Smoking cessation and associated factors during pregnancy

OBJECTIVE: To examine smoking habits before and during pregnancy, as well as factors associated with smoking cessation, in three European settings. METHODS: Women seeking antenatal care in Ashford (UK), Minorca and Barcelona (Spain) were recruited to the Asthma Multicenter Infant Cohort Study (AMICS). Questionnaires inquiring into the smoking habits of each woman and her partner, demographic data, occupation, educational level, number of previous children, breast feeding, alcohol intake, and history of asthma and of other allergic diseases were completed during pregnancy and in the first year after delivery. RESULTS: A total of 1,572 pregnant women were included in the three cohorts. Smoking prior to pregnancy was more common in Barcelona (46.2%) than in Minorca (39.8%) or Ashford (31.6%). Cessation rates during pregnancy also differed: 18% of women in Ashford, 20.4% in Minorca and 31.9% in Barcelona were still smoking during the first trimester. In a multivariate regression model, the factors showing a significant (negative) association with smoking cessation during pregnancy were having older children, having a partner who smoked and starting smoking at a young age. CONCLUSIONS: Baseline smoking habits and changes in smoking habits during pregnancy significantly differed between the three communities studied. Women pregnant with their first child, those who had started smoking at a later age and those whose partners were non-smokers were more likely to stop smoking when pregnant.     

Smoking during pregnancy and its effects on child cognitive ability from the ages of 8 to 12 years

Maternal smoking during pregnancy and subsequent child cognitive development and ability were examined in a birth cohort of New Zealand children studied to the age of 12 years. Analysis at a bivariate level showed that children whose mothers smoked during pregnancy scored significantly lower on standardised tests of intelligence, reading and mathematical ability than children whose mothers did not smoke. However, after adjustment for confounding covariates, the results showed no detectable relationship between smoking during pregnancy and child cognitive ability. These results suggest that children whose mothers smoked during pregnancy fared worse on tests of cognitive ability not because of possible causal effects of smoking, but rather because these children tended to come from families which provided a relatively disadvantaged home environment.     

基于8月龄婴儿的喂养行为评价方法与结果分析

目的 使用两种评价方法对调查地区户籍和流动8月龄婴儿的喂养行为进行分析,发现不合理喂养行为,为制定研究地区婴儿的喂养指导策略提供依据,同时对两种指标评价方法的优劣进行对比。方法 采用横断面研究,选取2014年在北京某社区接受常规儿童保健服务,排除早产、低出生体重、出生先天缺陷及心、肝、肾、血液系统疾病的所有8月龄婴儿为调查对象,并通过问卷收集婴儿喂养情况进行统计分析。结果 调查地区本市和流动8月龄婴儿在6月龄内辅食添加率分别为52.0%和65.1%(P<0.05)。8月龄婴儿喂养指数得分均值本市和流动分别为12.42±2.24和11.41±2.18(P<0.001)。喂养指数合格率本市大于流动(P=0.001)。喂养指数各分项中,过去24 h奶瓶喂养指数本市小于流动(P<0.001),过去1周食物添加频率中,奶类、鱼虾类、禽畜肉类、蔬菜水果类喂养指数本市大于流动(P<0.01)。婴儿早开奶率、最小膳食多样性、曾经母乳喂养率,本市均好于流动人口(P<0.05)。所有母乳喂养婴儿的最小合理膳食率均明显低于人工喂养婴儿(P<0.01)。结论 调查地区8月龄婴儿喂养情况本市好于流动,但整体状况不容乐观;两种评价方法各有千秋。     

Smoking during pregnancy and its effects on child cognitive ability from the ages of 8 to 12 years

Summary. Maternal smoking during pregnancy and subsequent child cognitive development and ability were examined in a birth cohort of New Zealand children studied to the age of 12 years. Analysis at a bivariate level showed that children whose mothers smoked during pregnancy scored significantly lower on standardised tests of intelligence, reading and mathematical ability than children whose mothers did not smoke. However, after adjustment for confounding covariates, the results showed no detectable relationship between smoking during pregnancy and child cognitive ability. These results suggest that children whose mothers smoked during pregnancy fared worse on tests of cognitive ability not because of possible causal effects of smoking, but rather because these children tended to come from families which provided a relatively disadvantaged home environment.     

