超选择性子宫动脉化疗栓塞治疗宫颈癌的临床价值

目的 探讨超选择性子宫动脉化疗栓塞治疗宫颈癌的临床价值.方法 对病理证实的56例宫颈癌患者先行双侧子宫动脉灌注化疗,化疗药物为DDP、EADM/THP、MMC和5-Fu;然后采用碘油乳剂和明胶海绵栓塞子宫动脉.6例介入治疗后行根治术.结果 56例均行双侧子宫动脉栓塞.术中造影显示子宫动脉明显增粗,肿瘤滋养血管呈螺旋状,肿瘤染色明显.本组治疗总有效率为94.6%.6例术后2周行子宫根治术+盆腔淋巴结清扫术,术中出血量减少,手术时间缩短,其中1例术中发现单侧卵巢坏死.主要不良反应为白细胞下降、恶心、呕吐和腹痛.结论 超选择性子宫动脉化疗栓塞治疗宫颈癌是安全有效的辅助治疗方法,并发症发生率低.     

术前介入化疗在子宫内膜癌的应用及对手术的影响

目的 探讨术前持续子宫动脉灌注化疗在子宫内膜癌治疗中的应用及其对随后手术的影响。方法 在DSA下超选择与肿瘤血管染色占优势侧的子宫动脉,持续动脉滴注顺铂100mg和阿霉素50mg5d,拔管后3－4周手术。选择化疗后手术的子宫内膜癌患者20例为NAC组,随机选择同期直接手术的40例作为对照,比较术中,术后情况。结果 术前化疗组20例中完全缓解率为5．0％,总反应率为60．0％,两组患者术中出血量、手术时间、术后膀胱肠道功能恢复和创口愈合情况均无差异。NAC组浸润肌层外1／2的例数和淋巴结转移率均低于对照组（P＜0．05）。结论 术前子宫动脉化疗可缩小肿块体积,消除亚临床转移,但并不增加随后手术的并发症。     

Ⅰb2～Ⅱa期宫颈癌根治性子宫切除术前子宫动脉栓塞化疗及髂内动脉前干支化疗的疗效比较

目的 探讨Ⅰb2～Ⅱa期宫颈癌根治性子宫切除术前不同动脉化疗方式的近期及远期疗效.方法　将151例患者分为研究组和对照组,研究组113例采取子宫动脉栓塞化疗术,对照组38例采取髂内动脉前干支化疗,术后2～4周内行根治性子宫切除术,观察化疗后2周内肿瘤变化及根治性子宫切除术后2、5年生存率.结果 介入术前测量肿瘤最大径平均为(4.58±0.37)cm,介入术后最大径平均值(2.11±0.24)cm.在研究组和对照组完全有效率分别为31.9%和21.1%;总有效率为94.7%(107/113)和76.3%(29/38),2周内疗效研究组明显好于对照组(P值均＜0.01).两组手术切缘均未见癌浸润,研究组3例切缘见脉管转移,5例见宫旁浸润,盆腔淋巴结转移6例;对照组1例切缘脉管转移,2例宫旁浸润,1例盆腔淋巴结转移.研究组2年生存为68/84,5年生存为47/64;对照组2年生存26/32,5年生存18/24.两组2年及5年生存率比无明显差异(P值均＞0.05).结论 子宫动脉化疗栓塞术短期内使宫颈癌肿瘤明显缩小,有利于外科手术剥离,近期疗效好于髂内动脉前干化疗,远期疗效无差异,是Ⅰb2～Ⅱa期宫颈癌的首选新辅助动脉化疗方式.     

