Comparison of minimally invasive surgery with laparotomic approach in the treatment of high risk endometrial cancer: A systematic review

ObjectiveTo analyze all published studies comparing minimally invasive surgery (MIS) with laparotomic one in the surgical treatment of high-risk endometrial cancer (EC) in term of operative, peri-operative and oncological outcomes.Data sourcesWe conducted a systematic literature search in PubMed between January 1995–March 2019.Methods of study selectionTitles and abstracts were analyzed by two reviewers. A set of explicit criteria was used for selection of literature: 1) randomized controlled trials (RCT), prospective or retrospective cohort studies, given the rarity of this tumor and the concomitant lack of data in the form of large trials, all reviewed original report publications with an appropriate number of subjects were considered and included; 2) participants of interest being patients who have suffered from high risk EC 3) the outcome measures including overall survival (OS), disease-free survival (DFS) and recurrence, (4) English language, (5) abstract available.ResultsThirty relevant articles were selected for full reading. For final analysis 20 studies were selected. Then, as second step, the full articles were evaluated to determine whether full inclusion criteria were met. In total, 9 papers were identified and included.ConclusionMIS appears to be safe in the management of high-risk EC patients, showing better perioperative and postoperative outcomes and comparable oncological outcomes than open surgery. Prospective randomized trial would be needed to confirm this data.     

Surgical complications occurring during minimally invasive sentinel lymph node detection in endometrial cancer patients. A systematic review of the literature and metanalysis

IntroductionEndometrial cancer (EC) is the most common gynecological cancer. Sentinel lymph node (SLN) technique has been adopted worldwide and showed lower morbidity and superimposable survival outcomes than the systematic lymphadenectomy (LND). Although these encouraging results, no meta-analyzes were performed on surgical complications during SLN research among patients undergoing laparoscopic (L) versus robotic surgery (R). The present review aims to report surgical complications during laparoscopic versus robotic SLN technique.MethodsThe Preferred Reporting Items for Systematic reviews and Meta-Analyzes (PRISMA) and the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines have been followed for the present meta-analysis.ResultsSix studies, including 769 participants, were included. L-LND resulted in a significantly higher risk of operative complications relative to L-SLN (RR 2.10 [95% CI 1.37 to 3.21]). The risk of complications was comparable between R-SLN and L-SLN (RR 2.32 [95% CI 0.04–121.02]) and between R-LND and L-LND (RR 2.17 [95% CI 0.04–126.69]). According to the SUCRA analysis, L-SLN and R-SLN had the highest chances of being ranked first among proposed surgical procedures (SUCRA 48.9% and 28.4% respectively).ConclusionsOur study reported a lower surgical complications rate in patients undergoing L-SLN technique compared to L-LND. A lower rate of surgical complications was also reported for the R-SLN technique compared to the R-LND. Both laparoscopic and robotic SLN surgical techniques were found to be safe surgical procedures.     

Uptake of minimally invasive surgery for early stage colorectal cancer and its effect on survival: A population-based study

PurposeThe uptake of minimally invasive surgery (MIS) for colorectal cancer (CRC) varies between jurisdictions. We aimed to identify the factors associated with the uptake of MIS for early-stage CRC and its oncologic outcomes in the Canadian province of Ontario.MethodsThis study includes all patients with CRC in Ontario from 2007 to 2017. A logistic regression analysis was used to identify the predictors of MIS and a flexible parametric survival model to estimate survival rates based on MIS versus open surgery.ResultsIn total, 14,675 patients with CRC were identified of which 29.5% had MIS resections. The likelihood of undergoing MIS decreased with age, disease stage, and distance to the regional cancer center, and increased with year of diagnosis. The likelihood of mortality for MIS was significantly lower compared to open surgery (p < 0.001). In terms of survival, MIS was most beneficial to older patients with stage II disease, despite their lower likelihood of receiving MIS.ConclusionsDespite the lower uptake of MIS among older patients and patients with stage II disease, these patients had the greatest long-term survival benefit from MIS. This suggests further use of laparoscopy to patient populations that are often excluded.     

