医院图书馆中西文图书数据库检索系统的开发与应用

根据我院临床医教研工作对图书数据的需求特点，我馆设置了以主题检索为主，分类检索和其它检索为辅，同时完成图书采购管理的中西文图书数据库检索系统。本文介绍了系统的开发与应用情况     

在ILAS系统中实现中文医学图书分类方法的探讨

ＩＬＡＳ（Ｉｎｔｅｇｒａｔｅｄ Ｌｉｂｒａｒｙ Ａｕｔｏｍａｔｉｏｎ Ｓｙｓｔｅｍ,图书馆自动化集成系统）系统不能进行中文图书的计算机分类,是有其多方面原因的。本文根据我馆多年从事计算机分类研究的体会,尝试着把在ＦｏｘＢＡＳＥ语言下开发的《医学图书分类编目》子系统,优化成为能在ＵＮＩＸ平台支持的ＦｏｘＰｒｏ环境下运行的《医学图书分类》模块,并成功地嵌入到了Ｉ－ＬＡＳ的《编目子系统》中。这种中文医学     

图书分类标引中对传记、史传小说、回忆录归类的认识

本文针对图书分类标引过程中出现人物传记、史传小说、回忆录类作品难以归类的现象,分析各自的含义、特点,以求作出正确的归类.     

慢性乙型、丙型肝炎遗传易感性研究进展

近年来随着分子生物学技术的进步 ,人们越来越注意到感染性疾病的发生及预后不仅与微生物本身的致病力有关 ,还与不同感染者个体的遗传因素密切相关。因此 ,有关感染性疾病遗传易感性的研究逐渐受到世人关注 ,其不仅有利于探索感染性疾病的发病机制 ,为患者预后提供依据 ,而且有利于开辟新的基因治疗途径、为解决感染性疾病慢性化的一些基本问题奠定理论基础。本文仅就慢性乙型、丙型肝炎的遗传易感性研究进展简要作一综述。     

介绍“新修订欧美淋巴瘤分类（1994）”

介绍＂新修订欧美淋巴瘤分类（１９９４）严庆汉关键词淋巴瘤，分类中国图书分类号Ｒ７３０．２６３自从７０年代中叶提出恶性淋巴瘤Ｋｉｅｌ分类和Ｌｕｋｅｓ＆Ｃｏｌｌｉｎｓ分类已有２０年。在此期间，由于免疫学和分子生物学技术的发展和广泛应用，以及相继报道了淋巴...     

抗病毒感染的固有免疫机制

病毒感染性疾病仍然是一个具有挑战性的全球健康问题.在人类传染病中,病毒感染性疾病高达60%～65%.虽然人类多年来的研究成果为预防、控制和治疗各类病毒感染性疾病做出了巨大的贡献,但是人类与病毒之间的战斗未有穷期,甚至有些已受控制的病毒感染性疾病可能卷土重来.已知机体抗病毒感染不仅依赖病毒特异性抗体的中和作用,更依赖于...     

肿瘤坏死因子基因多态性与感染性疾病

位于人类主要组织相容性复合体Ⅲ类基因区内的TNF基因具有多种多态性 ,这些多态性可从转录水平影响TNF的表达产量 ,并与个体对感染性疾病的易感性、发展、预后相关 ,探讨以TNF基因多态性为代表的免疫基因因素与感染性疾病的关系 ,不仅可以寻找判断预后的基因标志 ,还可以为感染性疾病的免疫基因治疗奠定基础。     

