述情障碍与情绪障碍的相关性研究

通过对259名被试对象TAS、SAS、SDS的测查分析,探讨述情障碍与焦虑、抑郁两种情绪障碍的关系,认为:心理健康水平在一定程度上取决于述情障碍的水平,送情障碍可能是引起焦虑、抑郁情绪的个性基础。     

酒精依赖综合征述情障碍调查

述情障碍是指不善于分辩自己的情绪和躯体感觉 ,往往借助躯体不适来表达情绪体验的一种人格模式 ,人际关系显得僵化、淡漠、刻板和保守 ,常见于酒精依赖综合征。为此 ,作者对 5 8例酒精依赖综合征进行了调查 ,现将结果报道如下。1　资料与方法1.1　资料　为 1998年 7月～ 2 0 0 3年 7月在我院门诊及住院治疗的酒精依赖综合征患者 (研究组 ) ,共计 5 8例。全部病例经重新评价再诊断均符合CCMD - 3中酒精依赖综合征的诊断标准[1] 。1.2　方法　自拟调查登记表 ,包括 :年龄、性别、职业、文化程度、婚姻、病前性格、初次饮酒年龄、饮酒时间、…     

高血压病和述情障碍

用多伦述情障碍量表(TAS)和流调用抑郁自评量表(CES-D)对70侧高血压病患者进行了问卷式调查。结果发现；高血压病患者不仅存在抑郁情绪，而且广泛存在述情障碍。作者对高血压病的心理治疗进行了探讨。     

述情障碍与抑郁关系的研究进展

述情障碍以不能识别情感、描述情感、不能与他人交流情感、缺乏幻想和外向性思维为特点。有的学认为述情障碍是一种稳定的人格特质，是抑郁症的易感因素，也有的学认为述情障碍是抑郁症的一种状态反应。本旨在对有关述情障碍与抑郁之间关系的研究献进行综述。     

葡萄糖耐量降低人群述情障碍发生率及其与焦虑抑郁障碍的相关性研究

目的 了解2型糖尿病高危人群即葡萄糖耐量降低人群(impaired glucose tolerance,IGT)中述情障碍发生率及其与焦虑、抑郁症状的相关性.方法 采用多伦多述情障碍量表(TAS-20)、抑郁自评量表(SDS)、焦虑自评量表(SAS)对62例IGT但未达到糖尿病诊断患者进行评估,调查述情障碍发生率,并对其与抑郁、焦虑症状进行相关性分析.结果 述情障碍发生率为37.1％,IGI组SDS、SAS评分均显著高于中国常模(P ＜0.005) TAS-20总分与SDS、TASk0总分与SAS存在线性正相关(P＜0.01),TAS-20中因子1(F1,难以识别自己的情感)、因子2(F2,难以描述自己的情感)分别与SAS、SDS均存在正相关(P＜0.05),因子3(F3,外向性思维)与SDS存在负相关(P＜0.05).结论 2型糖尿病高危人群存在明显的述情障碍,且与焦虑、抑郁障碍高度相关.     

青少年焦虑障碍患者的照顾者述情障碍对照研究

目的探讨有焦虑障碍青少年照顾者的述情障碍现状。方法选取有焦虑障碍的青少年的照顾者86例为研究组,同时选取年龄、性别及受教育程度相匹配的无精神障碍史的青少年的父母或其他主要照顾人80例为对照组。采用一般人口学调查表收集两组的社会人口学资料,采用多伦多述情障碍量表(TAS)评估两组的述情障碍程度。结果研究组TAS总评分及各因子评分均高于对照组(P0.05)。Logistic回归分析显示,照顾者中好的家庭经济状况(OR=0.68,95%CI:0.38~0.87)是青少年焦虑障碍的保护性因素;而照顾者的外向性思维(OR=1.362,95%CI:1.14~1.48)是焦虑障碍的危险性因素。结论有焦虑障碍的青少年的照顾者具有述情障碍表现,其外向性思维方式及家庭经济状况可能与青少年的焦虑障碍相关。     

酒依赖患者的情绪障碍和述情障碍

目的：探讨酒依赖患者的情绪障碍和述情障碍。方法：采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、多伦多述情障碍量表（TAS）以50例酒依赖患者和50例正常对照组进行比较研究。结果：酒依赖组与对照组在焦虑、抑郁情绪和述情障碍方面存在明显差异。结论：纠正情绪和述情障碍可能有利于戒酒成功。     

神经症和抑郁障碍患者的述情障碍及相关因素研究

目的探讨神经症和抑郁障碍患者的述情障碍及影响因素。方法对57例神经症和抑郁障碍患者运用多伦多述情障碍量表(TAS)进行评定，并与常模进行比较。结果神经症和抑郁障碍患者存在明显的述情障碍，TAS总分及各因子分明显高于常模，男女之间无显著性差异，多元回归分析进入方程的是SCL-90躯体化因子和焦虑因子。结论正确评定神经症和郁郁障碍患者的述情障碍及影响因素，具有重要的临床现实意义，对采用适当的心理治疗提供依据。     

