皮肤颗粒细胞瘤一例

患者男,68岁,因左大腿内侧皮下硬结12年余,加重4月余于2005年12月前来就诊。患者于12年前发现左大腿内侧皮下有一约花生米大小质硬肿物,无明显自觉症状,故一直未予以诊治。后发现肿物逐渐增大,近来肿物增大明显,且自觉瘙痒,遂来就诊。家族中其他成员无同类病史,患者一般情况良好,全身系统检查未见异常。     

面部巨大鳞状细胞癌并发皮角一例

<正>临床资料患者,女,88岁。主因左颞部肿物半年,增大伴渗出、疼痛45 d,于2014年3月19日就诊。半年前患者无明显诱因左侧颞部出现黄豆大小肿物,无明显自觉症状,肿物逐渐增大。45 d前肿物快速增至鸡蛋大,表面渗出,伴恶臭,疼痛明显;3个月前     

皮下型脂肪瘤1例

皮下型脂肪瘤比较多见,但位于足底部位,受压后可穿过跖骨间隙而到达足背皮下的脂肪瘤则少见.我们收治1例该病患者,现报道如下. 临床资料 患者女,60岁.左足跖、背部肿物伴疼痛10年,于2008年9月23日到我科就诊.患者10年前无明确诱因左足跖中前外1/3处出现一皮下肿物,逐渐增大,伴轻度压痛.     

获得性指状纤维角化瘤1例

临床资料患者男,23岁,机关干部。因左肘部肿物2个月于2004年3月就诊。患者2个月前无明显原因左肘部出现一红色皮疹,无自觉症状。皮疹逐渐增大,触之较硬。患者未曾诊治。2个月来皮疹增大为指状肿物,自觉影响穿衣。患者否认发病前该处有外伤史。发病以来皮疹未曾出血。患者曾用百     

特发性皮肤钙沉着症一例

正临床资料患者,男,15岁。主因左臀部肿物2年,于2015年9月1日就诊。2年前,无明显诱因患者左臀部出现一绿豆大小皮下肿物,无自觉症状,近半年来肿物逐渐增大。既往体健,发病前无局部注射史及外伤感染史,未接受钙剂治疗,家族中无类似疾病患者。体格检查:发育正常,营养中等,无突眼及甲状腺肿大,全身浅表淋巴结未触及增大。心、肺、腹查体均未见明显异常,四肢关节无畸形,肢端无硬化。     

肢端黑素瘤1例

正1临床资料患者女,53岁。左足底黑色斑片10年余,出现溃疡伴疼痛1年余。患者10余年前无明显诱因于左足底出现一拇指甲盖大小黑斑,无明显自觉症状,未引起重视,未予特殊治疗。以后黑斑逐渐增大形成斑片,无明显瘙痒及疼痛。1年余前无明显诱因于黑斑上出现一小指甲盖大小溃疡,时有少量渗血、渗液,自觉疼痛,自行外涂多种药物(具体药物不详)治疗,溃疡一直未愈合,并缓慢扩大。患者既往     

无症状臀部藏毛性窦道一例

<正>临床资料患者,男,19岁。主因左臀部肿物10年于2014年12月20日就诊于我科。患者10年前发现左臀沟处可触及一圆形、质韧肿物(具体大小不详),无疼痛、瘙痒感,皮色与周围皮肤色无异,无红肿溃破,无水疱脱屑,活动不受影响,无明显不适症状,故未引起重视,未就诊治疗。后肿物逐渐增大,患者自觉困扰,2011年于当地医院就诊,建议手术切除肿     

下背部冬眠瘤一例

患者女，27岁，因下背部肿物增大2年半就诊。患者2年半前无明显诱因下下背部发现鸽卵大肿物，无明显自觉症状，肿物逐渐增大。家族中无类似病史者。系统检查未见异常……     

肢端皮肤恶性黑素瘤1例

1临床资料患者女,71岁。左足底前外侧黑色皮肤肿物2年余。系统检查及实验室检查未见明显异常。皮肤科情况:左足底前外侧可见一5cm×5cm大小黑色结节状肿物,境界清楚,中间破溃并伴白色牛奶样液体渗出,压痛明显,全身浅表淋巴结未触及肿大(图1)。组织病理检查显示:表皮角化过度,棘     

