鼻内镜下成人腺样体切除术88例

目的探讨鼻内镜下成人腺样体肥大切除术的方法及疗效。方法对2000年4月至2007年3月在本科行鼻内镜下成人腺样体切除手术治疗由腺样体肥大引起的鼻阻塞、睡眠呼吸障碍和咽鼓管功能障碍等88例患者随访6个月，观察患者的临床症状及鼻内镜检查情况，并对临床资料进行回顾性分析。结果88例患者术后均无出血，无腺体残留，无咽鼓管咽口、咽鼓管圆枕、软腭损伤，无鼻咽黏连，术后6个月观察85例成人腺样体肥大患者症状完全消失（96.59%），2例症状好转（2.27%），1例无效（1.14%）。结论鼻内镜下电动吸引切割器切除腺样体直观、清晰、手术彻底、并发症少，是治疗成人腺样体肥大慢性炎症的有效方法，对鼻窦炎合并腺样体肥大两者同时手术效果良好。     

内镜下动力系统小儿腺样体切除术45例

<正>我科于2003年3月至2009年4月采用鼻内镜下动力系统对45例患儿经口腔行腺样体吸切术切除腺样体,效果良好,现报道如下。临床资料1一般资料腺样体肥大患儿45例,其中男30例,女15例,年龄4.5～8岁,平均年龄5.3岁。所有病例术前均行鼻内镜、鼻咽侧位片或鼻咽部CT检查,证实为腺样体肥大。患儿在     

儿童鼻内镜下腺样体刮除60例

我科自2005年8月～2006年10月采用插管全身麻醉鼻内镜下经口径路行儿童腺样体刮除术60例，疗效满意，报告如下。1资料与方法 .1一般资料60例患者中男34例，女26例，年龄3．5～10岁，临床症状为鼾症、鼻窦炎、分泌性巾耳炎。术前均经鼻咽部轴位CT或在表面麻醉下鼻内镜检查鼻咽，证实腺样体肥大，其中3例为腺样体切除术后腺样体再度增生。     

鼻内镜下儿童腺样体肥大的手术治疗

腺样体即咽扁桃体，位于鼻咽顶后壁中线处，为咽淋巴环的组成部分。腺样体肥大可引起分泌性中耳炎、鼻窦炎、鼾症等多种疾病，常用的检查方法是通过间接鼻咽镜、鼻内镜、纤维鼻咽镜下检查。治疗方法是经口腺样体刮除术。我院2004年3月-2006年6月收治儿童腺样体肥大患者36例，进行了鼻内镜下经鼻或经口腺样体肥大切除术，疗效确切，现报告如下。     

成人鼻咽腺样体肥大的影像诊断

目的探讨成人鼻咽部腺样体肥大影像学表现与诊断价值。方法回顾分析34例成人鼻咽腺样体肥大的影像学表现,所有病例均经活检和病理证实。结果鼻咽部侧位x线照片11例,表现为鼻咽腔顶后壁软组织增厚,范围11mm～17mm,绝对值均大于10mm。横断CT扫描23例,鼻咽后壁软组织厚度13mm-18mm,平均值14mm;所有病例均未见颅底骨质破坏。MR检查27例,鼻咽顶后壁粘膜增厚,厚度达5mm～10mm 5例,11mm～15mm 17例,15mm以上5例,均与头长肌分界清晰。5例可见1～4个咽旁或颈淋巴结增大,直径4mm～11mm。结论成人鼻咽部腺样体肥大的诊断不难;MRI具有良好的软组织分辨率,可分辨粘膜、腺样体增生肥大与肌层,诊断价值优于X线平片和CT检查。     

经口70°鼻内镜下腺样体切除术30例治疗体会

目的：探讨鼻内镜下腺样体切除治疗腺样体肥大的临床疗效。方法：采用70°鼻内镜下经口行腺样体切除术30治疗腺样体肥大患者30例。结果：30例患者手术均成功,术中出血约20mL,无1例出现并发症,术后鼾声消失,所有患者均1次治愈,30例患者术后随访6月,鼻v因部黏膜光滑,无1例发生软腭,咽鼓管咽口和圆枕损伤,均未出现症状复发。结论：经口70°鼻内镜下腺样体切除术是腺样体肥大较理想的治疗方法。     

鼻内镜下成人腺样体肥大的诊治

目的:总结探讨成人腺样体肥大在鼻内镜下的诊治。方法:鼻内镜检出成人腺样体肥大患者32例,在鼻内镜直视下,完整切除腺样体。结果:术后随访6～36个月,平均13个月,无复发。结论:鼻内镜的普及大大提高成人腺样体肥大的诊治水平。     

