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1.
Muhammad Shafiq Shahid Masato Ikegami Abdul Waheed Rob W. Briddon Keiko T. Natsuaki 《Viruses》2014,6(1):189-200
Samples were collected in 2011 from tomato plants exhibiting typical tomato leaf curl disease symptoms in the vicinity of Komae, Japan. PCR mediated amplification, cloning and sequencing of all begomovirus components from two plants from different fields showed the plants to be infected by Tomato
yellow
leaf
curl
virus (TYLCV) and Ageratum
yellow
vein
virus (AYVV). Both viruses have previously been shown to be present in Japan, although this is the first identification of AYVV on mainland Japan; the virus previously having been shown to be present on the Okinawa Islands. The plant harboring AYVV was also shown to contain the betasatellite Tomato leaf curl Java betasatellite (ToLCJaB), a satellite not previously shown to be present in Japan. No betasatellite was associated with the TYLCV infected tomato plants analyzed here, consistent with earlier findings for this virus in Japan. Surprisingly both plants were also found to harbor an alphasatellite; no alphasatellites having previously been reported from Japan. The alphasatellite associated with both viruses was shown to be Sida yellow vein China alphasatellite which has previously only been identified in the Yunnan Province of China and Nepal. The results suggest that further begomoviruses, and their associated satellites, are being introduced to Japan. The significance of these findings is discussed. 相似文献
2.
Anwar Hasan Siddiqui Nazia Tauheed Aquil Ahmad Zehra Mohsin 《Jornal brasileiro de pneumologia》2014,40(3):244-249
Objective:
Pregnancy brings about significant changes in respiratory function, as evidenced by alterations in lung volumes and capacities, which are attributable to the mechanical impediment caused by the growing foetus. This study was undertaken in order to identify changes in respiratory function during normal pregnancy and to determine whether such changes are more pronounced in twin pregnancy than in singleton pregnancy.Methods:
Respiratory function was assessed in 50 women with twin pregnancies and in 50 women with singleton pregnancies (during the third trimester in both groups), as well as in 50 non-pregnant women. We measured the following pulmonary function test parameters: FVC; FEV1; PEF rate; FEV1/FVC ratio; FEF25-75%; and maximal voluntary ventilation.Results:
All respiratory parameters except the FEV1/FVC ratio were found to be lower in the pregnant women than in the non-pregnant women. We found no significant differences between women with twin pregnancies and those with singleton pregnancies, in terms of respiratory function.Conclusions:
Despite its higher physiological demands, twin pregnancy does not appear to impair respiratory function to any greater degree than does singleton pregnancy. 相似文献3.
4.
5.
Yusuke Tomoi Mitsuyoshi Takahara Yoshimitsu Soga Masahiko Fujihara Osamu Iida Daizo Kawasaki Amane Kozuki Kenji Ando 《Journal of atherosclerosis and thrombosis》2021,28(11):1153
Aim: Originally developed for predicting the risk of stroke in patients with atrial fibrillation (AF), the CHA 2 DS 2 -VASc score also has the potential to predict the risk of other cardiovascular disease. This study aimed to investigate the prognostic value of the CHA 2 DS 2 -VASc score in patients with peripheral artery disease (PAD) requiring Femoral popliteal (FP) endovascular therapy (EVT). Methods: This multicenter, retrospective study analyzed the clinical database of 2190 patients who underwent FP EVT for symptomatic PAD (Rutherford categories 2–4) between January 2010 and December 2018. We calculated the CHA 2 DS 2 -VASc score and then investigated the association between the score, as well as AF, and their prognosis. Outcome measures were major adverse cardiovascular events (MACEs) and major adverse limb events (MALEs). Results: During a median follow-up of 3.0 years (interquartile range, 1.5–5.0 years), 532 MACEs and 562 MALEs occurred. The CHA 2 DS 2 -VASc score and AF were independently associated with an increased risk of MACEs; their adjusted hazard ratios [95% confidence intervals] were 1.28 [1.20–1.36] ( P <0.001) per 1-point increase and 1.49 [1.06–2.09] ( P =0.022), respectively. The CHA 2 DS 2 -VASc score was almost linearly associated with MACEs, without any clear threshold point. On the other hand, these variables were not associated with MALEs risk ( P =0.32 and 0.48). Conclusion: The CHA 2 DS 2 -VASc score and AF were independently associated with the increased risk of MACEs but not of MALEs in patients with symptomatic PAD who underwent FP EVT. The score might be useful in stratifying the MACEs risk in this type of patients. 相似文献
6.
