Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn＇t pay much attention. Later, it developed into vomiting after eating. After the vomiting, relieved, but with slight the discomfort would be hypodynamia. She was once diagnosed as having ‘neurogenic vomiting＇. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Xiaoyaosan decoction regulates food intake and body weight via the leptin-leptin receptor-proopiomelanocortin pathway in rats with chronic immobilization stress

OBJECTIVE: To evaluate the effects of the Xiaoyaosan(XYS) decoction on the food intake and body weight of rats with chronic immobilization stress(CIS), as well as the concentration of serum leptin and the expression of feeding-related neuropeptides [leptin receptor(Ob-R), proopiomelanocortin(POMC), and α-melanocyte-stimulating hormone(α-MSH)] in the hypothalamic arcuate nucleus(ARC).METHODS: We subjected rats to CIS for 3 h a day.The rats were randomly divided into the following groups: control group, 7-day stress group, 21-day stress group and XYS-treated group. The rats in the two stress groups were exposed to CIS for 7 or 21 d.The rats in the XYS-treated group were also exposed to CIS for 21 d and were intragastrically administered the XYS decoction before stress. The body weight and food intake of the rats were measured every day. The content of leptin in serum andα-MSH in the ARC were detected by ELISA, and the expression of neuropeptides in the ARC was assayed by immunofluorescence, Western blot and q RT-PCR.RESULTS: The food intake and body weight of rats exposed to CIS were lower than those of control rats. The serum leptin, and expression levels of ObR, POMC and α-MSH in the ARC were significantly higher than those in the control rats. Treatment with the XYS decoction improved the appetite and the body weight, and down-regulated serum leptin and Ob-R, POMC and α-MSH in hypothalamus ARC.CONCLUSION: The leptin-Ob-R-POMC pathway might be the part of the mechanism underlying XYS's improvement of somatic symptoms such as reduction in food intake and body weight related to CIS.     

Ginsenoside rg3 reduces body weight by regulating fat content and browning in obese mice

Objective:To determine the effects of ginsenoside rg3 on the body weight of C57BL/6J obese mice and to investigate its underlying weight loss mechanisms with a focus on white fat browning-related factors.Methods:Eight-week-old C57BL/6J male mice were fed a high-fat diet for 12 successive weeks to construct the obese model.C57BL/6J male mice were fed a standard chow diet to construct normal control group.After 8 weeks of intervention with ginsenoside rg3,the food intake,body weight,body fat mass,blood sugar,and lipid profiles of the mice in each group were detected.Hematoxylin and eosin(HE)staining was used to observe the histological morphology of the adipose tissues.Real-time polymerase chain reaction(RT-PCR)and Western blotting(WB)were applied to detect the gene and protein expression levels of peroxisome proliferators-activated receptor gama(PPARg),Peroxisome proliferatoractivated receptor-gamma coactivator-1alpha(PGC-1a),PR domain containing 16(PRDM16),and uncoupling protein 1(UCP-1).Results:Compared to normal control group mice,the body weight,food intake,body fat composition,and blood lipid levels of model group mice increased significantly.After 8 weeks of intervention with ginsenoside rg3,body weight,body fat composition,food intake,and blood lipid profiles decreased.HE staining showed that ginsenoside rg3 can improve white adipocyte hypertrophy to a certain extent.RTPCR and WB demonstrated that ginsenoside rg3 can increase the mRNA and protein expression levels of PPARg,PGC-1a,PRDM16,and UCP-1 in the adipose tissues of obese mice.Conclusion:The weight reduction effect of ginsenoside rg3 may be related to the promotion of white fat browning.     

Tuina for abdominal distension: A case report

Case Example The patient, male, 57 years old, senior engineer, was sick with the primary hepatocellular carcinoma. On March 23 of 1994, the tumor, which was in sized 13.5 cm × 8 cm, was removed smoothly by peridural anesthesia. After operation,the tube for peridural anesthesia was retained for intermittent injection of anesthetics and the nasal feeding was given to reduce the pressure in the stomach and intestmes.     