鼻内镜下经口腺样体切除30例疗效观察

腺样体肥大是儿童睡眠呼吸疾病的主要原因,也是慢性鼻窦炎和分泌性中耳炎重要的基础因素,常合并慢性扁桃体炎。我们自2002年1月～2004年1月,采用鼻内镜、腺样体刮匙、70°电动负压切割器经口直视下切除腺样体30例,效果满意,现报告如下。1资料与方法1.1临床资料30例腺样体肥大患者中,男12例,女18例;年龄4岁～12岁,病程1年￣5年。临床表现主要为睡眠打鼾及张口呼吸。其中6例伴慢性鼻窦炎,8例伴分泌性中耳炎,4例伴扁桃体肥大。全部患儿术前行鼻咽部X线检查及鼻内镜检查,证实腺样体肥大。1.2手术方法患儿取仰卧位,经口腔气管内插管,全麻成功后,…     

鼻内窥镜下腺样体刮除术56例报告

腺样体又称为咽扁桃体，位于鼻咽顶后壁中线处，为咽淋巴环内环的组成部分。腺样体肥大是小儿常见病、多发病。近年来鼻内镜下腺样体切除术已逐渐开展。我科自2002．10-2007．12月对56例腺样体肥大患者在鼻内镜直视下行腺样体刮除术，均取得满意效果，现报告如下。     

成人咽扁桃体的临床形态学

自古以来，人们一直认为咽扁桃体肥大常见于3－8岁的儿童，且多数认为门岁开始萎缩，至青春时则基本消失。自鼻内窥镜问世以来，我们自1996－1998年使其应用于临床，在检查治疗中发现成人鼻咽部有很多很高的腺样体。因此，我们对1996－1998年133例患者用鼻内窥镜进行检查（鼻咽部），其中62例取活组织，行HE染色光镜检查，进而对腺样体的发生演变以及成人咽扁桃体的特点进行探讨。临床资料与方法l一般资料取门诊与住院患者共133冽，其中男85例，女48例，年龄17－75岁，其中17－20岁月例，以递增10岁为1组，其余各组分别为：30‘34‘26、11…     

益智健脑颗粒联合针灸对阿尔茨海默病大鼠学习记忆的影响

目的观察益智健脑颗粒联合针灸对阿尔茨海默病（Alzheimers disease,AD）大鼠学习记忆的影响。方法将大鼠随机分为假手术组（A组）、模型组（B组）、针灸组（C组）、益智＋针灸组（D组）各10只,B、C、D 3组分别以海马CA1区注射β淀粉样蛋白25-35（Aβ25-35）造模,A组注射等量的双蒸水,各组分别治疗20 d后行Morris水迷宫试验,观察大鼠学习记忆能力变化。结果B组较A组的平均潜伏期明显延长,差异具有统计学意义（P〈0.05）;与B组比较,C组、D组的平均潜伏期明显缩短,过台次数增多,差异具有统计学意义（P〈0.05,P〈0.01）;与C组比较,D组的潜伏期缩短,过台次数增多,差异具有统计学意义（P〈0.05）。结论益智健脑颗粒联合针灸能够提高Aβ25-35介导的AD模型大鼠的学习记忆能力。     

Liuwei Dihuang,a traditional Chinese herbal formula,suppresses chronic inflammation and oxidative stress in obese rats

OBJECTIVE： To investigate the anti-inflammatory, anti-oxidative stress, and adipokine-ameliorating effects of Liuwei Dihuang （LWDH）, a traditional Chinese herbal formula, in obese rats. METHODS： After 2 weeks of acclimation with free access to regular rodent chow and water, obese-prone-caesarean-derived （OP-CD） rats were fed a modified AIN-93G diet containing 60% energy from fat. Treatment was performed twice daily by gavage feeding with 500, 1 500, or 3 500 mg/kg body weight LWDH suspended in water （n=12 rats per group）. Twelve obese-resistant-CD （OR-CD） rats were fed the atherogenic diet and gavaged with water, and served as the normal control. Blood biomarkers of inflammation, oxidative stress and adiponectin were measured post-sacrifice and used to determine the treatment effect of LWDH and assess the suitability of OR/OP-CD rats for studying these parameters. RESULTS： After 9 weeks of treatment, LWDH lowered serum C-reactive protein （CRP） and tumour necrosis factor-α （TNF-α） levels. Serum interleukin-6 （IL-6） levels showed a tendency towards reduction, but were not significantly different from the OP-CD control. Liver superoxide dismutase （SOD） activity was increased in response to all three doses of LWDH, while the levels of reduced （GSH） and oxidized glutathione （GSSG） and thiobarbituric acid reactive substances （TBARS） were unchanged. Serum adiponectin levels were increased in response to oral administration of LWDH at the dose of either 500 or 1 500 mg/kg body weight. In addition, comparisons between OR-CD and OP-CD rats revealed differential, and for some biomarkers, conflicting characteristics of high-fat diet-fed OP-CD rats in reference to obese human subjects in terms of inflammatory and oxidative stress biomarkers and circulating adiponectin levels. CONCLUSION： The results show, for the first time, the anti-inflammatory, anti-oxidative stress and adiponectin-ameliorating effects of LWDH in obese rats. The suitability of the OP-JOP-CD rat model as     