子宫动脉灌注化疗栓塞联合宫颈搔刮术治疗宫颈妊娠的临床价值

目的:探讨子宫动脉灌注化疗栓塞联合宫颈搔刮术治疗宫颈妊娠的临床价值.方法:回顾性分析15例宫颈妊娠患者的资料,均行双侧子宫动脉灌注氨甲喋呤(MTX),并使用明胶海绵粉和颗粒栓塞子宫动脉,栓塞术后24h观察血人绒毛膜促性腺激素(β-HCG)值与手术前的变化,第3天实施宫颈搔刮术.结果:15例患者双侧子宫动脉插管成功率100%.造影后经导管注入化疗药物及栓塞剂栓塞双侧子宫动脉,术后无严重并发症,术后24h血人绒毛膜促性腺激素(β-HCG)与术前比较明显下降,术后第3天行宫颈搔刮术胚胎组织易于剥离,出血量少在5～20ml之间.结论:子宫动脉灌注化疗栓塞联合宫颈搔刮术治疗宫颈妊娠,可有效的杀死胚囊,减少药物用量,易于刮除胚胎组织,防止发生致命性大出血,缩短病程,保全了患者的生育能力和生命安全.     

低流量低剂量甲氨蝶呤动脉灌注栓塞术在终止子宫瘢痕妊娠的应用

目的 探讨低流量低剂量甲氨蝶呤(MTX)动脉灌注栓塞术在终止剖宫产术后子宫瘢痕妊娠(CSP)中的应用价值.方法 对诊断明确的83例CSP患者行DSA血管造影、低流量低剂量MTX子宫动脉灌注加栓塞术,术后在宫腔镜下行清宫术,对疗效及出血量及月经恢复时间进行分析.结果 83例CSP的患者行低流量动脉灌注加栓塞术后,均在3～5天内行清宫术,恢复良好,术中出血量均＜20ml,平均出血量约(11.3 ±2.14)ml,清宫术前血β-HCG下降明显,术后β-HCG平均恢复正常时间为(22±3.86)天,术后平均月经恢复时间为(52±6.53)天.结论 低流量低剂量MTX动脉灌注栓塞术在终止CSP应用中,能明显减少MTX用量,血β-HCG值下降明显,恢复正常值时间缩短,减少清宫术中组织损伤及术中出血,月经恢复时间缩短,是一种安全、有效的治疗方法.     

宫颈癌（ⅡB~ⅢB 期）动脉灌注化疗栓塞的临床疗效研究

目的：探讨宫颈癌(ⅡB~ⅢB期)动脉灌注化疗栓塞(介入治疗)的临床疗效。方法134例经病理确诊的(ⅡB~ⅢB期)宫颈癌经导管肿瘤供血动脉灌注化疗,明胶海绵颗粒栓塞子宫动脉。介入治疗2~3周行 MRI 及妇科检查评估肿瘤缓解情况,若降期有手术机会者,立即行广泛子宫切除+盆腔淋巴结清扫术。比较介入治疗前后肿瘤组织病理变化情况。结果近期有效率80.6%,CR 6.0%,PR 74.6%。104例经介入治疗后切除肿瘤,手术切除率77.6%。术中见子宫颈肿瘤色泽发白、癌灶萎缩坏死。术后肿瘤组织病理示间质淋巴细胞浸润,肿瘤细胞退变。结论动脉灌注化疗栓塞可提高ⅡB~ⅢB 期宫颈癌的手术切除率。     

子宫动脉化疗栓塞术和子宫动脉栓塞术治疗子宫瘢痕妊娠的临床效果比较

目的：比较子宫动脉化疗栓塞术和子宫动脉栓塞术治疗剖宫产术后子宫瘢痕妊娠（cesarean scar pregnancy,CSP）的疗效。 方法：回顾分析山西医科大学第一医院2007年1月—2016年5月收治的诊断明确的CSP患者71例,分为A组33例和B组38例,A组行子宫动脉化疗栓塞术后行清宫术,B组行子宫动脉栓塞术后行清宫术。比较2组患者清宫过程的出血量、β-人绒毛膜促性腺激素（HCG）值下降至正常的时间及住院时间。 结果：2组患者的治疗成功率为100%,清宫过程中的出血量：A组为（40±30）ml,B组为（50±20）ml,差别无统计学意义。β-HCG值下降至正常的时间：A组为（16±3）d,低于B组的（21±5）d,差别有统计学意义。住院时间：A组为（11±3）d,低于B组的（13.5±4.5）d,差别有统计学意义。 结论：子宫动脉化疗栓塞术和子宫动脉栓塞术治疗CSP的成功率、清宫过程的出血量无明显差别,但子宫动脉化疗栓塞术能缩短患者的β-HCG值下降至正常的时间和住院时间。     