Essential role of medicine and food homology in health and wellness

Traditional Chinese medicine (TCM) is an ancient healing system that has been practiced for thousands of years in China and other East Asian countries. According to the TCM theory, medicine and food share the same origin and may have the same functions in the prevention and treatment of various health conditions. This is how the concept of medicine and food homology is developed and popularized. In China, an official list of medicine and food homology substances is promulgated by the China National Health Commission (formerly Ministry of Health) (NHC, 2002; NHC, 2020-1; NHC, 2020-2). All these substances are included in the Chinese Pharmacopoeia and safe to be used as food. 1.Significance and applications of medicine and food homology In TCM, the concept of medicine and food homology plays a crucial role in understanding the relationship between the body, food, and nature. It is believed that certain foods can have a profound impact on a person''s health and well-being, as they possess properties that can either support or counteract the body''s internal balance. For instance, some foods are believed to have warming or cooling properties, while others are thought to be moistening or drying. The significance of medicine and food homology in TCM also extends to the prevention and treatment of specific health conditions. In TCM, it is believed that many common ailments can be attributed to an imbalance in the body''s internal environment, which can be corrected by consuming the right combination of foods and herbs. For example, a person suffering from a cold, which is considered a "wind-cold" condition in TCM, may be advised to consume foods with warming properties, such as ginger and cinnamon, to help restore balance and alleviate the symptoms. One of the main applications of medicine and food homology in TCM is in the area of dietary therapy, which involves the use of foods and herbs to prevent and treat illness. This approach is based on the idea that certain foods have specific therapeutic effects on the body, and that by consuming these foods, a person can help maintain their overall health and well-being. For instance, a person with a weak digestive system may be advised to consume foods with strengthening properties, such as cooked grains and root vegetables such as Chinese yam, Dioscoreae Rhizoma (Shanyao in Chinese), to help improve their digestion and overall health. Another application of medicine and food homology in TCM is in the formulation of herbal remedies. TCM practitioners often use a combination of herbs and foods to create customized treatments for their patients, based on their unique health needs and the specific properties of the ingredients. This approach not only allows for a more personalized approach to healthcare, but it also helps to minimize the risk of side effects and interactions between different herbs and medications. 2.Examples of medicine and food homology substances There are many examples of medicine and food homology substances, ranging from everyday foods to more exotic herbs and ingredients. Some common examples include: (1) Ginger: This warming herb is widely used to treat digestive issues, colds, and flu. It is believed to have anti-inflammatory, anti-nausea, and immune-boosting properties, making it an ideal remedy for a variety of health conditions. (2) Goji berries (Lycii Fructus, Gouqizi in Chinese): These small red berries are a popular medicine and food homology substance, as they are believed to have numerous health benefits, including improving eyesight, boosting the immune system, and promoting longevity. They are considered a “superfood” due to their high antioxidant content and are often used in herbal tonics and teas. (3) Ginseng (Ginseng Radix et Rhizoma, Renshen in Chinese): This well-known adaptogenic herb is used to strengthen the body''s energy, or Qi, and improve overall vitality. It is believed to have a wide range of health benefits, including enhancing mental clarity, reducing stress, and supporting immune function. (4) Jujube (Ziziphi Jujubae Fructus): Also known as red dates, jujube is a popular ingredient in TCM and also a common food, as they are believed to have nourishing and calming properties. They are often used in treating insomnia, anxiety, and digestive issues. (5) Lotus seeds (Nelumbinis Semen, Lianzi in Chinese): These seeds are often used to treat a variety of health conditions, including insomnia, digestive problems, and heart palpitations. They are believed to have a calming effect on the body and are often used in herbal teas and soups for their soothing properties. 