Pleural mesothelioma and exposure to asbestos: evaluation from work histories and analysis of asbestos bodies in bronchoalveolar lavage fluid or lung tissue in 131 patients.

Exposure to asbestos was evaluated in 131 patients with pleural malignant mesothelioma in the Paris area between 1986 and 1992 using data from a detailed specific questionnaire and light microscopy analysis of the retention of asbestos bodies in bronchoalveolar lavage fluid or lung tissue. Probable or definite exposure to significant levels of asbestos dust was identified in only 48 (36.6%) subjects, and significant asbestos body counts (above 1 asbestos body/ml in bronchoalveolar lavage fluid or 1000 asbestos bodies/g of dry lung tissue) were found in only 45 (34.3%) subjects. Overall 50 subjects had experienced exposure to only low levels of asbestos or no exposure at all and showed no significant retention of asbestos bodies in the biological sample analysed. Previous studies have shown that light microscopy may be useful in the identification of subjects with previous exposure to asbestos. In this study, apart from cases with obvious exposure to asbestos, a large group of subjects seemed to have a history of exposure or lung retention of asbestos bodies suggestive of very low levels of cumulative exposure, similar to those described in the general population.     

Breastfeeding works: the role of employers in supporting women who wish to breastfeed and work in four organizations in England

An important factor influencing duration of breastfeeding is mother's employment status. The main aim of this study was to determine the experience and views of employees (n = 46) in four large public sector organizations concerning breastfeeding support at work. Participants were recruited if they were employed by one of four public service employers and if they were planning to go on maternity leave in the next 6 months, on maternity leave or within 6 months of return from maternity leave. They completed a questionnaire anonymously. Almost 80% of women wanted to continue breastfeeding after returning to work. However, 90% of all respondents were not aware of any employer policy nor offered any information concerning support to enable breastfeeding after returning to work, despite two organizations having a range of maternity- and breastfeeding-related policies in development and some facilities in place. Almost 90% of respondents stated the employers should do more to support breastfeeding. This should include providing pregnant staff with information about breastfeeding support that they should expect and could therefore plan to use, including access to facilities to express and to store breast milk, to enable them to work flexible hours and to take rest breaks during working hours. Recommendations are made for employers.     

Environmental exposure to asbestos in the area around Goor has been established as the cause of pleural mesothelioma in women

OBJECTIVE: To determine whether a disease cluster of 22 additional cases of pleural mesothelioma among women could be attributed to environmental asbestos exposure due to asbestos fibers from waste material on roads and property yards. The women studied were observed in an area with substantial environmental exposure to asbestos during the period 1989-2002. DESIGN: Ecological study. METHOD: In the study period of 1989-2002, all cases of mesothelioma among women, based on a strict histopathologic definition, occurring in the region of Twente, The Netherlands (n = 59) were provided by the regional cancer register. Additional information was collected on the occupational histories of the cases and their partners and addresses of residence through medical records, general practitioners, and next-of-kin. Environmental asbestos exposure was assigned to all cases that had had a long-term stay in a house in the area around Goor with demonstrated local environmental asbestos pollution and where any contact with asbestos through occupation or in the household had been excluded. RESULTS: In the risk area around Goor, out ofa total of 28 cases ofwomen with pleural mesothelioma, asbestos in the environment was found to be the only source of asbestos exposure for to women. In a further 4 women, environmental asbestos exposure was found to be the most likely cause of pleural mesothelioma. The average cumulative exposure was around 0.11 fiber/ml x exposure years. The observed extra incidence of 22 cases was attributed to the environmental exposure to asbestos in 64% (14/22) of cases. CONCLUSION: The environmental pollution to asbestos waste materials in the area around Goor was the main cause of the strongly increased incidence of pleural mesothelioma among women in this area. Taking into account an equal risk among men, the consequences of asbestos exposure in the area around Goor in the next 25 years are likely to result in 2 cases of pleural mesothelioma each year.     

Pleural mesothelioma and environmental exposure to mineral fibres: the case of a rural area in the Basilicata region, Italy

The main aspects of the sites characterized by environmental exposure to mineral asbestiform fibres are described. Several adverse health effects including high incidence of pleural mesothelioma are reported. The average concentration of airborne fibres is generally low but it rises significantly in association with mechanical disturb of materials with fibres. Multiple sources of exposure have been identified, fibres can be found in the soil and in many materials locally used, mainly in buildings. Three mesothelioma cases were observed in a small rural area of the Basilicata region (Italy). Two of them had a possible occupational exposure to asbestos, the third had a proved environmental exposure to tremolite. This fibre, found in the area, is the same observed in two of the three biological samples analysed.     