Uptake and survival effects of minimally invasive surgery for lung cancer: A population-based study

IntroductionDespite growing evidence supporting the safety of minimally invasive surgery (MIS) in the treatment of lung cancer, its uptake is still variable and its outcomes debated. This study examines the factors associated with MIS uptake and its effects on survival in patients with non-small cell lung cancer (NSCLC).MethodsAll patients in the Canadian province of Ontario with early stage NSCLC (stage I/II) from 2007 to 2017 were included. A logistic regression identified the predictors of MIS uptake, and a flexible parametric model was used to estimate survival rates based on MIS versus open resection.ResultsIn total, 8,988 patients underwent surgical resection; 53.6% had MIS. Year of diagnosis was associated with MIS uptake (OR = 1.33, p < 0.001); patients in later years were more likely to receive MIS. Rurality was a significant predictor of MIS, though distance from nearest regional cancer center did not predict MIS utilization. Patients with stage II disease were less likely to receive MIS compared to those with stage I disease (OR = 0.44, p < 0.001). MIS had a significantly higher 5-year survival compared to open resection for stage I and II disease. Patients >70 years had the greatest 5-year survival benefit from MIS.ConclusionsWe observed a substantial long-term survival benefit in patients undergoing MIS for early stage NSCLC. This difference was most pronounced in the oldest age group. These findings support the use of MIS in the treatment of lung cancer and challenge the notion that MIS compromises oncologic outcomes.     

机器人辅助子宫内膜癌分期手术的临床分析

目的 探讨机器人辅助子宫内膜癌分期手术的临床疗效及应用价值。方法回顾性分析2010年3月至2015年3月因子宫内膜癌行机器人辅助分期手术的30例患者的临床资料。结果机器人辅助子宫内膜癌分期手术的平均手术时间为（218.2±32.5）min,平均出血量为（136.8±60.1）ml,平均清扫淋巴结数为（23.9±4.4）个,术后肠道功能恢复平均时间为（1.3±0.6）d,抗生素平均使用时间为（5.1±3.7）d,平均住院时间为（9.2±5.3）d。术后发生3例泌尿系感染,1例淋巴囊肿,1例下肢血栓。结论 机器人辅助子宫内膜癌分期手术安全可行。     

Surgical and oncologic outcomes of minimally invasive surgery for stage I high-grade endometrial cancer

ObjectiveTo evaluate the prevalence and outcomes of minimally invasive surgery for stage I high grade endometrial cancer. We hypothesized that route of surgery is not associated with survival.MaterialsPatients diagnosed between 2010 and 2014, with stage I grade 3 endometrioid, serous, clear cell and carcinosarcoma endometrial carcinoma, who underwent hysterectomy with lymphadenectomy were drawn from the National Cancer Database. Patients converted to open surgery were excluded. Overall survival was assessed with Kaplan-Meier curves and compared with the log-rank test. A Cox model was constructed to control for confounders.ResultsA total of 12852 patients were identified. The rate of minimally invasive surgery was 62.2%. An increase in the use between 2010 and 2014 was noted (p < 0.001). Open surgery was associated with longer hospital stay (median 3 vs 1 day, p < 0.001), higher 30-day unplanned re-admission rate (4.5% vs 2.4%, p < 0.001) and 30-day mortality (0.6% vs 0.3%, p = 0.008). There was no difference in overall survival between patients who had open or minimally invasive surgery, p = 0.22; 3-yr overall survival rates were 83.7% and 84.4% respectively. After controlling for patient age, tumor histology, substage, type of insurance, type of reporting facility, receipt of radiation therapy and chemotherapy, extent of lymphadenectomy, the presence of comorbidities and personal history of another tumor, minimally invasive surgery was not associated with a worse survival (hazard ratio: 1.06, 95% confidence interval: 0.97, 1.15).ConclusionsMinimally invasive surgery for patients with stage I high grade endometrial cancer, was associated with superior short-term outcomes with no difference in overall survival noted.     