Smoking during pregnancy: Missouri longitudinal study

Maternal smoking during pregnancy has been shown to be associated with reduced birthweight and increased fetal and infant mortality. This paper examines these patterns in first and second maternally-linked singleton pregnancies from 1978 to 1990 among 176 843 Missouri resident women with known smoking status in both pregnancies. Generally women were more likely to smoke in their second pregnancies (27.4%), than in their first (25.8%). This pattern was strongest among those whose first pregnancies occurred as teenagers, and for black women. The relationships of smoking during the first and second preg-nancies to outcomes in the second pregnancies were examined primarily through multivariate logistic regression. The adjusted relative risk (RR) of low birthweight (<2500 g) in the second pregnancy to not smoking in either pregnancy was 1.82 for those who smoked during the second pregnancy only, and 1.87 for those who smoked in both pregnancies. For those who smoked in the first pregnancy only, the RR was 0.97, not significantly different from 1. Adjusted smoking RRs for small-for-gestational age were larger, while adjusted RRs for fetal and neonatal mortality were smaller than the smoking RRs for low birthweight.     

Smoking during pregnancy: Missouri longitudinal study

Maternal smoking during pregnancy has been shown to be associated with reduced birthweight and increased fetal and infant mortality. This paper examines these patterns in first and second maternally-linked singleton pregnancies from 1978 to 1990 among 176 843 Missouri resident women with known smoking status in both pregnancies. Generally women were more likely to smoke in their second pregnancies (27.4%), than in their first (25.8%). This pattern was strongest among those whose first pregnancies occurred as teenagers, and for black women. The relationships of smoking during the first and second preg-nancies to outcomes in the second pregnancies were examined primarily through multivariate logistic regression. The adjusted relative risk (RR) of low birthweight (<2500 g) in the second pregnancy to not smoking in either pregnancy was 1.82 for those who smoked during the second pregnancy only, and 1.87 for those who smoked in both pregnancies. For those who smoked in the first pregnancy only, the RR was 0.97, not significantly different from 1. Adjusted smoking RRs for small-for-gestational age were larger, while adjusted RRs for fetal and neonatal mortality were smaller than the smoking RRs for low birthweight.     

Smoking patterns and use of cessation interventions during pregnancy

BACKGROUND: Pregnant smokers should be counseled to quit smoking and offered effective cessation interventions. To improve understanding of how best to increase smoking-cessation rates during pregnancy, this study analyzed population-based surveillance data to describe women's smoking patterns and the use of cessation services during pregnancy. METHODS: Data were analyzed from the 2004 and 2005 New Jersey Pregnancy Risk Assessment Monitoring System, a population-based survey of postpartum women (n=4473). Measures of behaviors included the timing of quit relative to the learning of pregnancy, provider assistance, the use of cessation interventions, and barriers to quitting. Analyses were done in 2007 and 2008. RESULTS: An estimated 16.2% (95% CI=15.1, 17.3) of women smoked before pregnancy. Of these, 49.8% quit before entering prenatal care, and 5.2% quit after entering prenatal care. Almost all women reported that their prenatal care provider asked if they smoked, but only 56.7% reported that a provider counseled them to quit smoking. Only 11.5% of women who smoked in late pregnancy used a cessation method, including self-help materials (6.3%); medications (3.9%); face-to-face counseling (1.7%); telephone-based counseling (1.5%); Internet-based counseling (1.3%); and a class or program (1.0%). The most frequently reported barriers to quitting were cravings for a cigarette, stress, and being around people who smoked. CONCLUSIONS: Nearly half of pregnant New Jersey smokers quit before prenatal care, and very few quit later. Few continuing smokers used a smoking-cessation method when trying to quit or cut back. Efforts should be intensified to increase the knowledge, promotion, and referral to effective interventions to help pregnant smokers quit.     

Smoking before, during, and after pregnancy.

We report the first national data on smoking before, during, and after pregnancy. Estimates are based on the 1986 Linked Telephone Survey that reinterviewed 1,550 White women 20-44 years of age who were respondents to the 1985 National Health Interview Survey. An estimated 39 percent of White women who had smoked before pregnancy quit smoking while pregnant (27 percent when they found out they were pregnant and 12 percent later during pregnancy). Women with less than 12 years of education were five times as likely to smoke and one-fourth as likely to quit as those with 16 or more years of education. Women who smoked more than one pack of cigarettes per day before pregnancy were one-fifth as likely to quit as those smoking less. Of the women who quit, 70 percent resumed smoking within one year of delivery. Of those who relapsed, 67 percent resumed smoking within three months of delivery and 93 percent within six months. There is little evidence of educational differentials in relapse rates. The fact that relapse remains high suggests that while health of the fetus is a strong influence on women's smoking habits, women may be less aware of the effect of passive smoke on the infant.     