海洛因依赖者记忆力与氧化应激的关系

目的：探讨男性海洛因依赖者（MPHD）记忆力改变及其与氧化应激的关系。方法：对140例MPHD及75名健康者对照进行韦氏记忆量表（WMS）评估和氧化应激指标血清一氧化氮（NO）、丙二醛（MDA）、超氧化物歧化酶（SOD）、维生素C（VC）及总抗氧化能力（T-AOC）的检测。结果：MPHD组WMS的测验成绩显著差于对照组（P〈0．05）;MPHD组血清MDA水平高于对照组（P〈0．05）,T-AOC、VC、SOD水平低于对照组（P〈0．05或P〈0．01）;随戒断时间延长,MPHD组的记忆商数（MQ）有升高的趋势（P〉0．05）,血清MDA含量有下降的趋势（P〈0．01）,T-AOC、SOD含量有升高的趋势（P〈0．05）。MPHD组血清NO及MDA水平与WMS多个因子呈负相关（P〈0．05或P〈0．01）,T-AOC、VC及SOD水平与WMS多个因子呈正相关（P〈0．05或P〈0．01）。结论：海洛因依赖者存在明显的记忆力损害与氧化抗氧化反应失衡;其记忆力损害可能与氧化应激有关,血清NO、MDA、SOD、VC、T-AOC可能是与记忆力密切相关的氧化应激指标。     

多巴胺D4受体基因多态性与海洛因依赖及渴求程度的关系

目的 探讨DRD4 exon Ⅲ 48bp可变串连重复序列（VNTR）与海洛因成瘾及线索诱发海洛因渴求程度的关系。方法 采用美国ABI公司3100基因分析仪对380名海洛因依赖者（依赖组）和275名健康对照者（对照组）的DRD4 exon Ⅲ 48bpVNTR基因多态进行检测,并给予依赖组实施线索诱发海洛因渴求实验。比较依赖组和对照组的DRD4 exon Ⅲ 48bpVNTR多态的基因型及等位基因频率是否有差异,分析不同基因型与线索诱发海洛因渴求程度的关系。结果 （1）依赖组与对照组相比．DRD4exon Ⅲ 48bpVNTR多态的基因型和等位基因频率差异均无显著性（P〉0．05）。（2）依赖组中,DRD4 exon Ⅲ 48bpVNTR长重复基因型诱发的渴求高于短重复基因型（P〈0．05）。结论 未发现DRD4 exon Ⅲ 48bpVNTR基因多态与海洛因成瘾有关,但该基因多态与线索诱发海洛因的渴求程度有关,长重复基因型线索诱发的海洛因渴求程度明显高于短重复基因型。     

述情障碍与神经症的关系

目的综合国内关于述情障碍与神经症关系的研究（以TAS-26为测量工具）。方法对已有研究进行元分析。结果情感描述困难（Ⅰ）、情感识别困难（Ⅱ）、缺乏幻想（Ⅲ）、外向性思维（Ⅳ）各维度的平均效应量依次为0.52,1.08,0.03,0.69。结论述情障碍各维度中,Ⅱ、Ⅳ和Ⅰ参与了神经症的发生、发展过程。其中,Ⅱ和Ⅳ对躯体化障碍的影响最为显著,情感描述困难对各类神经症的发生、发展都有一定的影响。     

Relationship between mood state and information processing of negative versus positive emotional stimuli in brain-damaged patients

The present study investigates the relationship between affective mood state as assessed by self- and hetero-rating scales and information processing of negative versus positive emotional stimuli in unilateral brain-damaged patients. Results show a high positive correlation between depressive mood scores and rating of self-awareness. Left brain-damaged (LBD) patients do not differ significantly from right brain-damaged (RBD) patients on both rating scales. RBD patients mismatch negative emotional stimuli in the nonverbal matching task. Results are discussed with reference to interaction between expression of emotion and cognition. The selective neglect of negative information is interpreted as a more basic emotional impairment.     

精神分裂症患者述情障碍与应付方式的相关性

目的探讨精神分裂症患者述情障碍与应付方式特征及其相关性。方法本研究为单纯随机对照研究。将62例符合《国际疾病分类(第10版)》(ICD-10)诊断标准的精神分裂症患者作为研究组,选取70名正常健康者为对照组。采用多伦多述情障碍量表(TAS-20)和应付方式问卷(CSQ)对两组进行测评。结果研究组TAS-20各项因子评分高于对照组(P0.05或0.01),研究组CSQ的退避、幻想、自责因子评分高于对照组(P0.01),合理化和解决问题因子评分低于对照组(P0.01)。相关分析显示,研究组TAS-20的P1因子与CSQ的幻想、自责、合理化因子呈正相关(r=0.352~0.488,P0.05),与解决问题因子呈负相关(r=-0.327,P0.05);P2因子与CSQ的合理化因子呈正相关(r=0.256,P0.05),与解决问题因子呈负相关(r=-0.349,P0.05)。结论精神分裂症患者存在述情障碍和消极的应付方式,且述情障碍与应付方式存在一定的相关性。     

