椎—基底动脉供血不足患者脑干听觉诱发电位的观察

检查５８例椎－基底动脉供血不足患者脑干听觉诱发电位，异常率为６３．８％。ＢＡＥＰ异常可反映内耳前庭缺血，中枢缺血或两者皆有。ＢＡＥＰ检测对脑干缺血性疾病的诊断有一定的价值。     

椎——基底动脉供血不足患者的脑干听觉诱发电位分析

本文报道了椎—基底动脉供血不足的脑干听觉诱发电位(BAEP)118例,异常者100例占84.75％。主要表现为Ⅰ波的异常(内耳型);Ⅲ、Ⅴ波的异常或各波峰间潜伏期的延长(脑干型)或以上两型损害兼而有之(混合型)。异常率显著高于CT,BAEP检查可弥补CT扫描的不足。胞二磷胆碱与乙酰谷酰胺治疗收到了较好的疗效。     

椎基底动脉供血不足患者的BAEP观察

本文分析报告了38例椎基底动脉供血不足患者的BAEP。异常率为86.84％。结果表明:该病各波潜伏期及其双耳差、各峰间期双耳差、各波振幅较健康对照组均有极显著性差异(P<0.01),波形不规整是椎基底动脉长期供血不足引致的一种严重的病理性改变。     

椎基底动脉供血不足的扭颈脑干诱发电位研究

对椎基底动脉供血不足120例,与正常组60例或非VBI疾病对照组80例进行扭颈连续监测BAEP的结果:正常组全部阴性;对照组阳性率为17.5％,疾病组阳性率为89.1％,对照组与疾病组比较差异显著,P<0.01。     

椎基底动脉供血不足患者的脑干听觉诱发电位与经颅多普勒检查

目的 :探讨椎基底动脉供血不足 (VBI)患者的脑干听觉诱发电位 (BAEP)与经颅多普勒(TCD)的相关性。方法 :对 5 8例临床诊断VBI眩晕的患者及 30例非VBI眩晕的患者进行BAEP和TCD检测。结果 :VBI组BAEP异常率为 5 9% ,TCD异常率为 6 1% ,χ2 检验差异无显著意义 :非VBI组BAEP异常率 8% ,TCD异常率为 47% ,χ2 检验差异有显著意义。VBI组BAEP及TCD皆异常者为 6 4/116 ,皆正常者为 2 3/116 ,两者占 75 % ;非VBI皆异常者为 4/6 0 ,皆正常者为 32 /6 0 ,两者占 6 0 %。结论 :结合BAEP及TCD检查结果有助于VBI的诊断 ,而单独的TCD结果不足以作为诊断依据。     

椎基底动脉供血不足BAEP检查结果分析

目的：探讨脑干听觉诱发电位（ＢＡＥＰ）在椎基底动脉供血不足（ＶＢＩ）诊断中的意义。方法：对１０９例ＶＢＩ患者做常规ＢＡＥＰ检查，并对其结果按年龄、病程进行分析。结果：１０９例中异常８１例（７４３％），异常表现为各主波的潜伏期和波间期延长。其中病程＜２年者异常率为４０６％（１３／３２例），２～５年者为８７８％（３６／４１），＞５年者为８８９％（３２／３６）。结论：ＶＢＩ患者的ＢＡＥＰ异常率有随病程延长而增高的倾向。ＢＡＥＰ对ＶＢＩ缓解期病例的诊断有一定参考意义。     

椎—基底动脉缺血的脑干听觉诱发电位分析

目的：为了解椎－基底动脉缺血病人的脑干听觉诱发电位的改变。方法：使用美国Ｂｉｏ－Ｌｏｇｉｃ公司生产的诱发电位仪对９８例椎一基底动脉缺血的病人进行检查,结果：在异常的听觉诱发电位各项指标中,Ｉ－ＩＩＩ、ＩＩＩ－Ｖ、Ｉ－Ｖ波间期（ＬＰＬ）延长最为敏感,异常率为６５．２％,其中又以ＩＩＩ－Ｖ波间期延长为,其次为ＩＩＩ－Ｖ／Ｉ－ＩＩＩ〉１及波形改变,异常率分别为５９．１％和５３．０％,同时本检查还显示一侧耳异常较双侧耳更为常见,结论：脑干听诱发电位的测定对椎一基底动脉缺血病人的诊断有一定帮助。     

椎基底动脉供血不足患者治疗前后的BAEP比较

椎基底动脉供血不足 (ＶＢＩ)是神经科常见的疾病之一 ,多发于中老年人 ,其临床症状较多 ,体征少 ,治疗效果较好。为比较ＶＢＩ在治疗前后的脑听觉诱干发电位 (ＢＡＥＰ)变化 ,对 1997年 3月— 1999年 3月的 74例ＶＢＩ病人进行了治疗前后的ＢＡＥＰ检查 ,报告如下。1　 资料与方法　　病例组 :为临床诊断ＶＢＩ的病人 74例 ,其中男 39例 ,女35例 ,年龄 35～ 6 6岁 ,平均 48 6岁。ＶＢＩ的诊断标准[1] :①眩晕为旋转感或视物晃动或不稳感 ,多因头位和 (或 )体位改变而诱发 ;②眩晕同时至少尚有一种椎基底动脉缺血发作的其他症状 ,如眼症状 (…     