挡车女工听力与视力的职业危害

纺织行业挡车女工长期受到噪声、棉尘、湿热等多种职业危害。本文重点对噪声危害和精细作业引起挡车女工的视力减退进行了调查 ,结果报道如下。1　对象与方法1.1　布机挡车工 140名 ,均为女性 ,年龄 19岁～ 4 8岁 ,平均 32 .5岁 ;工龄 3年～ 2 5年 ,平均 11.4年。选择同行业从事其他工作 ,年龄和工龄与此相匹配的 16 7名女工作对照。1.2　使用ＮＤ2 精密声级计和ＳＴ— 80型数字式照度计测定噪声和照度 (仪器经国家计量院校准 ) ,噪声和照度监测采用网格式布点。1.3　用丹麦产ＡＳ— 72型听力计检查双耳听力 ,每耳查 50 0、1Ｋ、2ＫＨＺ三个…     

Self-reported work ability of Norwegian women in relation to physical and mental health,and to the work environment

Objectives  

To examine the self-reported level of work ability among female employees and the relationship between work ability and demographic characteristics, physical health, mental health, and various psychosocial and organizational work environment factors.     

Sexual dysfunction in women who were molested as children: one response pattern and suggestions for treatment

A common pattern of women who were sexually molested as children and seek treatment for sexual dysfunction is described. The arousal, rather than the orgasmic, component is involved. The reasons for the evolution of this particular dysfunction are discussed. Treatment should extend the period of sensate focus and address the issues of the woman's anger, her need for control, and her guilt. Excellent results can be achieved in helping the patient to experience physical intimacy and the pleasure of sexual arousal.     

Health and psychosocial work characteristics of employees who did or did not consult the general practitioner in relation to work

OBJECTIVES: To examine how health problems and psychosocial work characteristics are associated with having visited or not having visited the general practitioner (GP) in relation to work. METHODS: Baseline self-reported data of the Maastricht Cohort Study about fatigue at work were used to gather information about fatigue (Checklist Individual Strength), presence of at least one long-term disease, likelihood of having a mental illness (General Health Questionnaire), and psychosocial work characteristics (psychological job demands, decision latitude and social support at work, as measured with the Job Content Questionnaire). The cohort participants indicated having visited (VISITORS) or not having visited (NON-VISITORS) the GP in relation to work. Differences between these groups were measured by multiple logistic regression analyses. RESULTS: When compared with VISITORS and taking into account the influence of sociodemographic characteristics and mutual associations between reported health problems and psychosocial work characteristics, a lower percentage of NON-VISITORS reported at least one long-term disease and NON-VISITORS presented lower levels of fatigue and psychological job demands, and higher levels of decision latitude and social support at work. CONCLUSIONS: The results of this study indicate that NON-VISITORS reported fewer health problems and a more positive perception of their work environment than VISITORS did. Interrelationships between psychosocial work characteristics and health variables should be taken into consideration when studying their associations with visiting the GP in relation to work.     

Health problems and psychosocial work environment as predictors of long term sickness absence in employees who visited the occupational physician and/or general practitioner in relation to work: a prospective study

Aims: To determine whether psychosocial work environment and indicators of health problems are prospectively related to incident long term sickness absence in employees who visited the occupational physician (OP) and/or general practitioner (GP) in relation to work.

Methods: The baseline measurement (May 1998) of the Maastricht Cohort Study, a prospective cohort study among 45 companies and organisations, was used to select employees at work who indicated having visited the OP and/or GP in relation to work. Self report questionnaires were used to measure indicators of health problems (presence of at least one long term disease, likeliness of having a mental illness, fatigue) and psychosocial work environment (job demands, decision latitude, social support, job satisfaction) as predictors of subsequent sickness absence. Sickness absence data regarding total numbers of sickness absence days were obtained from the companies and occupational health services during an 18 month period (between 1 July 1998 and 31 December 1999). Complete data were available from 1271 employees.

Results: After adjustment for demographics and the other predictors, presence of at least one long term disease (OR 2.36; 95% CI 1.29 to 4.29) and lower level of decision latitude (OR 1.69; 95% CI 1.22 to 2.38) were the strongest predictors for sickness absence of at least one month. A higher likelihood of having a mental illness, a higher level of fatigue, a lower level of social support at work, and low job satisfaction were also significant predictors for long term sickness absence, but their effect was less strong.

Conclusion: In detecting employees at work but at risk for long term sickness absence, OPs and GPs should take into account not only influence of the psychosocial work environment in general and level of decision latitude in particular, but also influence of indicators of health problems, especially in the form of long term diseases.

