Effect of Aike Mixture(艾可合剂) on the Inflammatory Infiltration in Patients with Chronic Prostatitis Type Ⅲ A

Objective  

To observe the effect of Aike Mixture (艾可合剂, AKM) on prostatic inflammatory: infiltration in patients with chronic prostatitis type III A (III A-CP/CPPS) and evaluate its anti-inflammatory action.     

Study on the efficacy and safety of Xueyou Mixture (血友合剂) in treating hemophilia

Objective:To observe the effect of Xueyou Mixture(血友合剂,XYM) on blood coagulation factors and its safety in treating hemophilia.Methods:To the randomly selected 65 inpatients of hemophilia,XYM was administered accompanied with intravenous dripping of liver cell growth factor 60-100 mg once a day to protect the liver,with no blood products like concentrated Ⅷ and FⅨ factors or blood plasma given.The treatment lasted for 3 weeks.The short-term eff icacy and adverse reactions were observed.The long-term efficacy in patients was observed in a follow-up study of 6-12 months after they were discharged from the hospital but continuously took XYM orally.Results:The short-term markedly effective rate in the patients was 95.38%(62/65).After they were treated for 3 weeks,the level of FⅧ factor activity increased in 56 patients of type A from(3.32±2.21) % to(4.18±2.23) %,and in 9 of type B from(4.92±1.81) % to(5.64±1.96) %.Compared with that before treatment,the difference was signif icant in both of them(P<0.01).No obvious adverse reaction was found in the treatment period.The follow-up study showed that in 22 patients of type A,the FⅧ factor activity ratio increased from(3.25±2.11) % to(6.31±2.16) %,(8.36±1.05) %,and(16.38±2.71) % in the 2nd,3rd and 6th month after discharge respectively,all showing significant difference to that before treatment(P<0.01);and in 4 patients of type B,it increased from(4.15±2.26) % to 7.8% and 11.6%(mean value) in the 2nd and 6th month respectively.Conclusion:XYM could raise the activity of factors Ⅷ and Ⅸ in patients with hemophilia,and the degree of the rise is related with the duration of the therapy,with no obvious adverse reaction,which strikes out a new path and new train of thinking for the treatment of the disease by non-blood preparation.     

The Effect of Acupuncture on Serum IgE Level in Patients with Chronic Urticaria

The pathogenesis for chronic urticaria is not clear yet, and there has been no assured effective therapies for it. In the present study on the therapeutic effects of acupuncture for chronic urticaria and its mechanisms in immunity, the author put the stre…     

Effects of Zao Huang Mixture (藻黄合剂) on the Expressions of TGF-β1 and Col IV in Human Glomerular Mesangial Cells Cultured in High Glucose Environment

Objective: To investigate the effect of Zao Huang Mixture (藻黄合剂ZHM) on expressions of growth factor-β1 (TGF-β1) and collagen IV (Col IV) in human glomerular mesangial cells (GMC) cultured in high-glucose environment. Methods: After primary culture of GMC, in vitro culture was carried out in normal group, high glucose group and high glucose medium with ZHM of different concentrations, and the expressions of TGF-β1 and Col IV in the GMC group and in ZHM group were detected at 24 and 48 h respectively. Results...     

Clinical observation on chemical damage of nephron and the preventive and therapeutic effects of Baoshen Mixture (保肾合剂) on it

Objective:To observe the change of nephron damaged by chemotherapy and to evaluate the effect of Baoshen Mixture(保肾合剂,BSM) in protecting and treating damaged nephrons.Methods:Four hundred tumor patients with normal renal function and ready to receive chemotherapy were randomly assigned to two groups.Both groups received one cycle of chemotherapy program of 28-30 days with conventional hydratization,alkalization and chloridization.To the 200 cases in the treated group BSM was given orally thrice a day,150 mL every time for 15 successive days and the other 200 cases in the control group were treated by chemotherapy alone.The clinical efficacy was compared after treatment,and the changed condition of damaged nephrons were monitored dynamically and compared at different time points(the 3rd,7th,14th and 21st day after chemotherapy) by measuring the micro-globulin β2(β2-MG),albumin(Alb) and immunoglobulin G(IgG) levels in urine with radioimmunoassay(RIA).Results:(1) The effective rates in the treated group at the 4 time points of observation were all higher than those in the control group respectively(P<0.05 or P<0.01);(2) Less occurrence of abnormal β2-M,Alb and IgG levels on the 14th and 21st day in the treated group took place compared to that in the control group(P<0.01);(3) Urinary levels of β2-MG,Alb and IgG reached the peak on the 7th day in both groups,and then,they came down gradually and returned to the normal level on the 21st day.However,comparison between the two groups showed that all the three parameters in the treated group on day 3,14 and 21 were lower than the respective one at the corresponding time points in the control group(P<0.05 or P<0.01).Conclusion:The chemotherapy damage on nephron is regular in time,and reversible when treated suitably.TCM shows a marked effect in protecting and treating the damage on nephron caused by chemotherapy.     