脑干诱发电位V／I波幅比值和耳蜗电图对椎基底动脉供血不足的诊断价值

本文报告确诊为椎基底动脉供血不足者４２例（８４支耳），对其进行脑干诱发电位（ＡＢＲ）和耳蜗电图（ＥＣｏｃｈＧ）两项检测在本病时的应用价值研究。ＡＢＲ中Ⅰ—Ⅲ波ＩＰＬ延长（＞２．３０ｍｓ）占２０％．Ⅰ—Ⅴ波ＩＰＬ（＞４．５ｍｓ）占１２％，Ｉ／Ｖ比值）１．０占５８％。ＥＣｏｃｈＧ中ＡＰ（Ｎ１）下降占８４．５％，Ｎ２＞Ｎ１占２６％，ＳＰ／ＡＰ比值＞０．３７占２５％。认为利用单项ＡＢＲ或ＥＣｏｃｈＧ检测结果诊断椎基底动脉供血不足是不够全面的。     

椎基底动脉供血不足患者BAEP转颈试验结果分析

目的：探讨作脑干听觉诱发电位（ＢＡＥＰ）时进行转颈试验对椎基底动脉供血足（ＶＢＩ）的诊断意义。方法：对４２例 ＶＢＩ病人眩晕间歇期患者作 ＢＡＥＰ检测时做转颈试验,并与 ３３例正常人对照。结果：ＶＢＩ组ＢＡＥＰ转颈试验阳性率６２％（２６／４２）,与对照组比较有非常显著性差异。结论：转颈试验可提高ＢＡＥＰ的阳性率,对ＶＢＩ诊断有参考意义。     

体温过低对大鼠脑干听觉诱发电位和中潜伏期反应的影响

目的：探讨体温过低对大鼠脑干听觉诱发电位（BAEP）和中潜伏期反应（MLR）的影响。方法：计算机平均叠加技术颅表记录大鼠BAEP和MLR，体表物理降温法逐步降低大鼠体温，传感探头式数字体温计监测大鼠直肠温度，体温每降低1 ℃测试1次BAEP和MLR，观察波峰潜伏期（PL）和波幅的变化及各波消失的临界体温。结果：随体温逐渐降低（36 ℃-22 ℃），BAEP和MLR各波PL逐步延长；BAEP Ⅰ、Ⅱ、Ⅳ 3主波和MLR N1、P3 2主波的波幅在体温过低至26 ℃以下时方先后出现显著降低；BAEP和MLR各波在体温19 ℃-21 ℃全部消失，且两者同步消失。结论：体温过低对大鼠BAEP和MLR均有显著影响。     

脑干听觉诱发电位检测对亚临床肝性脑病的诊断价值

对无临床肝性脑病的 30例非酒精性肝硬化患者进行脑干听觉诱发电位 (BAEP)检测。结果显示 :肝硬化组 6 0 ?EP异常 ,BAEP的Ⅰ、Ⅲ、Ⅴ波潜伏期及Ⅰ—Ⅴ、Ⅲ—Ⅴ波峰间期均比正常对照组明显延迟 ,提示肝硬化在发生临床肝性脑病前 ,脑干功能已有明显损害 ,存在亚临床肝性脑病     

兔脑缺血的视觉和听觉诱发电位的变化

阻断兔双侧椎动脉（ＢＶＡ）和左颈总动脉（ＬＣＣＡ）后，夹闭右颈总动脉（ＲＣＣＡ）３、５、７ｍｉｎ，松开ＲＣＣＡ再灌流，记录听觉脑干诱发电位（ＢＡＥＰｓ）、中潜伏期听觉诱发电位（ＭＡＥＰｓ）以及视觉诱发电位（ＶＥＰｓ）。发现不全阻断脑血流后２．５ｍｉｎ，ＭＡＥＰｓ Ｎ０消失；４．５ｍｉｎ，ＶＥＰｓ Ｎ１和Ｐ２消失，ＢＡＦＰ３ Ⅰ～Ⅴ波峰值潜伏期延长，而振幅无明显变化。完全阻断脑血流１．５ｍｉｎ，ＶＥ     

Noise-induced tinnitus: auditory evoked potential in symptomatic and asymptomatic patients

OBJECTIVES:

We evaluated the central auditory pathways in workers with noise-induced tinnitus with normal hearing thresholds, compared the auditory brainstem response results in groups with and without tinnitus and correlated the tinnitus location to the auditory brainstem response findings in individuals with a history of occupational noise exposure.

METHOD:

Sixty individuals participated in the study and the following procedures were performed: anamnesis, immittance measures, pure-tone air conduction thresholds at all frequencies between 0.25–8 kHz and auditory brainstem response.

