Comparison of laparoendoscopic single-site versus conventional multiple-port laparoscopic herniorrhaphy: a systemic review and meta-analysis

Purpose

We systemically reviewed published literatures and performed meta-analysis to compare the surgical outcomes between laparoendoscopic single-site over the multiple-port total extraperitoneal approach in hernia repair.

Methods

We did a systemic search of PubMed^® and Cochrane review for all randomized controlled trials and comparative trials that compared the efficacy and safety between LESS-TEP and MP-TEP. The evaluated outcomes included perioperative parameters (operative time, conversion rate), hospital stay and complications (seroma, delayed return of bladder function, postoperative pain and recurrence). The Cochrane Collaboration Review Manager software (RevMan^®, version 5.2.6) was used for statistical analysis.

Results

There were 10 trials met the inclusion criteria and included for meta-analysis. Totally, there were 595 and 514 patients underwent LESS-TEP and MP-TEP, respectively. The LESS-TEP took significantly longer-operative time than the MP-TEP in unilateral hernia repair (weighted mean difference (WMD) 4.11 min, 95 % CI 0.76–7.46, p = 0.02) while not in bilateral hernia repair (WMD 3.87 min, 95 % of CI ?2.59–10.33, z = 1.17, p = 0.24). There were no significant differences in surgical outcomes with regard to postoperative pain scale, conversion rate, hospital stay, recurrence rate and complication rate between two groups. The length of the sub-umbilical wound was the same in both groups. The result of cosmesis was not compared because of the limited data.

Conclusion

In experienced hands, LESS-TEP is a feasible alternative to MP-TEP with comparable surgical efficacy and morbidity, but with longer operation time in unilateral hernia repair. Potential advantages of LESS-TEP including better cosmesis, less postoperative pain and less trocar-associated complications were not clearly shown.

     

Transgastric endoscopic pneumoperitoneum versus laparoscopy: effects on host systemic and peritoneal inflammatory responses in a porcine model

Background  

The host systemic and peritoneal immune responses during natural orifice transluminal endoscopic surgery (NOTES) continues to be delineated. The immune response to laparoscopy (LAP) has been favorably depicted. However, the immunologic effects of NOTES are yet to be determined, and the introduction of contaminants via the host orificium may have deleterious effects. The purpose of this study was to characterize the effect that NOTES would have on porcine systemic and peritoneal immune function.     

小儿经脐单孔腹腔镜下肾盂成形术的初步经验

目的 探讨经脐单孔腹腔镜(LESS)下手术治疗小儿肾盂输尿管连接处梗阻的手术技巧和临床应用价值. 方法 2010年6-12月对24例肾盂输尿管连接处梗阻患儿行经脐LESS下离断式肾盂成形术.男16例,女8例.年龄2～62个月,平均14个月.左侧18例,右侧6例.腔镜下用5-0可吸收线行离断式肾盂输尿管吻合,经吻合口顺行放置双J管.手术均由同一医师完成.结果 24例手术均获成功,无中转开放手术,脐孔外无添加鞘管或切口,术中无并发症发生.术中发现异位血管2例.手术时间70 ～ 300 min,平均145 min;出血量5～20 ml,平均10 ml;术后腹腔引流管引流2～9 d;术后住院时间6～10 d,平均7d.术后发一尿漏2例,分别于术后第4、7天停止.采用超声和利尿性肾核素扫描检查进行随访,随访时间3 ～12个月,平均6个月.术后肾盂直径明显减少23例,肾盂直径减少不明显1例,但分肾肾小球滤过率由术前29 ml/min增至术后6个月46mL/min. 结论 小儿经脐LESS肾盂输尿管成形术安全有效,患儿美观效果满意.     

Transgastric pure-NOTES peritoneoscopy and endoscopic ultrasonography for staging of gastrointestinal cancers: a survival and feasibility study

Background

Human natural orifice transluminal endoscopic surgery (NOTES) has mainly been based on simultaneous laparoscopic assistance (hybrid NOTES), forgoing the theoretical benefits of the NOTES technique. This is due to a lack of NOTES-specific instruments and endoscopes, making pure-NOTES procedures difficult and time consuming. An area where pure NOTES could be adopted at its present stage of development is minimally invasive staging of gastrointestinal (GI) cancer. The aim of this study is to evaluate the feasibility of combining transgastric (TG) pure-NOTES peritoneoscopy and intraperitoneal endoscopic ultrasonography (ip-EUS) with intraluminal EUS (il-EUS) for peritoneal evaluation.

Methods

This was a feasibility and survival study where il-EUS followed by ip-EUS and peritoneoscopy was performed in 10 pigs subjected to TG pure NOTES. A score was given with regard to achieved visualisation of predefined anatomical structures. Survival was assessed at postoperative day (POD) 14.

