中老年膝骨关节炎发病的相关因素分析

目的分析中老年膝骨关节炎发病的相关因素，作为预防和治疗膝骨关节炎的依据。方法对2011年4月~2014年4月收治的120例骨关节炎患者以及120例健康的中老年人进行研究，将膝骨关节炎患者作为观察组，健康的中老年人作为对照组，分析中老年膝骨关节炎发病的相关因素。结果观察组患者的体重指数与对照组患者的体重指数有显著差异(<0.01)。体重指大于25的观察组患者数量与对照组患者数量有显著差异，提示体重质量越高的人群患有膝骨关节炎的几率更高；观察组的劳动强度和对照组的劳动强度没有显著差异，差异没有统计学意义(P<0.05)。同一级别的劳动强度比较，观察组和对照组之间也没有显著差异；观察组患者的骨密度和对照组成员骨密度的比较有显著差异，差异有统计学意义(P<0.05)。结论体重指数、劳动强度和骨密度是中老年膝骨关节炎发病的危险因素，控制体重、保持健康的生活方式可以降低膝骨关节炎发病的几率。     

膝骨关节炎女性伸膝肌力、步态时空参数与峰值膝关节屈曲/内收力矩关系

背景：已有研究表明膝骨关节炎患者的膝关节力矩会发生改变，但对于力矩变化与伸膝肌力及步态时空参数之间的相关性报道较少。目的：探索女性膝骨关节炎患者伸膝肌力及步态时空参数与峰值膝关节屈曲/内收力矩之间的相关性。方法：选取2022年2-8月在北京积水潭医院贵州医院住院治疗的20例单膝患病女性膝骨关节炎患者作为膝骨关节炎组，另外选取20例无肌肉骨骼疾病的女性健康人作为对照组。利用Biodex等速仪测量60 (°)/s向心伸膝肌力，并采用意大利BTS红外运动捕捉系统和测力台采集步态时空参数和峰值膝关节屈曲力矩和膝关节内收力矩。通过Pearson相关性分析探索肌力、步态时空参数和峰值膝关节内收力矩和膝关节屈曲力矩的关联，并进一步将与膝关节力矩显著相关的变量纳入多元逐步回归分析。结果与结论：(1)与对照组相比，膝骨关节炎组60 (°)/s向心伸膝肌力、步速、步频、步长以及峰值膝关节屈曲力矩均更低(P <0.05)；(2)Pearson相关性分析结果显示60 (°)/s向心伸膝肌力、步速、步频、步长与峰值膝关节屈曲力矩呈正相关，与峰值膝关节内收力矩呈负相关，差异有显著性意义(P <0.05...     

骨代谢指标与骨关节炎及绝经后骨质疏松症的关系

背景：研究显示,在绝经后骨质疏松症及骨关节炎状态下,原本正常的骨转换平衡状态被破坏,血清、尿液中一些特异性指标可以较敏感地反映出骨转换的具体变化过程。 目的：测量绝经后原发性膝骨关节炎及绝经后骨质疏松症患者的骨密度及骨代谢指标,分析两疾病骨密度及骨代谢指标的变化特点。 方法：选取248例绝经女性受试者,行骨密度、膝关节X射线片检查,最终选出180例进入试验,分为骨关节炎组、骨质疏松组及对照组。对比分析各组观察对象的骨代谢指标：骨碱性磷酸酶、骨钙素、Ⅰ型胶原交联C末端肽、血清抗酒石酸酸性磷酸酶5b。通过二元Logistic回归分析判断两疾病发病与各项指标间的相关性。 结果与结论：与对照组比较,骨关节炎组腰椎骨密度升高,Ⅰ型胶原交联C末端肽值降低;骨质疏松组腰椎及全髋部骨密度降低,骨钙素、Ⅰ型胶原交联C末端肽、血清抗酒石酸酸性磷酸酶5b升高。血清Ⅰ型胶原交联C末端肽水平的降低与骨关节炎发病具有显著相关性;血清骨钙素、Ⅰ型胶原交联C末端肽、血清抗酒石酸酸性磷酸酶5b水平的升高与骨质疏松发病具有显著相关性。提示绝经女性骨关节炎患者骨吸收速率减低,骨质疏松患者骨转换率加快,骨代谢水平的差异导致两疾病患者骨密度呈现出负相关趋势。监测Ⅰ型胶原交联C末端肽、血清抗酒石酸酸性磷酸酶5b、骨钙素,特别是Ⅰ型胶原交联C末端肽血清水平对骨关节炎及骨质疏松的早期诊断及治疗有一定的参考价值。 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程全文链接：     

