白内障超声乳化联合房角粘连分离术治疗闭角型青光眼合并白内障

目的:观察白内障超声乳化人工晶状体植入联合房角粘连分离术治疗闭角型青光眼的疗效以及术后房角形态的改变。方法:白内障超声乳化联合房角分离术治疗闭角型青光眼48例(54眼),对手术前后的视力、眼压、视野、中央前房深度、房角形态进行对照观察。结果:术后随访3～6mo,54眼中48眼视力较前有明显提高。54眼前房深度均加深,术前前房深度(1.612±0.354)mm,术后前房深度(3.296±0.243)mm。54眼术后眼压明显降低,术前眼压(22.42±3.53)mmHg,术后眼压(13.52±3.24)mmHg。房角镜检查术后1mo和3mo随访房角均开放,未发现房角再粘连。48例术后6mo复查视野无缩小。结论:白内障超声乳化房角分离术可有效治疗闭角型青光眼合并白内障的患者。     

白内障超声乳化联合房角分离术治疗原发性慢性闭角型青光眼

目的:探讨超声乳化白内障吸除及人工晶状体植入术联合房角分离术治疗原发性慢性闭角型青光眼的疗效。方法:采用白内障超声乳化及人工晶状体植入联合房角分离术治疗合并白内障的原发性慢性闭角型青光眼32例32眼,比较手术前后的眼压、视力、前房深度、房角形态,观察术后并发症等情况。结果:术后随访6mo～2a;所有病例术后最佳矫正视力均提高;术后眼压明显降低,术前平均眼压15.2±8.1mmHg,术后11.2±5.0mmHg,差异有显著统计学意义(t=3.126,P<0.01);术后中央前房深度显著加深,术前平均中央前房深度2.22±0.39mm,术后3.36±0.43mm,差异有显著统计学意义(t=-14.371,P<0.01);术后房角粘连范围有减少,无严重并发症出现。结论:白内障超声乳化房角分离术能有效的治疗并发白内障的原发性慢性闭角型青光眼。     

超声乳化及房角分离术治疗闭角型青光眼合并白内障临床观察

目的观察超声乳化及房角分离术治疗闭角型青光跟合并白内障的临床疗效。方法回顾性分析22例(22只眼)闭角型青光眼合并白内障患者,房角关闭小于1/2者单纯行白内障超声乳化摘除及折叠人工晶状体植入术,房角关闭大于1/2者行白内障超声乳化摘除及折叠人工晶状体植入联合房角分离术。结果术后随访22只眼眼压均控制在正常范围内,平均眼压为(12.1±3.9)mmHg,全部病例术后视力均有提高,视力0.5及以上者16只眼,中央前房深度较术前增加,19只眼术后房角全部开放。结论白内障超声乳化及房角分离术治疗闭角型青光眼合并白内障具有安全、降眼压确切、增进视力和开放房角的效果。     

白内障超声乳化吸除联合房角粘连分离术治疗慢性闭角型青光眼合并白内障的临床疗效

目的观察白内障超声乳化吸除人工晶状体植入联合房角粘连分离术治疗慢性闭角型青光眼合并白内障的临床疗效及术后房角形态的改变。方法白内障超声乳化吸除人工晶状体植入联合房角粘连分离术治疗慢性闭角型青光眼61例（73只眼）,对其手术前后的视力、眼压、视野、中央前房深度、房角形态进行对照,术后随访6～11个月。结果 61例（73只眼）中有69只眼视力较术前明显提高（P〈0.05）。73只眼术后中央前房深度均加深,术前前房深度（1.572±0.314）mm,术后前房深度（3.186±0.217）mm（P〈0.05）。66只眼术后眼压明显降低,术前眼压（22.42±3.53）mm Hg,术后眼压（13.52±3.24）mm Hg（P〈0.05）。房角镜术后2个月检查有71只眼房角开放,术后6个月房角镜未发现房角再次粘连,64只眼术后6个月复查视野无缩小。结论超声乳化白内障吸除人工晶状体植入联合房角粘连分离术可有效降低眼压、提高视力,是闭角型青光眼同时合并白内障患者安全有效的治疗途径。     