髓源性抑制细胞在感染性疾病中的作用北大核心

感染性疾病是指病原微生物感染人体后引起的疾病,常见的病原微生物主要包括病毒、细菌、真菌和寄生虫等。近年来,由于受易感人群递增、新病原微生物出现及细菌耐药性增加等多种因素影响,感染性疾病的治疗已陷入瓶颈,急需寻找新的更加高效低毒的治疗途径。而免疫因素在感染性疾病中扮演着重要角色,其在感染性疾病进程中的调控作用已被证明与感染性疾病的发生、发展密切相关。髓源性抑制细胞(myeloid-derived suppressor cell,MDSC)在机体的免疫机制中占据重要地位,是一种具有代表性的发挥免疫抑制作用的未成熟细胞,其在肿瘤免疫、自身免疫性疾病等方面的作用已被广泛证明,但在感染性疾病中研究甚少。该文系统总结MDSC在由各种病原微生物引起的感染性疾病中的研究进展及其作用机制,以期寻找以MDSC为调控靶点的治疗感染性疾病的新思路和新方法。     

晋城矿区与周围地区住院患儿呼吸道疾病情况分析

目的:分析晋城市不同地区儿童呼吸道感染性疾病的患病情况及原因,以进一步做好该地区儿童呼吸道感染性疾病的预防、保健、治疗工作.方法:收集2005年~2010年在晋煤总医院住院的呼吸道感染性疾病患儿2085例的病案资料,根据资料对矿区与周围地区呼吸道感染性疾病的患病情况进行统计和分析.结果:不同地区患儿大叶性肺炎构成比差异无统计学意义(P>0.05);矿区患儿上呼吸道感染和支气管炎的构成比高于周围地区(P<0.05);而支气管肺炎构成比矿区低于周围地区(P<0.05).结论:不同地区儿童呼吸道感染性疾病与矿区的环境污染有密切的关系,提示我们在今后的工作中更应重视环境污染问题,提高空气质量以降低儿童呼吸道感染性疾病的发生.     

喹酮酸类药物的临床应用进展

喹酮酸类(Quinolones)药物于1962年问世,近10年起发展迅速,成为抗菌药物中引人注目的一类,目前应用于临床的品种日益增多,在感染性疾病的治疗中起着重要的作用。氟喹酮酸类药物的崛起是使喹酮酸类迅速发展的主要原因,氟喹酮酸类具有广谱、     

Level of functioning of siblings and parents of probands of varying degrees of retardation

A further analysis of already published data supports the position that retardates of low ability level less frequently have retarded siblings, retarded parents, and parents low in occupational level than do retardates higher in ability level. The analysis supports the position that there are two types of retarded individuals, persons retarded as a result of gene or chromosomal anomalies, brain injury, etc., who more frequently occur in the lower-level retardate group, and persons whose retardation represents polygenic segregation, who more frequently occur in the higher-level group.     

Modes of Inheritance of Errors of Refraction

Eighteen families in which both parents had refractions within the range of +4·0 D to −4·0 D and axial lengths seen in emmetropia (22·3-26·0 mm) showed coefficients of correlation of the order 0·5 indicative of polygenic inheritance. Such coefficients were seen for axial length (0·407) and for the cornea (0·487), but not for the lens (which is known to be yoked to the axial length). No such coefficients were seen in 19 families in which one of the parents had axial length outside the emmetropic range (nine families with long axes and 10 with short axes).

The pattern of polygenic inheritance for emmetropia (completely correlated optical components) and errors of refraction up to 4·0 D (inadequately correlated components: correlation ametropia) follows that seen in stature and other measurable characters. In contrast the high refractive errors with their abnormal axial lengths (component ametropia) are—like the extremes in stature—pathological anomalies with monofactorial inheritance.

     

Aspects of the problem of direct introduction of Standards of International Organizations

Editorial note. This article is published as part of a discussion. Particular issues of the article are disputable. First of all, this concerns the so-called “folder” method of introduction of international standards for medical devices to domestic medical practice (i.e., by direct translation of the standards and their publication as standardizing documents). Nevertheless, at least one of the problems, the problem of coordination between domestic state standards for medical devices and international recommendations of ISO and IEC, is undoubtedly of topical importance. Advancement of new health service legislation which is to be approved by law-makers will definitely introduce corrections into the present situation. The Editorial Board of Meditsinskaya Tekhnika believes this article will lessen these problems and to be welcomed by readers.