表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌应用的瓶颈——获得性耐药

以表皮生长因子受体酪氨酸激酶抑制剂（epidermal growth factor receptor-tyrosine kinase inhibitor,EGFR-TKI）分子靶向治疗研究为肇始,转化性研究使基础实验和临床实践间的鸿沟迅速填平,改变着人们认识治疗肺癌的视角。无可否认,EGFR-TKI上市后极大地延伸了肿瘤学家治疗肺癌的手段,但不管从临床经验、临床研究数据、分子生物学层面还是文献计量学的角度,     

程丑夫教授论治情志病验案举隅

程丑夫是国家级名老中医,湖南中医药大学第一附属医院主任医师、教授、博士生导师,享受政府特殊津贴专家,出身于中医世家,从医40余年,经验丰富,对于内科系统及疑难杂症的治疗颇有心得,笔者有幸跟师学习,聆听教诲,受益匪浅,现将程师论治情志病的经典验案略陈一二。1思虑伤脾案患者肖某,女,27岁。初诊：2014年5月20日。半年前因婚变后出现忧心忡忡,多思多虑,近1月来反复腹部胀满,刻诊：腹胀,食后为甚,呃逆,无反酸,通气后可减轻,无腹痛,不欲食,夜寐不安,二便调。舌红苔厚白腻,脉弦,BP：110／70mmHg。     

补肾活血方对PCOS大鼠模型卵巢中PAI-1mRNA表达的影响

目的探讨补肾活血方对大鼠PCOS模型卵巢局部纤溶酶原激活物抑制因子-1（PAI—1mRNA）表达的影响。方法选用未成年24d龄SD雌性大鼠60只,随机分为模型组、克罗米酚组、补肾活血方高剂量组、补肾活血方低剂量组、正常对照组5组。用Bogovich法建立大鼠多囊卵巢病理模型。以克罗米酚为对照。用原位杂交法观察补肾活血方对多囊卵巢大鼠局部PAI—1mRNA的影响。结果模型组卵巢局部PAI—1mRNA存在卵泡膜间质细胞显著增高,用补肾活血方高、低剂量与克罗米酚药后,卵巢局部PAI-1mRNA的表达明显降低．差异具有统计学意义（P〈0．05、P〈0．01）。补肾活血方高剂量组与克罗米酚组比较,差异具有显著统计学意义（P〈0．01）;低荆量组与克罗米酚组比较差异无统计学意义（P〉0．05）,补肾活血方高、低剂量组比较,低剂量组卵泡膜间质细胞上PAI-1的基因表达增高更明显,但二者差异无统计学意义（P〉0．05）。结论PAI-1mRNA可能与多囊卵巢综合征的发病机制有关。以补肾活血立法的补肾活血方能降低多囊卵巢大鼠局部PAI—1mRNA的显著增高表达．降低PAI—1mRNA卵巢局部的作用。提示补肾活血方可能通过PAI—1mRNA途径促进卵巢排卵的机制。     

UniPron is A Fully Effective Non-hormonal Reversible Contraceptive in Baboon Model （Papio Anubis）

Objective To determine the safety and efficacy of UniPron as a reversible contraceptive.
Methods Vaginal swabs were obtained before and after UniPron administration, cultured onto appropriate culture media and bacteria identification was done based on type of media used, Gram stain reactions, colony morphology and biochemical tests. Vaginal biopsy tissues were processed using paraffin wax method, stained with hematoxylin and eosin and examined under light microscopy to determine the effect of the product on vaginal tissues. The effect of UniPron on sperm was examined by mixing the product with electroejaculated spermatozoa in vitro at different concentrations. For efficacy studies, male baboons of proven fertility were mated with UniPron treated or untreated females of proven fertility during the fertile stages.
Results All the five females （100%） that were treated with UniPron did not conceive and they regained total fertility when the treatment was stopped while all the controls conceived. At a concentration of 40%, UniPron completely immobilized spermatozoa in an in-vitro system. UniPron mechanism of action was by lowering the vaginal pH and on application in baboon, the pH was lowered for at least 3 h after which it went back to normal.
Conclusions As we plan for a study to test UniPron as a microbicide to prevent STIs including HIV, our current study has established that this novel product is effective in contraception and harmless to vaginal tissues and vaginal microbial flora in a baboon model （Papio anubis）.     