子宫动脉化疗栓塞术在剖宫产瘢痕妊娠保守治疗中的作用

目的：探讨双侧子宫动脉化疗栓塞术在剖宫产瘢痕妊娠保守治疗中的作用。方法：回顾性分析我院自2007年1月-2009年3月临床确诊的剖宫产术后瘢痕妊娠患者38例,均合并程度不等阴道出血。其中28例出血相对较重患者行双侧子宫动脉氨甲喋呤灌注化疗及明胶海绵颗粒栓塞,术后第2-4天行人工流产（吸-刮宫术）,10例轻症患者药物保守治疗4-7 d后行吸-刮宫术。结果28例行双侧子宫动脉MTX化疗灌注及栓塞术的患者阴道出血迅速停止,吸-刮宫术中及术后出血量均少于100 ml。10例药物保守治疗患者中,5例吸刮宫术中大出血（其中1例子宫切除,4例行急诊子宫动脉栓塞止血）,5例出血少于1000 ml,采用宫缩剂、宫内填塞及输血等措施,出血逐渐停止。结论：双侧子宫动脉化疗栓塞术结合吸-刮宫术能快速终止妊娠,有效预防大出血,保留患者子宫,可以作为治疗此类疾病的常规保守治疗方法。     

妇科恶性肿瘤术后复发的DSA表现及介入治疗

我们采用盆腔动脉DSA诊断妇对恶性肿瘤术后复发15例，并对复发灶供血动脉行灌注化疗和栓塞，取得满意疗效，报告如下。1资料和方法1．工临床资料：妇科恶性肿瘤，行子宫、附件切除和淋巴清扫病人15例。年龄12～63岁，平均45岁。其中卵巢癌9例，宫颈癌4例，子宫内膜癌1例，子宫肉瘤1例。手术后病人均接受2～6个疗程全身化疗，平均3个疗程。盆腔动脉DSA和灌注化疗栓塞术在手术后3～smo进行。l二2方法：均经股动脉穿刺插管。先将6F猪尾导管端置于L。。椎间隙水平，60％泛影葡胺20～24ml，10～12ml／s行双侧骼总动脉DSA，观察盆腔内复发灶…     

介入治疗在骨盆肿瘤中的临床应用

目的 :研究介入治疗在骨盆肿瘤术前的临床应用价值。方法 :对 2 1例骨盆肿瘤 (其中 15例恶性 ,6例良性 )做了 30人次的介入治疗 ,所有病例均行 DSA造影 ,并用明胶海绵条做了供养动脉栓塞 ,其中 15例恶性骨肿瘤 (MBT)在灌注化疗的基础上实施动脉内栓塞。于栓塞后 1～ 7d进行手术。结果 :所有病例 DSA造影均表现为相应区域内的肿瘤染色和供应血管增粗 ;并均经手术和 (或 )病理证实 ,肿瘤均有不同程度的坏死、液化和囊变 ,术中易剥离 ,出血少 ,术野清楚 ,缩短手术时间。结论 :术前栓塞能有效减少术中出血 ,提高手术成功率 ,是一种有价值的术前辅助性治疗方法。动脉内化疗优于全身化疗 ,动脉内化疗加栓塞明显优于单纯灌注的疗效 ,介入治疗是骨盆肿瘤治疗的一种行之有效的辅助治疗方法     

超选择子宫动脉化疗栓塞治疗宫颈癌的临床应用

目的探讨超选择子宫动脉化疗栓塞治疗宫颈癌的临床价值,并讨论其疗效与操作技术。方法对33例经病理证实的宫颈癌经双侧髂内动脉做局部灌注化疗,然后采用真丝线段做子宫动脉栓塞治疗,部分病例辅以明胶海绵栓塞髂内动脉。治疗后定期复查。结果完全缓解(CR) 部分缓解(PR)为96.9%(32/33),无变化(NC)为3.1%(1/33)。24例化疗栓塞后1~3月手术切除。结论超选择子宫动脉化疗栓塞治疗宫颈癌疗效好且副反应轻,采用真丝线段作为栓塞剂是安全和有效的。     