Pedro Gon?alo Ferreira Susana Costa Nuno Dias António Jorge Ferreira Fátima Franco 《Jornal brasileiro de pneumologia》2014,40(3):313-318
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor used as an
antidepressant. Interindividual variability and herb-drug interactions can lead to
drug-induced toxicity. We report the case of a 35-year-old female patient diagnosed
with synchronous pneumonitis and acute cardiomyopathy attributed to venlafaxine. The
patient sought medical attention due to dyspnea and dry cough that started three
months after initiating treatment with venlafaxine for depression. The patient was
concomitantly taking Centella asiatica and Fucus
vesiculosus as phytotherapeutic agents. Chest CT angiography and chest
X-ray revealed parenchymal lung disease (diffuse micronodules and focal ground-glass
opacities) and simultaneous dilated cardiomyopathy. Ecocardiography revealed a left
ventricular ejection fraction (LVEF) of 21%. A thorough investigation was carried
out, including BAL, imaging studies, autoimmune testing, right heart catheterization,
and myocardial biopsy. After excluding other etiologies and applying the Naranjo
Adverse Drug Reaction Probability Scale, a diagnosis of synchronous
pneumonitis/cardiomyopathy associated with venlafaxine was assumed. The herbal
supplements taken by the patient have a known potential to inhibit cytochrome P450
enzyme complex, which is responsible for the metabolization of venlafaxine. After
venlafaxine discontinuation, there was rapid improvement, with regression of the
radiological abnormalities and normalization of the LVEF. This was an important case
of drug-induced cardiopulmonary toxicity. The circumstantial intake of inhibitors of
the CYP2D6 isoenzyme and the presence of a CYP2D6 slow metabolism phenotype might
have resulted in the toxic accumulation of venlafaxine and the subsequent clinical
manifestations. Here, we also discuss why macrophage-dominant phospholipidosis was
the most likely mechanism of toxicity in this case. 相似文献
7.
Kjell Nikus Yochai Birnbaum Markku Eskola Samuel Sclarovsky Zhan Zhong-qun Olle Pahlm 《Current Cardiology Reviews》2014,10(3):229-236
The electrocardiogram (ECG) findings in acute coronary syndrome should always be interpreted in the context of the clinical findings and symptoms of the patient, when these data are available. It is important to acknowledge the dynamic nature of ECG changes in acute coronary syndrome. The ECG pattern changes over time and may be different if recorded when the patient is symptomatic or after symptoms have resolved. Temporal changes are most striking in cases of ST-elevation myocardial infarction. With the emerging concept of acute reperfusion therapy, the concept ST-elevation/non-ST elevation has replaced the traditional division into Q-wave/non-Q wave in the classification of acute coronary syndrome in the acute phase.
Keypoints:
In acute coronary syndrome, in addition to the traditional electrocardiographic risk markers, such as ST depression, the 12-lead ECG contains additional, important diagnostic and prognostic information. Clinical guidelines need to acknowledge certain high-risk ECG patterns to improve patient care. 相似文献8.
Duchenne muscular dystrophy (DMD) is characterized by increased
muscle damage and an abnormal blood flow after muscle
contraction leading to a state of functional ischemia. Abundant
evidence suggests that endothelial circulating progenitor
cells (EPCs) play an important role in mediating vascular and
muscle repair mechanisms and that the stromal cell-derived
factor (SDF)-1 α chemokine is responsible for both progenitor
cell mobilization from the bone marrow to peripheral blood and
homing to the sites of vascular and tissue injury. Since normal
neovascularization is disrupted in DMD pathogenesis and may
contribute ultimately to heart failure and sudden death, the aim
of the present study is to investigate whether the (SDF)-1 α, and
EPCs surface receptors in terms of CD34, CD133 and kinase domain
receptor (KDR) are involved in DMD pathophysiology. In
the present study, peripheral blood concentrations of circulating
CD34, CD133, and CD34/ CD 133 progenitor cells were measured
by flow cytometry, together with serum levels of (SDF)-1α
and hypoxia inducible factor (HIF-1α.), in 28 DMD patients vs.