WHO西太区与“世界中医药学会联合会”中医名词术语国际标准比较研究：精、神、气、血、津、液部分

精、神、气、血、津、液是中医理论中6个非常重要的概念，有关术语在《WHO西太区传统医学国际标准名词术语》中一共收录了59条，“世界中医药学会联合会”（以下简称世中联）《中医基本名词术语中英对照国际标准》中收录了58条。血、津、液的内涵较为具体，有一定的物质基础，理解并不困难。翻译上虽有差异，但亦不难统一。精、神、     

Mechanical tests on the reconstructed anterior cruciate ligament fixed with allogenetic cortical bone cross-pin on the femoral side

Background Anterior cruciate ligament reconstruction （ACLR） has developed dramatically in the last century.Now,ACLR has become a reliable and productive procedure.Patients feel satisfied in 〉90% cases.The aim of this study was to evaluate the feasibility of allogenetic cortical bone cross-pin （ACBCP） used as a clinical fixation method in anterior cruciate ligament reconstruction on the femoral side based on biomechanical tests in vitro.Methods The specimens were provided by the bone banks of the First Affiliated Hospital of People＇s Liberation Army of General Hospital from September 2011 to June 2012.Fresh deep frozen human allogenetic cortical bone was machined into cross-pins which is 4.0 mm in diameter and 75.0 mm in length.Biomechanical parameters compared with Rigidfix were collected while cross-pins were tested in double-shear test.The load-to-failure test and cycling test were carried out in a goat model to reconstruct anterior cruciate ligament with Achilles tendon autograft on the femoral side fixed by human 4.0 mm ACBCP and 3.3 mm Rigidfix served as control.Maximum failure load,yield load,and stiffness of fixation in single load-to-failure test were compared between the two groups.Cycle-specific stiffness and displacement at cycles 1,30,200,400,and 1 000 were also compared in between.Results In double-shear test both maximum failed load and yield load of 4.0 mm humanACBCP were （1 236.998±201.940） N.Maximum failed load and yield load of Rigidfix were （807.929±110.511） N and （592.483±58.821） N.The differences of maximum failed load and yield load were significant between ACBCP and Rigidfix,P 〈0.05.The shear strength of ACBCP and Rigidfix were （49.243±8.039） MPa and （34.637±3.439） MPa,respectively,P 〈0.05.In the load-to-failure test ex vivo,yield load and maximum failed load of ACBCP fixation complexity （（867.104±132.856）N,（1 032.243±196.281） N） were higher than those of Rigidfix （（640.935±42.836） N,（800.568±64.890） N,P 〈0.05）.However,s     

New Mechanism of Herb-herb Interaction between Ginseng and Trogopterus Based on CYPs in Rat Livers

The study was designed to investigate the potential mechanism of herb-herb interaction between ginseng and Trogopterus （Trg） based on Cytochrome P450 isozymes （CYPs） in rat livers. We estimated the influence on CYP1A2, CYP2E1, and CYP3A1/2 activity caused by ginseng and Trg used in combination. The CYP1A2 and CYP2E1 enzyme activity were induced by ginseng and Trg used in combination. And this induction effect was caused via inducing CYP1A2 and CYP2E1 protein expression which was supposed caused by inducing the gene expression of CYP1A2 and CYP2E1.     

中医疗法治疗运动性疲劳的研究进展

随着竞技体育的发展，运动员经常承受着大负荷、超强度的体力训练，因此极易产生运动性疲劳。疲劳的出现使肌内压增高，局部缺血，造成氧化代谢、H^＋排出率与pH值降低，血乳酸增高，从而影响肌纤维神经传导速度和肌内收缩力量，减弱了肌肉保护能力。致使较多的冲击力传到骨骼上，故易导致疲劳骨折的发生,严重影响了运动员的训练和比赛成绩，对运动员身心产生不必要的伤害。运动性疲劳消除手段的研究一直是竞技体育工作和运动医学关注和研究的焦点。