3. Modern research and evidence are needed for integrating medicine and food homology into modern healthcare practices While the concept of medicine and food homology has been an integral part of TCM for centuries, it has only recently begun to gain attention in the scientific community and food industry. Modern research is increasingly supporting the idea that medicine and food homology substances can play a significant role in promoting health and preventing illness. For instance, studies have shown that many of the foods and herbs used in TCM, such as ginger (Di et al., 2010) (Mashhadi et al., 2012), goji berries (Ma et al., 2019), and ginseng (Riaz et al., 2019) have potent antioxidant, anti-inflammatory, and immune-boosting properties, which can help protect the body against a variety of health issues. While more research is needed to fully understand the mechanisms behind medicine and food homology, these findings provide a strong foundation for the continued integration of TCM principles into modern healthcare practices. As the concept of medicine and food homology continues to gain attention in the health and wellness industry, there is a growing need for healthcare professionals to integrate these principles into their practice. This can involve a variety of strategies, such as incorporating TCM-inspired dietary recommendations into patient care plans, collaborating with TCM practitioners to develop holistic treatment plans, and promoting the use of medicine and food homology substances in functional foods and dietary supplements. By embracing the principles of medicine and food homology, healthcare professionals can offer their patients a more comprehensive and personalized approach to health and wellness, while also supporting the sustainability and resilience of the global food system. 4. Challenges and future prospects of medicine and food homology in health and wellness industry While the concept of medicine and food homology holds significant promise for the future of health and wellness, there are also a number of challenges that must be addressed in order to fully realize its potential. One of the main challenges is the need for more rigorous scientific research to validate the efficacy and safety of medicine and food homology substances. This will not only help to build credibility and trust among healthcare professionals and patients, but it will also enable the development of standardized guidelines and best practices for the use of medicine and food homology in modern healthcare. Another challenge is the need for greater collaboration and communication between TCM practitioners and conventional healthcare providers. By fostering a more integrated and interdisciplinary approach to healthcare, professionals from both fields can work together to develop innovative and effective prevention and treatment strategies that incorporate the principles of medicine and food homology, while also addressing the unique needs and preferences of individual patients. Despite these challenges, the future prospects of medicine and food homology in the health and wellness industry are bright. The growing interest in natural and holistic approaches to health and wellness, coupled with the increasing recognition of the importance of a balanced diet and sustainable food systems, suggests that the principles of medicine and food homology will continue to gain momentum in the years to come. 5. Global influence of medicine and food homology While the concept of medicine and food homology originated in China, its influence has spread far beyond its borders. Today, TCM is practiced in many countries around the world, and the principles of medicine and food homology are increasingly being recognized as a valuable tool for promoting health and wellness. In addition, the growing interest in traditional and natural approaches to health and wellness has led to the development of many TCM-inspired dietary and herbal products, which are widely available in health food stores and online. This trend is expected to continue, as more people seek out natural and holistic remedies for their health concerns. 6. Conclusions In conclusion, the concept of medicine and food homology is a fundamental aspect of Traditional Chinese Medicine, which emphasizes the role of food and herbs in promoting health and preventing illness. While the scientific evidence supporting these principles is still emerging, the growing interest in natural and holistic approaches to health and wellness suggests that the principles of medicine and food homology will continue to gain attention in the years to come. Healthcare professionals and food scientists are responsible for embracing the essential role of medicine and food homology in shaping the future of health and wellness. By integrating these principles into practice and product development, a more comprehensive and personalized approach to healthcare will serve better to people all over the world, while also supporting the sustainability and resilience of the global food system. So, let us embrace the concept of medicine and food homology and work towards a healthier and more sustainable future for all.     