Results

All animals survived until POD 14. Median total procedural time was 94?min (range 74–130?min). Median time for il-EUS, ip-EUS and peritoneoscopy was 11?min (range 7–14?min), 13?min (range 8–20?min) and 10?min (range 6–23?min). Il-EUS, ip-EUS and peritoneoscopy resulted in a score of 15/15 points (range 14–15 points), 6/9 points (range 1–8 points) and 12/13 points (range 8–13 points).

Conclusions

TG pure-NOTES peritoneoscopy and ip-EUS combined with il-EUS is feasible and provides sufficient peritoneal evaluation. The technique could have potential for minimally invasive staging of GI cancers.     

Bladder wall injection of mesenchymal stem cells ameliorates bladder inflammation,overactivity, and nociception in a chemically induced interstitial cystitis-like rat model

Introduction and hypothesis

We investigated the effects of bladder wall injection of mesenchymal stem cells (MSCs) on bladder tissues, function, and nociceptive behavior in a chemically induced interstitial cystitis-like rat model.

Methods

Chemical cystitis of female rats was induced by intravesical instillation of 0.1 N hydrochloride (HCl) once a week for 2 weeks. Bladders were harvested 1, 2, 3, and 4 weeks after the second application for histological examination. Adipose-derived MSCs (HCl?+?MSCs) or phosphate-buffered saline (HCl?+?PBS) was injected into the bladder wall at the time of the second application of HCl. Histological examination, nociceptive behavior, and cystometrograms were evaluated 2 weeks after the injection compared with controls, which received instillation and injection of PBS into the bladder (sham + PBS).

Results

The number of mast cells and expression of tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β) were significantly increased at 1 and 2 weeks, and expression of collagen fibers was significantly increased from 2–4 weeks after the second application of HCl. Significantly increased nociceptive behavior, number of mast cells, expression of TNF-α, TGF-β, and collagen fibers were observed in HCl?+?PBS compared with sham?+?PBS, whereas these changes were significantly decreased in HCl?+?MSCs compared with HCl?+?PBS. In addition, bladder capacity and voiding threshold pressures were significantly decreased in HCl?+?PBS but not in HCl?+?MSCs compared with sham?+?PBS.

Conclusions

The results suggest that bladder injection of MSCs ameliorates inflammation and fibrosis in bladder tissues, bladder overactivity, and nociception in a rat model of chemically induced cystitis.

     

55例单切口泌尿系腹腔镜手术回顾分析

目的:总结单切口腹腔镜泌尿外科手术的手术经验与体会,探讨单切口腹腔镜手术在泌尿外科的应用价值。方法:回顾分析2009年6月至2011年10月为55例患者行单切口腹腔镜手术的临床资料,其中前列腺癌根治术10例,肾部分切除术6例,肾上腺切除术20例,肾盂成形术3例,输尿管切开取石术9例,输尿管膀胱再植术3例,肾囊肿去顶减压术4例。结果:55例手术均获成功,无一例中转开放或中转普通腹腔镜手术。手术时间68～320 min,平均(105±38)min;出血量10～120 ml,平均(60±35)ml,无输血病例;平均住院(6.1±2.4)d,术后随访1～24个月,无肾脏萎缩及肿瘤局部复发、远处转移征象。结论:单切口腹腔镜手术安全、可行,具有微创、美观等优点,但操作难度较传统腹腔镜手术增加,应谨慎把握手术适应证,术者具备扎实的普通腹腔镜操作技术方可开展。     

经后腹膜腔单孔腹腔镜下肾上腺切除术的可行性和安全性研究

目的 探讨应用经后腹膜腔单孔腹腔镜下肾上腺切除术的可行性和安全性. 方法 2009年10月至2012年1月应用单孔4通道技术,经后腹膜腔途径进行肾上腺切除术7例.患者年龄39 ～55岁,平均46岁.肿瘤最大径1.8 ～3.6 cm,平均2.3 cm.术中应用标准腹腔镜器械和5 mm头端可弯腹腔镜.记录患者手术时间、术中出血量、术中并发症、留置引流管时间、术后视觉模拟疼痛量表(visual analog pain scale,VAPS)评分、术后住院时间、术后病理等临床资料,并对结果进行分析.结果7例手术均顺利,无中转标准腹腔镜或开放手术者,无另加腹腔镜手术操作通道者.手术时间70～180 min,平均106 min;术中出血量5～200 ml,平均59 ml.术后第一天VAPS评分1～3分,平均2分;引流管留置时间2～3d,平均2d;术后住院时间3～6d,平均5d.无围手术期并发症.术后病理:肾上腺皮质腺瘤5例,肾上腺嗜铬细胞瘤1例,肾上腺囊肿1例. 结论 经后腹膜腔单孔腹腔镜下肾上腺切除术具有良好的临床可行性和安全性.     