Uterine neoplasms: MR imaging

Magnetic resonance (MR) studies were performed on 20 healthy volunteers and 41 patients with proved cervical and uterine neoplasms. MR imaging demonstrated normal uterine landmarks in all patients. On T2-weighted images, the normal uterine wall could be differentiated into three distinct layers: a central high-intensity zone, a junctional low-intensity band, and a peripheral medium-intensity area. While most of the normal cervices had only two distinct zones (central high-intensity zone and peripheral low-intensity zone), a small percentage had three layers of signal intensity, similar to the uterine body. Primary cervical and uterine neoplasms could be identified on MR images. In 18 of 22 patients with proved carcinoma, a mass with a signal intensity higher than that of normal cervical lips was seen on T2-weighted images. Endometrial carcinoma was most often identified as expansion of the central high-intensity area; discrete tumor nodules were visible in nine of 15 patients. Mixed müllerian sarcoma appeared as a large pelvic mass with complete obliteration of normal uterine landmarks. MR imaging delineates primary cervical and endometrial carcinoma better than computed tomography does.     

急诊肝动脉栓塞治疗肝癌破裂出血

目的:探讨急诊肝动脉栓塞治疗原发性肝癌破裂出血的方法、临床效果、意义。方法:回顾性分析14例原发性肝癌破裂出血患者的病例资料,其中巨块型肝癌10例、结节型3例、小肝癌1例。所有患者均行急诊肝动脉超选择插管,采用弹簧圈、明胶海绵及碘化油等栓塞出血动脉。结果:14例原发性肝癌出血得到完全控制,患者术后生存期均在5个月以上,其中1例半年后死亡,5例随访24个月均存活。结论:急诊肝动脉栓塞治疗原发性肝癌破裂出血疗效肯定,创伤小,是安全、可靠的抢救手段。     

Uterine cervical cancer: assessment with high-field MR imaging

Nineteen patients with histologically proved cervical carcinoma were evaluated with magnetic resonance (MR) imaging. Clinical, MR, and surgical findings were compared to determine accuracy and clinical usefulness of MR in demonstrating mass and extent of disease. MR imaging enabled clear differentiation of corpus uteri, cervix, vagina, uterine ligaments, and tumor. Tumor was demonstrated as a high-intensity mass deforming the low-intensity cervix; the low background intensity of normal structures provided high contrast to the mass. MR imaging accurately demonstrated the tumor in all ten patients with locally advanced cervical carcinoma and showed a normal cervix in nine patients with early cancer. On sagittal images, the shape of corpus uteri, cervix, and vagina, and their relationship to the mass were clearly assessed, with their long axes usually in a single plane. On axial images, assessment of parametrial tumor extension was facilitated by clear definition of the low-intensity cervix and uterine ligaments. Although more study is needed to determine the accuracy of MR in staging, MR is a promising method in evaluating cervical carcinoma.     

单纯子宫动脉栓塞术在宫颈妊娠刮宫术前预防出血的应用

目的：探讨单纯子宫动脉栓塞术联合刮宫术治疗宫颈妊娠的临床疗效。方法对31例确诊宫颈妊娠患者,行超选择性子宫动脉插管后注射明胶海绵颗粒进行栓塞治疗,术后24-48h再行刮宫术。结果31例患者双侧子宫动脉超选择性插管及栓塞成功率均为100％,血β-HCG水平术后7-15天恢复正常,术后24-48h行刮宫术胚胎组织易于剥离,出血量少在5-25ml之间。结论单纯子宫动脉栓塞术能明显降低宫颈妊娠刮宫术中大出血的风险,成功率高、安全有效。     

外生型宫颈浸润癌介入治疗的探讨

目的探讨超选择性子宫动脉化疗栓塞治疗53例外生型宫颈浸润癌的意义。方法常规采用Seld ing's技术,经皮股动脉穿刺插管,髂内动脉造影及子宫动脉化疗栓塞治疗。结果超选择子宫动脉化疗栓塞治疗后突起子宫颈局部肿瘤大部分或全部坏死脱落。结论采用超选择性子宫动脉化疗栓塞是治疗中晚期宫颈癌的一种安全有效的方法。     