超声乳化联合房角粘连分离术治疗慢性闭角型青光眼合并白内障

目的:探讨白内障超声乳化联合前房角粘连分离术治疗慢性闭角型青光眼合并白内障的临床疗效。方法:分析2008-01/2011-01在我科住院治疗的慢性闭角型青光眼合并白内障患者57例57眼,施行白内障超声乳化后房型人工晶状体植入联合前房角粘连分离术,随访8～15(平均10.8)mo,观察眼压、房角、最佳矫正视力、中央前房深度的变化。结果:术后52眼无需加用降眼压药物,眼压<21mmHg。另4眼随访期内加用1种降眼压药物(10g/L布林佐胺滴眼液)后,眼压<21mmHg,1眼加用2种降眼压药物(10g/L布林佐胺滴眼液和5g/L噻吗洛尔滴眼液)后,眼压<21mmHg;全部患者术后房角开放;除1例术前明显视神经萎缩病例术后视力无提高,其余病例术后视力提高两行或以上;术后中央前房深度3.35±0.54mm,较术前(2.01±0.05mm)明显加深。结论:对于慢性闭角型青光眼合并白内障,白内障超声乳化后房型人工晶状体植入联合前房角粘连分离术是一种安全有效的方法,患者不仅视力明显提高,而且远期眼压也能得到有效控制。     

超声乳化白内障吸除联合小梁切除术治疗闭角型青光眼合并白内障

目的:观察超声乳化白内障吸除人工晶状体植入联合小梁切除术治疗闭角型青光眼合并白内障的临床效果。方法:对闭角型青光眼并白内障36例46眼行超声乳化白内障吸除折叠式人工晶状体植入联合小梁切除手术治疗。术前、术后分别详细记录患者视力、眼压、滤过泡、前房深度、房角及眼底情况。结果:术后随访3mo～2a,43眼(93.5%)视力较术前明显提高,44眼(95.7%)眼压保持在正常范围,术后眼压<21mmHg。35例46眼患者前房深度术前平均为2.1±0.3mm,术后平均3.8±0.4mm,术后所有患者前房深度均加深,术前关闭的前房角也有不同程度的开放。6眼(13.0%)角膜水肿,无角膜内皮失代偿。结论:合并白内障的闭角型青光眼患者行超声乳化白内障吸除联合小梁切除术安全有效,能够有效降低眼压、加深前房、开放房角,提高视力。     

超声乳化联合房角分离术治疗青光眼合并白内障的疗效

目的:观察超声乳化联合房角分离手术治疗合并闭角型青光眼白内障的临床效果。方法:对合并闭角型青光眼的白内障患者56例56眼均在表面麻醉+球后麻醉下行透明角膜切口的白内障超声乳化联合房角分离术。结果:术后仅5眼在4d内眼压轻度增高(25～30mmHg),经治疗后眼压降至20mmHg以下,随访3～24mo眼压正常。术后视力较术前明显提高,达0.3～0.8,中央前房深度、房角与术前相比均有不同程度改善。结论:对于部分合并闭角型青光眼的白内障患者,超声乳化联合房角分离术是一种便捷、安全、有效的方法,具有降压和增视的双重效果。     

超声乳化联合房角分离术治疗合并闭角型青光眼的白内障临床观察

目的:观察超声乳化联合房角分离手术治疗合并闭角型青光眼白内障临床效果。方法:对合并闭角型青光眼的白内障患者56例60眼均在表面麻醉下行透明角膜切口的白内障超声乳化联合房角分离术。结果:术后仅3眼在1wk内眼压轻度增高(22～28mmHg),经治疗后眼压降至正常,随访3～12mo眼压正常。术后视力较术前明显提高,中央前房深度、房角与术前相比均有不同程度改善。结论:对于部分合并闭角型青光眼的白内障患者,超声乳化联合房角分离术是一种便捷、安全、有效的方法,具有降压和增视的双重效果。     