Smoking during pregnancy is harmful for mother and child

Smoking is an important adverse foetal exposure with a high prevalence in Western countries. Mothers who smoke during pregnancy have a strongly increased risk of delivering children born preterm or with a low birth weight. Recent studies suggest that foetal smoke exposure also leads to structural and functional developmental adaptations with permanent postnatal consequences. These adaptations may be beneficial in short term, but might lead to cardiovascular and metabolic disease in later life. Future research is needed to explore the underlying mechanisms. For now, clinicians should explain to pregnant women that smoking during pregnancy is not only harmful for their own health, but also affects their children's health many years later.     

Smoking during pregnancy among northwest Native Americans.

There is little available information on the smoking habits of Native Americans. The authors used data from the Washington State birth certificate to determine the prevalence of smoking during pregnancy among Native American mothers in Washington State. From 1984 through 1988, 39.8 percent of all Native Americans smoked during their pregnancy. Smoking patterns during pregnancy differed markedly between Native Americans and whites according to maternal age and marital status. The smoking prevalence in Native Americans, adjusted for maternal age and marital status, was 1.3 times higher than that found in Washington State white women. This is the first analysis of statewide smoking rates during pregnancy among Native Americans. The birth certificate can serve as a readily accessible and low cost surveillance system for populations such as Native Americans, who are otherwise difficult to study. Smoking intervention programs need to be targeted at Native Americans, and how their smoking patterns differ from those of the general population needs to be recognized.     

Smoking during pregnancy, 1967-80.

Data from two national samples of live births to married mothers (the 1967 and 1980 National Natality Surveys) were used to document changes in smoking during pregnancy. Smoking among married teenagers remained essentially constant between 1967 and 1980. For married mothers age 20 and over, the prevalence of smoking during pregnancy decreased from 40 to 25 per cent among Whites and 33 to 23 per cent among Blacks. There were striking differences in the magnitude of the decrease by educational attainment. Among the White married mothers age 20 and over, the prevalence of smoking during pregnancy decreased from 48 to 43 per cent for those with less than 12 years education and from 34 to 11 per cent for those with 16 or more years education.     

Smoking and the sudden infant death syndrome

The aims of this review are (a) to critically examine the epidemiologic evidence for a possible association between smoking and the sudden infant death syndrome (SIDS), (b) to review the pathology and postulated physiological mechanism(s) by which smoking might be causally related to SIDS, and (c) to provide recommendations for SIDS prevention in relation to tobacco smoking. Over 60 studies have examined the relation between maternal smoking during pregnancy and risk of SIDS. With regard to prone-sleep-position intervention programs, the pooled relative risk associated with maternal smoking was RR = 2.86 (95% CI = 2.77, 2.95) before and RR = 3.93 (95% CI = 3.78, 4.08) after. Epidemiologically, to distinguish the effect of active maternal smoking during pregnancy from involuntary tobacco smoking by the infants of smoking mothers is difficult. Clear evidence for environmental tobacco smoke exposure can be obtained by examining the risk of SIDS from paternal smoking when the mother is a non-smoker. Seven such studies have been carried out. The pooled unadjusted RR was 1.49 (95% CI = 1.25, 1.77). Consideration of the pathological and physiological effects of tobacco suggests that the predominant effect from maternal smoking comes from the in utero exposure of the fetus to tobacco smoke. Assuming a causal association between smoking and SIDS, about one-third of SIDS deaths might have been prevented if all fetuses had not been exposed to maternal smoking in utero.     

北京某社区户籍与流动8月龄婴儿喂养和营养状况比较研究

目的 了解调查地区户籍与流动8月龄婴儿的喂养及营养情况,为有针对性的对不同户籍儿童喂养指导提供依据。方法 采用横断面研究,选取2014年在北京某社区接受常规儿童保健,排除早产、低出生体重、先天缺陷及心、肝、肾、血液系统疾病的所有8月龄婴儿为调查对象,并通过问卷收集婴儿喂养及营养情况进行统计分析。结果 调查地区本市和流动人口婴儿6月龄内辅食添加率分别为52%和65.1%(P<0.05),早开奶率分别为41.8%和21.9(P<0.05),最小膳食多样性分别为57.7%和36.7%(P<0.05),奶瓶使用率分别为78.6%和54.4%(P<0.01)。本市和流动人口婴儿年龄别身长(LAZ)均值分别为0.93±1.071和0.54±1.130(P<0.01),年龄别头围(HCZ)均值分别为0.44±0.910和0.11±0.978(P<0.01),低体重率分别为0.5%和4.1%(P<0.05),贫血患病率分别为27.6%和47.3%(P<0.01)。母亲喂养知识掌握情况本市户籍优于流动人口(P<0.01)。结论 调查地区流动人口8月龄婴儿喂养和营养状况不容乐观。     

Adverse pregnancy outcomes and infant mortality after quadrivalent HPV vaccination during pregnancy

Background

Few studies have studied the association between unintended human papillomavirus (HPV) vaccination and adverse pregnancy outcomes. This study set out to determine the association between HPV vaccination during pregnancy and subsequent risk of spontaneous abortion, stillbirth, and one-year infant mortality.