LECTURES ON ACUPUNCTURE——Part Ⅰ Clinical Acupuncture Lecture Eighteen OBESITY

If the food intake is more than the food consumption, the extra food will be stored in the body in the form of fat. And if the fatty degree is over 20% of weight, it is called obesity. Over weight means the fatty degree is 10% over the normal body weight. When the weight (quality)index is over 24[weight(kg)/height^2(m^2)],obesity can appear.     

Treatment of a case of stubborn disease by acupuncture

Case's Data 1. Main complaint Poor appetite and emaciation for 10 years. 2. Medical history From the new year's day to spring festival of 1986,the patient ran for 10 kilometers every day without clothes on the upper body, then he gradually appeared the symptoms of poor appetite, sallow and dim complexion, dizziness and tinnitus, blurred vision and intolerance of light, lassitude, palpitation and short breath with the mouth open and shoulder lifted, oppressed feeling in chest and pain in hypochondriac region, being as thin as a lath (174 cm in height and 39 kg in weight), weakness of limbs, unstable walking, aversion to cold and preference for warm.     

How to Diagnose and Treat Peptic Ulcer ？

Ulcer of the stomach and duodenum, also called ulcerative disease, is a sharply circumscribed loss of the tissue lining those parts of the digestive tract exposed to gastric juice containing acid and pepsin. Because its formation and development are closely related to the digestive effect of acidic gastric juice and pepsase, the disease is called peptic ulcer. It is a common disease, belonging to epigastric pain in TCM, mainly caused by cold attacking the stomach, stagnated liver-qi affecting the stomach, or spleen and stomach deficiency with deficiency and cold of the middle-jiao. Regulating qi to stop pain is the principle for its treatment. Peptic ulcer is usually differentiated as the following TCM syndromes.     

温针灸治疗早泄验案(英文)

1Clinical Data A patient,39years old.Two years prior to the visit,the patient began to feel that his penile erection maintained a short time,with its dynamics inadequate,ejaculation powerless,and his low back and knees weak.He was mentally fatigued,with low sexual desire.He looked a bit pale,cold limbs and aversion to cold,and had a pale tongue with a thin coating.He was diagnosed with premature ejaculation.     

SECRETS OF PROPORTIONAL BODY WITH ACUPUNCTURE

Excessive fat accumulation will cause obesity. Weight is influenced by age, gender, genetic, food and drink, and environment. Obesity caused by Genetic, hormonal, unhealthy lifestyle, and eating habit. To reduce weight does not mean that the body will be skinny and weary. There are many ways to lose weight, but if it is done by removing body fluids, the fat will still not be removed and the body is drained. The location where fat is accumulation will influence the shape of our body. This will effect to our health. Generally, shape of the body can be classified into 2 types： Apple and Pear. Fat accumulated at upper abdomen called apple shape. The fat is accumulated mostly on the lower body （hip） called pear shape. Because of the effect of the endocrine system and metabolism, obesity for men will cause diabetes mellitus, lipoidemia, heart coroner and hypertension. For female also cause complication such as malfunction of the ovary, breast cancer, infertility, sexual dysfunction. There are several ways to treat this problem with acupuncture, such as body acupuncture, ear acupuncture, moxibustion and seven star needle. The main points are Gongsun （SP4） and Liangqiu （ST34）, Endocrine. There are also additional points for each specific case, such as for large lower and upper abdomen, front and back elbow, thigh, calf, obesity after giving birth. The result obtained is for 110 cases, 30 cases lose weight from 5 Kg and above, 60 cases lose weight until 5 Kg, and 20 cases lose weight from 1 - 3 kg. In conclusion, there are several ways to build a proportional body and a healthy life. Firstly, acupuncture should be done regularly, adjust right eating habit, do exercise regularly, control emotion, and finally do a correct diet.     

Understanding "medicine and food homology", developing utilization in medicine functions