5-氨基酮戊酸光动力疗法治疗面部角化棘皮瘤1例

<正>1临床资料患者男,70岁。鼻背部肿物渐进性增大70余天,破溃20d。70余天前无明显诱因患者发现鼻背部一暗红色肿物,约黄豆大小,表面光滑,伴轻微痒感,无其他明显不适,未行诊治。后肿物渐进性增大,30余天前肿物逐渐增大至一元硬币大小,自服排毒药物治疗(具体不详),无明显效果。20d前肿物开始明显增大,伴有局部破溃出血,并逐渐侵及鼻孔上缘。患者自诉近期偶感头痛、头晕,伴纳差,无其他特殊不适,曾就诊于外院行     

Pathogenesis of ulcerations in deficiency of prolidase. The role of angiopathy and of deposits of amyloid

The structure of the skin and the pattern of alteration in chronic ulcerations associated with deficiency of prolidase have been studied superficially in the past. We examined histologically several biopsies taken from apparently normal skin and from ulcerations afflicting a young woman with such a syndrome. Deposits of amyloid were found within the walls of medium-sized vessels and occasionally occluding their lumens. Impaired cutaneous microcirculation resulting from statis, moderate vasculitis, and abnormal structure of the dermis may be responsible for the regional preponderance of deposits of amyloid and ulcerations in the legs.     

外阴Pinkus纤维上皮瘤

报告1例外阴Pinkus纤维上皮瘤。患者女，71岁。左大阴唇外侧斑块10余年。皮肤科检查见左大阴唇外侧一2cm&#215;2cm灰黑色浸润性斑块．质地中等，边缘清楚，表面散在红色点状糜烂面，无明显渗液。皮损组织病理检查：棘层下方大量基底样细胞增生．增生的细胞呈条索状嵌入真皮增生的纤维间质中，彼此吻合形成网状，基底细胞胞核大而深染，胞质少，呈嗜碱性，表皮基膜完整，真皮内有以淋巴细胞为主的大量炎性细胞浸润。诊断：外阴Pinkus纤维上皮瘤。     

Epidemiological evidence of carcinogenicity of sunbed use and of efficacy of preventive measures

The International Agency for Research on Cancer classified, in July 2009, exposure to artificial tanning devices (sunbeds) as carcinogenic to humans. This classification was based on evidence from epidemiological and experimental animal studies. The present chapter will review these epidemiological evidences. The summary risk estimates from 27 epidemiological studies obtained through a meta‐analysis showed an increased risk of melanoma: summary relative risk (SRR) = 1.20 [95% confidence interval (CI) 1.08–1.34]. The risk was higher when exposure took place at younger age (SRR = 1.59; 95% CI 1.36–1.85). The risk was independent of skin sensitivity or population and a dose response was evident. A meta‐analysis of 12 studies was conducted for non‐melanoma skin cancers and showed a significantly increased risk for basal cell carcinoma (SRR = 1.29; 95% CI 1.08–1.53) and for squamous cell carcinoma (SRR = 1.67; 95% CI 1.29–2.17). As for melanoma, the risk for other skin cancers increased for first exposures at young age. Epidemiological studies have gradually strengthened the evidence for a causal relationship between indoor tanning and skin cancer and they fit with prior knowledge on relationship between UV exposure and skin cancer. Additionally, several case–control studies provided consistent evidence of a positive association between use of sunbed and ocular melanoma, also with greater risk for first exposures at younger age. Preventive measures based on information on risk or by requiring parental authorization for young users proved to be inefficient in several studies. The significant impact of strong actions or total ban, such as performed in Iceland, or a total ban of sunbed use, as in Brazil or Australian states, needs to be further assessed.