Differences between self-referred and physician-referred hospital admissions

Aim  

Compare self- and physician-referred hospital admissions.     

Adult Intussusception — Need for en-bloc resection

Background  

Adult intussusception is an uncommon surgical presentation.     

Ease of access is a principal factor in the frequency of paracetamol overdose

Background  

In Ireland, 30% of non-fatal overdoses involve paracetamol.     

Percutaneous vertebroplasty — initial clinical experience in osteoporotic and myelomatous compression fractures

Background  

To review the clinical impact of vertebroplasty in osteoporotic and myelomatous compression fractures     

Urology out-patient non-attenders: are we wasting our time?

Background  

Out-patient non-attendance leads to inefficiency and patient morbidity.     

Scabies management in the community

Background  

Unidentified and undertreated cases of scabies are the source of continued spread.     

Defining small bowel strictures

Background  

Strictures of the intestine can be difficult to detect despite current radiological techniques.     

Evaluation of stroke management in an Irish university teaching hospital: the Royal College of Physicians stroke audit package

Background  

There are few data regarding the standard of stroke care in Ireland.     

Cardiac rehabilitation service provision in Ireland: the Irish Association of Cardiac Rehabilitation survey

Background  

The first national survey of cardiac rehabilitation services was conducted.     

Realgar-induced apoptosis of cervical cancer cell line Siha via cytochrome c release and caspase-3 and caspase-9 activation

Objective:To explore the molecular mechanism of realgar-induced apoptosis of cervical cancer cells.Methods:The cervical cancer cell line Siha was used to determine the cell viability and apoptosis after treatment with realgar using MTT assay and flow cytometry.The activities of caspase-3,-8,and-9 were detected by fluorescence resonance energy transfer technology and colorimetric assay,while the levels of Bcl-2,cytochrome c,and Bax were detected by Western blot method.Results:Induction of apoptosis by realgar was detected in Siha cell line in a dose-dependent manner.The apoptosis was accompanied by a significant increase in cytochrome c release and activation of caspase-3 and caspase-9 but not caspase-8.Further,the realgar-induced apoptosis was inhibited by a broad-spectrum caspase inhibitor,a caspase-3 inhibitor,and a caspase-9 inhibitor but not by a caspase-8 inhibitor.Bcl-2 and Bax protein expressions were not changed by realgar.Conclusion:The induction of apoptosis by realgar is mediated through a cytochrome c-dependent pathway,which sequentially activates caspase-9 and caspase-3.     

Solitary plasmacytoma: experiences from Central Anatolia

Background  

Solitary plasmacytoma localised to bone or soft tissue without myeloma.     

Facial nerve schwannoma of the internal auditory canal

Background  

Facial nerve schwannoma of the internal auditory canal is a very rare tumour.     

Factors associated with self-reported depression and self-esteem among school-going adolescents from a geographically defined region in Ireland

Background  

Recent reviews indicate that mental health problems in the young are increasing.     

Hypertension in Ireland: public awareness and doctors choice of therapy

Background  

Hypertension is the commonest medical condition in Ireland.     

17β-Estradiol attenuates diet-induced insulin resistance and glucose intolerance through up-regulation of caveolin-3

Background  

Although estrogen contributes to glucose homeostasis, its mechanisms remain unclear.     

Inhaled nitric oxide in combination with volume resuscitation refines a porcine model of endotoxic shock

Background  

Existing porcine models of endotoxic shock poorly represent the human situation.     

Feasibility of a men’s health promotion programme in Irish primary care

Background  

To assess the feasibility of offering health promotion and preventive medicine initiatives in primary care.     

Splenic mass with remote trauma history: a management dilemma

Background  

Delayed presentation of splenic trauma is a well described entity.     

Initial experiences with isolated limb perfusion for unresectable melanoma of the limb

Aims  

Our initial results with isolated limb perfusion (ILP) using melphalan ± TNF alpha in patients with unresectable melanoma of the limb were analyzed.