自制含漱液治疗牙龈与牙周炎的疗效观察

甲乙含漱液由我院制剂室研制,其主要成分为甲硝唑、乙酰螺旋霉素和葡萄糖酸洗必泰,适用于牙龈炎、牙周炎等。从95年3月至97年5月观察40例,有效率为62.5％,对照组有效率为32.5％,可见甲乙含漱液疗效显著。 1 对象与方法 1.1 观察对象 牙龈炎、牙周炎患者,近周来尚未服用抗菌素及使用任何含漱液,血常规、血小板、出凝血时间正常,且同意接受治疗者。排除患者未完成疗效者,及在使用含漱液期间服用其它药物者。随机双盲法分甲乙含漱液组,牙龈炎16人、牙周炎24人共40人,平均年龄37.5岁,以及1:5000洗必泰含漱液组(对照组)牙龈炎16人、牙周炎24人共40人,平均年龄38.3岁。 1.2 用药方法 治疗组用甲乙含漱液,对照组用1:5000洗必泰含漱液,两组均按一日4次、每次15ml,含漱1～2min后吐出,不再用清水漱口,一周后观察临床效果。     

二氧化氯含漱液治疗牙龈炎、控制牙菌斑的临床效果

目的：评价二氧化氯含漱液治疗牙龈炎、控制牙菌斑的临床效果。方法：采用双盲对照方法，选择100名患有牙龈炎的17～20岁的健康男女学生作为研究对象，随机分成两组，每组50人，男女均等。实验组给以口腔爽（有效成份是二氧化氯）含漱液，对照组给以口泰含漱液，观察使用含漱液7d后两组受试者前后的牙龈指数和菌斑指数的变化，依此来评价口腔爽的临床效果。结果：使用口腔爽含漱液受试者的平均牙龈指数和菌斑指数分别减少0.66和0.91，均有统计学显著性意义（P〈0.001）；与对照组（0.64、1.06）相比，差异无显著性（P〉0.5）。结论：二氧化氯含漱液对治疗牙龈炎、控制牙菌斑有明显效果，与口泰相比无显著差异，临床上未发现任何副作用。     

不同含漱液控制菌斑和消除牙龈炎症效果的比较

目的：研究护齿含漱剂、口泰含漱液、万宝林牙齿、口腔清洁液在控制菌斑和牙龈炎的作用．方法：选择２０３例牙龈炎患者，随机分为护齿含漱剂组、口泰含漱液组、万宝林牙齿、口腔清洁液组、多贝尔氏液组和蒸馏水组，用药前后检查牙龈指数（ＧＩ）、牙龈出血指数（ＳＢＩ）、菌斑指数（ＰＬＩ）．结果：用药后护齿含漱剂、口泰含漱液、万宝林牙齿、口腔清洁液组的ＧＩ、ＳＢＩ、ＰＬＥ均比用药前有明显降低（ｐ＜０．０１），且优于多贝尔氏液和蒸馏水组．结论：护齿含漱剂、口泰含漱液、万宝林牙齿、口腔清洁液能有效控制菌斑及牙龈炎     

西帕依固龈含漱液治疗慢性牙龈炎的临床效果观察

目的：观察西帕依固龈含漱液治疗慢性牙龈炎的临床疗效.方法：选取慢性牙龈炎患者150例作为研究对象,随机分研究组和对照组.研究组使用西帕依固龈含漱液,对照组使用朵贝氏液含漱.对比两组病例牙龈充血水肿改善情况,龈沟出血指数以及菌斑指数的变化情况.结果：研究组治疗后牙龈指数临床总有效率92％,龈沟出血有效率88％,菌斑指数有效率80％,均优于对照组的80％、72％和64％,两组比较差异具有统计学意义（P＜0.05）.结论：西帕依固龈含漱液治疗牙龈炎疗效较好、较安全,有较好的临床应用前景.     