Minimizing the impact of colorectal surgery in the older patient: The role of minimally invasive surgery in the geriatric population

With an aging population comes a greater incidence of colorectal cancer and a corresponding need for surgical resection in the geriatric population. This heterogeneous group of patients may benefit from multidisciplinary pre-operative evaluation and optimization, prehabilitation, enhanced recovery protocols, and a minimally invasive approach to resection. Concerns regarding the ability of the older patient to tolerate the physiologic demands of pneumoperitoneum have not been validated. Conversely, these vulnerable patients may experience a greater reduction in morbidity than their younger counterparts through the use of minimally invasive techniques.     

3D胸腔镜系统在胸部微创手术中的初步应用

背景与目的：随着3D技术的发展,医学腔镜微创外科手术已经进入3D时代。3D全高清腹腔镜手术较传统腹腔镜手术视觉效果更佳、安全性更高的优势已经得到广泛认可。该研究旨在探讨3D胸腔镜系统在胸部微创手术中的初步应用效果。方法：2014年3月—10月使用KARL STORZ 3D胸腔镜系统完成胸腔镜手术96例,包括3D胸腔镜肺叶切除术33例,肺段切除术2例,肺楔形切除术10例,纵隔肿瘤切除术27例,食管肿瘤切除术20例,贲门失弛缓症4例。统计手术时间、术中出血量、胸管引流时间、术后住院日及并发症等数据。结果：96例手术均获成功。手术时间为30~237 min,其中肺局部切除术为30~120 min,平均为52 min;肺叶切除术为63~122 min,平均为75 min;纵隔手术为35~125 min,平均为77 min;食管手术为57~237 min,平均为189 min。术中出血量肺部手术为2~85 mL,平均为50 mL;纵隔手术为15~72 mL,平均为47 mL;食管手术为30~186 mL,平均为118 mL。术后胸管引流时间肺部手术为1~5 d,纵隔手术为1~3 d,食管手术为2~6 d。术后住院日肺部手术为2~10 d,平均为6.3 d;纵隔手术为3~6 d,平均为4.2 d;食管手术为4~19 d,平均为13.3 d。所有患者术后随访3个月均未出现手术并发症或复发转移征象。结论：3D胸腔镜系统既保留了电视胸腔镜手术(video-assisted thoracoscopic surgery,VATS)的微创特点,又兼有高清立体视野下精细操作的优势,手术安全性增高;由于该系统恢复了类似开放手术的自然视觉优势,操作更容易,学习曲线更短。     

超声引导微创旋切术治疗非哺乳期乳腺炎的临床效果

目的探讨超声引导微创旋切术治疗非哺乳期乳腺炎的临床效果。 方法采用回顾性分析方法,选取2013年1月至2016年6月南方医科大学附属小榄医院乳腺外科收治的36例非哺乳期乳腺炎患者作为研究对象,对患者实施超声引导下微创旋切手术,术后辅以持续负压引流,并观察该术式的治疗效果、术后恢复时间和复发情况。 结果本组36例患者经术后病理证实均为浆细胞性乳腺炎或肉芽肿性乳腺炎。术后24例拔管后一期痊愈无复发;8例行局部反复冲洗治愈;4例于术后5个月内出现复发,复发率为11.1%(4/36),再次予以微创手术治疗后痊愈,其余患者术后随访1年未见复发。 结论在非哺乳期乳腺炎的治疗中,采用超声引导微创旋切术具有切口小,患者疼痛轻,复发率低的优点,是非哺乳期乳腺炎有效的治疗方法之一。     

Long-term outcomes following minimally invasive and open esophagectomy in Finland: A population-based study