经脐单孔腹腔镜在不同类型全子宫切除术应用

目的探讨分析经脐单孔腹腔镜手术(laparoendoscopic single-site surgery,LESS)技术应用于全子宫切除术的安全性,并根据子宫大小、是否合并盆腔粘连分成单纯型和复杂型全子宫切除术绘制其学习曲线。 方法回顾性分析东南大学附属中大医院2017年3月至2019年11月的80例LESS全子宫切除术的临床资料,均由同一位熟练掌握妇科标准腹腔镜技术的术者施行。定义术中探查子宫大小如孕周数≤8周、无盆腔粘连者为单纯型全子宫切除术,子宫大小如孕周数>8周、合并盆腔粘连者定义为复杂型全子宫切除术。结合手术例数和手术时间绘制2组学习曲线。 结果80例手术全部顺利完成,无术中并发症发生,无术中更改手术方式。所有病例术后随访暂未发现切口感染、脐疝等术后并发症。观察2组学习曲线,单纯型全子宫切除术经过约20例后,手术时间渐趋平稳;复杂型全子宫切除术经过约26例后,手术时间渐趋平稳。 结论LESS在全子宫切除术中是安全、可行的,单纯型和复杂型全子宫切除术的学习曲线分别为20例和26例。     

Feasibility and safety of retroperitoneal laparoendoscopic single-site dismembered pyeloplasty: a clinical report of 10 cases

Abstract Objective: To retrospectively review our experience with respect to evaluating the feasibility and safety of laparoendoscopic single-site (LESS) dismembered pyeloplasty for ureteropelvic junction obstruction (UPJO) through a retroperitoneal approach. Patients and Methods: Between March 2011 and January 2012, 10 consecutive patients underwent LESS retroperitoneoscopic dismembered pyeloplasty performed by one experienced laparoscopic surgeon at our institution. A single-port access was inserted through a 2.5-cm transverse skin incision below the 12th rib along the midaxillary line. Standard steps of the multisite retroperitoneoscopic Anderson-Hynes dismembered pyeloplasty technique using conventional instruments or a combination of conventional and bent laparoscopic instruments were performed. Follow-up studies were conducted by intravenous urography (IVU), diuretic renal scan, and renal ultrasonography. Results: LESS retroperitoneoscopic dismembered pyeloplasty was successful in 9 patients, whereas 1 required four-port retroperitoneoscopic conversion because of difficulties in remaining in the retroperitoneal space due to a peritoneal tear during the procedure. The mean operative time was 148.4 minutes (range, 103-210 minutes). The mean estimated blood loss was 31?mL (range, 10-70?mL), and the mean postoperative hospital stay was 5.7 days (range, 3-13 days). Intraoperative complications were limited to the one case of peritoneal tear. An aberrant crossing vessel was noted in 4 patients, and transposition was not required in these patients. Urine leakage occurred in 1 patient postoperatively and was successfully treated by conservative management. The mean follow-up period was 6.2 months (range, 5-10 months). Satisfactory drainage with decreased hydronephrosis on IVU, diuretic renal scan, and renal ultrasonography was observed in all cases at the 3-month imaging studies. Conclusions: In experienced hands, LESS retroperitoneoscopic dismembered pyeloplasty is a feasible and safe alternative for correcting UPJO, although it remains technically challenging. The long-term outcome awaits further studies.     

Comparison of robotic and laparoendoscopic single-site surgery systems in a suturing and knot tying task

Background

Laparoendoscopic single-site (LESS) surgery has been established for various procedures. Shortcomings of LESS surgery include loss of triangulation, instrument collisions, and poor ergonomics, making advanced laparoscopic tasks especially challenging. We compared a LESS system with a robotic single-site surgery platform in performance of a suturing and knot-tying task under clinically simulated conditions.

Methods

Each of five volunteer minimally invasive surgeons was tasked with suturing a 5 cm longitudinal enterotomy in porcine small intestine with square knots at either end, using a laparoendoscopic or da Vinci robotic single-site surgery platform, within a 20 min time limit. A saline leak test was then performed. Each surgeon performed the task twice using each system. The time to completion of the task and presence of a leak were noted. Fisher’s exact test was used to compare the overall completion rate within the defined time limit, and a Wilcoxon rank test was used to compare the specific times to complete the task. A p value of <0.05 was considered significant.

Results

All surgeons were able to complete the task on the first try within 20 min using the robot system; 60 % of surgeons were able to complete it after two attempts using the LESS surgery system. Time to completion using the robot system was significantly shorter than the time using the standard LESS system (p < 0.0001). There were no leaks after closure with the robot system; the leak rate following the standard LESS system was 90 %.

Conclusions

Surgeons demonstrated significantly better suturing and knot-tying capabilities using the robot single-site system compared to a standard LESS system. The robotic system has the potential to expand single-site surgery to more complex tasks.     

Total laparoendoscopic single-site surgery (LESS) hysterectomy in low-risk early endometrial cancer: a pilot study

Background  

In the last few years, technical advances have produced a dramatic shift from traditional open surgery toward a minimally invasive approach, even in oncological procedures. We present our initial experience with laparoendoscopic single-site surgery (LESS) in the surgical treatment of early-stage endometrial cancer patients.