复方洗必泰含漱液和复方硼酸含漱液治疗口腔炎症性疾病的近期疗效观察

复方洗必泰含漱液和复方硼酸含漱液治疗口腔炎症性疾病的近期疗效观察常州市钟楼口腔医院陈兰萍，唐玲燕常州市第一人民医院胡祥珍口腔含漱液品种较多，常用的有复方硼酸含漱液（即朵贝尔氏液）和复方洗必泰含漱液（即口泰），２年多临床应用复方洗必泰含漱液的疗效明显优...     

稳定性二氧化氯含漱液治疗牙龈炎的临床研究

目的　验证稳定性二氧化氯含漱液 (口腔爽含漱液 )治疗牙龈炎的临床效果。方法　采用双盲临床对照试验方法 ,选择 10 0名患有牙龈炎的 17～ 2 0岁的男女学生作为研究对象 ,随机分成两组 ,每组 5 0人 ,男女均等。试验组给以口腔爽含漱液 ,对照组给以口泰含漱液 ,观察两组受试者使用含漱液 7d前后的牙龈指数和菌斑指数的变化 ,依此来评价口腔爽含漱液的临床效果。结果　使用口腔爽含漱液受试者的平均牙龈指数和菌斑指数分别减少0 .6 6和 0 .91,均有统计学显著性意义 (P <0 .0 0 1) ;与对照组分别为 0 .6 4、1.0 6比较 ,差异无显著性意义 (P >0 .5 0 )。结论　口腔爽含漱液对治疗牙龈炎、控制牙菌斑有明显效果 ,与口泰无显著差别 ,且口感好 ,未发现任何副作用 ,是一种新型的口腔含漱液 ,值得在临床上推广应用。     

几种含漱液的临床疗效观察

几种含漱液的临床疗效观察广东省口腔医院（５１０２６０）叶树芬本文收集了本院门诊中，将口炎含漱液、口泰含漱液、儿茶素含漱液分别应用于牙龈炎和复发性阿弗它口炎的疗效资料，报告如下：材料与方法牙龈炎患者２９５例，其中男性１５７例，女性１３８例，年龄１３一６...     

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目的观察口泰和复方茶多酚含漱液在固定正畸治疗中对牙龈炎的防治效果。方法选取2005—2006年在遵义医学院附属口腔医院门诊进行固定正畸矫治的病例40例,随机分为两组(每组各20例),分别使用口泰和复方茶多酚含漱液,观察正畸治疗前及治疗后1,2,3个月时牙龈炎发生情况,对牙龈指数(GI)、菌斑指数(PLI)进行检测,并对两组情况进行比较。结果使用不同含漱液后两组之间的GI、PLI差异均有统计学意义(P<0.05或<0.01)。结论复方茶多酚含漱液对固定正畸患者牙龈炎症的预防效果优于口泰。     

复方硼酸含漱液治疗智齿冠周炎的临床应用

目的评价复方硼酸含漱液的治疗作用。方法对临床上随机应用复方硼酸含漱液、口泰含漱液和安慰剂3种含漱液的3组冠周炎患者的治疗效果进行追踪研究。结果复方硼酸含漱液治疗组与口泰含漱液治疗组的疗效相似，其治愈率显著高于安慰剂组。结论复方硼酸含漱液是一种优质、有效、廉价的为患者所接受的含漱液。     

西吡氯铵含漱液治疗牙龈炎、牙周炎疗效分析

目的观察西吡氯铵含漱液治疗牙龈炎、牙周炎的临床疗效。方法通过多中心随机平行对照试验观察,试验组用0.1%西吡氯铵含漱液,对照组用复方氯已定含漱液治疗,7d为一疗程,共使用14d。观察用药前后PLI、SBI、GI、PD、牙龈疼痛、口臭的变化及不良反应。结果试验组14d后菌斑下降率为63.0%,牙龈炎有效率为83.3%,牙周炎有效率为36.7%;而对照组则分别为49.5%、50%和16.7%。经统计学处理,试验组对牙龈炎的疗效明显优于对照组(P<0.01);2组含漱液对牙周炎的疗效也有显著性差异(P<0.05)。结论0.1%西吡氯铵含漱液对牙周组织疾病有明显疗效。     

