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1.
A novel human leukocyte antigen (HLA)-B*40 allele, officially named B*4081, was identified during routine high-resolution sequence-based typing in a Chinese potential hematopoietic stem cell transplantation donor. The HLA-B*4081 allele shows one nucleotide difference from B*400101 in exon 2 at nucleotide position 124 where G→C (codon 18 GGG→CGG) resulting in a coding change, 18Gly is changed to Arg, this is a unique nucleotide change among the HLA class I alleles, suggesting a point mutation mechanism. 相似文献
2.
A novel human leukocyte antigen-B (HLA-B) allele, B*9526, was identified. The B*9526 allele has one nucleotide change from the closest matching allele B*1507 resulting in an amino acid change from Y(TAC) to C(TGC) at codon 142. 相似文献
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We report here a novel human leukocyte antigen (HLA)-B*5411 allele identified by sequence-based typing in a Chinese individual. The novel B*5411 is identical to B*5404, with the exception of four base substitutions at position 120 (A>C), 134 (G>C), 143 (C>G), and 156 (A>T) of exon 3 resulting in codon no. 131, changed from AGC (Ser) to CGC (Arg), and codon no. 143, changed from ACC (Thr) to TCC (Ser). 相似文献
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HLA-B*4071 allele shows six nucleotides difference from B*4005 allele in exon 3 at nucleotides 419A>T, 420C>A, 463C>A, 477C>G, 486G>C and 527A>T, resulting in three amino acid changes Tyr116Leu, Arg131Ser and Glu152Val. 相似文献
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Human leukocyte antigen-B*9550 is a novel allele identified in a Mexican Mestizo bone marrow donor from Veracruz. 相似文献
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A novel HLA-B*40 allele, B*4086, was identified by sequence-based typing in a Chinese donor 总被引:1,自引:0,他引:1
We report the identification of a novel HLA-B*40 allele, B*4086, which was detected during our routine sequence-specific oligonucleotide (SSO) HLA typing of a sample from a bone marrow donor and confirmed with sequence-based typing. The name HLA-B*4086 was officially assigned by the WHO Nomenclature Committee in February 2008. 相似文献
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Human leukocyte antigen (HLA) class I sequence-based typing (SBT) for hematopoietic unrelated donor searching in a Romanian Caucasian patient showed the presence of a novel HLA-B allele defined as B*0777. HLA-B*0777 has two nucleotides changes at the same codon from B*0707, resulting an amino acid replacement 99Y > 99S. 相似文献
9.
The full length sequence of HLA-B*3818 differs from HLA-B*380201 at nt 660 in exon 4 (C→A) and genomic position 2133 in intron 5 (A→C). 相似文献
10.
Three novel alleles, human leukocyte antigen (HLA)-B*4613, HLA-B*4614 and HLA-B*4618, were identified in Chinese individuals. HLA-B*4613 shows four nucleotides difference from B*460101, resulting in two amino acids change from Glu to Val at codon 152 and Trp to Leu at codon 156. HLA-B*4614 has a single nucleotide difference at position 97 T→C compared with HLA-B*460101, with an amino acid change from Tyr to His at codon 9. HLA-B*4618 shares the sequence of exon 2 with B*4601 and sequences of exons 3 and 4 with B*55, B*54 or B*59, together resulting in eight amino acids change compared with HLA-B*460101. 相似文献
11.
A novel human leukocyte antigen-B allele officially named B*3589, was found in an indigenous individual of Jehai ethnicity when sequencing was performed to investigate human genome variation in a research project. B*3589 differs form B*3505 in a point mutation at codon 169 (CGC to TGC) resulting in an amino acid change from Arg to Cys. 相似文献
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目的 鉴定中国人群中人类白细胞抗原(human leukocyte antigen,HLA)新等位基因HLA-B*9526,并进行核苷酸序列分析.方法 使用序列特异性寡核苷酸PCR技术进行HLA基因分型,发现1个反应格局异常的等位基因,应用分子克隆和DNA双向测序技术测定新等位基因的核苷酸序列,并与已知等位基因进行序列比对分析.结果 检出反应格局异常的DNA样本,经过克隆测序得到两个等位基因,分型结果一个为B*5403,另一个的核苷酸序列与已知的HLA等位基因均不同,该基因序列与同源性最高的HLA-B*1507基因序列相比在第3外显子区域中425位碱基发生A→G突变,导致142位编码氨基酸由酪氨酸变成半胱氨酸.结论 一个新的HLA-B等位基因被确认,并被世界卫生组织HLA因子命名委员会正式命名为HLA-B*9526. 相似文献
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A new human leukocyte antigen (HLA)-B allele, named B*3580, with an amino acid substitution at residue 156, has been identified during the sequence-based typing of a patient waiting for a hematopoietic cell transplantation. 相似文献
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One nucleotide difference was shown at position 594 in exon 3 from C to T between human leukocyte antigen (HLA)-B*550203 and HLA-B*550201, which does not alter amino acids in the mature protein. 相似文献
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A novel human leukocyte antigen (HLA) class I allele, HLA-B*3713, has been identified in a Chinese individual. The HLA-B*3713 allele differs from the closest matching allele B*370101 by one nucleotide substitutions in exon 3 at nt 527(T-->A), resulting in an amino acid change from Val (GTG) to Glu (GAG) at codon 152. 相似文献
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We report here the sequence of a novel human leukocyte antigen B*37 allele, B*370105, which is identical to B*370101 except for a single nucleotide substitution in exon 3 at nucleotide 558 where C>A, codon 162 GGC>GGA, no coding change. 相似文献
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The novel human leukocyte antigen-Cw*0821 allele differs from the closest allele Cw*080101 by single nucleotide change at genomic DNA nucleotide 419 A>G (codon73 ACT>GCT) in exon 2, which results in an amino acid change Thr73Ala. 相似文献
18.
A new human leukocyte antigen-B allele, B*5410, has been detected in Taiwan. It has one nucleotide change from B*5401 at codon 156 (C T G→C G G), resulting in one amino acid change (L→R). 相似文献
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A novel human leucocyte antigen (HLA)-B35 (HLA-B*3570) allele has been identified in a Caucasian family from Middle Europe using single allele-specific sequencing strategy. This allele is identical to the HLA-B*3503 allele except for one point mutation in exon 4 at codon 188 (CAC-->CGC), resulting in an amino acid change from histidine to arginine. 相似文献
20.
A novel human leukocyte antigen-B*40 (HLA-B*40) allele was identified in the Korean population and designated HLA-B*4073. The HLA-B*4073 allele shows one nucleotide difference from B*400102 in exon 2 at nucleotide position 299 (A→T), resulting in an amino acid change, Glu76Val. 相似文献