BackgroundStudies of long-term survival after minimally invasive and open esophagectomy are needed. The aim of this study was to compare long-term outcomes following minimally invasive and open esophagectomy for esophageal cancer at the population level.MethodsAll patients undergoing minimally invasive (n = 159) or open transthoracic (n = 431) esophagectomy for esophageal cancer in Finland between 2004 and 2014 were identified from nationwide registries. Propensity score matching was used to create groups of 150 minimally invasive and open esophagectomies with balanced baseline characteristics (sex, age, comorbidity, center volume, year of surgery, histology, stage (local or locally advanced), and neoadjuvant therapy). The primary outcome was 1-year survival after surgery. Secondary outcomes were the 3-year, 5-year, and 90-day survival.ResultsThe propensity matched 1-year survival rate was 85.3% after minimally invasive and 74.7% after open esophagectomy (adjusted HR 0.53, 95% CI 0.31–0.89; P = 0.0174). At 3 years, those were 68.7% and 55.6% (adjusted HR 0.62; 95% CI 0.43–0.91; P = 0.0144), respectively; at 5 years, survival rates were 61.8% and 51.9% (adjusted HR 0.68, 95% CI 0.47–0.97; P = 0.0347). The 30- and 90-day survival rates after minimally invasive and open surgery were 99.3% vs. 98.0% and 97.3% vs. 92.0%, respectively, without statistical significance.ConclusionsIn this population-based propensity matched study, minimally invasive esophagectomy was associated with improved long-term survival. Due to multiple confounding factors replication studies are needed.     

Use of uterine manipulator in endometrial cancer: A French survey from Francogyn group

IntroductionSince the LACC study in 2018, the use of the uterine manipulator (UM) has been questioned in Oncological surgery. Nowadays, there are few data on UM use in patients eligible for minimally invasive surgery for endometrial cancer. Our objective was to evaluate the practices and modalities of UM use by French onco-gynecologic surgeons in the management of endometrial cancer.MethodsWe surveyed the practices of 3 French medical societies-affiliated onco-gynecological surgeons with a web questionnaire composed of 16 questions.ResultsA total of 165 responses were collected. In the case of minimally invasive hysterectomy for endometrial cancer, the routine use of UM was 42.7%. Of the 40.9% of surgeons who never used UM, 83.6% justified it with the risk of tumor spillage. When UM was used, surgeons mentioned reducing operating time and reducing complications in 67.0% and 59.8% of cases respectively as its main advantages. UM was set up without laparoscopic control in 54.6% of cases. In 47.4% of cases, the medical student was in charge of UM instrumentation. Tubal obliteration at the beginning of the procedure was performed systematically in 35.4% of cases. For 63.5% of UM users, the adjuvant treatment could be modified in case of uterine perforation.ConclusionThis survey confirms the heterogeneity of practices regarding the use of UM in endometrial cancer surgery. Prospective data on the benefit (reduction of surgical complications)/risk (impact on survival) balance are needed to recommend or not the use of this device.     

微创手术治疗前列腺癌的疗效研究

目的：探讨经腹腔入路腹腔镜微创手术治疗前列腺癌患者的临床效果。方法选取经腹腔入路腹腔镜微创手术治疗的53例患者作为微创组,及采用开放经耻骨前列腺癌根治术治疗的47例患者作为对照组,比较两组患者手术相关指标及并发症的发生率。结果两组患者术后淋巴结阳性率、精囊阳性率、切缘阳性率差异均无统计学意义（P﹥0.05）;微创组患者的手术时间长于对照组患者,差异有统计学意义（P﹤0.05）;微创组患者术中出血量、导尿管留置时间、胃肠道功能恢复时间、术后下床时间、住院时间均低于对照组患者,差异有统计学意义（P﹤0.05）;术后3个月、6个月,两组患者尿控率、生化复发率差异均无统计学意义（P﹥0.05）。结论经腹腔入路腹腔镜微创手术治疗前列腺癌与传统开腹手术效果相当,但是具有手术创伤小、恢复快的优势。     

Laparoscopic surgery for endometrial cancer: increasing body mass index does not impact postoperative complications

Objective

To determine the effect of body mass index on postoperative complications and the performance of lymph node dissection in women undergoing laparoscopy or laparotomy for endometrial cancer.