Preliminary Study on Therapeutic Effect of Oxymatrine in Treating Patients with Chronic Hepatitis C

Preliminary Study on Therapeutic Effect of Oxymatrine in Treating Patients with Chronic Hepatitis C@李继强@李超群@曾民德@范建高@华静@邱德凯@萧树东@佘祥奎@李国软     

Clinical Observation on the Effect of Zengse Pill (增色丸) in Treating Patients with Vitiligo of Qi-stagnancy and Blood-stasis Syndrome Type

Objective:To observe the clinical efficacy of Zengse Pill(增色丸,ZSP)on patients with vitiligo of qi-stagnancy and blood-stasis syndrome type(V-QB),and to preliminarily explore its mechanism of action.Methods:Sixty-five V-QB patients,with their diagnosis confirmed by clinical examination,were randomized by digital table method into two groups,with 31 patients in the control group and 34 in the treatment group.Cobamamide(2 tablets)was administered orally to all patients,and Psoralea tincture(a self-formulated preparation)was applied externally thrice a day.In addition,for patients in the treatment group,ZSP was given orally,at 5 pills per dose,3 times every day.The therapeutic course for both groups was 3 months.Patients were re-examined every half-month,and changes in the skin lesions were observed and recorded.The levels of lymphocyte subsets,serum immune globulin,and complement C3 and C4 in patients were determined before and after the therapeutic course and compared with the corresponding indexes determined in 21 healthy subjects.Results:The total effective rate in the treatment group was 82.4%,which was markedly higher than that in the control group(54.8%),showing a significant difference(P<0.05).After treatment,CD_4~ percentage,CD_4~ /CD_8~ ratio,and blood levels of C3 and C4 increased,while CD_8~ percentage decreased in the treatment group(P<0.05 or P<0.01).All these indexes remained unchanged in the control group,and the respective comparisons between groups showed significant differences(P<0.01).Conclusion:ZSP has a definite clinical effect on the treatment of V-QB but with no evident adverse reactions,and it can increase the CD_4~ percentage,CD_4~ /CD_8~ ratio,and the levels of serum C3 and C4,thus regulating the immunity of the organism,which might be one of its mechanisms of action.     

Effect of Weikangfu Granule (胃康复冲剂) on the Physiopathologic Figure of Precancerosis of Gastric Mucosa in Patients of Chronic Gastritis with Pi-Deficiency Syndrome

Objective: To study the physiopathologic basis of Weikangfu Granule ( 胃康复冲剂, WKFG)in treating precancerosis of gastric mucosa in patients of chronic gastritis with Pi-deficiency syndrome (CG-PDS). Methods: One hundred and fifteen patients of CG-PDS who suffered from intestinal metaplasia (IM)and atypical hyperplasia (ATHP) of gastric mucosa, were divided into two groups. The treated group (n =61 ) was treated by WKFG with its ingredients modified according to the syndrome type of patients. The constructural changes were detected by optical microscope, screening electronic microscope, transmission electronic microscope and histochemical staining; the nuclear and mitochondrial ultrastructure of gastric mucosa were analyzed with energy dispersion X-ray analyser and image analysis system. And the changes of cAMP,lipid peroxide (LPO), superoxide dismutase (SOD) before and after treatment in the treated group were measured and compared with those of the health control group consisting of 15 volunteers. Results: The symptomatic and pathological therapeutic effect in the treated group were significantly superior to those in the control group (P＜0.05). The contents of Zn, Cu, cAMP, SOD and 3H-TdR LCT in gastric mucosa of the treated group before treatment were all lower than those of the healthy control group, yet all these indexes markedly increased after treatment, while serum LPO level, which increased before treatment was lowered after treatment. All the changes showed statistical significance (P＜0.05 or P＜0.01). Conclusion: WKFG can reverse IM and ATHP in patients of CG-PDS, and the effect may be realized by way of increasing the level of Zn, Cu, cAMP and SOD in gastric mucosa, promoting cell differentiation, enhancing cellular immunity and reducing oxygen free radicals and lipid peroxidation.     