西吡氯铵漱口液对牙龈炎、牙周炎疗效的临床评价

目的：评价1g/L西哟氯铵（CPC）漱口液对牙龈炎、牙周炎的疗效，以及对口腔环境的清洁作用。方法：受试者除保持原有口腔卫生习惯外，每天两次使用漱口水，每次含漱60s，为期4周。在实验前、后观察临床指标和实验室指标。结果：1g/L CPC漱口后，临床观察指标、菌斑生成 指数均明显低于阴性对照组。结论：受试者在保持正常的口腔护理习惯下，每日两次使用1g/L CPC漱口液能降低各类口腔卫生指数，减轻牙龈炎、牙周炎症状。     

Comparative efficacy of two daily use mouthrinses: randomized clinical trial using an experimental gingivitis model

Two antimicrobial agents, a fixed combination of essential oils (EOs) and 0.07% cetylpyridinium chloride (CPC) are found in commercially available mouthrinses, Listerine? Antiseptic and Crest? Pro HealthTM, respectively. Both mouthrinses have been shown to control dental plaque and gingivitis in short and longer term studies. The aim of this study was to determine the comparative effectiveness of these two mouthrinses using a 2-week experimental gingivitis model. Qualified subjects were randomly assigned to one of three mouthrinse groups: a fixed combination of EOs, 0.07% CPC, or negative control (C) rinse. Following baseline clinical assessments and a dental prophylaxis, subjects began a two-week period in which they rinsed twice daily with their assigned rinse and abstained from any mechanical oral hygiene procedures or other oral care products. Subjects were reassessed at the end of the two-week period. One hundred and forty-seven subjects were randomized and 142 completed this study. After two weeks use, the EOs rinse was superior (p < 0.011) to the CPC rinse in inhibiting the development of gingivitis, plaque, and bleeding, with 9.4% and 6.6% reductions compared to CPC for gingivitis and plaque, respectively. Both rinses were superior to the negative control rinse (p < 0.001). This study demonstrates that the essential oil-containing mouthrinse has superior antiplaque/antigingivitis effectiveness compared to the 0.07% CPC-containing mouthrinse without mechanical oral hygiene influence.     

Superiority of an essential oil mouthrinse when compared with a 0.05% cetylpyridinium chloride containing mouthrinse: a six‐month study

Objective : To evaluate the antiplaque/antigingivitis effectiveness of an essential oils containing mouthrinse as compared to a 0.05% cetylpyridinium chloride mouthrinse. Method : Generally healthy subjects with mild to moderate levels of plaque and gingivitis participated in a 6?month, examiner‐blind, single centre, randomised, parallel‐group controlled clinical trial. They were randomised into three mouthrinse groups –‐ control (C), 0.05% cetylpyridinium chloride (CPC), or a fixed combination of essential oils (EO). Subjects received a dental prophylaxis at baseline and rinsed twice daily in addition to their usual oral hygiene for six months. Plaque Index and Modified Gingival Index were determined at 3 and 6 months. Results : At 6 months, the EO group exhibited statistically significantly lower mean scores for MGI and PI than CPC (32.4% and 56.2% reductions, respectively). Compared to control, EO provided statistically significantly lower mean MGI and PI scores (36.3% and 69.7 %, respectively). The CPC group showed statistically significantly lower mean MGI and PI scores than the C group (5.8% and 30.7%, respectively). Conclusion : This study demonstrated the superiority of an EO rinse compared to a 0.05% CPC rinse in reducing plaque and gingivitis and confirmed that the daily use of an EO containing mouthrinse can provide a clinically significant benefit in reducing plaque and gingivitis.     