膝骨关节炎严重程度与关节液和血清中chemerin含量的关系

背景：研究发现,chemerin受刺激后可进一步扩增炎症信号,导致炎症因子和基质金属蛋白酶的释放。提示chemerin可能作为软骨代谢的重要调控因子,在骨关节炎的病理过程中发挥重要的作用。 目的：分析膝骨关节炎患者关节液和血清中chemerin水平与骨关节炎严重程度的相关性。 方法：选择经临床确诊的膝骨关节炎患者80例,采用酶联免疫吸附试验(ELISA)法对关节液和血清中的chemerin水平进行检测,骨关节炎影像学严重程度评分采用国际公认的Kellgren-Lawrence(K-L)评分系统。 结果与结论：患者关节液和血清中chemerin水平与Kellgren-Lawrence分级有显著相关性(r=0.981,P < 0.001和r=0.901,P < 0.001),且血清中chemerin水平与关节液中chemerin水平呈正相关(r=0.596,P < 0.01)。结果表明,骨关节炎患者关节液和血清中chemerin水平与影像学K-L分级严重程度正相关,chemerin水平可作为骨关节炎诊断及判断严重程度的参考指标。  中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程全文链接：     

血脂与骨密度：新疆男性高血压患者相关性

背景：有研究表明绝经后女性血脂与骨密度有一定相关性,但针对男性对象的研究较少,且结论不一。 目的：通过分析新疆乌鲁木齐市地区维吾尔族与汉族男性高血压患者血脂与骨密度的关系,探讨血脂水平与骨质疏松及骨量减少的相关性,以及民族间的差异。 方法：将193例男性高血压患者,按照民族分为2组,维吾尔族73例,汉族120例,再根据是否合并骨质疏松和骨量减少,将上述2组患者再分别分为2个亚组,分析各组骨密度与血脂的相关性,并用二元Logistic逐步回归方法分析血脂和其他相关因素与骨质疏松之间的相关性。 结果与结论：高血压维吾尔族骨质疏松及骨量减少患者中,胆固醇与股骨颈(r= 0.43,P=0.01)、Ward三角区(r=0.42,P=0.01)均为正相关,而在汉族高血压患者中未见明显相关性。应用二元Logistic回归方法进行分析,在控制体质量指数、年龄和民族因素后,仅胆固醇与骨质疏松及骨量减少的发生有关(OR=1.48,P=0.03)。结果证实,新疆男性维吾尔族与汉族高血压患者中,血脂与骨密度存在一定相关性,可能为骨质疏松发生的影响因素。     

膝骨关节炎患者的临床表现及相关影响因素

背景：目前膝骨关节炎的确切病因及发病机制尚不完全清楚。 目的：调查膝骨关节炎患者的临床表现,分析其相关影响因素。 方法：收集2007-07/2009-11青岛某医院住院治疗的315例膝骨关节炎患者的一般情况、现病史、既往史、体格检查、X 射线片检查、疾病诊断和实验室检查等资料,采用SPSS 13.0软件进行χ2检验,分析膝骨关节炎发病的影响因素。 结果与结论：①左膝骨关节疼痛占21.6%,右膝疼痛占29.5%,总体上右膝关节疼痛检出率高于左膝(P  < 0.01)。单膝疼痛占51.1%,双膝疼痛占48.9%,单双膝差异无显著性意义(P > 0.05)。②女性临床膝骨关节炎检出率高于男性(P   < 0.01)。男女检出率均与年龄有关,且随年龄的增加发病率升高。③肥胖人群的膝骨关节炎检出率较非肥胖人群高(P  < 0.01),不同性别差异无显著性意义。④不同劳动强度人群膝骨关节炎检出率差异具有显著性意义(P  < 0.01),劳动强度越大检出率越高。⑤绝经女性膝骨关节炎检出率较未绝经女性检出率高(P  < 0.05),绝经情况分布年龄范围为45~60岁(60岁以上被调查者均已绝经)。提示性别、年龄、体质量指数、职业(工人、家务)、遗传因素等是中老年膝骨关节炎发病的危险因素,其中以年龄因素危险度最高。     