Maternal growth during pregnancy and decreased infant birth weight

We used stature and measurement of knee height to measure continued maternal growth during adolescent pregnancy in a sample of young gravidas (primigravidas and multiparas) and mature pregnant control subjects. Growth during pregnancy has been masked by a tendency of all gravidas to shrink while pregnant (approximately 0.5 cm over 6 mo of observation). Consequently, growth of many adolescent gravidas has not been clinically apparent. There was no effect on maternal growth during a first pregnancy in adolescence but this may be a result of the relatively good prepregnant nutrition status of the young gravidas in developed countries. Maternal growth during pregnancy, however, is associated with significantly decreased (-282 g, p less than 0.05) birth weight for infants when maternal growth continues during a subsequent adolescent pregnancy. This observation is consistent with the hypothesized competition between the metabolic demands of the growing adolescent mother and the nutrient needs of her developing fetus.     

Smoking during pregnancy and lactation and its effects on breast-milk volume

The influence of cigarette smoking on daily breast-milk volume was measured by the dose-to-mother deuterium-dilution method in 10 smoking and 10 nonsmoking mothers. After administration of deuterium to the mother, breast milk and infant saliva were sampled over 14 d and analyzed by mass spectrometry. Nonsmoking mothers had a significantly greater breast-milk volume than did smokers [961 +/- 120 vs 693 +/- 110 g/d, mean +/- SD; t = 5.21, P less than 0.0001). Growth rates of the infants were also measured. Weight increase of infants of non-smoking mothers was 550 +/- 130 g whereas of infants of smoking mothers it was only 340 +/- 170 g (t = 3.11, P less than 0.01). These results indicate that cigarette smoking has a negative influence on breast-milk volume whereas the lower infant-growth rates of the smoking mothers suggest also that their breast-milk output was insufficient to support the energy requirements of their infants.     

Smoking during pregnancy affects speech-processing ability in newborn infants

BACKGROUND: Tobacco smoking during pregnancy is known to adversely affect development of the central nervous system in babies of smoking mothers by restricting utero-placental blood flow and the amount of oxygen available to the fetus. Behavioral data associate maternal smoking with lower verbal scores and poorer performance on specific language/auditory tests. OBJECTIVES: In the current study we examined the effects of maternal smoking during pregnancy on newborns' speech processing ability as measured by event-related potentials (ERPs). METHOD: High-density ERPs were recorded within 48 hr of birth in healthy newborn infants of smoking (n = 8) and nonsmoking (n = 8) mothers. Participating infants were matched on sex, gestational age, birth weight, Apgar scores, mother's education, and family income. Smoking during pregnancy was determined by parental self-report and medical records. ERPs were recorded in response to six consonant-vowel syllables presented in random order with equal probability. RESULTS: Brainwaves of babies of nonsmoking mothers were characterized by typical hemisphere asymmetries, with larger amplitudes over the left hemisphere, especially over temporal regions. Further, infants of nonsmokers discriminated among a greater number of syllables whereas the newborns of smokers began the discrimination process at least 150 msec later and differentiated among fewer stimuli. CONCLUSIONS: Our findings indicate that prenatal exposure to tobacco smoke in otherwise healthy babies is linked with significant changes in brain physiology associated with basic perceptual skills that could place the infant at risk for later developmental problems.     

Organochlorine exposures during pregnancy and infant size at birth

BACKGROUND: Organochlorines, including polychlorinated biphenyls (PCBs) and pesticides, are environmentally persistent contaminants that concentrate in the food chain as well in human adipose tissue and readily cross the placenta. METHODS: To follow up on studies suggesting an association of organochlorine exposure with reduced birth size, we investigated the association of PCBs and organochlorine pesticides (including p,p'-dichlorodiphenyl dichloroethene [p,p'-DDE], the major degradation product of p,p'-dichlorodiphenyl trichloroethane [p,p'-DDT], and hexachlorobenzene [HCB]), with birth weight, crown-heel length, and head circumference. We evaluated a cohort of 722 infants born between 1993 and 1998 to mothers residing near a PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. RESULTS: Small negative associations were observed for PCBs and birth weight; associations were weaker for birth length and head circumference. There was evidence for effect modification by smoking during pregnancy on the association between PCBs and birth weight. No associations were found with p,p'-DDE or HCB for any measures of birth size. CONCLUSIONS: This study supports the growing literature that demonstrates at most a weak association between very low-level organochlorine exposure and birth size.