Methods

Retrospective chart review of all patients undergoing surgery for endometrial cancer between 8/2004 and 12/2008. Complications graded and analyzed using Common Toxicity Criteria for Adverse Events ver. 4.03 classification.

Results

168 women underwent surgery: laparoscopy n=65, laparotomy n=103. Overall median body mass index 36.2 (range, 18.1 to 72.7) with similar distributions for age, body mass index and performance of lymph node dissection between groups. Following laparoscopy vs. laparotomy the percent rate of overall complications 53.8:73.8 (p=0.01), grade ≥3 complications 9.2:34.0 (p<0.01), ≥3 wound complications 3.1:22.3 (p<0.01) and ≥3 wound infection 3.1:20.4 (p=0.01) were significantly lower after laparoscopy. In a logistic model there was no effect of body mass index (≥36 and<36) on complications after laparoscopy in contrast to laparotomy. Para-aortic lymph node dissection was performed by laparoscopy 19/65 (29%): by laparotomy 34/103 (33%) p=0.61 and pelvic lymph node dissection by laparoscopy 21/65 (32.3%): by laparotomy 46/103 (44.7%) p=0.11. Logistic regression analysis revealed that for patients undergoing laparoscopy for stage I disease there was an inverse relationship between the performance of both para-aortic lymph node dissection and pelvic lymph node dissection and increasing body mass index (p=0.03 and p<0.01 respectively) in contrast to the laparotomy group where there was a trend only (p=0.09 and 0.05).

Conclusion

For patients undergoing laparoscopy, increasing body mass index did not impact postoperative complications but did influence the decision to perform lymph node dissection.     

Surgery by a minimally invasive approach is associated with improved textbook outcomes in oesophageal and gastric cancer

IntroductionTextbook outcome (TBO) is a composite measure of a number of peri-operative and clinical outcomes in oesophagogastric malignancy. It has previously been shown that TBOs are associated with improved overall survival in both oesophageal and gastric cancer. The influence of a minimally invasive approach (MIA) on TBO is not well defined. The purpose of this study is to validate TBO in our population, examine the influence of a MIA on achieving a TBO, and the impact of TBO on long-term survival.Methods269 patients undergoing oesophagectomy and 258 patients undergoing subtotal or total gastrectomy were included in this study. Demographic, clinical and pathological differences between patients with and without a TBO were compared using univariable and multivariable analysis. Overall survival for those with and without a TBO was examined. The influence of MIA on overall survival and TBO was determined using Cox proportional hazard models.ResultsPatients undergoing oesophagectomy and gastrectomy were significantly more likely to achieve a TBO when MIA was used (p = 0.01 and 0.001 respectively). When MIA is included as an outcome measure patients achieving a TBO show improved overall survival in both oesophageal and gastric cancer. MIA, clear resection margins and no unplanned admission to critical care are the strongest predictors of overall survival from the putative bundle of TBO parameters.ConclusionMinimally invasive surgery is associated with improved TBO. Completion of a minimally invasive approach should be considered for inclusion as a textbook parameter.     

International survey on opinions and use of minimally invasive surgery in small bowel neuroendocrine neoplasms