Chinese medicine is a very big concept of medicine. In Shen-nong era, medicine and food do not divide. "Medicine and food homology", which is called “Chinese medicine and dietary application”, refers to that many foods are drugs, and there is no absolute demarcation line between them. At that time, seventy poisons were encountered in a day for experimental accusations, herbal medicines are divided into upper, middle and lower categories, the safe and non-toxic Chinese medicines are the upper product, which can be consumed, but is just a difference in dosage. Ancient medical scientists applied the theory of "four natures" and "five tastes" of traditional Chinese medicine (TCM) into food, believing that each food also has "four natures" and "five tastes". "Medicine and food homology" means that Chinese medicine and food are of the same origin. The theory of "medicine and food homology" based on practice has existed in Chinese traditional medicine since ancient times. In ancient primitive society, people discovered the sexual taste and efficacy of various foods and medicines in the process of searching for food, realizing that many foods can be used medicinally and many medicinal materials can be used as dietary supplement. The theory holds that many foods are both food and medicine, and that they are just as effective in preventing disease as drugs. Therefore, this theory of "medicine and food homology" is also the basis of food therapy. Strictly speaking, in the TCM, drugs and food are indiscriminate. Food has fewer side effects, but drugs have more. This is another meaning of medicine and food homology. Hence, the source of Chinese medicine and food is the same. Some things can only be used to treat diseases, known as drugs, some things can only be used for diet, known as foods. The line between medicine and food is not very clear because they all have healing powers. Such as orange, hawthorn, black plum, walnuts, almonds, fennel, cinnamon, pumpkin seeds and so on, they are not only Chinese medicine with a good curative effect, but also nutritious delicious food that people often eat. The common point of TCM and food is to have a healthy function to prevent and control diseases. The difference between them is that the TCM has strong therapeutic effect, which is often called "strong drug". When the medicine is used correctly, the effect is prominent. However, the therapeutic effect of food is not as prominent and rapid as that of TCM. The important issue cannot be ignored is that medicaments will not be often taken commonly though their action is strong, and food we eat every day though food action is weak. Our daily diet, in addition to the supply of essential nutrients, will also be more or less due to the performance of the food on the balance and physiological function of the adverse or favorable impact, accumulation, from quantitative change to qualitative change, the impact becomes very obvious. In this sense, they are no less effective than TCM. Accordingly, adjusting food correctly and reasonably, with long-term adherence, can have the effect that medicaments cannot achieve. In this issue of CHM journal, we organized four articles on Lycium barbarum, Gardenia jasminoides, Taraxacum mongolicum, and Moringa oleifera (Gouqizi, Zhizi, Pugongying, and Lamu in Chinese, respectively) with medicine and food functions, focusing on the analysis and discussion of the current research status and put forward the views or opinions of authors on the development of these four Chinese medicines. The present paper on Lycium barbarum focuses on the legal plant resource and reviews the main research in medicinal field including botanical identification, ethnopharmacological functions, phytochemistry, pharmacological effects, clinic usages, and safety issues. Fruits of Gardenia jasminoides haves been used as dietary supplement and traditional Chinese medicine for thousands of years. Recent studies of Gardenia jasminoides reveal that the extracts or the active components play an essential role in oxidative stress, inflammation, hepatoprotection, neuroprotection, anti-diabetes, antitumor and so on. Here, we reviewed Gardenia jasminoides in the botanical identity, chemical ingredients, pharmacology, and pharmacokinetics, safety and toxicity evaluation, clinical application, etc. Taraxacum mongolicum has been used in TCM and dietary application, and T. officinale has been applied in medicinal and food use in other regions and cultures around the globe. Authors summarized the phytochemical constituents of dandelion (particularly from T. mongolicum and T. officinale). Recent published health benefits of dandelion, such as anti-oxidant activity, anti-inflammatory activity, blood sugar and lipids regulation and hepatoprotective activity, as well as its safety data were highlighted. The limited human clinical study and pharmacokinetics information lead to the thought that well-designed human clinical study should be the focus and opportunity for the future research area to truly understand efficacy function and health benefit of dandelion for its application in medicine and health food area. Moringa oleifera is one of the most widespread species belonging to family Moringaceae. Almost each part of this tree has enormous properties in nutrition, medicine or other industrial purposes. This review mainly introduces nutritional ingredients, bioactive compounds, applications, and potentials of this tree including leaves, seeds, pods, flowers, root barks, and gum in order to bring convenience to industries and researchers all over the world focusing on each part of this amazing plant. Moreover, the review also analyzes the current application situation of M. oleifera in China. Authors concluded that most current researches focus on the leaves and seeds of this plant, and the most concerned property of M. oleifera is the antioxidant ability. Medicine and food dual-use plants of China have a long history of application, and the medicine-food dual-use plants have both certain physiological effects and long-term edible safety. For people with potential risk of onset, healthy products developed by edible and edible dual-use plants can prevent disease occurrence and maintain health, and are more scientific and rational than drug treatment after disease occurrence. The development and utilization has broad market prospects. According to the research and development status of Chinese plant resources, the development and utilization of medicine-food dual-use plants is facing challenges. Evaluation and selection of efficacy in research and development, study of functional substance basis and mechanism of action, functional product positioning and composition design, and plant resource germplasm evaluation, planting process management, post-harvest storage, etc. involved in functional food quality control process. A series of key technical issues, such as intensive processing and comprehensive utilization of resources, require efforts to carry out research in order to provide certain theoretical guidance and practice for the development and utilization of dual-use plant resources in China.     