20 healthy age and socioeconomic matching controls. Results
showed a significant increase in the number of mononuclear cells
bearing EPC markers, HIF-1α mRNA expression and serum
(SDF)-1 α, indicating that regeneration is an ongoing process in
these patients. However, this regeneration cannot counterbalance
the damage induced by dystrophine mutation.Key words: Duchenne dystrophy, stromal cell-derived factors, EPCs surface receptors 相似文献
9.
Leonardo Bruno Paz Ferreira Barreto Maria Cristina da Silva Louren?o Valéria Cavalcanti Rolla Valdiléia Gon?alves Veloso Gisele Huf 《Jornal brasileiro de pneumologia》2014,40(2):148-154
OBJECTIVE:
To compare the accuracy of the amplified Mycobacterium tuberculosis direct (AMTD) test with reference methods for the laboratory diagnosis of tuberculosis in HIV-infected patients.METHODS:
This was a study of diagnostic accuracy comparing AMTD test results with those obtained by culture on Löwenstein-Jensen (LJ) medium and by the BACTEC Mycobacteria Growth Indicator Tube 960 (BACTEC MGIT 960) system in respiratory samples analyzed at the Bioassay and Bacteriology Laboratory of the Oswaldo Cruz Foundation Evandro Chagas Clinical Research Institute in the city of Rio de Janeiro, Brazil.RESULTS:
We analyzed respiratory samples collected from 118 patients, of whom 88 (74.4%) were male. The mean age was 36.6 ± 10.6 years. Using the AMTD test, the BACTEC MGIT 960 system, and LJ culture, we identified M. tuberculosis complex in 31.0%, 29.7%, and 27.1% of the samples, respectively. In comparison with LJ culture, the AMTD test had a sensitivity, specificity, positive predictive value, and negative predictive value of 87.5%, 89.4%, 75.7%, and 95.0%, respectively, for LJ culture, whereas, in comparison with the BACTEC MGIT 960 system, it showed values of 88.6%, 92.4%, 83.8%, and 94.8%, respectively.CONCLUSIONS:
The AMTD test showed good sensitivity and specificity in the population studied, enabling the laboratory detection of M. tuberculosis complex in paucibacillary respiratory specimens. 相似文献10.
Yusuke Akiyama Tetsuya Matoba Shunsuke Katsuki Susumu Takase Soichi Nakashiro Yasuhiro Nakano Kensuke Noma Hiroyuki Tsutsui 《Journal of atherosclerosis and thrombosis》2022,29(3):379
Aims: Previous studies suggested that implantation with a 1st-generation DES was associated with coronary endothelial dysfunction, which was associated with Rho-kinase activation. Second-generation drug-eluting stents (DESs) may preserve coronary endothelial function in stented coronary arteries; however, because of methodological limitations, further study is needed to clarify the association between 2 nd -generation DESs and coronary endothelial dysfunction. Methods: We retrospectively analysed the CuVIC trial database, where we identified 112 patients who underwent coronary stenting in the left coronary arteries with either a bare metal stent (BMS, n =53) or 2 nd -generation DES ( n =59). We compared vasomotions of target vessels with stents and non-target vessels without stents. Furthermore, we measured the Rho-kinase activation detected in mononucleocytes from aortic and coronary sinus blood. Results: ACh-induced vasoconstrictive responses of target vessels were not enhanced with a 2 nd -generation DES (45±21% vs. 44±20%, P =0.56, paired t -test), but significantly enhanced in the coronary arteries with a BMS (50±18% vs. 42±20%, P =0.002). Rho-kinase activation did not differ between patients with a BMS and 2 nd -generation DES. In the target vessels with a BMS, large late lumen loss and acute coronary syndrome (ACS) at the index percutaneous coronary intervention (PCI) were associated with ACh-induced enhanced coronary vasoconstrictive responses. Conclusions: Evaluation of ACh-induced vasomotion of target vessels comparing with non-target vessels revealed that 2 nd -generation DESs were not associated with coronary endothelial dysfunction in target vessels, nor activation of Rho-kinase in the coronary sinus blood 6-8 months after stenting. 相似文献
11.
12.