剪切波弹性超声成像测量股四头肌及肌腱弹性与膝骨关节炎功能的相关性

背景：已有研究表明膝骨关节炎患者肌肉弹性会发生变化,但目前的研究多关注于肌张力、肌肉力量的评估,对于股四头肌及其肌腱弹性的评估却鲜有报道。目的：探究膝骨关节炎患者股四头肌及其肌腱弹性模量特征,并分析其与膝关节疼痛、功能的关系,为膝骨关节炎的防治提供一定依据。方法：采用剪切波弹性超声成像技术测量30例临床确诊为膝骨关节炎的患者(膝骨关节炎组)和28名无膝关节疼痛的志愿者(对照组)股四头肌及其肌腱的弹性模量。使用西安大略和麦克马斯特大学骨关节炎指数量表(WOMAC)评估入组患者膝关节的疼痛和功能。比较两组受试者股四头肌弹性模量的变化,统计学分析股四头肌弹性模量与WOMAC评分的相关性。结果与结论：(1)膝骨关节炎组的股直肌、股中间肌、股内侧肌、股外侧肌、股四头肌肌腱的厚度均小于对照组,但仅膝骨关节炎组的股外侧肌弹性模量值明显大于对照组,差异均有显著性意义(P <0.05)。(2)选取与对照组有特征性差异的肌肉弹性模量进行相关性分析,膝骨关节炎组的股外侧肌弹性模量值与WOMAC疼痛量表呈低度线性相关(r=0.367,P <0.05)。在自我报告的疼痛中,膝骨关节炎患者股外侧肌的弹...     

末梢指节间的骨关节炎有关位点基因组扫描:染色体2q上位点的证据

骨关节炎 ( OA)是人类肌病与骨骼病的常见病因 ,杂合型患者以关节处退化和活性改变为特征。考虑到环境和遗传因素的影响 ,进一步研究象骨关节炎这样的复杂疾病的遗传发生 ,精确的表型鉴定是很必要的。在骨关节炎的诊断中放射学的变化比临床证明更为重要。估计在女性患者中手和膝的骨关节炎占 39%～ 65 %。芬兰人中严重的手骨关节炎在 5 0岁以下的人中发生率很低 ( 4 0～ 49岁间只有 0 .0 4 % ) ,而在 5 0～ 5 9岁则迅速增高 ( 0 .1 8% )。有证据表明末梢指骨关节炎 ( DIP)累及对称关节 ,女性占优势 ,Heberden结节是带有遗传成分骨关节炎…     

膝内侧骨关节炎患者膝关节功能与不稳定性的关系

背景：膝内侧骨关节炎患者身体缺陷与骨性关节炎发展的关系尚不清楚。 目的：调查膝内侧骨关节炎患者的身体功能和膝关节不稳定性,探讨二者间的关系。 方法：纳入诊断性膝内侧骨关节炎患者104例,采用膝关节日常生活活动评估量表衡量膝关节不稳,功能的自我评估采用膝伤和骨性关节炎结果评分,应用计时爬梯试验评估基于体能的身体功能,并进行放射影像学评估。 结果与结论：不同程度膝关节不稳患者的内侧松弛度、外侧松弛度、对线角度、标准化最大随意等长收缩及爬梯时间比较差异无显著性意义(P > 0.05)。但不同程度膝关节不稳患者在疼痛、症状、日常生活活动、运动和膝关节相关生活质量子集得分方面差异有显著性意义(P < 0.05)。在膝内侧骨关节炎患者中,自报膝关节不稳与内侧松弛度、股四头肌无力、内翻对线无直接联系。     