Part Ⅱ The Typical Cases of Chest Pain Syndrome

Mr Wang, 47 years old. His first visit was on May 7th, 1995. Chief complaints: At the treatment time, chest distress and pain had attacked again and again for six years and worsened for ten days.     

Effects of Ginsenoside Rb1 on Skeletal Muscle Insulin Resistance and Adenosine Monophosphate-activated Protein Kinase Signaling Pathway in Obese Mice

Objectives: The objective of the study is to observe the effects of ginsenoside Rb1 on indexes of body weight, body composition, blood lipid, skeletal muscle endurance, and insulin sensitivity in obese mice, probe into its pharmacological action, and further explore its effects on adenosine monophosphate-activated protein kinase(AMPK) signaling pathway in skeletal muscle. Materials and Methods: Eight-week-old C57 BL/6 J mice were fed with high-fat diet for 12 weeks to establish obese mouse model. The model-establishment obese mice were randomly divided into three groups including model control group, metformin group, and ginsenoside Rb1 group. In the normal control group, normal diet was administered. The intervention period was 8 weeks. Body weight and food intake of the mice were measured regularly every week. The treadmill test was performed at weeks 3 and 7, and the oral glucose tolerance test was carried out at weeks 4 and 8. Body composition of the mice was detected by applying NMR Animal Body Composition Analyzer at week 8. Four parameters of blood lipids and free fatty acid(FFA)levels were detected. The m RNA expression of AMPKα and proliferator-activated receptor gamma coactivator-1α(PGC-1α) in skeletal muscle was examined by real-time fluorescence quantitative polymerase chain reaction, and the influence of ginsenoside Rb1 on protein expression of AMPKα, p-AMPKα, and PGC-1α was observed by western blotting. Results: The body weight(since the 5 th week of drug administration)and food intake of the mice in the ginsenoside Rb1 group were significantly lower than those in the model control group(P 0.05) in a time-dependent manner. Ginsenoside Rb1 could significantly reduce the levels of triglyceride and low-density lipoprotein cholesterol, while increase the high-density lipoprotein cholesterol level(P 0.05). In addition, ginsenoside Rb1 could reduce the serum FFA level(P 0.05).After the administration of ginsenoside Rb1 for 8 weeks, the body fat mass of obese mice decreased and the lean mass increased(P 0.05).The skeletal muscle endurance and the oral glucose tolerance of the obese mice improved using ginsenoside Rb1. At the molecular level,ginsenoside Rb1 could up-regulate the mRNA and protein expression of AMPKα in skeletal muscle, and increase the content of p-AMPK protein significantly(P 0.01). At the same time, the mRNA and protein level of PGC-1α was also un-regulated, correspondingly(P 0.01).Conclusion: Ginsenoside Rb1 exerts effects on reducing body weight, decreasing blood lipid levels, enhancing the skeletal muscle endurance,and increasing the insulin sensitivity in obese mice by activating the related proteins in AMPK signaling pathway in skeletal muscle.     