白内障超声乳化联合房角粘连分离术治疗慢性闭角型青光眼

目的观察白内障超声乳化人工晶体植入联合房角粘连分离术治疗慢性闭角型青光眼的疗效以及术后房角形态的改变。方法白内障超声乳化联合房角粘连分离术治疗慢性闭角型青光眼32例(36只眼),对其手术前后的视力、眼压、视野、中央前房深度、房角形态进行对照观察。结果术后随访3~7个月,32例(36只眼)有31例(35只眼)视力较术前明显提高。36只眼术后中央前房深度均加深,术前前房深度(1.557±0.338)mm,术后前房深度(3.382±0.197)mm。35只眼术后眼压明显降低,术前眼压(26.655±3.274)mmHg,术后眼压(13.96±4.045)mmHg。房角镜和UBM术后1月检查32例(36只眼)房角均开放,术后3月房角镜和UBM检查未发现房角再次粘连。26例(28只眼)术后6月复查视野无缩小。结论白内障超声乳化房角分离术可有效治疗合并白内障的慢性闭角型青光眼。     

两种方法治疗急性闭角型青光眼合并白内障的疗效对比

目的:探讨白内障超声乳化摘除术以及白内障超声乳化摘除联合改良式房角分离术治疗急性闭角型青光眼合并白内障的效果.方法:急性闭角型青光眼合并白内障的患者84眼随机分为两组,对照组行白内障超声乳化摘除术,观察组行白内障超声乳化摘除联合改良式房角分离术,观察两组术前及术后的眼压、最佳矫正视力、中央前房深度、前房角宽度和瞳孔大小.结果:术后所有病例眼压明显低于术前眼压,具有统计学意义(P＜0.05);83眼视力较术前均有不同程度的改善,1眼视力较术前无明显提高;前房深度及前房角宽度均较术前明显增加.对照组与观察组相比,术后视力及中央前房深度无明显差异,观察组在眼压控制、增加前房角宽度方面具有较好疗效.结论:白内障超声乳化摘除术以及联合改良式房角分离术能有效治疗急性闭角型青光眼合并白内障,其中白内障超声乳化摘除联合房角分离术能更有效的降低眼压及增加前房角宽度.     

滤过试验结合可拆缝线在小梁切除术中的应用

目的　探讨小梁切除术术中做滤过试验结合可拆缝线的应用对预测和控制术后滤过量及预防浅前房的疗效。方法　对 92例 ( 113眼 )原发性青光眼 ,在小梁切除术术中根据滤过试验结果来决定固定缝线和可拆缝线缝合的位置和数量。术后 1～ 7天 ,抽出可拆缝线。回顾性总结术中缝合种类、数量及术后前房深度、眼压、滤过泡、视野。结果　术中 40眼 ( 3 5 40 % )采用一针固定缝线和一至二针可拆缝线 ,5 1眼 ( 45 14 % )采用二针固定缝线和一至二针可拆缝线。术后无一例持续性浅前房。术后第 7天眼压平均 13 5± 3 3 0mmHg。追踪观察 6～ 2 4个月 ,形成功能性滤过泡 89眼( 78 76% ) ,眼压控制 <2 1mmHg 91眼 ( 80 5 3 % ) ,视野不变 98眼 ( 86 73 % )。结论　小梁切除术术中根据滤过试验的结果 ,通过对固定缝线和可拆缝线缝合的位置和数量的选择能有效预测和控制术后滤过量并预防术后浅前房     

超声乳化联合前房角分离治疗伴白内障的青光眼

目的：：观察晶状体超声乳化联合前房角分离术对伴有白内障的慢性闭角型青光眼患者的治疗效果。方法：无并发症伴有白内障的慢性闭角型青光眼50例50眼,施行晶状体超声乳化吸出人工晶状体植入联合前房角分离术。术后随访3mo,记录并比较术前及术后最佳矫正视力、眼压、前房深度及前房角。各指标均采用均数±标准差(x±s)表示,术前及术后3mo的最佳矫正视力、眼压、前房深度及前房角的情况进行比较。结果：术后3 mo的最佳矫正视力较术前明显提高,差异有统计学意义( t=8.76, P=0.001);术后3 mo 的眼压为15.63±3.11mmHg,较术前(45.12±5.30mmHg)明显下降,差异有统计学意义(t=6.27,P=0.000);术后3mo的前房深度为3.57±0.02mm,较术前(1.43±0.25mm)明显加深,差异有统计学意义(t=8.16,P=0.001);术前、术后前房角情况的比较,差异有统计学意义(Z=-4.432,P=0.000;Z=-2.432,P=0.016;Z=-4.379,P=0.000;Z=-4.538, P=0.000)。结论：晶状体超声乳化吸出人工晶状体植入联合前房角分离术治疗伴有白内障的慢性闭角型青光眼,能够有效控制眼压,提高视力,是一种安全、有效的手术方法。     