Effect of Shengmal Powder(生脉散) on Symptoms and Markers of Inflammatory Damage of Patients with Acute Viral Myocarditis

Objective: To evaluate the efficacy of Sheng-mai Power (SMP) in treating acute viral myocarditis. Methods: 102 patients with acute viral myocarditis were randomized to SMS group (n = 52) and placebo control group (n = 50 ). Semiquantitative integral methods were taken to observe changes of clinical symptoms such as dyspnea, palpitation and chest pain after 4 weeks of treatment, simultaneously EKG, 24h Holter, concentration of serum cardiac troponin-I, cardiac troponin T and neutralizing antibody test to the Coxsackie B virus were determined. Results: Dyspnea improved much more obvious in SMP group than in the placebo     

Effect of Jiang Zhuo Mixture on Blood Glucose Level and Insulin Resistance in Diabetes

Based on the knowledge of diabetes in traditional Chinese medicine and modem biomedical sciences,Dr. Wang Hui (王晖) designed Jiang Zhuo Mixture (降浊合剂) , a preparation for treatment of fat diabetes type 2. Jiang Zhuo Mixture showed good actions of strengthening the spleen and stomach,separating the clear from the turbid, resolving the stasis and decreasing the blood glucose level. These were reported as follows.     

Clinical Observation on Treatment of Vitiligo with Xiaobai Mixture(消白合剂)

Clinical Observation on Treatment of Vitiligo with Xiaobai Mixture(消白合剂)@刘志军$Department of Dermatology, the First Affiliated Hospital, Nanhua University! Hunan (421001) @向亚萍$Hunan College of Traditional Chinese Medicine     

Effect of Yufeining (愈肺宁) on Induced Sputum Interleukin-8 in Patients with Chronic Obstructive Pulmonary Disease at the Stable Phase

Airway inflammation is a prominentfeature of pathologic changes in chronic ob-structive pul monary disease(COPD).Chro-nic airway inflammation in COPDis charac-terized by neutrophilic inflammation(1).In-terleukin-8(IL-8)is a chemokine for neu-trophils and closely associated with airflowli mitation in patients with COPD(2).IL-8plays an i mportant role in the pathogenesisof COPD.The objective of this project is toassess the effect of traditional Chinese medi-cine Yufeining(愈肺宁)oninduc…     

Effect of Aoshaen Injection (奥沙恩注射液) on Inflammatory Infiltration In Myocardlal Ischemla/Reperfuslon Injury

Objective: To study the effect and molecular mechanism of Aoshaen Injection(ASEI) on inflammatory infiltration in myocardial ischemia-reperfu-sion injury. Methods: Canine myocardial ischemia/ reperfusion model was made by left decending corornary artery ligation and reperfusion to observe the protective effect of ASEI in different phases. Results: ASEI restrained the augment of sinus cor-onaries blood leukocytes of different phases and decreased interlukin-1 (IL-1), interlukin-6 (IL-6 ) and tumor necrosis factor-a (TNF-a) evidently. However, no significant change of interlukin-8 was detected. ASEI obviously inhibited the inflammatory coefficient 30 min, 120 min, 180 min and 240 min after modeling, and reduced the infarcted area,     

Clinical Pathologic Study on Effect of Qianggan Capsule (强肝胶囊) in Treating Patients of Chronic Hepatitis B with Liver Cirrhosis

Objective: To explore the clinical therapeutic effect of Qianggan Capsule (QGC) in treating chronic hepatitis B with liver fibrosis from the pathological aspect. Methods: Sixty-three patients of chronic hepatitis B with liver fibrosis were randomly divided into the treated group (n=45) and the control group (n=18). Both groups were treated with general liver protective drugs, such as Glucurone and vitamins B complex for 6 months. To the treated group, QGC was used additionally. The levels of serum alanine transaminase and liver fibrosis indexes including hyaluronic acid (HA), collagen type Ⅳ (C-Ⅳ) and laminin (LN) as well as the pathological examination of liver biopsy were observed before and after treatment. Results: The liver cirrhosis indexes, HA, C-Ⅳ and LN, were improved significantly in the treated group after treatment, P<0.05. The liver function improvement rate in the treated group and the control group was 90.3% and 66.7% respectively, comparison of the two groups showed insignificant difference, P>0.05. Pathological examination showed that the effective rate of treatment on liver inflammatory necrosis activity grade in the treated group was 57.8% and that on liver fibrosis stage was 75.6%, which were significantly improved as compared with those before treatment (P<0.05 and P<0.01), while in the control group, no significant improvement was found after treatment (P>0.05). Conclusion: QGC has marked effects in reversing liver fibrosis and alleviating hepatic inflammatory necrosis in patients of chronic hepatitis B with liver fibrosis, and could lower the serum liver fibrosis related indexes effectively.     