RESULTS:

The mean auditory brainstem response latencies were lower in the Control group than in the Tinnitus group, but no significant differences between the groups were observed. Qualitative analysis showed more alterations in the lower brainstem in the Tinnitus group. The strongest relationship between tinnitus location and auditory brainstem response alterations was detected in individuals with bilateral tinnitus and bilateral auditory brainstem response alterations compared with patients with unilateral alterations.

CONCLUSION:

Our findings suggest the occurrence of a possible dysfunction in the central auditory nervous system (brainstem) in individuals with noise-induced tinnitus and a normal hearing threshold.     

Hyperactive auditory processing in Williams syndrome: Evidence from auditory evoked potentials

The neurophysiologic aberrations underlying the auditory hypersensitivity in Williams syndrome (WS) are not well defined. The P1‐N1‐P2 obligatory complex and mismatch negativity (MMN) response were investigated in 18 participants with WS, and the results were compared with those of 18 age‐ and gender‐matched typically developing (TD) controls. Results revealed significantly higher amplitudes of both the P1‐N1‐P2 obligatory complex and the MMN response in the WS participants than in the TD controls. The P1‐N1‐P2 complex showed an age‐dependent reduction in the TD but not in the WS participants. Moreover, high P1‐N1‐P2 complex was associated with low verbal comprehension scores in WS. This investigation demonstrates that central auditory processing is hyperactive in WS. The increase in auditory brain responses of both the obligatory complex and MMN response suggests aberrant processes of auditory encoding and discrimination in WS. Results also imply that auditory processing may be subjected to a delayed or diverse maturation and may affect the development of high cognitive functioning in WS.     

52位正常人听觉P50诱发电位结果分析

目的 :探讨正常人听觉P5 0诱发电位特征。方法 :采用条件 (C) 试验 (T)刺激模式记录5 2位正常人的听觉P5 0诱发电位 ,分别对不同性别、不同年龄组之间P5 0的差异进行组间比较分析。结果 :①P5 0波峰潜伏期为 5 7 9± 7 6ms ,C P5 0与T P5 0潜伏期差为 3 1± 2 5ms。②T P5 0波幅较C P5 0波幅显著降低 ,试验 /条件 (T/C)率为 5 8 9± 12 7%。③女性组P5 0波幅较男性组显著升高 (P <0 0 5 ) ,潜伏期和T/C率均无差异 ;年龄组比较P5 0诸成分均无显著性差异。结论 :听觉P5 0诱发电位是一种具有抑制特征的电位活动。T/C率不受性别、年龄的影响 ,其变化可以反映大脑正常感觉门控的机能状态     

Stimulus duration influences the dipole location shift within the auditory evoked field component N100m

The equivalent source of the neuromagnetic auditory evoked field (AEF) component N100m shifts systematically within its latency range. In the current study, possible effects of stimulus duration on this shift were analysed. 15 subjects were stimulated monaurally with tones of different duration (50, 100, 200 ms) and AEFs were recorded successively over both hemispheres. Dipoles were calculated in 5-ms-steps from 15 ms before to 15 ms after the N100m peak maximum. A dipole location shift within the N100m latency from posterior to anterior and from superior to inferior was observed. The shift in anterior-posterior direction was found to be larger in the right compared to the left hemisphere. Stimulus duration significantly affected the degree of dipole shift in this direction. It was found to be shorter the shorter the stimulus.     

海风藤对犬脑干缺血后BAEP的影响

目的观察海风藤对犬脑干缺血后脑干听觉诱发电位（ＢＡＥＰ）的影响。方法建立犬脑干缺血模型，给药组和对照组各２０只犬，分别于阻断基底动脉前３ｈ向十二指肠注入海风藤溶液（按０．３ｇ／ｋｇ）和等体积生理盐水，于缺血前和缺血后０．５、３、６和１２ｈ分别记录ＢＡＥＰ。结果给药组ＢＡＥＰ的Ⅰ、Ⅲ、Ⅴ波潜伏期和Ⅰ－Ⅲ、Ⅲ－Ⅴ、Ⅰ－Ⅴ波峰间期明显缩短。结论海风藤可改善犬脑干对缺血的耐受程度，减小半暗带的范围，减轻病变的程度。     

Rate of stimulus repetition changes evoked potential amplitude: Dental and auditory modalities compared

Summary Vertex evoked potentials (40-500 ms) elicited by painful dental stimulation were compared with those elicited by innocuous auditory stimuli across three rates of stimulus repetition: one second, four seconds, and eight seconds. In both modalities peak amplitude of the major waveform components increased linearly over log rate as stimulus repetition was slowed, and latency of the latest positive component was increased. No changes in subjective stimulus intensity across rate of repetition were reported. These observations demonstrate that the normally close relationship between subjective pain report and EP amplitude is not invariant, and they suggest that the development of EP methodology in human pain research should proceed conservatively.Supported by NIDR Grant DE 04004-06, from the National Institute for Dental Research, and Grants GM 07202-02 and GM 27621-01 from the National Institute of General Medical Sciences, US National Institutes of Health