患者180例随机分为中药方剂组、西药鼻喷雾剂组和中西医联合治疗组,每组60例。中药方剂组给予玉屏风散合苍耳子散,日1剂,口服,每日3次;西药组给予组胺H1受体拮抗剂鼻喷雾剂,每个鼻孔各2喷(每喷0.07ml,每喷含盐酸氮卓斯汀0.07mg),每日早、晚各1次;联合治疗组给予中药方剂和盐酸氮卓斯汀喷雾剂联合治疗,用法同上,均3周为1疗程。观察结果,并对治疗前后的症状和体征计分比较。结果:3组患者在治疗1疗程后,中西医联合治疗组显效率80%,明显高于中药复方制剂组的43%(P<0.05),西药鼻喷雾剂组的52%(P<0.05);无明显的不良反应。结论:采用中西医联合治疗变应性鼻炎,比单纯采用中药方剂或组胺H1受体拮抗剂治疗的临床效果更佳,安全有效,值得临床推广应用。     

Treatment of 48 cases of perennial allergic rhinitis with thunder-fire moxibustion

Perennial allergic rhinitis is an allergic reaction of the nasal mucosa.It is characterized by paroxysmal and repeated runny nose,sneeze,stuffy nose,rhinocnesmus and nasal mucosa edema.The author used "Doctor ZHAO's thunder-fire moxibustion" in treating 48 cases of this disease.Now it is reported as follows.     

应用针灸四步法治疗过敏性鼻炎疗效观察

目的：探讨应用针灸四步法治疗过敏性鼻炎的临床疗效。方法：将30例过敏性鼻炎患者应用针灸四步法采用针刺鼻三针、穴位注射（定喘、风门、肺腧）、中药包五子散（吴茱萸、莱菔子、白芥子、菟丝子、苏子）推烫头面部、颈后项部、背部、腹部等重要穴位、配合神阙穴温和灸治疗,1次／d,治疗7d为1个疗程。总计1个程结束后停药,随访半年以上。结果：痊愈11例,显效18例,有效1例,愈显率为96．67％,总有效率为100％。结论：应用针灸四步法治疗过敏性鼻炎有良好的临床疗效,且操作简便经济、疗程短见效快、针刺穴位少、患者痛苦小、不良反应少、便于医护人员操作,值得临床推广。     

针刺运动疗法治疗过敏性鼻炎疗效观察

目的：探讨针刺运动疗法治疗过敏性鼻炎的临床效果;方法：将40例过敏性鼻炎患者运用针刺运动疗法进行治疗,1次／天,治疗10天为一个疗程,每个疗程休息2天,3个疗程后结果：显效30例,占75％,好转10例,占25％,无效0例,总有效率100％。结论：运用针刺运动疗法治疗过敏性鼻炎疗程短,见效快,经济实惠,无副作用,值得临床推广。     

针刺治疗过敏性鼻炎研究概述

综述近五年针刺治疗过敏性鼻炎(Allergic Rhinitis,AR)的文献,发现针刺治疗包括单纯针刺法;局部取穴、局部+远端取穴、透刺;针刺配合药物;针刺蝶腭神经节。通过临床研究发现针刺治疗过敏鼻炎可以提高过敏性鼻炎患者近期及远期生活质量。对于针刺治疗过敏鼻炎的机制有待进一步研究。     

中医综合疗法治疗变应性鼻炎疗效观察

目的:探讨中医综合治疗变应性鼻炎的疗效。方法:将90例变应性鼻炎患者分为治疗组和对照组。治疗组45例,采用自拟中药方剂配合刺灸鼻通穴位治疗。对照组45例只采用口服自拟中药方剂治疗,进行两组疗效对比。结果:治疗组总有效率为93.33%,对照组总有效率为80%,经卡方检验,两组治疗总有效率有显著差异性(P0.05)。结论:自拟中药方剂配合刺灸鼻通穴治疗变应性鼻炎,效果满意,比单纯口服中药有优势。     

补中益气汤加减治疗变应性鼻炎23例的疗效观察

目的 观察补中益气汤加减治疗变应性鼻炎的临床疗效.方法 采用随机数字表法将46例变应性鼻炎患者随机分为两组各23例,治疗组采用补中益气汤加减治疗,对照组口服盐酸西替利嗪片治疗.疗程结束后观察两组患者总体疗效、临床症状消失时间、症状评分及环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)、IL-6、IL-8等指标的变化,并对...     

以督脉为主治疗过敏性鼻炎74例

过敏性鼻炎又称变应性鼻炎。以督脉为主治疗过敏性鼻炎取得了很好的效果,值得临床推广使用。     

A panel study to evaluate quality of life assessments in patients suffering from allergic rhinitis after treatment with a Chinese herbal nasal drop

Allergic rhinitis impairs quality of life (QOL). To assess the changes in QOL of patients with perennial allergic rhinitis (PAR) after treatment with Allergic Rhinitis Nose Drops (ARND), 35 patients were divided into 2 groups in a randomized, double‐blinded and placebo‐controlled study, with a cross‐over arrangement over 7 weeks, applying ARND or placebo. Group A (n = 20) started with ARND first for 2 weeks followed by a 3‐week washout before placebo for the last 2 weeks, while Group B (n = 15) started with placebo first and finished with ARND after washout. The changes in Clinical Symptoms Score (CSS) and QOL were observed. A decrease in CSS was observed in patients of both groups after treatment with ARND, but no change was observed with the placebo. Group A patients also showed significant improvements in complexion and sleep (P < 0.05 for both) after treatment with ARND, but no change with the placebo. Group B patients showed significant improvements in appetite and digestion (P < 0.01) as well as joy (P < 0.05) after cross‐over treatment with ARND, but no change with the placebo. ARND may have a therapeutic effect by relieving clinical symptoms and improving the QOL in patients with PAR. Copyright © 2009 John Wiley & Sons, Ltd.     

腹针治疗变应性鼻炎82例临床观察

目的：观察腹针引气归元法治疗变应性鼻炎82例。方法：采用腹针疗法治疗2周。结果：大部分患者经2个疗程治疗都取得了较好的疗效,82例患者中痊愈48例,占58.7%;有效29例,占35．6%;无效5例,占5.7%。总有效率为94.3%。结论：腹针治疗变应性鼻炎效果显著。     

三联疗法治疗过敏性鼻炎疗效观察

过敏性鼻炎是临床常见病之一,喷嚏、鼻痒、流涕和鼻塞是最常见的四大症状。多因接触花粉、尘土及冷空气等诱发,常引起头昏,头痛;憋气窒息等症状,严重影响日常生活和工作;且此病较易复发。笔者采用三联疗法治疗过敏性鼻炎,取得较满意疗效,报道如下。     

艾灸百会穴治疗小儿过敏性鼻炎的护理观察

目的：探讨艾灸百会穴治疗小儿过敏性鼻炎的临床疗效和护理配合。方法：将我科治疗的过敏性鼻炎患儿94例分成观察组和对照组,每组47例,均给予常规治疗,观察组联合艾灸百会穴治疗并配合穴位按摩迎香穴等中医特色护理操作干预,观察两组临床治疗效果。结果：观察组治疗的总有效率高于对照组,组间对比差异具有统计学意义（P〈0.05）。结论：对过敏性鼻炎患儿给予艾灸百会穴并配合穴位按摩迎香穴等中医特色护理操作能够提高治疗效果,值得在临床大力推广使用。