选择性左冠状动脉主干病变的介入治疗

目的冠状动脉旁路移植术(CABG)是多支血管病变血运重建的最佳方法,是无保护性左冠状动脉主干(LMCA)病变的标准治疗.本研究探讨无保护性LMCA病变介入治疗的疗效和可行性.方法总结分析1996年10月～2000年8月间20例住院的冠心病左主干病变患者接受直接支架术治疗.入选患者例行左室造影(LVEF>45%),冠状动脉血管成形术及其疗效评判采用常规标准,合并右冠脉严重弥漫狭窄病变或前降支(LAD)与回旋支(LCX)同时严重狭窄者不行该术.结果 20例中男17例、女3例,年龄42～71(平均64±12)岁,临床呈心绞痛Ⅱ-Ⅲ级,其中合并高血压9例、糖尿病(2型)1例.冠脉造影显示,左冠脉主干病变呈单纯狭窄者8例,其中近中段狭窄(50%～80%)者6例、开口狭窄(50%～60%)者2例,左主干夹层分离者2例,动脉瘤者1例,合并LAD或LCX病变(狭均>70%)者9例(狭窄50%～70%).全部患者左主干病变均进行直接支架术,其中6例伴LAD或LCX病变者先行PTCA或支架术后再进行左主干病变的支架置入术.置入左主干内的支架均为管状宽径短支架,16例为4.0 mm×9 mm(直径×长度)支架,3例为3.5 mm×9 mm支架,1例冠状动脉瘤者应用4.5 mm×9mm支架.左主干支架术成功率为100%,无残余狭窄或残余狭窄<10%,无任何并发症如支架血栓形成、急性心肌梗死、紧急CABG及死亡等.9例合并LAD(6例)或LCX(3例)狭窄者,先行LAD或LCX的PTCA术,其中3例PTCA术后残余狭窄<20%,5例残余狭窄30%～40%者中2例置入3.0×16mm支架、1例3.5×20mm支架、1例3.0×14 mm支架,1例LCX开口后狭窄(75%)者因PTCA后发生夹层放置3.5×12 mm支架,造影示夹层消失,无残余狭窄.冠状动脉瘤行带膜支架术者造影示瘤体消失,左主干管壁平整.随访1～4年,14例心绞痛发作消失、6例心绞痛复发但显著减轻(心绞痛Ⅰ级),后者有4例于术后半年～1年内复查冠脉造影提示早期再狭窄,其中2例单纯LMCA再狭窄者再次行冠脉血管成形术、2例LMCA合并LAD再狭窄者行CABG手术,无急性心肌梗塞或死亡等严重心脏事件发生,患者均能维持正常生活.结论本研究结果表明,选择性无保护性左冠状动脉主干病变支架术在临床上切实可行、疗效显著,可以是继CABG的另一治疗选择.     

Simultaneous triple kissing stenting in an unprotected left main coronary artery

A 76-year-old hypertensive male smoker with diabetes mellitusand a family history of coronary artery disease was urgentlyreferred to the cardiac catheterization     

Successful stenting of catheter-induced unprotected left main coronary artery dissection

Catheter-induced left main coronary artery (LMCA) dissection is a dramatic, although uncommon complication of diagnostic coronary angiography and requires prompt treatment. We describe a case of iatrogenic occlusive dissection of the LMCA during coronary angiography, treated by subsequent percutaneous recanalisation.     

High-risk left main coronary stenting supported by percutaneous Impella Recover LP 2.5 assist device

Percutaneous coronary intervention (PCI) of complex coronary lesions in patients with severely depressed left ventricular (LV) function may increasingly constitute an alternative to surgical revascularization. The availability of hemodynamic support devices offers a promising option to reduce PCI-related complications in such high-risk procedures. We report the case of successful distal left main coronary artery T-stenting supported by the Impella Recover LP 2.5 assist device in a patient with severe LV dysfunction.     

High-risk left main coronary stenting supported by percutaneous Impella Recover LP 2.5 assist device

Percutaneous coronary interventions (PCI) of complex coronary lesions in patients with severely depressed left ventricular (LV) function may increasingly constitute an alternative to surgical revascularization. The availability of hemodynamic support devices offers a promising option to reduce PCI-related complications in such high-risk procedures. We report the case of a successful distal left main coronary artery T-stenting supported by the Impella Recover LP 2.5 assist device in a patient with severe LV dysfunction.     

Endovascular stenting of an unprotected left main coronary artery stenosis in a heart transplant patient

Endoluminal revascularization of left main coronary artery vessels is considered to be relatively contraindicated because of a high procedural mortality and restenosis rate. This report describes the first successful case of endovascular stenting in an unprotected left main coronary artery stenosis in a heart transplant patient.     

Management of failed stenting of the unprotected left main coronary artery

Percutaneous coronary intervention (PCI) is increasingly accepted as treatment for unprotected left main coronary artery (ULMCA) disease especially in those patients who are unsuitable for cardiac surgery. Treatment of any stent failure is associated with increased complexity and worse clinical outcomes when compared with de novo lesion revascularization. Intracoronary imaging has provided new insight into mechanisms of stent failure and treatment options have developed considerably over the last decade. There is paucity of evidence on the management strategy for stent failure in the specific setting of ULMCA. Treating any left main with PCI requires careful consideration and consequently treatment of failed stents in ULMCA is complex and provides unique challenges. Consequently, we provide an overview of ULMCA stent failure, proposing a tailored algorithm to guide best management and decision in daily clinical practice, with a special focus on intracoronary imaging characterization of causal mechanisms and specific technical and procedural considerations.     