Phenotypic Modulation of Mesangial Cells in Diabetic Rats and Effect of Tujian Mixture (菟箭合剂) on It

Phenotypic Modulation of Mesangial Cells in Diabetic Rats and Effect of Tujian Mixture (菟箭合剂) on It@尹德海$Peking Union Medical College Hospital!Beijing (100730) @梁晓春$Peking Union Medical College Hospital!Beijing (100730) @郑法雷$Peking Union Medical College Hospital!Beijing (100730) @朴元林$Peking Union Medical College Hospital!Beijing (100730)…     

The Effect of Evening Primrose Oil on Thromboxane A2 and Angiotension Ⅱ Levels in Patients with Chronic Renal Insufficiency

ＴｈｅＥｆｆｅｃｔｏｆＥｖｅｎｉｎｇＰｒｉｍｒｏｓｅＯｉｌｏｎＴｈｒｏｍｂｏｘａｎｅＡ_２ａｎｄＡｎｇｉｏｔｅｎｓｉｏｎⅡＬｅｖｅｌｓｉｎＰａｔｉｅｎｔｓｗｉｔｈＣｈｒｏｎｉｃＲｅｎａｌＩｎｓｕｆｆｉｃｉｅｎｃｙＧａｏＨｕｂｉｎ；（高沪滨）Ｙｕｚｈｏ?..     

Effect of Qingfei Mixture (清肺合剂) on Pediatric Mycoplasma Pneumoniae Pneumonia with Phlegm Heat Obstructing Fei (Lung) Syndrome

Objective: To explore the effect and mechanism of Qingfei Mixture(清肺合剂), a Chinese medicine, in treating mycoplasma pneumonia(MP) in MP patients and rat model. Methods: A total of 46 MP children with phlegm heat obstructing Fei(Lung) syndrome were randomly assigned to two groups by the method of random number table, with 23 children in each group. The control group was treated with intravenous infusion of azithromycin; the treatment group received intravenous infusion of azithromycin and oral administration of Qingfei Mixture. The treatment course was 7 days. Major symptoms and minor symptoms were observed and scored before and after treatments. A rat model of MP was also established. A total of 120 wistar rats were randomly divided into 5 groups: a normal group, infection group, Qingfei Mixture treatment group, azithromycin treatment group, and Qingfei Mixture + azithromycin treatment group. Each group contained 24 rats, from which every 6 were euthanatized 1, 3, 7 and 14 days after infection. MP DNA in pulmonary tissue homogenates was detected using real-time fluorescence quantitative polymerase chain reaction. Pathology was assessed after hematoxylin(HE) staining and lung tissue pathology scores were determined in pulmonary tissue. Transmission electron microscopic detection and electronic image analysis were performed on lung tissue 3 days after infection. Interleukin(IL)-17 was detected in serum using enzymelinked immunosorbent assay(ELISA) 7 days after infection. Results: In the clinical study, both control and the treatment group showed improved results on removing symptoms of phlegm heat syndrome compared to the control group(P0.05). In animal experiments, On the 7th day after MP infection, as detected by electron microscopy, the pulmonary capillary basement membranes of the azithromycin + Qingfei Mixture treatment group were much thinner than those of the azithromycin or Qingfei mixture treatment groups(P0.05). The level of serum IL-17 in the azithromycin + Qingfei Mixture treatment group was lower than that in the azithromycin or Qingfei Mixture groups(P0.01). Conclusion: Both Qingfei Mixture and azithromycin have therapeutic effects on mycoplasma pneumoniae pneumonia, but the combination of both agents had the greatest effect.     

Clinical Study on Effect of Osteoking (恒古骨伤愈合剂) in Preventing Postoperational Deep Venous Thrombosis in Patients with Intertrochanteric Fracture

An increasing trend of morbidity of intertro-chanteric fracture (ITF) appears along with thecoming of aged population, with additional influ-ences brought in by trauma ,operation and motionstatics , which causes the progressively increasingoccurrence of deep venous thrombosis (DVT) dayby day ,and therefore the prevention of postopera-tional DVTin ITF patients has become an i mpor-tant and often faced task for the orthopaedic de-part ment . It has been found in clinical practicethat Osteoki…