Gelastic epilepsy possibly following antirabies vaccine

A case of child with gelastic epilepsy following administration of antirabies vaccine is presented. No associated structural brain could be identified in the patient. Possibility of relationship between antirables vaccine and gelastic epilepsy is discussed.     

Guillain-Barre syndrome in Korean children

Guillain-Barre syndrome is known as one of the autoimmune disease, but the etiology, pathophysiology relating immune reaction, as well as the treatment are not established. It still causes physical handicap although its rate is low. The causes, clinical symptoms and outcome of 132 cases of Guillain-Barre syndrome have been analyzed. The patients' ages ranged from 4 months to 15 years. The antecedent events for 56.1% of the patients were known. These were upper respiratory tract infection, unexplained fever, vomiting, diarrhea, vaccination, measles, german measles, shigellosis, mumps, hepatitis, pertussis and surgery in order of frequency. The CSF protein level reached a maximum at 12.3 +/- 9.5 days. Steroids did not influence the outcome of this disease. More studies are necessary to conquer the disease.     

Guillain-Barre syndrome complicated by acute fatal rhabdomyolysis

Guillain-Barre syndrome (GBS) is a heterogenous group of peripheral-nerve disorders with similar clinical presentation characterized by acute, self-limited, progressive, bilateral and relatively symmetric ascending flaccid paralysis, which peaks in 2-4 weeks and then subsides. The usual complications, which occur in a patient of GBS are pneumonia, sepsis, pulmonary embolism, respiratory insufficiency and cardiac arrest. The clinical course of GBS complicated by acute rhabdomyolysis is extremely rare. We present the case of GBS with marked elevation in serum creatine kinase, serum myoglobin levels and persistent hyperkalemia as a result of associated acute rhabdomyolysis.     

吉兰-巴雷综合征患者神经电生理检测结果分析

目的：探讨吉兰-巴雷综合征(GBS)患者的神经电生理特点。方法：对25例GBS患者进行肌电图(EMG)、运动神经传导速度(MCV)、F波及感觉神经传导速度(SCV)检测，共检测126条运动神经、89条感觉神经及57块肌肉，并对结果进行分析。结果：上、下肢神经远端潜伏期延长占53．2％，MCV减慢占70．6％，F波异常占92．0％，SCV减慢占64．0％，EMG提示神经源性改变占68．4％。结论：GBS为广泛的周围神经损害，存在以脱髓鞘为主伴有轴索变性的神经电生理改变。神经电生理检测对GBS的诊断是极为重要的诊断手段。     

吉兰-巴雷综合征早期电生理变化特点分析

目的：分析吉兰-巴雷综合征（GBS）早期（1～7d）的电生理改变特点,探讨其对GBS的早期诊断价值。方法：采用回顾性分析方法对69例GBS患者的电生理检测结果与临床特点进行分析,比较发病7d之内和大于7d的神经电生理变化特点。结果：运动神经传导速度（MCV）的异常率为55％,发病7d内为45％,发病7d后为55％;F波异常率为77％,发病7d内为52％,发病7d后为48％,感觉神经传导速度（SCV）异常率为52％,发病7d内及7d后均为50％;运动神经复合肌肉动作电位（CMAP）波幅降低异常率为64％,发病7d内为52％,发病7d后为48％;上肢感觉神经动作电位（SNAP）异常同时伴有腓肠神经SNAP正常者占39％,发病7d内占44％,发病7d后为56％。结论：GBS患者早期（7d之内）即可出现神经传导速度、F波、运动及感觉神经传导的改变,以F波更为明显,因此神经电生理检查在GBS中的早期诊断具有重要的作用。