膝骨关节炎患者跌倒恐惧影响因素分析及列线图模型构建

背景：跌倒恐惧会加重膝骨关节炎患者的膝关节不稳定性,导致患者减少活动而身体整体功能衰退,因此,对膝骨关节炎患者跌倒恐惧影响因素进行筛选及构建列线图模型,能够减少跌倒恐惧产生的伤害并为个体化诊疗方案制定提供借鉴。目的：探讨膝骨关节炎患者跌倒恐惧的影响因素及状况,并尝试建立膝骨关节炎患者跌倒恐惧列线图预测模型。方法：应用横断面研究方法,纳入2019年9月至2021年2月于上海中医药大学附属曙光医院就诊的膝骨关节炎患者560例,其中跌倒恐惧组469例,无跌倒恐惧组91例。分析比较两组患者一般资料、膝骨关节炎指数评分量表及医院焦虑抑郁量表评分后得出膝骨关节炎患者跌倒恐惧的影响因素,将影响因素绘制受试者工作特征曲线,得到具有跌倒恐惧诊断价值的约登指数,各因素约登指数最大值为膝骨关节炎跌倒恐惧的最佳诊断值(截断值),绘制列线图,建立膝骨关节炎患者跌倒恐惧预测模型。结果与结论：(1)Logistic回归分析表明,身高、男性为膝骨关节炎患者跌倒恐惧的保护因素,年龄、失业、膝骨关节炎指数僵硬量表评分、焦虑量表评分为膝骨关节炎患者跌倒恐惧的危险因素;(2)受试者工作特征曲线结果表明,膝骨关节炎指数僵硬量表...     

Prevalence of Osteoporosis in Female Patients with Advanced Knee Osteoarthritis Undergoing Total Knee Arthroplasty

This study sought to demonstrate bone mineral density (BMD) conditions in elderly female patients with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA). In addition, we sought to determine whether their BMD conditions differ from those of community-based females without knee OA. Finally we sought to determine whether clinical statuses are related to BMD in the knee OA patients. BMD conditions in 347 female patients undergoing TKA and 273 community-based females were evaluated. Additionally, comparative analyses of BMD between age and body mass index-matched knee OA groups (n=212) and the control groups (n=212) were performed. In the pre-matched knee OA group, regression analyses were performed to determine whether preoperative clinical statuses were related to BMD. Considerable prevalence of coexistent osteoporosis (31%) was found in the pre-matched knee OA patients undergoing TKA. We found no significant differences of the BMD T-scores and the prevalence of osteoporosis between the age and body mass index-matched knee OA and control groups. In the pre-matched knee OA patients, poorer preoperative clinical scores were related to poorer BMD T-scores in the proximal femur and/or lumbar spine. Our study suggests that more attention should be paid to identify and treat osteoporosis in elderly female patients with advanced knee OA undergoing TKA.

Graphical Abstract

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A study of the relationship between meniscal injury and bone microarchitecture in ACL reconstructed knees

Background

Anterior cruciate ligament (ACL) tears increase the risk of developing knee osteoarthritis. This risk increases further with concurrent meniscus injury. The role of bone changes during knee osteoarthritis development are not well-understood, but may be important to its etiology.

骨保护素基因G1181C多态性与绝经妇女骨密度的Meta分析

背景：遗传学研究显示骨保护素基因G1181C多态性与绝经妇女骨密度可能存在关系,但研究结论存在一定差异。 目的：采用Meta分析方法研究骨保护素基因G1181C(rs2073618)多态性与绝经后妇女骨密度的关系。 方法：检索PubMed、Embase、CNKI、万方数据库中关于骨保护素基因rs2073618位点G1181C多态性与骨密度关系的观察性研究。以标准化均数差为效应指标,并根据异质性检验结果选择随机效应模型或固定效应模型计算标准化均数差。 结果与结论：纳入9篇文献,测定椎骨骨密度8 799人,测定股骨颈骨密度9 365人。分析结果显示,携带G等位基因的绝经妇女椎体骨密度比携带C等位基因者低,高加索人群亚组分析显示相同结果。此外,高加索人群的亚组分析显示,携带GG基因型的绝经妇女股骨颈骨密度低于携带GC和CC基因型者。说明骨保护素基因G1181C多态性与绝经后妇女骨密度存在相关性,G等位基因是发生骨密度降低的危险因子。     