Effect of moxibustion on survival status and nutritional metabolic factor in tumor-bearing rats with gastric cancer

Objective:To observe the effect of moxibustion on the survival status and nutritional metabolic factors of tumor-bearing rats with gastric cancer and explore the inhibitory effect of moxibustion on the tumorbearing rats.Methods:A total of 40 SD rats were randomly divided into a blank group,a sham-operated group,a model group and a moxibustion group,10 rats in each group.Gastric cancer models were established in the model group and the moxibustion group.The rats of all the groups underwent the same constraining procedure for 20 min every day.Additionally,moxibustion was applied at acupoints for 20 min in the rats of the moxibustion group.There were two groups of acupoints.One group included"Zusanli(足三里ST 36)""Zhongwan(中脘CV12)"and"Guanyuan(关元CV4)".The other group included bilateral"Pishu(脾俞BL 20)"and"Weishu(胃俞BL 21)".Moxibustion was applied for 20 min every day at the acupoints of the two groups alternatively and lasted for 14 days.The survival status of rats was observed and the score of survival status and body weight of rats were recorded every day.At the end of intervention,the orbital blood was collected and the rats were sacrificed for sample collection.The viscera-free body weight was recorded.Using biochemical analyzer,the blood glucose(GLU),albumin(ALB),total protein(TP)and triglyceride(TG)in serum were detected.Results:(1)Regarding the score of the survival status,after modeling,the scores in the model group and the moxibustion group were all higher than those of the sham-operation group(both P0.05).After intervention,the score in the moxibustion group was lower than that of the model group(P0.05).(2)After modeling,the body weight in the moxibustion group and the model group was lower than those of the blank group,indicating a statistical significance(both P0.05).The body weight in the moxibustion group was higher than that of the model group after intervention,indicating the statistical significance(P0.05).(3)Regarding the viscera-free body weight,it was lower in the model group compared with the sham-operation group,indicating the statistical significance(P0.05).Compared with the model group,the viscera-free body weight was higher in the moxibustion group,indicating the statistical significance(P0.04).(4)Regarding the nutritional metabolic factors,compared with the sham-operation group,the levels of GLU and ALB in the model group were lower and TP was higher,presenting the statistical significance(all P0.05).Compared with the model group,the levels of GLU and ALB were higher in the moxibustion group and TP was lower,presenting the statistical significance(all P0.05).Conclusion:Moxibustion improves the survival status of tumor-bearing rats with gastric cancer,increases the body weight,the viscera-free body weight and the levels of GLU and ALB in serum and reduces TP of the tumor-bearing rats with gastric cancer and inhibits the growth of gastric cancer.     

Toxicity of Danshen Injection in Beagle’s Dogs by Repeated iv Injection

Objective To re-evaluate the potential toxicity of Danshen Injection(DI)in Beagle’s dogs by repeated iv injection.Methods DI was iv given to the dogs at the doses of 0,1.6,5.4,and 16.0 g/(kg·d)(4 per sex per group)for 13weeks.During the test period,the clinical signs,mortality,body weights,food consumption,rectal temperature,ophthalmoscopy,electrocardiography,urinalysis,hematology,serum biochemistry,organ weights,gross findings,and histopathology were examined.Results Dogs iv given with DI at the doses of 0,1.6,5.4,and 16.0 g/(kg·d)for13 weeks had no drug-related changes in mortality,body weight,food consumption,temperature,electrocardiography,ophthalmoscopy,urinalysis parameters,and organ weights.The hematological parameter data showed a significant decrease in red blood cells and hemoglobin concentration in the high-dose group and a significant increase in activated partial thromboplastin time suggesting an effect on haemopoiesis.For biochemical parameters,a significant decrease in glucose and a significant increase in total bilirubin were observed in the high-dose group,and the latter was considered to be toxicologically insignificant as lack of histopathological correlate.However,the histopathological examinations of the injection site showed that DI could cause dose-dependent focal inflammation.Conclusion That the iv injection with DI into dogs at 16 g/(kg·d)for 13 weeks could cause the decreases in red blood cell parameters and glucose,as well as the lesions of the injection site.The no observed adverse effect level is5.4 g/(kg·d),which suggests that safe clinical dosing be possible.     