Clinical trial of oral malodor treatment in patients with periodontal diseases

Pham TAV, Ueno M, Zaitsu T, Takehara S, Shinada K, Lam PH, Kawaguchi Y. Clinical trial of oral malodor treatment in patients with periodontal diseases. J Periodont Res 2011; 46: 722–729. © 2011 John Wiley & Sons A/S Background and Objective: Only a few clinical research studies have assessed different therapeutic approaches to oral malodor in subjects affected by periodontal diseases. The aim of this study was to evaluate the effects of periodontal treatment and tongue cleaning on oral malodor parameters in periodontitis and gingivitis patients. Material and Methods: The subjects were 102 periodontitis and 116 gingivitis patients with oral malodor. Oral malodor was measured by organoleptic test and Oral Chroma™. Oral health status, including tooth conditions, periodontal health, tongue coating and proteolytic activity of the BANA test in tongue coating were assessed. Subjects in each periodontal disease group were randomly assigned into two subgroups depending on the sequence of treatment: periodontal treatment and tongue cleaning. Oral malodor and oral health parameters were compared by groups and sequence of treatment. Results: For subjects in the periodontitis group, there were statistically significant reductions in oral malodor after periodontitis treatment or tongue cleaning; however, major reductions were found after periodontitis treatment. For those in the gingivitis group, there were also statistically significant reductions in oral malodor after gingivitis treatment or tongue cleaning, but the most marked reductions were observed after tongue cleaning. At the completion of treatment, all oral malodor parameters fell below the threshold levels in all subgroups. Conclusion: The present study indicated that periodontal treatment played an important role and tongue cleaning contributed to a lesser extent to reduction in oral malodor in periodontitis patients. In contrast, tongue cleaning alone can be the primary approach to reduce oral malodor in gingivitis patients.     

A comparison of mouthrinses containing two concentrations of chlorhexidine

A 3-month clinical trial was conducted to compare the effects of two concentrations of a chlorhexidine mouthrinse on gingivitis and plaque accumulation. Six hundred (600) adults were divided into three treatment groups matched for age, sex, and initial gingivitis severity. Following a thorough examination and prophylaxis at baseline, subjects were given a mouthrinse containing either 0.12% or 0.20% chlorhexidine gluconate or a placebo mouthrinse. Subjects were evaluated after 6 weeks and 3 months of mouthrinse use. After 3 months, both chlorhexidine groups showed significantly less gingivitis and plaque than the placebo group. The group using the 0.12% chlorhexidine gluconate mouthrinse demonstrated 27–27 % less gingivitis occurrence and 28–28% less gingivitis severity than the placebo group. The 0.12% chlorhexidine gluconate group also had 48–48% less gingival bleeding and 36% less plaque than the placebo group. There were no significant advantages for the 0.20% mouthrinse over the 0.12% mouthrinse. It is therefore concluded that a 0.12% chlorhexidine gluconate mouthrinse offers the same clinical benefits as a 0.20% chlorhexidine gluconate mouthrinse.     

Serum IgG reactivity to subgingival bacteria in initial periodontitis, gingivitis and healthy subjects

BACKGROUND/AIMS: Established periodontal diseases may be associated with antibody responses to periodontal pathogens, but it is not known at which stage of disease this antibody response is initiated. This study aimed to characterize the host systemic response in initial periodontitis, gingivitis, and periodontal health, to evaluate whether elevated serum antibodies to subgingival species could be detected in initial periodontitis. METHOD: Human systemic immune response were evaluated to 40 subgingival bacterial species in 16 healthy, 21 gingivitis, 11 initial periodontitis and 5 progressing recession adults. Subjects had minimal periodontal attachment level (AL) loss at baseline. Disease categories were determined after 12 months monitoring at three-month intervals. Increased AL loss > or = 1.5 mm (disease activity) at interproximal sites defined initial periodontitis, recession was characterized by AL loss at buccal sites. Serum IgG antibodies were evaluated semi-quantitatively by immunoblot from blood taken at baseline, active and final visits. RESULTS: No antibody was detected from 55% of reactions. When detected, levels were below those reported for advanced periodontitis subjects. There were no major differences in serum antibody levels between healthy, gingivitis and initial periodontitis subjects, despite differences in the subgingival microbiota. Serum antibodies for more species were detected in recession subjects, compared with the other study subjects. No changes in antibody levels were detected between baseline, active, and final visits. No systematic association between species colonization and presence of systemic antibody was observed. CONCLUSIONS: This study did not detect differential elevation of mean serum antibody levels in initial periodontitis subjects, suggesting that serum antibody levels are not sensitive risk markers for initial periodontitis.     