骨代谢指标在骨质疏松患者椎体变形中的意义

背景：骨质疏松常导致胸腰段椎体变形,鉴于骨代谢指标可灵敏的反映个体骨转换过程,结合骨密度可减少漏诊,预测骨折风险,提前干预可降低重度椎体畸形的发生率。 目的：分析骨代谢指标在骨质疏松患者椎体变形中的意义。 方法：将157例老年人骨质疏松患者按是否存在椎体变形分为椎体变形组和椎体形态正常组,椎体变形组中根据骨密度的不同分为骨密度正常和骨密度减低亚组,进行骨密度和总Ⅰ型胶原氨基端前肽、β胶原特殊序列、N端骨钙素骨代谢指标进行检测,比较了2组间及椎体变形组内骨密度正常和骨密度减低亚组间各骨代谢指标的差异。 结果与结论：椎体变形组总Ⅰ型胶原氨基端前肽、β胶原特殊序列、N端骨钙素水平较椎体形态正常组增高(P < 0.05);骨密度正常亚组总Ⅰ型胶原氨基端前肽与β胶原特殊序列水平较骨密度减低亚组增高(P < 0.05),N端骨钙素在2亚组间差异无显著性意义(P > 0.05)。结果表明骨质疏松患者中椎体变形者总Ⅰ型胶原氨基端前肽、β胶原特殊序列、N端骨钙素的骨代谢水平高于无椎体变形者,在存在椎体变形的患者中,骨密度正常者总Ⅰ型胶原氨基端前肽、β胶原特殊序列的骨代谢水平高于骨密度降低者,骨代谢水平增高结合骨密度及椎体变形可用于骨质疏松的诊断和椎体脆性骨折的预测。 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程全文链接：     

Two-year fixation and ten-year clinical outcomes of total knee arthroplasty inserted with normal-curing bone cement and slow-curing bone cement: A randomized controlled trial in 54 patients

BackgroundThe normal-curing Refobacin® Bone Cement R (RR) and slow-curing Refobacin® Plus Bone Cement (RP) were introduced after discontinuation of the historically most used bone cement, Refobacin®-Palacos® R, in 2005. The aim of this study was to compare total knee arthroplasty component fixation with the two bone cements.Methods54 patients with primary knee osteoarthritis were randomized to either RR (N = 27) or RP (N = 27) bone cement and followed for two years with radiostereometric analysis of tibial and femoral component migration and dual-energy x-ray absorptiometry measured periprosthetic bone mineral density (BMD). Further, patients were followed up at ten years with clinical outcome scores (OKS and KOOS).ResultsAt two-years follow-up, tibial total translation was 0.31 mm (95% CI: 0.19 – 0.42) for the RP group and 0.56 mm (95% CI: 0.45 – 0.67) (p < 0.01) for the RR group. There was continuous tibial component migration from one to two years follow-up (MTPM > 0.2 mm) in 13/27 patients from the RR and in 12/26 patients from the RP group. There was no difference between groups in BMD baseline values or changes during follow-up, as well as no correlation between change in BMD and tibial component migration. At ten-years follow-up, the improvement in the clinical outcome scores was similar between groups. There were no prosthesis related complications during the 10-year follow-up.ConclusionAt two years, tibial total translation was lower in the RP compared with the RR cement group, but BMD changes were similar. At ten years, no components were revised and clinical outcome scores were similar between groups.     

骨关节炎患者骨髓间充质干细胞功能状态与病情进展的相关性

背景：研究表明骨髓间充质干细胞功能状态的改变是骨关节炎的病因之一。 目的：探讨骨关节炎患者骨髓间充质干细胞功能状态与病情进展的相关性。 方法：收集45例患者的临床资料,其中15例为关节镜下进行膝关节交叉韧带重建患者(对照组),15例为轻度骨关节炎患者(轻度骨关节炎组),15例为重度骨关节炎患者(重度骨关节炎组)。体外培养获得3组患者骨髓间充质干细胞,观察其形态变化,检测其增殖能力及软骨向诱导分化能力。 结果与结论：原代骨髓间充质干细胞经24 h培养后呈整齐排列状,且为长梭形,3组骨髓间充质干细胞形态基本一致,不存在显著差异。骨髓间充质干细胞成软骨诱导14 d后行甲苯胺蓝染色鉴定,爬片可见甲苯胺蓝异染颗粒,3组成软骨诱导分化能力无明显差异。CCK-8法检测各组患者骨髓间充质干细胞的增殖能力,其中以对照组增殖能力最强,重度骨关节炎组增殖能力最弱,结果表明骨关节炎患者骨髓间充质干细胞功能状态与病情进展之间存在一定的相关性。中国组织工程研究杂志出版内容重点：干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程     

Investigating meniscal symptoms in patients with knee osteoarthritis—Is MRI an unnecessary investigation?