S. Nozaki M. Kawai R. Shimoyama N. Futamura T. Matsumura K. Adachi Y. Kikuchi 《Acta myologica》2010,29(3):392-397
The purpose of this study is to evaluate whether the range of motion exercise of the temporo-mandibular joint (jaw ROM exercise) with a hot pack and massage of the masseter muscle improve biting disorder in Duchenne muscular dystrophy (DMD). The subjects were 18 DMD patients (21.3 ± 4.1 years old). The jaw ROM exercise consisted of therapist-assisted training (2 times a week) and self-training (before each meal every day). The therapist-assisted training consisted of the application of a hot pack on the cheek of the masseter muscle region (15 minutes), the massage of the masseter (10 minutes), and jaw ROM exercise (5 minutes). The self-training involved jaw ROM exercise by opening the mouth to the maximum degree, ten times. These trainings continued for six months. Outcomes were evaluated by measuring the greatest occlusal force and the distance at the maximum degree of mouth opening between an incisor of the top and that of the bottom. Six months later, the greatest occlusal force had increased significantly compared with that at the start of jaw ROM exercise (intermediate values: from 73.8N to 97.3N) (p = 0.005) as determined by the Friedman test and Scheffé''s nonparametric test. The patients'' satisfaction with meals increased. However, the maximum degree of mouth opening did not change after six months of jaw ROM exercise. Jaw ROM exercise in DMD is effective for increasing the greatest occlusal force.Key words: Duchenne muscular dystrophy, exercise, occlusal
force 相似文献
13.
14.
Regina Terse Trindade Ramos Maria Angélica Pinheiro Santana Priscila de Carvalho Almeida Almério de Souza Machado Júnior José Bouzas Araújo-Filho Cristina Salles 《Jornal brasileiro de pneumologia》2013,39(6):667-674
OBJECTIVE:
To determine the prevalence of nocturnal hypoxemia and its association with pulmonary function, nutritional status, sleep macrostructure, and obstructive respiratory events during sleep in a population of clinically stable children and adolescents with cystic fibrosis (CF).METHODS:
This was a cross-sectional study involving 67 children and adolescents with CF between 2 and 14 years of age. All of the participants underwent polysomnography, and SpO2 was measured by pulse oximetry. We also evaluated the Shwachman-Kulczycki (S-K) scores, spirometry findings, and nutritional status of the patients.RESULTS:
The study involved 67 patients. The mean age of the patients was 8 years. The S-K scores differed significantly between the patients with and without nocturnal hypoxemia, which was defined as an SpO2 < 90% for more than 5% of the total sleep time (73.75 ± 6.29 vs. 86.38 ± 8.70; p < 0.01). Nocturnal hypoxemia correlated with the severity of lung disease, FEV1 (rs = −0.42; p = 0.01), FVC (rs = −0.46; p = 0.01), microarousal index (rs = 0.32; p = 0.01), and apnea-hypopnea index (rs = 0.56; p = 0.01).CONCLUSIONS:
In this sample of patients with CF and mild-to-moderate lung disease, nocturnal oxygenation correlated with the S-K score, spirometry variables, sleep macrostructure variables, and the apnea-hypopnea index. 相似文献15.
Carlos Fernando de Mello Junior Hélio Antonio Guimar?es Filho Camila Albuquerque de Brito Gomes Camila Caroline de Amorim Paiva 《Jornal brasileiro de pneumologia》2013,39(1):98-101
Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction
occurring at the level of the pharynx during sleep. Although cephalometric analysis
is an important method in the diagnosis of craniofacial deformities, CT and magnetic
resonance imaging have been highlighted as the major imaging methods to investigate
the possible causes of OSA, which, in most cases, is multifactorial. Magnetic
resonance and CT both allow an excellent evaluation of the various anatomical planes
of the site of obstruction, which enables better clinical assessment and surgical
approach. This pictorial essay aims to describe the aspects that must be evaluated in
the diagnostic imaging of patients presenting with the major predisposing factors for
OSA. 相似文献
16.
Rodrigo Guellner Ghedini Julio de Oliveira Espinel Elaine Aparecida Felix Artur de Oliveira Paludo Rodrigo Mariano Arthur Rodrigo Ronconi Holand Cristiano Feijó Andrade 《Jornal brasileiro de pneumologia》2013,39(4):490-494
Every year, a large number of individuals become dependent on mechanical
ventilation because of a loss of diaphragm function. The most common causes are
cervical spinal trauma and neuromuscular diseases. We have developed an
experimental model to evaluate the performance of electrical stimulation of the
diaphragm in rabbits using single-channel electrodes implanted directly into the
muscle. Various current intensities (10, 16, 20, and 26 mA) produced tidal
volumes above the baseline value, showing that this model is effective for the
study of diaphragm performance at different levels of electrical stimulation 相似文献
17.