Six-month study of the effects of a chlorhexidine mouthrinse on gingivitis in adults

The effects of a chlorhexidine gluconate mouthrinse on plaque and gingivitis were studied among 430 adults in a six-month clinical trial. Subjects were divided in two comparable treatment groups matched for age, sex, and initial gingivitis severity. Following a thorough oral prophylaxis, they were instructed to rinse twice a day for 30 seconds with 15 ml of a 0.12% chlorhexidine gluconate mouthrinse or a placebo mouthrinse. After three and six months of mouthrinse use, the chlorhexidine group had significantly less gingivitis, gingival bleeding, and plaque accumulation compared to the placebo group. As expected, accumulation of dental calculus and extrinsic dental stain increased in the chlorbexidine group. No significant differences in adverse oral soft tissue effects were observed between the two groups.
Since use of oral antimicrobial agents has been reported to produce tooth and tongue stain, gingivitis examinations were done with and without tooth covers to eliminate the potential for examiner bias. Comparable reductions in the Gingival Index scores and gingival bleeding were obtained when the evaluations were conducted with or without the tooth covers.
It was concluded that a 0.12% chlorhexidine gluconate mouthrinse can provide an important adjunct to the prevention and control of gingivitis when used with regular personal oral hygiene procedures and professional care.     

Effectiveness of a sanguinarine regimen after scaling and root planing

BACKGROUND: A variety of chemical agents have been evaluated relative to their abilities to inhibit dental plaque and to improve gingival health. Chlorhexidine gluconate is the best known and most widely used member of these agents, but its long-term use is compromised by different side effects, especially extrinsic tooth and tongue staining. Another agent, sanguinarine, which is currently used in both a mouthrinse and toothpaste, leads in some cases only to a transient burning sensation and could be used on a long-term basis. The purpose of this 14-week controlled clinical trial was to assess the effectiveness of a toothpaste and oral rinse containing sanguinaria extract after scaling, root planing and a chlorhexidine regimen. METHODS: Sixty patients diagnosed as having adult periodontitis received initial periodontal therapy including scaling and root planing, followed by a 2-week oral care regimen which included rinsing with 0.2% chlorhexidine gluconate oral rinse. Upon completion of this 2-week initial therapy phase, patients were randomly assigned to either sanguinarine toothpaste and oral rinse or to control toothpaste and oral rinse without sanguinarine. Plaque (modified Quigley-Hein index) and gingivitis (gingival index) were measured prior to periodontal therapy, at the end of the chlorhexidine phase (2 weeks), and after 8 and 14 weeks. RESULTS: Sanguinarine-containing toothpaste and oral rinse significantly inhibited the redevelopment of gingivitis through the 12 weeks following the chlorhexidine phase compared to the control toothpaste and rinse. Patients in the test group had 26% fewer bleeding sites at 8 weeks, and 32% fewer at 14 weeks, than the control group. CONCLUSIONS: Our results support the combined use of chlorhexidine mouthrinse for a short term (2 weeks) followed by sanguinaria mouthrinse and toothpaste up to 3 months in order to optimize the effectiveness of chlorhexidine without side effects. Further studies on the long-term effect of this combination should be established.