Insecure attachment and alexithymia in young men with mood symptoms

According to attachment theorists, affect regulation and quality of attachment are closely linked. As a personality trait associated with deficits in the cognitive processing and regulation of affects, alexithymia has been hypothesized to correlate with insecure attachment. To test this hypothesis, we studied the relationships between alexithymia, adult attachment style, and retrospective memories of separation anxiety symptoms during childhood in 100 young men with clinically significant mood symptoms. The most common DSM-IV diagnosis (N = 72) was adjustment disorder with depressed mood, with anxiety, or with mixed anxiety and depressed mood. Each participant completed the Twenty-Item Toronto Alexithymia Scale (TAS-20), the Beck Depression Inventory (BDI), the state form of the State-Trait Anxiety Index (STAI), the Attachment Style Questionnaire (ASQ), the Relationship Questionnaire (RQ), and the Separation Anxiety Symptom Inventory (SASI). Alexithymic traits were more pronounced in those participants who had patterns of insecure attachment and who reported more severe symptoms of separation anxiety during childhood, independently of the severity of their current anxiety and depressive symptoms. Among the subgroup of participants with insecure attachment styles, those with preoccupied or fearful patterns had a higher prevalence of alexithymia (65% and 73%, respectively) than those with a dismissing pattern (36%). These data suggest a role for early developmental factors in the etiology of alexithymia     

Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone

OBJECTIVE: To compare severity of negative mood and physical symptoms between women with different progesterone, allopregnanolone, and pregnanolone plasma concentrations during sequential Hormone Replacement Therapy (HRT) with vaginal progesterone suppositories. DESIGN: A randomized, placebo-controlled, double-blind, crossover study. METHOD: Postmenopausal women (n=36) with climacteric symptoms were treated with 2mg estradiol daily during three 28-day cycles. Vaginal progesterone suppositories with 400, 800 mg/day or placebo were added sequentially for 14 days per cycle. Daily symptom ratings using a validated rating scale were kept. Blood samples for progesterone, allopregnanolone, and pregnanolone radioimmunoassays were collected during each treatment cycle. RESULTS: Women were divided into three groups (low, medium, and high) based on plasma allopregnanolone concentration during progesterone treatment. The concentration of allopregnanolone in the medium group corresponds to the concentration seen during the mid luteal phase of the menstrual cycle. Within women with medium allopregnanolone concentration significantly more negative mood and physical symptoms were rated during progesterone treatment compared to treatment with unopposed estrogen or placebo. Between women significantly more negative mood symptoms were seen during progesterone treatment cycles with medium allopregnanolone concentration compared to cycles with low concentration. Plasma progesterone, allopregnanolone, and pregnanolone concentrations increased with increasing progesterone dose. Progesterone and allopregnanolone plasma concentrations increased 2h after vaginal administration of progesterone at 400 and 800 mg/day. CONCLUSION: Vaginal progesterone in sequential HRT causes negative mood, most likely mediated via allopregnanolone.     

Association between heroin dependence and prodynorphin gene polymorphisms

Dynorphin peptides and k-opioid receptor are important in the rewarding effects of drugs of abuse such as heroin. This study examined potential association between heroin dependence and four single nucleotide polymorphisms (SNPs) of prodynorphin (PDYN) gene (rs35286281 in promoter region and rs1022563, rs2235749, rs910080 in 3'UTR). Participants included 304 heroin-dependent subjects and 300 healthy controls. Genotype, allele frequencies and difference between groups were analyzed by HaploView 4.0 and SPSS 11.5 software. The analysis indicated a significant higher frequency of the PDYN 68bp VNTR (rs35286281) H allele in heroin-dependent subjects than in controls (p=0.002 after Bonferroni correction). Strong linkage disequilibrium was observed between rs1022563, rs2235749 and rs910080 polymorphism (D'>0.9). Significantly more TCT haplotypes were found in heroin-dependent patients than in the controls (p=0.006 after Bonferroni correction). We found significant pointwise correlation of these three variants (rs1022563, rs2235749 and rs910080) with heroin dependence. These findings support the important role of PDYN polymorphism in heroin dependence, and may guide future studies to identify genetic risk factors for heroin dependence.     

酒依赖患者应对方式与家庭环境的关系

目的:探讨酒依赖患者应对方式与家庭环境的相关性。方法:对58例酒依赖患者(研究组)和60名无嗜酒史的当地市民(对照组)进行应对方式问卷(CSQ)和中文版的家庭环境量表(FES)调查,分析酒依赖患者应对方式与家庭环境因素的关系。结果:研究组CSQ中退避、幻想和自责因子分显著高于对照组(t=2.41,t=3.22,t=4.15;P0.05或P0.01);FES中亲密度、情感表达、娱乐性、道德宗教观、组织性评分显著低于对照组,矛盾性和控制性评分显著高于对照组(P0.05或P0.01)。研究组FES中亲密度、情感表达、独立性、成功性评分与CSQ解决问题评分呈正相关,情感表达评分与求助评分呈正相关,娱乐性评分与自责评分呈负相关(P0.05或P0.01)。结论:酒依赖患者应用不成熟的应对方式,不良家庭环境是其影响因素。