Uterine artery embolization: the role in obstetrics and gynecology

OBJECTIVE: Evaluation of the studies for the use of uterine artery embolization in various conditions in both obstetrics and gynecology. DESIGN: Literature review. RESULTS: Uterine artery embolization was successful in controlling postpartum hemorrhage in 94.9% of the cases. It was effective in controlling the bleeding in 96% of cases with uterine arteriovenous malformations and in 100% of the cases with abdominal and cervical pregnancies. Recently, it has been introduced as a line of treatment for uterine fibroids. It controlled bleeding in 82-92% of cases, and lead to 20-64% reduction in size of fibroids. CONCLUSIONS: Uterine artery embolization is of significant value in treating certain hemorrhagic conditions in obstetrics and gynecology including postpartum hemorrhage, ectopic pregnancy, and arteriovenous malformations. Its use in treatment of uterine fibroids is new and needs more collaborative studies by gynecologists and intervention radiologists to evaluate issues related to necrosis of the tumor, sepsis, and the long-term effect on size and recurrence rate.     

肾动脉栓塞治疗肾脏疾病的临床评价

目的 研究肾动脉栓塞术在肾外伤出血及肾肿瘤术前病人的临床应用。方法 对106例进行超选择性肾动脉栓塞，其中72例为肾肿瘤术前栓塞，34例为肾外伤性出血，应用明胶海绵碎屑及金属圈．栓塞肿瘤血管及出血动脉。结果 肾肿瘤术中易剥离，出血少，术野清晰、缩短术时；肾出血34例，除一例肾切除外．其余栓塞后出血均停。结论 肾动脉栓塞有助于肾肿瘤的手术切除。对肾外伤出血者采用超选择性肾动脉栓塞．可降低开放手术率．最大限度保存肾脏。     

Staging of carcinoma of the uterine cervix and endometrium

Carcinoma of the uterine cervix and endometrium are common gynecologic malignancies. Both carcinomas are staged and managed by means of the International Federation of Gynecology and Obstetrics (FIGO) staging system. In uterine cervical cancer, the FIGO staging system is determined preoperatively by limited conventional procedures. Although this system is effective for early stage disease, it has inherent inaccuracies in advanced stage diseases and does not address nodal involvement. CT and MR imaging are widely used as comprehensive imaging modalities to evaluate tumor size and extent, and nodal involvement. MR imaging is an excellent modality for depicting invasive cervical carcinoma and can provide objective measurement of tumor volume, and provides high negative predictive value for parametrial invasion and stage IVA disease. In contrast, endometrial cancer is surgically staged. Beside recognition of the important prognostic factors, including histologic subtype and grade, accurate assessment of the tumor extent on preoperative MR imaging is expected to greatly optimize surgical procedure and therapeutic strategy. Contrast-enhanced MR imaging can offer “one stop” examination for evaluating the depth of myometrial invasion cervical invasion and nodal metastases. Evaluation of myometrial invasion on MR imaging may be an alternative to gross inspection of the uterus during the surgery.     

子宫动脉栓塞在宫颈或切口妊娠人工流产手术前的作用

目的:将双侧子宫动脉栓塞术应用于宫颈或切口妊娠中止前,期望减少人工流产手术的危险性和出血量。材料和方法:12例宫颈或切口妊娠患者,术前采用明胶海绵进行双侧子宫动脉超选择性栓塞术,术后即刻或24h左右进行清宫手术,观察术中出血量和术后伴发症状。结果:双侧子宫动脉栓塞治疗过程非常顺利,12例清宫手术均安全顺利完成,出血量仅10~20ml,没有出现栓塞术或清宫手术的并发症。术后随访血液HCG均在4周内消失。结论:宫颈妊娠或切口妊娠在清宫手术前进行双侧子宫动脉栓塞的辅助治疗,安全性好,并发症少,操作简单,可有效地控制宫颈或切口妊娠中止手术中的出血量。