环喷托酯在屈光参差儿童散瞳验光中的应用

目的比较分析1%盐酸环喷托酯与1%阿托品对3~12岁屈光参差儿童散瞳验光效果。设计回顾性病例系列。研究对象2010年10月~2011年2月在北京同仁医院眼科斜弱视门诊就诊的3~12岁屈光参差儿童40例(80眼)。方法对以上40例患儿按年龄分成3组,即3~6岁组,7~9岁组和10~12岁组。全部患儿均首先用1%盐酸环喷托酯进行散瞳验光,待其瞳孔完全恢复正常(1周后)再行1%阿托品散瞳验光,比较两种方法的验光结果。主要指标屈光值(球镜度数、柱镜度数及轴向)。结果用1%盐酸环喷托酯散瞳验光结果(球镜:+1.18 D±4.90 D,柱镜:+1.47 D±1.16 D,散光轴向:80.50°±38.62°)与用1%阿托品散瞳验光结果(球镜:+1.20 D±4.91 D,柱镜:+1.47 D±1.15 D,散光轴向:80.06°±38.48°)比较,差异均无统计学意义(P均>0.05)。在80眼中,球镜值相同或相差≤0.50 D者77眼,符合率为96.25%;柱镜值在69眼中,结果相同或相差≤0.50 D者65眼,符合率为94.20%;散光轴向在69眼中,结果相同或相差≤5°者67眼,符合率为97.10%。三个年龄组间的球镜、柱镜和散光轴向符合率差异均无统计学意义(P均>0.05)。结论 1%盐酸环喷托酯可以替代1%阿托品用于3~12岁屈光参差儿童散瞳验光,其结果可以作为配镜的依据。     

Bilateral CNV associated with optic nerve drusen treated with photodynamic therapy with verteporfin

PURPOSE: To report a case of bilateral choroidal neovascularization (CNV) associated with optic nerve drusen (OND) treated with photodynamic therapy (PDT) with verteporfin. METHODS: A 10-year-old girl with juxtapapillary CNV in the right eye and juxtapapillary and juxtafoveal CNV in the left eye associated with OND underwent PDT with verteporfin in both eyes. RESULTS: Visual acuity increased from 20/160 to 20/25 in the right eye and from 20/1000 to 20/25 in the left eye after two sessions of PDT and 2 years of follow-up. CNV showed no leakage after two PDT sessions in both eyes and no recurrence was observed. CONCLUSIONS: Subfoveal CNV is an uncommon complication of OND and excellent anatomic and functional results can be obtained with PDT.     

Epikeratoplasty with nonlyophilized tissue in children with aphakia

We studied 75 epikeratoplasty procedures using nonlyophilized tissue performed by eight ophthalmic surgeons in 70 eyes (47 patients) to correct for aphakia in children less than 8 years of age (mean age, 3.4 +/- 2.1 years). Of the 47 patients in the study, 24 were girls and 23 were boys; 23 patients had bilateral surgery. Seven of the epigrafts required removal; two were not replaced, and five underwent successful repeat epikeratoplasty. Overall, the success rate (that is, the percentage of epigrafts that remained optically and functionally clear throughout the course of this study) for the epikeratoplasty procedure was 89% (62 of 70 eyes) for initial surgery and 96% (67 of 70 eyes) for repeat surgery. The average spherical equivalent was +14.4 +/- 3.7 diopters preoperatively and +0.3 +/- 2.9 diopters one year after the operation. One year after the final surgical procedure, 42 of 56 eyes (75%) were within 3 diopters of emmetropia. In the 29 verbal patients, best-corrected visual acuity was 20/100 or better in 25 (86.2%) one year after the operation.     