IntroductionAlthough minimally invasive surgery is becoming the standard technique in gastrointestinal surgery, implementation for small bowel neuroendocrine neoplasms (SB-NEN) is lagging behind. The aim of this international survey was to gain insights into attitudes towards minimally invasive surgery for resection of SB-NEN and current practices.MethodsAn anonymous survey was sent to surgeons between February and May 2021 via (neuro)endocrine and colorectal societies worldwide. The survey consisted of questions regarding experience of the surgeon with minimally invasive SB-NEN resection and training.ResultsA total of 58 responses from five societies across 20 countries were included. Forty-one (71%) respondents worked at academic centers. Thirty-seven (64%) practiced colorectal surgery, 24 (41%) endocrine surgery and 45 (78%) had experience in advanced minimally invasive surgery. An open, laparoscopic or robotic approach was preferred by 23 (42%), 24 (44%), and 8 (15%) respondents, respectively. Reasons to opt for a minimally invasive approach were mainly related to peri-operative benefits, while an open approach was preferred for optimal mesenteric lymphadenectomy and tactile feedback. Additional training in minimally invasive SB-NEN resection was welcomed by 29 (52%) respondents. Forty-three (74%) respondents were interested in collaborating in future studies, with a cumulative median (IQR) annual case load of 172 (86–258).ConclusionsAmong respondents, 69% applies minimally invasive surgery for resection of SB-NEN. Arguments for specific operative approaches differ, and insufficient training in advanced laparoscopic techniques seems to be a barrier. Future collaborative studies can provide better insight in selection criteria and optimal technique.     

Robot-assisted laparoscopy versus laparotomy for infrarenal paraaortic lymphadenectomy in women with high-risk endometrial cancer: A randomised controlled trial

PurposeTo investigate if robot-assisted laparoscopic surgery (RALS) was non-inferior to laparotomy (LT) in harvesting infrarenal paraaortic lymph nodes in patients with presumed stage I–II high-risk endometrial cancer.Patients and methodsPatients with histologically proven endometrial cancer, presumed stage I–II with high-risk tumour features, were randomised to hysterectomy, bilateral salpingo-oophorectomy, pelvic and paraaortic lymphadenectomy by either RALS or LT. Primary outcome was paraaortic lymph node count. Secondary outcomes were perioperative events, postoperative complications and total health care cost.ResultsOverall 120 patients were randomised and 96 patients were included in the per protocol analysis. Demographic, clinical and tumour characteristics were evenly distributed between groups. Mean (±SD) paraaortic lymph node count was 20.9 (±9.6) for RALS and 22 (±11, p = 0.45) for LT. The difference of means was within the non-inferiority margin (−1.6, 95% CI −5.78, 2.57). Mean pelvic node count was lower after RALS (28 ± 10 versus 22 ± 8, p < 0.001). There was no difference in perioperative complications or readmissions between the groups. Operation time was longer (p < 0.001) but total blood loss less (<0.001) and hospital stay shorter (<0.001) in RALS group than LT group. Health care costs for RALS was significantly lower (mean difference $1568 USD/€1225 Euro, p < 0.05).ConclusionOur results demonstrate non-inferiority in paraaortic lymph node count, comparable complication rates, shorter hospital length and lower total cost for RALS over laparotomy. Generalisability of the latter finding requires a high-volume setting and high surgical proficiency. In women with high-risk endometrial cancer confined to the uterus, RALS is a valid treatment modality.Clinical trials registrationsClinicalTrials.gov NCT01847703.     

Integration of robotics into two established programs of minimally invasive surgery for endometrial cancer appears to decrease surgical complications

Objective

To compare peri- and postoperative outcomes and complications of laparoscopic vs. robotic-assisted surgical staging for women with endometrial cancer at two established academic institutions.

Methods

Retrospective chart review of all women that underwent total hysterectomy with pelvic and para-aortic lymphadenectomy by robotic-assisted or laparoscopic approach over a four-year period by three surgeons at two academic institutions. Intraoperative and postoperative complications were measured. Secondary outcomes included operative time, blood loss, transfusion rate, number of lymph nodes retrieved, length of hospital stay and need for re-operation or re-admission.