The aim of this study was to evaluate the relationship between radiographic knee osteoarthritis and the presence of a relevant meniscal tear detected on MRI in symptomatic patients over the age of 60.Seventy seven patients over the age of 60 who had been investigated with a knee MRI over a 1-year period were identified. Sixty patients had a full set of data available for analysis. Their plain radiographs were blindly graded for osteoarthritis using the Kellgren-Lawrence (K-L) scale. The indications for the MRI were subdivided into: meniscal symptoms, general knee pain and “other”. These indications were correlated with the K-L grade and result of the MRI.Overall, 40% of patients with a K-L grade of 0 had a meniscal tear compared to 89% of patients with a K-L score of 3, and 88% with a K-L score of 4. The indications for an MRI were grouped into meniscal symptoms (49), general pain (6) and other (5). In the group investigated for meniscal symptoms, the incidence of meniscal tears was 92% and 100% with a K-L grade of 3 and 4 respectively. This equated to a positive predictive value of 93% for K-L grade 3 and above, and 100% for K-L grade 4 alone.Given the predictability of the MRI findings in patients with significant osteoarthritis as well as meniscal symptoms, we conclude that this is an unnecessary investigation when used for this indication.     

兔膝骨关节炎合并骨质疏松症动物模型的建立

背景：临床发现同时患有骨质疏松症和骨关节炎患者占相当大的比例,而且目前对骨质疏松与骨关节炎相互关系的认识不一致。 目的：建立骨关节炎合并骨质疏松症的动物模型。 方法：将14只新西兰大白兔随机等分为模型组和正常组。模型组新西兰大白兔行双侧卵巢切除,正常组新西兰大白兔不作任何处理。 结果与结论：去除卵巢10周后,模型组大白兔关节软骨出现明显的退变,血清雌二醇、股骨骨密度水平较正常组显著下降(P < 0.01),而关节软骨Mankin评分比正常组显著增高(P < 0.01);且软骨Mankin评分与骨密度和血清雌二醇呈负相关,而骨密度与血清雌二醇水平呈正相关,表明实验成功建立了兔膝骨关节炎合并骨质疏松症动物模型。     

The association of anthropometric measures and osteoarthritis knee in non-obese subjects: a cross sectional study

OBJECTIVE:

Body mass index (BMI) and knee osteoarthritis have a strong association, but other anthropometric measures lack such associations. To date, no study has evaluated non‐obese knee osteoarthritis to negate the systemic and metabolic effects of obesity. This study examines the validity of the contention that BMI and other anthropometric measures have a significant relationship with knee osteoarthritis.

METHODS:

In total, 180 subjects with a diagnosis of knee osteoarthritis were recruited and classified according to Kellgren‐Lawrence (KL) grades. Body mass index, mid‐upper arm circumference, waist‐hip ratio and triceps‐skinfold thickness were recorded by standard procedures. Osteoarthritis outcome scores (WOMAC) were evaluated.

RESULTS:

(1) In both genders, the BMI was significantly higher for KL grade 4 than for grade 2; triceps‐skinfold thickness was positively correlated with the joint space width of the tibial medial compartment. (2) In males, triceps‐skinfold thickness significantly increased as the KL grades moved from 2 to 4; the significantly higher BMI found in varus aligned knees was positively correlated with WOMAC scores. (3) In females, the waist‐hip ratio was significantly higher for KL grade 4 than for grade 2; a significant correlation was found between BMI and WOMAC scores. The waist‐hip ratio was significantly associated with varus aligned knees and it positively correlated with WOMAC scores and with the joint space width of the tibial medial compartment. The mid‐upper arm circumference demonstrated no correlation with knee osteoarthritis.

CONCLUSION:

This study validates the contention that BMI and other anthropometric measures have a significant association with knee osteoarthritis. Contrary to common belief, the triceps‐skinfold thickness (peripheral fat) in males and the waist‐hip ratio (central fat) in females were more strongly associated with knee osteoarthritis than BMI.