雷珠单抗联合玻璃体切割术治疗DR合并新生血管性青光眼

目的：探究雷珠单抗联合玻璃体切割术治疗DR合并新生血管性青光眼(NVG)的临床效果。

方法：选取2016-01/2018-02我院眼科收治的DR合并NVG患者198例,根据治疗方案不同分为观察组(103例)和对照组(95例),观察组采用术前注射雷珠单抗联合玻璃体切割术治疗,对照组单纯采用玻璃体切割术治疗,玻璃体切割术后10～15d Ⅱ期实施Ahmed房水引流阀植入。观察两组治疗后眼压、BCVA、VEGF等指标变化情况。

结果：观察组的玻璃体切割术的手术时间、新生血管出血次数、电凝次数均低于对照组(P<0.001)。观察组在玻璃体切割术后1wk和Ⅱ期Ahmed房水引流阀植入术后1mo BCVA、眼压均低于对照组(P<0.001)。观察组Ⅱ期Ahmed房水引流阀植入术前VEGF和术后1mo视网膜黄斑中心凹厚度均低于对照组(P<0.001)。观察组总并发发生率低于对照组(10.7% vs 28.4%,P<0.05)。

结论：雷珠单抗联合玻璃体切割术治疗DR合并NVG的疗效显著,且使Ⅱ期Ahmed房水引流阀植入手术难度下降,对患者视力、眼压水平恢复较好。     

合并成型性渗出的急性前葡萄膜炎与HLA-B27的相关性研究

目的 探讨急性渗出性前葡萄膜炎与HLA-B27的相关性。方法 对53例前房内出现成型性渗出的急性前葡萄膜炎（AAUPE）患者及61例前房内无成型性渗出的急性前葡萄膜炎（AAU）患者进行HLA-B27的检测,并结合临床表现加以分析。结果 成型性渗出的AAUPE患者的HLA-B27阳性率为100％,而无成型性渗出的AAU患者的HLA-B27阳性率仅为50.8％。二者有显著差异性（P<0.01）。两组HLA-B27阳性的病人强直性脊柱炎发生率分别为50.0％和42.9％。结论 结果进一步证实了HLA-B27与成型性渗出密切相关的论点。提示检测AAU患者HLA-B27的阳性率,发现成型性渗出裂隙灯检查似与血清法检测同样准确。     

Levodopa-carbidopa with occlusion in older children with amblyopia

PURPOSE: To study the role of levodopa-carbidopa in supplementing occlusion therapy in older children with strabismic or anisometropic amblyopia. Methods: A clinical study was performed on 40 amblyopic children (19 strabismic and 21 anisometropic), 6 to 18 years old (mean age, 10.9 years). They received an average dose of 1.86 mg/kg/day (1.33-2.36 mg/kg/day) of levodopa and carbidopa (4:1 ratio) or a placebo in 3 divided doses over a 4-week period, combined with full-time occlusion. The occlusion was continued for the study duration of 3 months. Early Treatment Diabetic Retinopathy Study visual acuity charts and Cambridge low-contrast gratings for contrast sensitivity (CS) were used to assess visual functions. Tolerance and compliance with occlusion and capsule consumption were assessed. RESULTS: Visual acuity of the nonamblyopic eye did not deteriorate during the study in either group. CS decreased by 22 units in the levodopa group and increased in the placebo group by 53 units at the first month. The CS in the levodopa group recovered later by the third month of follow-up. Both the levodopa and the placebo groups showed significant improvement in visual function in the amblyopic eye (P <.001). Overall changes in logarithm of minimum angle of resolution values and CS in the amblyopic eyes were similar in both groups (P >.05). Strabismic and anisometropic amblyopes did not behave differently. Drug tolerance, occlusion compliance, and capsule ingestion compliance were similar between the groups, with no significant side effects. CONCLUSIONS: Clinically, levodopa supplementation does not offer any advantage over occlusion alone. Moreover, the risk of occlusion amblyopia could increase with the use of drugs like levodopa that might affect the plasticity of the visual cortex.