     

A rodent model of protein turnover used to design an experiment for measuring the rates of channeling, recycling and protein synthesis

We described previously a mechanistic model of whole-body protein turnover in rodents. Channeling was defined as the flow of amino acids from the extracellular compartment to aminoacyl tRNA and protein synthesis. Recycling was defined as the flow of amino acids from protein degradation to aminoacyl tRNA (protein synthesis) without mixing with the intracellular pool of amino acids. In this paper, the model is applied to tissues and whole body and is used to develop an experimental protocol for estimating protein fractional synthesis rate, recycling and channeling. Channeling, recycling and protein synthesis must be estimated simultaneously because changes in specific radioactivities over time are highly dependent on the rate of protein synthesis. Injection-specific radioactivities, body weights and experimental variation were used with the model to generate data at different rates of recycling and channeling. The data generated were then used to determine the best time points and experimental method to estimate percentages of recycling, channeling and protein synthesis rate by the iterative Method of Maximum Likelihood. Specific radioactivity at each time point was based on simulated data from three rodents at each of six time points. Predicted protein synthesis rates were within 5%/d of observed rates for all methods. Predicted rates of recycling and channeling were generally within 15% of observed rates except recycling in muscle at high channeling and high recycling. Standard deviations of the predictions of percentages of channeling and recycling were between 0.148 and 44.5% for the pulse dose method, 0.0655 and 197% for the continuous infusion method and 0.351 and 962% for the flooding dose method. The experimental design that yields the best estimates of channeling, recycling and protein synthesis is the pulse dose. Changes in amino acid specific radioactivities in the extracellular, aminoacyl tRNA and protein pools were greatest and should be measured at 2, 6, 10, 40, 70 and 100 min in the pulse method.     

农村孕产妇及儿童非典型肺炎防治工作的思考

非典型肺炎是一场突如其来的重大灾害 ,它的流行对妇幼保健工作提出了新的挑战。根据流行病学规律与经验 ,任何一种传染病的流行 ,作为易感染者的孕产妇和儿童尤其需要重点保护。阜宁县 4月下旬发生 1例输入性非典型肺炎临床诊断病例以来 ,积极采取有效措施 ,疫情在全县无蔓延     

Primary osteoarthrosis of the knee in men and women as a result of lifelong physical load from work

OBJECTIVES: This study investigated the effect of lifelong physical load from work on the development of knee osteoarthrosis (OA) leading to prosthetic surgery among men and women. METHODS: In a population-based case-referent study, men and women (N=625) who had had prosthetic surgery due to primary tibiofemoral OA were compared with referents (N=548) as to job titles and exposure to physical load in occupational work, housework, and leisure-time activities from 15 to 50 years of age. RESULTS: Male forestry and construction workers, and both male and female farmers ran the highest risk of knee OA. The men had considerably higher exposure to lifting at work, and also to jumps and vibration, than the women. Among the men there was an association between lifting at work [odds ratio (OR) 3.0, 95% confidence interval (95% CI) 1.6-5.5], squatting or knee bending (OR 2.9, 95% CI 1.7-4.9), kneeling (OR 2.1, 95% CI 1.4-3.3), and jumping (OR 2.7, 95% CI 1.7-4.1) with knee OA. Exposure to physically demanding tasks at home, such as taking care of an elderly or handicapped person, was associated with knee OA among the women (OR 2.2, 95% CI 1.3-3.6). CONCLUSIONS: Working as a farmer or as a construction worker could be associated with the development of knee OA and lead to prosthetic surgery. Men and women differ in the quality and quantity of reported physical load and also in the strength of the risk estimates. A reduction of high physical load at work and at home could probably lower the risk of knee OA later in life.     

Changes in daily occupations and the meaning of work for three women caring for relatives post-stroke

Abstract

Study aim: This qualitative study explored how some working Austrians experienced and coped with changes in their daily occupations after becoming informal carers of persons who had had a stroke. The study provides insights into the working carers' occupational experiences and strategies during a period of pronounced life changes. Methods: Three participants, who were employed in full- or part-time work, as well as being informal carers of persons who had had a stroke, were interviewed on two occasions. The data from these interviews were analysed using Interpretative Phenomenological Analyses. Results: Carers found themselves in an ongoing process, ranging from the disruption of daily occupations to their eventual restructure. First, the stroke led to involuntary changes in the carers' daily life, which resulted in challenges in their own, and in shared, occupations. Second, carers actively changed their values and performance of occupations, which appeared to be a strategy to shape their well-being. Paid work was found to be a stabilizing and balancing occupation, which contributed to coping and the well-being of carers. Conclusions: The authors' findings demonstrate the benefits of paid work and engagement in meaningful occupation for the carers' well-being. These results should encourage occupational therapists to be sensitive to the complexity of the lives of working informal carers.     

Profile of nurses who work in the care of pregnant,parturient, and puerperal women at institutions in Sorocaba/SP (1999)

This study aimed at verifying the institutions where pregnant, parturient and puerperal women were given care. It also aimed at identifying the nurses who participate in such caregiving, the activities performed and the problems faced by them and their level of satisfaction at work. Seventy-four nurses were interviewed in the 35 institutions found in Sorocaba, of whom 27% were specialists and 28% were qualified obstetricians. The others had not been trained in that area. The major problems reported were the lack of skills to perform prenatal nursing consultations, shortage of staff and materials and the accumulation of. Seventy-three percent of the interviewees reported to be satisfied in relation to their jobs.