A CASE OF TRUE BULLAR PARALYSIS TREATED BY ACUPUNCTURE

The patient,male,60 years old,Hannatiionatity,married,a machinist,had suf-fered from choking over his food,hoarse-ness,dysphagia for 4 days.On the seventhof April,1992,when he had supper,espe-cially drank water he choked,on the ninth,he went to visit a doctor at clinic and tooksome Chinese medicine,but the Symptomswere not relieved.On the tenth,he went tothe department of neurology of a hospitaland was diagnosised as true bullar paraly-sis.He was admitted to the hospital imme-     

How to Diagnose the State of a Dynamic System

When analyzing a system, it is not only the easily quantified parameters （like where an item, e.g. the location of a planet in the planetary system or the weight, the temperature, and the blood pressure of a patient）, but also the instantaneous changes of these parameters （e.g. the speed which is, of course, the magnitude of the instantaneous change of the location or even the acceleration which is the magnitude of the instantaneous change of the speed） that are crucial for determining its future development. While Newton observed 300 years ago that just knowing the mass, the location, and the speed of two celestial bodies in a 2-body system at some given moment suffices to predict its future, these simple and absolutely basic ideas seem not yet to have found full recognition in medical analysis and diagnostics. However, investigations by Johannes Greten seem to suggest that the situation （for Westerners sometimes weird looking vocabularies and concepts in traditional Chinese medicine） seems to be heading for exactly this.     

Toxicity study of ethanol extract from Oroxylumindicum(L.) Vent in rats

OBJECTIVE: To evaluate the safety of Oroxylumindicum(L.) Vent extract administered for 26 weeks in Wistar rats.METHODS: Oroxylumindicum(L.) Vent extract was administrated to male and female rats by gavage once daily at doses of 54, 225, and450 mg·kg-1·d-1.The rats were sacrificed after administration for13 weeks and 26 weeks. Part of the rats in each group were allowed to recover for 4 weeks after 26-week administration. Systematic examinations including haematology, urology, blood biochemistry and histomorphology were performed at the end of13, 26 weeks of administration and 4 weeks of recovery.RESULTS: No treatment related adverse effect shappened on rats' general status, body weight, food consumption, urinary index and histomorphologyexamination. Although during the administration,in some rats of extract's groups, the value of Red blood cell count(RBC), white blood cell counts(WBC), hemoglobin(HGB), haematocrit(HCT) and K iron were decreased, and biochemistry index,such as glucose(GLU), triglyceride(TG), alanine transaminase(ALT) and blood urea nitrogen(BUN)were increased, the above parameters were within the normal ranges and all returned to baseline after the drug stopping for 4 weeks.CONCLUSION: The administration of Oroxylumindicum(L.) Vent extractat levers up to 450 mg/kg(equals to 75 times of clinical dose) is well toleratedfor both genders without significant toxicity within the administration duration in this study.     

西洋蓍草提取物对糖尿病大鼠的β细胞保护活性及降糖、降脂作用(英文)

AIM:To evaluate the therapeutic uses of Achillea millifolium in diabetic rats.METHODS:Diabetes was induced bysingle intraperitoneal injection of freshly prepared solution of alloxan monohydrate(150 mg·kg.1 body weight) in Wistar rats of150.200 g body weight.In this study,the aqueous and methanolic extract of Achillea millifolium was studied for its hypoglycemic andhypolipidemic properties.The rats were divided into several groups,serving as Normal group,Diabetic Control group,Diabetictreated with glibenclamide,and extract treated groups.The blood serum collected from the various groups of rats was analysed for itsvarious biochemical parameters like glucose,cholesterol,triglycerides,VLDL,SGOT,SGPT and ALP.On the 14th day of the experimentthe rats were scarified and pancreas was collected for histopathological studies.RESULTS:The extracts at dose levels of 250and 500 mg·kg.1 body weight showed significant(P ≤ 0.05) decrease in blood glucose level,TGL,VLDL,cholesterol,SGOT,SGPT,and ALP in diabetic rats.The extracts prevented the β-cells of pancreas from the cytotoxic effects of Alloxan monohydrate.CONCLUSION:The results indicate that the extracts as mentioned above are effective in hyperglycemia and can effectively protectagainst other metabolic aberrations caused by alloxan monohydrate.