Claudio Andre Barbosa de Lira Fábio Carderelli Minozzo Bolivar Saldanha Sousa Rodrigo Luiz Vancini Marília dos Santos Andrade Abrah?o Augusto Juviniano Quadros Acary Souza Bulle Oliveira Antonio Carlos da Silva 《Jornal brasileiro de pneumologia》2013,39(4):455-460
OBJECTIVE:
To compare lung function between patients with post-poliomyelitis syndrome and those with sequelae of paralytic poliomyelitis (without any signs or symptoms of post-poliomyelitis syndrome), as well as between patients with post-poliomyelitis syndrome and healthy controls.METHODS:
Twenty-nine male participants were assigned to one of three groups: control; poliomyelitis (comprising patients who had had paralytic poliomyelitis but had not developed post-poliomyelitis syndrome); and post-poliomyelitis syndrome. Volunteers underwent lung function measurements (spirometry and respiratory muscle strength assessment).RESULTS:
The results of the spirometric assessment revealed no significant differences among the groups except for an approximately 27% lower mean maximal voluntary ventilation in the post-poliomyelitis syndrome group when compared with the control group (p = 0.0127). Nevertheless, the maximal voluntary ventilation values for the post-poliomyelitis group were compared with those for the Brazilian population and were found to be normal. No significant differences were observed in respiratory muscle strength among the groups.CONCLUSIONS:
With the exception of lower maximal voluntary ventilation, there was no significant lung function impairment in outpatients diagnosed with post-poliomyelitis syndrome when compared with healthy subjects and with patients with sequelae of poliomyelitis without post-poliomyelitis syndrome. This is an important clinical finding because it shows that patients with post-poliomyelitis syndrome can have preserved lung function. 相似文献18.
Silvana Gomes Nunes Piva Maria da Concei??o Nascimento Costa Florisneide Rodrigues Barreto Susan Martins Pereira 《Jornal brasileiro de pneumologia》2013,39(4):476-483
OBJECTIVE:
To determine the prevalence of nutritional deficiency among patients with pulmonary tuberculosis.METHODS:
This was a cross-sectional study using data obtained from the Brazilian Case Registry Database and from the medical records of patients diagnosed with pulmonary tuberculosis (15-59 years of age) residing in one of the municipalities that make up the 16th Regional Health District of the state of Bahia. We calculated the incidence, lethality, and mortality rates, as well as the prevalence of nutritional deficiency, as evaluated by body mass index. Demographic, social, clinical, and epidemiological data were collected.RESULTS:
Of the 72 confirmed cases of tuberculosis, 59 (81.9%) were in males, and 21 (29.2%) of the patients were in the 40-49 year age bracket. The majority (85.3%) described themselves as Mulatto or Black; 55.2% reported using alcohol; and approximately 90% were treated as outpatients. In the district and age bracket studied, the incidence of pulmonary tuberculosis was 30.6/100,000 population. Among the 72 patients, data regarding nutritional status was available for 34. Of those, 50% and 25%, respectively, presented nutritional deficiency at the beginning and at the end of treatment. No statistically significant differences were found between normal-weight and malnourished patients regarding the characteristics studied.CONCLUSIONS:
The prevalence of nutritional deficiency was high among our sample of patients with pulmonary tuberculosis. This underscores the importance of nutritional follow-up for the assessment of tuberculosis treatment in the decision-making process regarding therapeutic interventions. 相似文献19.
20.
Antonieta Guerrero-Plata 《Viruses》2013,5(6):1553-1570
Lung dendritic cells (DC) play a fundamental role in sensing invading pathogens, as well as in the control of tolerogenic responses in the respiratory tract. Their strategic localization at the site of pathogen entry makes them particularly susceptible to initial viral invasion. Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) belong to the Paramyxoviridae family, within the Pneumovirus and Metapneumovirus genera, respectively. hRSV and hMPV are significant human respiratory pathogens that cause similar clinical manifestations and affect many of the same subpopulations. However, they differentially activate the host immune response, including DC, which represents a fundamental link between the innate and adaptive immune response. In this review, the role of DC in the immune response against hRSV and hMPV infections, as well as the inhibitory effects of these paramyxoviruses on the DC immunity will be discussed. 相似文献