Ventricular arrhythmias during left ventricular assist device support

Left ventricular assist devices (LVADs) have been used effectively as a "bridge" to cardiac transplantation and as destination therapy in patients with advanced heart failure. Ventricular arrhythmias (VAs) have been reported to occur in LVAD-supported patients, although their incidence, risk factors, and clinical significance have not been characterized. In this study, 111 patients who received LVAD support as a bridge to cardiac transplantation at the University of Pittsburgh Medical Center from January 1987 to June 2001 were evaluated. Clinically significant VA was defined as ventricular fibrillation, sustained ventricular tachycardia, or nonsustained ventricular tachycardia with symptoms requiring antiarrhythmic therapy. Patients were grouped on the basis of the presence or absence of VAs. VAs occurred in 24 patients (22%) during device support. Ischemic heart disease was the cause of heart failure in 71% of patients (17 of 24) in the VA group and 45% of patients (39 of 87) in the group without VAs (p <0.05). The mortality rate was significantly higher (p <0.001) during LVAD support in the group with VAs (33%) compared with the group without VAs (18%). In the group with VAs, the early (1 week) occurrence (9%). In conclusion, although clinically significant VAs occur in patients with heart failure receiving LVAD support, the overall incidence is low. VAs are more frequent in patients with ischemic heart failure, and their occurrence is associated with greater mortality. The occurrence of VAs early after LVAD implantation, in particular, predicts a higher mortality rate.     

Subacute left ventricular rupture supported with a percutaneous left ventricular assist device

Cardiac rupture is a fatal complication of transmural myocardial infarction that is associated with high mortality. We describe the successful management of a case of subacute cardiac rupture and cardiogenic shock supported by a percutaneous left ventricular assist device (LVAD) as a bridge to surgery.     

Elective stenting of unprotected left main coronary disease

For the 12-mo period of 1995, we encountered seven consecutive patients with symptomatic unprotected left main coronary stenosis requiring revascularization. There were five males and two females, age ranging 48–76 years. One patient was referred to coronary bypass surgery. Of the remaining six patients, three refused surgery and the other three, including one with previous bypass surgery and two with previous interventional procedures, preferred percutaneous revascularization. All six had successful elective stenting of their left main coronary stenoses with the new short Palmaz-Schatz stents, P084 and PS104. There were no complications and all remained totally asymptomatic at 3–14 months followup. We conclude that with proper patient selection and the availability of appropriate stents, elective stenting of unprotected left main coronary stenosis is safe with good immediate and medium term results. © 1996 Wiley-Liss, Inc.     

Percutaneous stenting of chronic total occlusion of unprotected left main coronary artery

Chronic total occlusion of the left main coronary artery is very rare. We report a case in which a totally occluded, unprotected distal left main coronary artery was successfully revascularized percutaneously, establishing normal flow in the left main, left anterior descending and left circumflex coronary arteries.     

Transradial unprotected left main coronary artery stenting in an octogenarian with severe angina and Leriche syndrome

Coronary artery disease in octogenarians is often diffuse and difficult to manage due to concomitant peripheral vascular disease. The authors describe a case in which an unprotected left main coronary artery was successfully treated by transradial stenting in a patient with severe angina and Leriche syndrome.     

Left stellate ganglion block for continuous ventricular arrhythmias during percutaneous left ventricular assist device support

A 58-year-old man presented with chest pain and tightness and was diagnosed with a Q-wave anterior myocardial infarction. He then developed pulseless ventricular arrhythmias, which were treated with repeated direct-current shocks and intravenous amiodarone. He underwent emergency cardiac catheterization: stents were deployed in the left anterior descending coronary artery and right coronary artery, and an intra-aortic balloon pump was inserted. Severe refractory cardiogenic shock and incessant ventricular arrhythmias compelled us to place a TandemHeart percutaneous left ventricular assist device 4 hours later. The patient's hemodynamic status stabilized, but the arrhythmias persisted for 36 hours. Multiple doses of intravenous amiodarone and lidocaine and multiple external direct-current shocks were all tried, but these measures failed to terminate the life-threatening ventricular arrhythmias. We performed a pharmacologic block of the left stellate ganglion, and this resulted in a return to sinus rhythm after 1 direct-current shock. To our knowledge, this is the 1st patient with refractory ventricular arrhythmias to have been treated with TandemHeart support and left stellate ganglion block.     

Revascularization for unprotected left main stem coronary artery stenosis stenting or surgery

For coronary artery disease with unprotected left main stem (LMS) stenosis, coronary artery bypass grafting (CABG) is traditionally regarded as the "standard of care" because of its well-documented and durable survival advantage. There is now an increasing trend to use drug-eluting stents for LMS stenosis rather than CABG despite very little high-quality data to inform clinical practice. We herein: 1) evaluate the current evidence in support of the use of percutaneous revascularization for unprotected LMS; 2) assess the underlying justification for randomized controlled trials of stenting versus surgery for unprotected LMS; and 3) examine the optimum approach to informed consent. We conclude that CABG should indeed remain the preferred revascularization treatment in good surgical candidates with unprotected LMS stenosis.     

Spontaneous dissection of the left main coronary artery treated with percutaneous coronary stenting

Spontaneous coronary artery dissection is a rare and often fatal cause of acute myocardial ischemia occurring predominantly in young or middle-aged and otherwise healthy patients. We report a case of spontaneous dissection of the left main coronary artery in a young woman who was successfully treated with percutaneous coronary stent implantation.     

Percutaneous intervention for unprotected left main disease prior to explantation of a left ventricular assist device.

Percutaneous coronary intervention of unprotected left main coronary arterial disease is an alternative to surgical revascularization in selected patients. In this report, a patient with an implanted left ventricular assist device (LVAD) underwent successful coronary intervention prior to its planned removal. The implanted LVAD clearly assisted the technical performance of the intervention.