Digoxin-like immunoreactive substance in renal transplant patients.

Digoxin-like immunoreactive substance (DLIS) has been detected in several patient populations that were not receiving digoxin, including those patients with end-stage renal disease. The structure and physiologic significance of this compound are unknown, and the fate of DLIS after renal transplantation has not been studied. The authors prospectively evaluated 163 patients (not receiving digoxin) before and after transplantation for the presence of DLIS. Three different assays were used: radioimmunoassay (RIA), affinity mediated immunoassay (ACA), and fluorescence polarization immunoassay (TDX I). Depending on the assay method used, 11% (RIA), 6% (ACA), and 9% (TDX) of patients had detectable DLIS pretransplant. Using all 3 assays, a total of 34 patients (21%) were found to have DLIS. The mean serum digoxin concentration was 0.41 +/- 0.13 ng/mL (range: 0.2-1.2 ng/mL) and DLIS was detectable by greater than 1 assay method in seven patients. DLIS persisted longer in patients who had delayed allograft function (13.7 +/- 7 days) than in those who did not (3 +/- 1.9 days), P less than .05. In summary, detection of DLIS in renal transplant recipients appears to be an infrequent occurrence when using a single digoxin assay method. When detected, the concentration of DLIS is often below the usual therapeutic range for digoxin and disappears once allograft function is established. The authors conclude that the presence of DLIS is unlikely to be clinically significant in the renal transplant population.     

中医药院校中药炮制学双语教学的思考

目的中药炮制学在中医药教育体系中有着十分重要的地位,开展中药炮制学双语教学对扩大中医药在国际的影响很有必要。方法从双语教学的目的、意义和教学过程中的教材、教学模式、教学方法和评价体系等方面,对中医药院校开展中药炮制学双语教学进行了思考。结果通过中药炮制学双语教学,不仅可以提高学生的英语水平和中医药专业素质,也可以促进教师业务水平的提高。结论开展中药炮制学双语教学是中医药学发展的必然趋势,也是中医药教育国际化的必经之路。     

让中药为美丽加分

中药药橱中的很多药材已经跨越了小抽屉的界限，加入到美食行列，或者有些本身就能够作为食品。它们在餐盘中出现，你知道是怎样在你的身体中起作用的吗？[第一段]     

血浆内源性地高辛样因子在肾病综合征中的变化

目的：了解肾病综合征患者血浆内源性地高辛样因子（endogenous digoxin—like factor，EDF）水平的变化及意义。方法：肾病综合征患者62例，根据血压及尿蛋白分为：肾病综合征正常血压组；肾病综合征高血压组；肾病综合征恢复期组；健康人67例为对照组。用放免分析法检测以上各组血浆EDF水平。结果：（1）与正常对照组相比，肾病综合征正常血压组血浆EDF水平明显降低（P〈0．05），肾病综合征高血压组和肾病综合征恢复期组血浆EDF水平明显增高（P〈0．05或P〈0．01）。（2）肾病综合征正常血压组血浆EDF水平与尿蛋白呈负相关r=-0．581，P〈0．01）。（3）肾病综合征高血压组血浆EDF水平与尿蛋白呈负相关，与平均动脉血压呈正相关（R=0．797，P〈0．01）。结论：肾病综合征患者血浆EDF水平下降可能是该病高度浮肿的又一因素；血容量、血压是影响血浆EDF水平的重要因素。     

医院常见抗感冒中成药临床用药分析

目的 对临床选用抗感冒药进行分析总结,指导临床用药.方法 收集深圳市龙岗中心医院2010年7月至2012年7月感冒患者病历资料436例,并进行回顾性分析.结果 436例病历资料中涉及中成药884种,其中风寒感冒药101种（1 1.4％）,以使用感冒清热软胶囊者为主,占52.6％（229例）;风热感冒药417种（47.2％）,以使用风热感冒颗粒和银翘解毒片者为主,分别占38.7％（169例）和30.3％（132例）;暑湿感冒药250种（28.3％）,以使用藿香正气水及相关剂型者为主,占88.1％（384例）;体虚感冒药72种（8.1％）,使用参苏宣肺丸与玉屏风颗粒者所占比例分别为43.6％（190例）和45.4％（198例）;时行感冒药44种（5.0％）,以使用清热解毒口服液者为主,占82.6％（360例）.结论 合理选用抗感冒中成药物,可有效保证临床疗效.     

Traditional Chinese medicine in COVID-19

COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across the globe, posing an enormous threat to public health and safety. Traditional Chinese medicine (TCM), in combination with Western medicine (WM), has made important and lasting contributions in the battle against COVID-19. In this review, updated clinical effects and potential mechanisms of TCM, presented in newly recognized three distinct phases of the disease, are summarized and discussed. By integrating the available clinical and preclinical evidence, the efficacies and underlying mechanisms of TCM on COVID-19, including the highly recommended three Chinese patent medicines and three Chinese medicine formulas, are described in a panorama. We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19, but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM.     

中药药剂学与方剂学关系研究

目的 对中药药剂学与方剂学之间的关系进行研究.方法 对两个学科之间的关系研究主要是从中药制剂学与方剂学的概念,中药药剂学是方剂学发生的条件以及方剂学是中药药剂学的发展的基础等几个方面进行分析.结果 中药药剂学的概念和方剂学的概念存在一定的区别和联系,同时中药药剂学则是方剂学发展的条件,然而方剂学又是中药制剂学进行发展的基础.结论 方剂学和药剂学存在着十分紧密的关系,其是相辅相成的关系,同时又是紧密联系和共同发展的两个重要学科.     