Results

Four hundred and thirty-two cases were identified: 187 patients with robotic-assisted and 245 with laparoscopic staging. Both groups were statistically comparable in baseline characteristics. The overall rate of intraoperative complications was similar in both groups (1.6% vs. 2.9%, p=0.525) but the rate of urinary tract injuries was statistically higher in the laparoscopic group (2.9% vs. 0%, p=0.020). Patients in the robotic group had shorter hospital stay (1.96 days vs. 2.45 days, p=0.016) but an average 57 minutes longer surgery than the laparoscopic group (218 vs. 161 minutes, p=0.0001). There was less conversion rate (0.5% vs. 4.1%; relative risk, 0.21; 95% confidence interval, 0.03 to 1.34; p=0.027) and estimated blood loss in the robotic than in the laparoscopic group (187 mL vs. 110 mL, p=0.0001). There were no significant differences in blood transfusion rate, number of lymph nodes retrieved, re-operation or re-admission between the two groups.

Conclusion

Robotic-assisted surgery is an acceptable alternative to laparoscopy for staging of endometrial cancer and, in selected patients, it appears to have lower risk of urinary tract injury.     

副乳腺微创切除术

目的探讨微创切除术对副乳腺的疗效。方法用Mammatome微创方法切除副乳腺。结果从2008年8月至2009年8月期间,本院对16例28个腋窝副乳腺进行微创切除术,切口2～3mm,术后48h全部治愈出院,无切口感染、裂开及血肿等并发症发生。结论微创切除术具有操作简单、安全有效及愈合快等优点。     

直肠癌患者微创保肛手术效果研究

目的：探讨直肠癌患者微创保肛手术效果。方法分别采取微创保肛手术和传统手术患者,将100例直肠癌患者随机分为微创保肛组和对照组各50例,对比两组患者的手术效果和手术并发症等情况。结果与对照组相比,微创保肛组患者术中出血量较少[（63.5±9.6）ml vs（89.2±12.7）ml]、手术切口较短[（4.1±0.4）cm vs（6.2±0.8）cm]、手术持续时间较短[（174.5±30.1）min vs（208.4±14.8）min]、住院时间较短[（7.8±0.9）天 vs（9.5±1.2天）]、切口拆线时间较早[（6.6±0.5）天 vs（8.2±1.1）天]、开始排气时间较早[（4.1±0.4）天vs （5.2±0.6）天]、导尿管拔除时间明显较短[（4.0±0.5）天vs（5.4±0.8）天],两组差异均具有统计学意义（均P＜0.001）。微创保肛组患者与对照组患者相比,其总的并发症发生率较低（12%vs 30%,P＝0.027）,大便次数增多的并发症发生率较低（6%vs 20%,P＝0.037）。结论微创保肛术能够提高患者的手术效果,降低术后并发症发生率,值得在临床上广泛应用。     

微创小切口手术对早期胸中下段食管癌患者的治疗效果及对其疼痛的影响

目的 探究微创小切口手术对早期胸中下段食管癌患者的治疗效果及对其疼痛的影响。方法 选取2016年3月—2017年3月在我院接受治疗的早期胸中下段食管癌患者160例,随机分为常规手术组和微创小切口手术组各80例,常规手术组患者使用常规手术治疗,微创小切口手术组患者使用微创小切口手术治疗。对肺活量(Vital capacity,VC)、一秒用力呼气容积(Forced expiratory volume 1,FEV1)检测、视觉模拟评分法(Visual analogue scale,VAS)、住院时间、手术时间及术中出血量进行统计,酶联免疫法检测应激激素如生长激素(Growth hormone,GH)、皮质醇(Cortisol,Cor)、白介素-8(Interleukin-8,IL-8)水平,并对两组患者不良反应发生情况进行统计。结果 微创小切口手术组VC、FEV1水平显著高于常规手术组,出血量、手术时间、及住院时间短于常规手术组,GH、Cor水平、VAS评分、不良反应发生率低于常规手术组,IL-8高于常规手术组,差异均具有统计学意义(P＜0.05)。结论 微创小切口手术治疗早期胸中下段食管癌效果显著,能够缓解患者疼痛,减少不良反应。