中药促血管新生的研究进展

近年来,缺血性疾病的发病率越来越高,尤其是心肌梗死等血管系统疾病,已成为人类死亡的重要原因之一。治疗性血管新生正逐渐成为该领域的研究热点,大量研究表明,某些中药提取物及其活性成分和中药的成方制剂在诱导血管新生方面具有很好的疗效。为进一步研究中药在血管新生中的促进作用,将近几年国内外的文献进行综述。     

ICP-MS法比较矿物类中药在传统饮片和中药配方颗粒中微量元素的含量

本文采用电感耦合等离子体质谱(ICP-MS)结合微波消解的方法,比较煅龙骨、煅牡蛎、生石膏、滑石、芒硝、代赭石、琥珀、瓦楞子等8种矿物类中药传统饮片和其配方颗粒中微量元素铅、铜、锰、镍、铬、锌、砷、锑、镉的含量.结果表明矿物类中药和其配方颗粒的微量元素含量存在一定差异.     

Traditional Chinese herbal medicine

Herbal medicine, acupuncture and moxibustion, and massage are the three major constituent parts of traditional Chinese medicine. Although acupuncture is well known in many Western countries, Chinese herbal medicine, the most important part of traditional Chinese medicine, is less well known in the West. This article gives a brief introduction to the written history, theory, and teaching of Chinese herbal medicine in China. It also describes modern scientific research into and the quality control of Chinese herbal medicines in China. Some examples of how new drugs derived from Chinese herbs have been developed on the basis of traditional therapeutic experience are presented. Finally, the situation of Chinese herbal medicine in the West is discussed.     

慢性肾脏病患者血清内源性洋地黄物质的变化

测定了 41例慢性肾脏疾病患者血清内源性洋地黄物质 ( EDL S)的含量。结果显示 ,慢性肾功能衰竭、肾后综合征及慢性肾盂肾炎患者血清 EDLS均值均显著高于正常 ( P<0 .0 5 ) ,提示血清 EDL S水平可作为估计肾功能损害程度及预后的一个指标。     

中药及其制剂在中毒性疾病治疗中的应用进展

中毒性疾病是威胁人类健康的一类特殊疾病,由于社会的快速发展,生存环境的恶化,人类接触的有毒物质日益增多,发生中毒的概率与日俱增,所以中毒性疾病已是当前急诊医学、危重病医学、职业病学、毒理学、环境医学等共同研究的重要课题.近年来,随着急诊医学和危重病医学的迅速发展,中毒性疾病的救治水平有了很大的提高,其中我国传统中药及其制剂在救治中毒性疾病中发挥了重要的作用.     

浅谈中药炮制与中医疗效

分析中药炮制在中医临床用药中的作用与关系.中药的炮制方法,根据药物的理化性质和作用趋向的不同,要进行相应的调整,使药物的有效成分得到充分的利用,从而达到理想的治疗效果.     

Undeclared drugs in traditional Chinese antirheumatoid medicine

Thirty samples of traditional antirheumatoid drugs freely available in Chinese drug stores in Singapore and West Malaysia were analysed for undeclared synthetic drugs using thin layer chromatography, high performance liquid chromatography, micro-colour test and infra-red spectroscopy. Four of the samples were found to contain undisclosed synthetic drugs, two contained paracetamol and two prednisolone.     

Typical toxic components in traditional Chinese medicine

Introduction: Traditional Chinese medicine (TCM) is widely used around the world. However, with its wide use has been the identification of a number of toxicological issues that have severely restricted its use in clinical treatment. The identification of these toxic substances within TCM has become somewhat of a hot topic in recent years.

Areas covered: This article reviews literature published on professional authoritative journals in the last 10 years on the toxic constituents and toxicology of TCM, including chemical structures, absorption and metabolism. The literature search for this article was based, but not limited to, toxic constituents including: alkaloids, glycosides, toxic proteins, polypeptide, amino acids, phenols or organic acids, terpenes and lactones. The authors discuss the toxic substances referring to their toxicity on organs, tissues and systems.

Expert opinion: More and more toxic constituents from different TCMs have been identified, in addition to information on how they act in the body at a molecular level. However, the toxicology of TCMs is very complex, and although some progress has been made, a lot work is still needed in order to put an end to toxic incidents.     

蛋白质组学在中药研究中的应用

系统生物学着眼于系统组成成分的构成、动态与发生,与中药对机体的整体而又动态的调节相符合,它的出现给中药研究带来了曙光。作为系统生物学的重要组成部分,蛋白质组学在中药研究中的应用已经越来越多。本文综述了蛋白质组学的常用技术以及近三年来这些技术在中药复方、中药有效部位和中药活性成分等方面的应用。     

家庭病床开展中医疗法的体会

目的 中医具有经济、安全、实用、操作方便等特点.为了更好地达到家庭病床患者的康复治疗的目的,我们应该让中医同归民间,让中医治疗走进社区,走进千家万户.方法 结合医院实际工作,分析家庭病床的现状及风险,阐述中医疗法的作用及优点.结果 中医疗法适合在家庭病床中开展,但受到政策、观念的影响.家床中医治疗率:2007-2009...     

Pharmacological basis of 'Yang-invigoration' in Chinese medicine

The 'Yin-Yang' theory is an ancient Chinese philosophy that underlies the practice of traditional Chinese medicine. Although Yang-tonic herbs tend to boost body function possibly through enhancing the mitochondrial oxidative processes, the Yin property (i.e. antioxidant potential) of these herbs can also play a role in safeguarding mitochondrial ATP generation. The pharmacological basis of 'Yang-invigoration' by Chinese tonic herbs might be due primarily to the enhancement of mitochondrial ATP generation.